Failure of absorption of baclofen after rectal administration

Pediatric Neurology

Volumn 16, Issue 4, 1997, Pages 351-352

  Kriel, Robert L ^a,c   Krach, Linda E ^a   Hoff, David S ^b   Gormley, Mark ^a   Jones Saete, Carolyn ^a  

^a GILLETTE CHILDREN'S SPECIALTY HEALTHCARE   (United States)

^b Zaske and Associates   (United States)

^c HENNEPIN COUNTY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BACLOFEN; BENZODIAZEPINE;

ADULT; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG ABSORPTION; DRUG BLOOD LEVEL; DRUG HALF LIFE; FEMALE; HUMAN; HUMAN EXPERIMENT; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; RECTAL DRUG ADMINISTRATION;

ABSORPTION; ADMINISTRATION, ORAL; ADMINISTRATION, RECTAL; ADULT; BACLOFEN; FEMALE; HUMANS; TREATMENT FAILURE;

EID: 0030809308     PISSN: 08878994     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0887-8994(97)00033-7     Document Type: Article

References (5)

1. Graves NM, Kriel RL. Rectal administration of antiepileptic drugs in children. Pediatr Neurol 1987;3:321-6.
2. Roy CW, Wakefield IR. Baclofen pseudopsychosis: Case report. Paraplegia 1986;24:318-21.
3. Reynolds JEF, ed. Martindale: The extra pharmacopoeia, 13th ed. London: The Pharmaceutical Press, 1993:xxi.
4. Gennaro AR, Chase GD, Gibson MR, et al., eds. Remington's pharmaceutical sciences, 17th ed. Easton, PA: Mack Printing, 1985: 925-6.
5. Steward BH, Kugler AR, Thompson PR, Bockbrader HN. A saturable transport mechanism in the intestinal absorption of gabapentin is the underlying cause of the lack of proprotionality between increasing dose and drug levels in plasma. Pharm Res 1993;10:276-81.