Development and characterization of antibodies against the N terminus of the human dopamine D4 receptor

Journal of Neurochemistry

Volumn 69, Issue 5, 1997, Pages 2169-2178

  Lanau, Fabienne ^a   Brockhaus, Manfred ^a   Pink, J Richard L ^a   Franchet, Christelle ^a   Wildt Perinic, Dunja ^a   Goepfert, Corine ^a   Probst, Alphonse ^b   Hartman, Deborah S ^a,c  

^a Preclinical Neuroscience   (United Kingdom)

^b UNIVERSITY HOSPITAL BASEL   (Switzerland)

^c Hoffman La Roche Department of Metabolic Diseases   (United States)

Author keywords

DFR1 monoclonal antibody; Epitope mapping; Schizophrenia

Indexed keywords

DOPAMINE 4 RECEPTOR; EPITOPE; MONOCLONAL ANTIBODY; RECEPTOR ANTIBODY; RECEPTOR PROTEIN;

ADULT; AGED; AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; BRAIN MEMBRANE; BRAIN TISSUE; CHO CELL; CONTROLLED STUDY; EPITOPE MAPPING; FEMALE; FLOW CYTOMETRY; FLUORESCENCE MICROSCOPY; HUMAN; HUMAN TISSUE; MALE; MOLECULAR WEIGHT; MOUSE; NONHUMAN; PERSONALITY DISORDER; PRIORITY JOURNAL; PROTEIN GLYCOSYLATION; SCHIZOPHRENIA;

ANIMALIA; CRICETINAE; CRICETULUS GRISEUS;

EID: 0030808689     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.1997.69052169.x     Document Type: Article

References (33)

1. Altshul S. F., Gish W., Miller W., Myers E. W., and Lipman D. J. (1990) Basic local alignment search tool. J. Mol. Biol. 215, 403-410.
2. Ashgari V., Sanyal S., Buchwaldt S., Paterson A., Jovanovic V., and Van Tol H. H. M. (1995) Modulation of intracellular cyclic AMP levels by different human dopamine D4 receptor variants. J. Neurochem. 65, 1157-1165.
3. Benjamin J., Li L., Patterson C., Greenberg B. D., Murphy D. L., and Hamer D. H. (1996) Population and familial association between the D4 dopamine receptor gene and measures of novelty seeking. Nat. Genet. 12, 81-84.
4. Carlsson A. and Winblad B. (1976) Influence of age and time interval between death and autopsy in dopamine and 3-methoxytyramine levels in human basal ganglia. J. Neural Transm. 38, 271.
5. Catalano M., Nobile M., Novelli E., Nothen M. M., and Smeraldi E. (1993) Distribution of a novel mutation in the first exon of the human dopamine D4 receptor gene in psychotic patients. Biol. Psychiatry 34, 459-464.
6. Ebstein R. P., Novick O., Umansky R., Priel B., Osher Y., Blaine D., Bennett E. R., Nemanov L., Katz M., and Belmaker R. H. (1996) Dopamine D4 receptor (D4DR) exon III polymorphism associated with the human personality trait of novelty seeking. Nat. Genet. 12, 78-80.
7. Fishburn C. S., Carmon S., and Fuchs S. (1995) Molecular cloning and characterization of the gene encoding the murine D4 dopamine receptor. FEBS Lett. 361, 215-219.
8. Fong T. M. and Strader C. D. (1994) Functional mapping of the ligand binding sites of G-protein coupled receptors. Med. Res. Rev. 14, 387-399.
9. Fu M. (1995) Anti-peptide antibodies against an autoimmune epitope on human muscarinic receptor mimic functional autoantibodies against the same epitope in patients with idiopathic dilated cardiomyopathy. Eur. Heart J. 16 (Suppl. O), 89-91.
10. Galea E., Dupouey P., and Feinstein D. L. (1995) Glial fibrillary acidic protein mRNA isotypes: expression in vitro and in vivo. J. Neurosci. Res. 41, 452-461.
11. LaHoste G. J., Swanson J. M., Wigal S. B., Glabe C., Wigal T., King N., and Kennedy J. L. (1996) Dopamine D4 receptor gene polymorphism is associated with attention deficit hyperactivity disorder. Mol. Psychiatry 1, 121-124.
12. Lanau F., Zenner M.-T., Civelli O., and Hartman D. S. (1997) Epinephrine and norepinephrine act as potent agonists at the recombinant human dopamine D4 receptor. J. Neurochem. 68, 804-812.
13. Lichter J. B., Barr C. L., Kennedy J. L., Van Tol H., Kidd K. K., and Livak K. J. (1993) A hypervariable segment in the human dopamine receptor D4 (DRD4) gene. Hum. Mol. Genet. 2, 767-773.
14. 2 receptor subtypes to protein kinase C. J. Neurochem. 59, 2311-2317.
15. Mansour A., Meng F., Meador-Woodruff J. H., Taylor L. P., Civelli O., and Akil H. (1992) Site-directed mutagenesis of the human dopamine D2 receptor. Eur. J. Pharmacol. 227, 205-214.
16. Matsumoto M., Hidaka K., Tada S., Tasaki Y., and Yamaguchi T. (1995) Full-length cDNA cloning and distribution of human dopamine D4 receptor. Mol. Brain Res. 29, 157-162.
17. Meador-Woodruff J. H., Grandy D. K., Van Tol H. H. M., Damask S. P., Little K. Y., Civelli O., and Watson S. J. (1994) Dopamine receptor gene expression in the human medial temporal lobe. Neuropsychopharmacology 10, 239-248.
18. Mrzljak L., Bergson C., Pappy M., Huff R., Levenson R., and Goldman-Rakic P. S. (1996) Localization of dopamine D4 receptors in GABAergic neurons of the primate brain. Nature 381, 245-248.
19. Murray A. M., Hyde T. M., Knable M. B., Herman M. M., Bigelow L. B., Carter J. M., Weinberger D. R., and Kleinman J. E. (1995) Distribution of putative D4 dopamine receptors in postmortem striatum from patients with schizophrenia. J. Neurosci. 15, 2186-2191.
20. Neve K. A., Cox B. A., Henningsen R. A., Spanoyannis A., and Neve R. L. (1991) Pivotal role for aspartate-80 in the regulation of dopamine D2 receptor affinity for drugs and inhibition of adenylyl cyclase. Mol. Pharmacol. 39, 733-739.
21. Nothen M. M., Cichon S., Hemmer S., Hebebrand J., Remschmidt H., Lehmkuhl G., Poustka F., Schmidt M., Catalano M., Fimmers R., Korner J., Rietschel M., and Propping P. (1994) Human dopamine D4 receptor gene: frequent occurrence of a null allele and observation of homozygosity. Hum. Mol. Genet. 3, 2207-2212.
22. 125I]-L-750,667, a novel radioligand for the dopamine D4 receptor. Mol. Pharmacol. 50, 1658-1664.
23. 4 receptors increased in schizophrenia? J. Neurochem. 63, 1576-1577.
24. Reynolds G. P. and Mason S. (1995) Absence of detectable striatal dopamine D4 receptors in drug-treated schizophrenia. Eur. J. Pharmacol. 281, R5-R6.
25. Richards J. G., Schoch P., Haring P., Takacs B., and Mohler H. (1987) Resolving GABAA/benzodiazepine receptors: cellular and subcellular localization in the CNS with monoclonal antibodies. J. Neurosci. 7, 1866-1886.
26. Riva C. M. and Easter S. S. (1995) Expression of glial fibrillary acidic protein and its relation to tract formation in embryonic zebrafish. J. Comp. Neurol. 359, 365-381.
27. A receptors and benzodiazepine receptors in the brain shown by monoclonal antibodies. Nature 314, 168-171.
28. Schoots O., Sanyal S., Guan H.-C., Jovanovic V., and Van Tol H. H. M. (1996) Cryptic initiation at the human D4 receptor reveals a functional role for the amino terminus. Biochemistry 35, 3614-3618.
29. Seeman P., Guan H. C., and Van Tol H. (1993) Dopamine D4 receptors elevated in schizophrenia [see comments]. Nature 365, 441-445.
30. 3H] raclopride binding in postmortem caudate nucleus of subjects with schizophrenia or major depression. Brain Res. 681, 109-116.
31. Valerio A., Belloni M., Gorno M. L., Tinti C., Memo M., and Spano P. (1994) Dopamine D2, D3, and D4 receptor mRNA levels in rat brain and pituitary during aging. Neurobiol. Aging 15, 713-719.
32. Van Tol H. H. M., Wu C. M., Guan H.-C, Ohara K., Bunzow J. R., Civelli O., Kennedy J., Seeman P., Niznik H. B., and Jovanovic V, (1992) Multiple dopamine D4 receptor variants in the human population. Nature 358, 149-152.
33. 2 dopamine receptor using site-directed mutagenesis. J. Neurochem. 66, 394-402.