메뉴 건너뛰기




Volumn 69, Issue 5, 1997, Pages 2162-2168

Ethanol specifically inhibits NMDA receptors with affinity for ifenprodil in the low micromolar range in cultured cerebellar granule cells

Author keywords

Ethanol; Fura 2; Ifenprodil; Image analysis; NMDA receptors; Rat cerebellar granule cells

Indexed keywords

ALCOHOL; CALCIUM ION; DIZOCILPINE; FURA 2 ACETOXYMETHYL ESTER; GLYCINE; IFENPRODIL; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; POTASSIUM CHLORIDE; RECEPTOR SUBTYPE;

EID: 0030808688     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.1997.69052162.x     Document Type: Article
Times cited : (26)

References (42)
  • 2
  • 3
    • 0028816069 scopus 로고
    • Allosteric regulation of the N-methyl-D-aspartate receptor-linked ion channel complex and effects of ethanol in ethanol-withdrawal seizure-prone and -resistant mice
    • Carter L. A., Belknap J. K., Crabbe J. C., and Janowsky A. (1995) Allosteric regulation of the N-methyl-D-aspartate receptor-linked ion channel complex and effects of ethanol in ethanol-withdrawal seizure-prone and -resistant mice. J. Neurochem. 64, 213-219.
    • (1995) J. Neurochem. , vol.64 , pp. 213-219
    • Carter, L.A.1    Belknap, J.K.2    Crabbe, J.C.3    Janowsky, A.4
  • 4
    • 0024093449 scopus 로고
    • Glutamate neurotoxicity and diseases of the nervous system
    • Choi D.W. (1988) Glutamate neurotoxicity and diseases of the nervous system. Neuron 1, 623-634.
    • (1988) Neuron , vol.1 , pp. 623-634
    • Choi, D.W.1
  • 5
    • 0023180067 scopus 로고
    • NMDA receptors - Their role in long-term potentiation
    • Collingridge G. L. and Bliss T. V. P. (1987) NMDA receptors - their role in long-term potentiation. Trends Neurosci. 10, 288-293.
    • (1987) Trends Neurosci. , vol.10 , pp. 288-293
    • Collingridge, G.L.1    Bliss, T.V.P.2
  • 6
    • 0026646351 scopus 로고
    • Interactions between phospholipase C-coupled and N-methyl-D-aspartate receptors in cultured cerebellar granule cells: Protein kinase C mediated inhibition of N-methyl-D-aspartate responses
    • Courtney M. J. and Nicholls D. G. (1992) Interactions between phospholipase C-coupled and N-methyl-D-aspartate receptors in cultured cerebellar granule cells: protein kinase C mediated inhibition of N-methyl-D-aspartate responses. J. Neurochem. 59, 983-992.
    • (1992) J. Neurochem. , vol.59 , pp. 983-992
    • Courtney, M.J.1    Nicholls, D.G.2
  • 7
    • 0024995941 scopus 로고
    • Dual-component NMDA receptor currents at a single central synapse
    • D'Angelo E., Rossi P., and Garthwaite J. (1990) Dual-component NMDA receptor currents at a single central synapse. Nature 346, 467-469.
    • (1990) Nature , vol.346 , pp. 467-469
    • D'Angelo, E.1    Rossi, P.2    Garthwaite, J.3
  • 12
  • 13
    • 0024348985 scopus 로고
    • N-Methyl-D-aspartate receptors and ethanol: Inhibition of calcium flux and cyclic GMP production
    • Huffman P. L., Rabe C. S., Moses F., and Tabakoff B. (1989) N-Methyl-D-aspartate receptors and ethanol: inhibition of calcium flux and cyclic GMP production. J. Neurochem. 52, 1937-1940.
    • (1989) J. Neurochem. , vol.52 , pp. 1937-1940
    • Huffman, P.L.1    Rabe, C.S.2    Moses, F.3    Tabakoff, B.4
  • 14
    • 0027469106 scopus 로고
    • The glycine site of the NMDA receptor-five years on
    • Kemp J. A. and Leeson P. D. (1993) The glycine site of the NMDA receptor-five years on. Trends Pharmacol. Sci. 14, 20-25.
    • (1993) Trends Pharmacol. Sci. , vol.14 , pp. 20-25
    • Kemp, J.A.1    Leeson, P.D.2
  • 15
    • 0027717219 scopus 로고
    • Ethanol inhibits glutamate-induced currents in heteromeric NMDA receptor subtypes
    • Kuner T., Schoepfer R., and Korpi E. R. (1993) Ethanol inhibits glutamate-induced currents in heteromeric NMDA receptor subtypes. Neuroreport 5, 297-300.
    • (1993) Neuroreport , vol.5 , pp. 297-300
    • Kuner, T.1    Schoepfer, R.2    Korpi, E.R.3
  • 17
    • 0025951641 scopus 로고
    • Ifenprodil blocks N-methyl-D-aspartate receptors by a two-component mechanism
    • Legendre P. and Westbrook G. L. (1991) Ifenprodil blocks N-methyl-D-aspartate receptors by a two-component mechanism. Mol. Pharmacol. 40, 289-298.
    • (1991) Mol. Pharmacol. , vol.40 , pp. 289-298
    • Legendre, P.1    Westbrook, G.L.2
  • 18
    • 0024601948 scopus 로고
    • Ethanol potentiates and blocks NMDA-activated single-channel currents in rat hippocampal pyramidal cells
    • Lima-Landman M. T. R. and Albuquerque E. X. (1989) Ethanol potentiates and blocks NMDA-activated single-channel currents in rat hippocampal pyramidal cells. FEBS Lett. 247, 61-67.
    • (1989) FEBS Lett. , vol.247 , pp. 61-67
    • Lima-Landman, M.T.R.1    Albuquerque, E.X.2
  • 19
    • 0028998695 scopus 로고
    • Developmental decrease in ethanol inhibition of N-methyl-D-aspartate receptors in rat neocortical neurons: Relation to the actions of ifenprodil
    • Lovinger D. M. (1995) Developmental decrease in ethanol inhibition of N-methyl-D-aspartate receptors in rat neocortical neurons: relation to the actions of ifenprodil. J. Pharmacol. Exp. Ther. 274, 164-172.
    • (1995) J. Pharmacol. Exp. Ther. , vol.274 , pp. 164-172
    • Lovinger, D.M.1
  • 20
    • 0024535962 scopus 로고
    • Ethanol inhibits NMDA-activated ion current in hippocampal neurons
    • Lovinger D. M., White G., and Weight F. F. (1989) Ethanol inhibits NMDA-activated ion current in hippocampal neurons. Science 243, 1721-1724.
    • (1989) Science , vol.243 , pp. 1721-1724
    • Lovinger, D.M.1    White, G.2    Weight, F.F.3
  • 21
    • 0025407309 scopus 로고
    • NMDA receptor-mediated synaptic excitation selectively inhibited by ethanol in hippocampal slice from adult rat
    • Lovinger D. M., White G., and Weight F. F. (1990) NMDA receptor-mediated synaptic excitation selectively inhibited by ethanol in hippocampal slice from adult rat. J. Neurosci. 10, 1372-1379.
    • (1990) J. Neurosci. , vol.10 , pp. 1372-1379
    • Lovinger, D.M.1    White, G.2    Weight, F.F.3
  • 22
    • 0023125256 scopus 로고
    • The physiology of excitatory amino acids in the central nervous system
    • Mayer M. L. and Westbrook G. L. (1987a) The physiology of excitatory amino acids in the central nervous system. Prog. Neurobiol. 28, 197-276.
    • (1987) Prog. Neurobiol. , vol.28 , pp. 197-276
    • Mayer, M.L.1    Westbrook, G.L.2
  • 23
    • 1842313410 scopus 로고
    • Cellular mechanisms underlying excitotoxicity
    • Mayer M. L. and Westbrook G. L. (1987b) Cellular mechanisms underlying excitotoxicity. Trends Neurosci. 12, 444-450.
    • (1987) Trends Neurosci. , vol.12 , pp. 444-450
    • Mayer, M.L.1    Westbrook, G.L.2
  • 25
    • 0021978874 scopus 로고
    • Are the toxicities of pentobarbital and ethanol mediated by the GABA-benzodiazepine receptor-chloride ionophore complex?
    • Mendelson W. B., Martin J. V., Wagner R., Roseberry C., Skolnick P., Weissman B. A., and Squires R. (1985) Are the toxicities of pentobarbital and ethanol mediated by the GABA-benzodiazepine receptor-chloride ionophore complex? Eur. J. Pharmacol. 108, 63-70.
    • (1985) Eur. J. Pharmacol. , vol.108 , pp. 63-70
    • Mendelson, W.B.1    Martin, J.V.2    Wagner, R.3    Roseberry, C.4    Skolnick, P.5    Weissman, B.A.6    Squires, R.7
  • 27
    • 0028117645 scopus 로고
    • 3H] ifenprodil sites in the rat brain: Possible relationship to NMDAR2B receptors and calmodulin
    • 3H] ifenprodil sites in the rat brain: possible relationship to NMDAR2B receptors and calmodulin. J. Neurochem. 63, 2248-2258.
    • (1994) J. Neurochem. , vol.63 , pp. 2248-2258
    • Nicolas, C.1    Carter, C.2
  • 28
    • 0028324378 scopus 로고
    • 3H] spermidine from rat striatal slices in vitro
    • 3H] spermidine from rat striatal slices in vitro. J. Neumchem. 62, 1835-1839.
    • (1994) J. Neumchem. , vol.62 , pp. 1835-1839
    • Nicolas, C.1    Fage, D.2    Carter, C.3
  • 29
    • 0025285784 scopus 로고
    • Glycine site associated with the NMDA receptor modulates long-term potentiation
    • Oliver M. W., Kessler M., Larson J., Schottler F., and Lynch G. (1990) Glycine site associated with the NMDA receptor modulates long-term potentiation. Synapse 5, 265-270.
    • (1990) Synapse , vol.5 , pp. 265-270
    • Oliver, M.W.1    Kessler, M.2    Larson, J.3    Schottler, F.4    Lynch, G.5
  • 30
    • 0025230835 scopus 로고
    • Role of glycine in the N-methyl-D-aspartate mediated neuronal cytotoxicity
    • Patel J., Zinkand W. C., Thompson C., Keith R., and Salama A. (1990) Role of glycine in the N-methyl-D-aspartate mediated neuronal cytotoxicity. J. Neurochem. 54, 849-854.
    • (1990) J. Neurochem. , vol.54 , pp. 849-854
    • Patel, J.1    Zinkand, W.C.2    Thompson, C.3    Keith, R.4    Salama, A.5
  • 31
    • 0027939614 scopus 로고
    • Subtypes of NMDA receptor in neurones cultured from rat brain
    • Priestly T., Ochu E., and Kemp J. A. (1994) Subtypes of NMDA receptor in neurones cultured from rat brain. Neuroreport 5, 1763-1765.
    • (1994) Neuroreport , vol.5 , pp. 1763-1765
    • Priestly, T.1    Ochu, E.2    Kemp, J.A.3
  • 32
    • 0025684618 scopus 로고
    • Glycine site-directed agonists reverse the actions of ethanol at the N-methyl-D-aspartate receptor
    • Rabe C. S. and Tabakoff B. (1990) Glycine site-directed agonists reverse the actions of ethanol at the N-methyl-D-aspartate receptor. Mol. Pharmacol. 38, 753-757.
    • (1990) Mol. Pharmacol. , vol.38 , pp. 753-757
    • Rabe, C.S.1    Tabakoff, B.2
  • 33
    • 0028219211 scopus 로고
    • Changing subunit composition of heteromeric NMDA receptors during development of rat cortex
    • Sheng M., Cummings J., Roldan L. A., Jan Y. N., and Jan L. Y. (1994) Changing subunit composition of heteromeric NMDA receptors during development of rat cortex. Nature 368, 144-147.
    • (1994) Nature , vol.368 , pp. 144-147
    • Sheng, M.1    Cummings, J.2    Roldan, L.A.3    Jan, Y.N.4    Jan, L.Y.5
  • 34
    • 0027510699 scopus 로고
    • Inhibition of NMDA-evoked electrophysiological activity by ethanol in selected brain regions: Evidence for ethanol-sensitive and ethanol-insensitive NMDA-evoked responses
    • Simson P. E., Criswell H. E., and Breese G. R. (1993) Inhibition of NMDA-evoked electrophysiological activity by ethanol in selected brain regions: evidence for ethanol-sensitive and ethanol-insensitive NMDA-evoked responses. Brain Res. 607, 9-16.
    • (1993) Brain Res. , vol.607 , pp. 9-16
    • Simson, P.E.1    Criswell, H.E.2    Breese, G.R.3
  • 35
    • 0027405992 scopus 로고
    • Radioligand binding to the N-methyl-D-aspartate receptor/ionophore complex: Alterations by ethanol in vitro and by chronic in vivo ethanol ingestion
    • Snell L. D., Tabakoff B., and Hoffman P. L. (1993) Radioligand binding to the N-methyl-D-aspartate receptor/ionophore complex: alterations by ethanol in vitro and by chronic in vivo ethanol ingestion. Brain Res. 602, 91-98.
    • (1993) Brain Res. , vol.602 , pp. 91-98
    • Snell, L.D.1    Tabakoff, B.2    Hoffman, P.L.3
  • 36
    • 0005208313 scopus 로고
    • Ethanol stimulates γ-aminobutyric acid receptor-mediated chloride transport in rat brain synaptoneurosomes
    • Suzdak P. D., Schwatz R. D., Skolnick P., and Paul S. M. (1986) Ethanol stimulates γ-aminobutyric acid receptor-mediated chloride transport in rat brain synaptoneurosomes. Proc. Natl. Acad. Sci. USA 83, 4071-4075.
    • (1986) Proc. Natl. Acad. Sci. USA , vol.83 , pp. 4071-4075
    • Suzdak, P.D.1    Schwatz, R.D.2    Skolnick, P.3    Paul, S.M.4
  • 37
    • 0027440215 scopus 로고
    • Preferential co-assembly of recombinant NMDA receptors composed of three different subunits
    • Wafford K. A., Bain C. J., Le Bourdelles B., Whiting P. J., and Kemp J. A. (1993) Preferential co-assembly of recombinant NMDA receptors composed of three different subunits. Neuroreport 4, 1347-1349.
    • (1993) Neuroreport , vol.4 , pp. 1347-1349
    • Wafford, K.A.1    Bain, C.J.2    Le Bourdelles, B.3    Whiting, P.J.4    Kemp, J.A.5
  • 38
    • 0025096750 scopus 로고
    • Ethanol inhibits NMDA-activated current but does not alter GABA-activated current in an isolated adult mammalian neuron
    • White G., Lovinger D. M., and Weight F. F. (1990) Ethanol inhibits NMDA-activated current but does not alter GABA-activated current in an isolated adult mammalian neuron. Brain Res. 507, 332-336.
    • (1990) Brain Res. , vol.507 , pp. 332-336
    • White, G.1    Lovinger, D.M.2    Weight, F.F.3
  • 39
    • 0027525324 scopus 로고
    • Ifenprodil discriminates subtypes of the N-methyl-D-aspartate receptor: Selectivity and mechanisms at recombinant heteromeric receptors
    • Williams K. (1993) Ifenprodil discriminates subtypes of the N-methyl-D-aspartate receptor: selectivity and mechanisms at recombinant heteromeric receptors. Mol. Pharmacol. 44, 851-859.
    • (1993) Mol. Pharmacol. , vol.44 , pp. 851-859
    • Williams, K.1
  • 40
    • 0027405347 scopus 로고
    • Developmental switch in the expression of NMDA receptors occurs in vivo and in vitro
    • Williams K., Russell S. L., Shen Y. M., and Molinoff P. B. (1993) Developmental switch in the expression of NMDA receptors occurs in vivo and in vitro. Neuron 10, 267-278.
    • (1993) Neuron , vol.10 , pp. 267-278
    • Williams, K.1    Russell, S.L.2    Shen, Y.M.3    Molinoff, P.B.4
  • 41
    • 0025019986 scopus 로고
    • Ethanol inhibition of N-methyl-D-aspartate-stimulated endogenous dopamine release from rat striatal slices: Reversal by glycine
    • Woodward J. J. and Gonzales R. A. (1990) Ethanol inhibition of N-methyl-D-aspartate-stimulated endogenous dopamine release from rat striatal slices: reversal by glycine. J. Neurochem. 54, 712-715.
    • (1990) J. Neurochem. , vol.54 , pp. 712-715
    • Woodward, J.J.1    Gonzales, R.A.2
  • 42
    • 0028873973 scopus 로고
    • Expression of mRNAs encoding subunits of the NMDA receptor in developing rat brain
    • Zhong J., Carrozza D. P., Williams K., Pritchett D. B., and Molinoff P. B. (1995) Expression of mRNAs encoding subunits of the NMDA receptor in developing rat brain. J. Neurochem. 64, 531-539.
    • (1995) J. Neurochem. , vol.64 , pp. 531-539
    • Zhong, J.1    Carrozza, D.P.2    Williams, K.3    Pritchett, D.B.4    Molinoff, P.B.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.