H-ras oncogene point mutations in arthritic synovium

Arthritis and Rheumatism

Volumn 40, Issue 9, 1997, Pages 1636-1643

  Roivainen, Anne ^a,b   Jalava, Jari ^a   Pirilä, Laura ^a   Yli Jama, Tuomas ^a   Tiusanen, Hannu ^a   Toivanen, Paavo ^a  

^a TURKU UNIVERSITY   (Finland)

^b UNIVERSITY OF TURKU   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; AGED; ARTICLE; CODON; CONTROLLED STUDY; FEMALE; GENE ACTIVATION; HUMAN; HUMAN TISSUE; MAJOR CLINICAL STUDY; MALE; ONCOGENE H RAS; OSTEOARTHRITIS; POINT MUTATION; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; RHEUMATOID ARTHRITIS; SYNOVIUM;

ADULT; AGED; ARTHRITIS, RHEUMATOID; BASE SEQUENCE; DNA; DNA PRIMERS; DNA PROBES; FEMALE; GENES, RAS; HUMANS; MALE; MIDDLE AGED; MOLECULAR SEQUENCE DATA; OSTEOARTHRITIS; POINT MUTATION; POLYMERASE CHAIN REACTION; POLYMORPHISM, RESTRICTION FRAGMENT LENGTH; PROTO-ONCOGENE PROTEINS P21(RAS); SYNOVIAL MEMBRANE;

EID: 0030808458     PISSN: 00043591     EISSN: None     Source Type: Journal    
DOI: 10.1002/art.1780400913     Document Type: Article

References (40)

1. Gay S, Gay RE: Cellular basis and oncogene expression of rheumatoid joint destruction. Rheumatol Int 9:105-113, 1989
2. Hamilton JA: Hypothesis: in vitro evidence for the invasive and tumor-like properties of the rheumatoid pannus. J Rheumatol 10:845-851, 1983
3. Bromley M, Woolley DE: Histopathology of the rheumatoid lesion: identification of cell types at sites of cartilage erosion. Arthritis Rheum 27:857-863, 1984
4. Lafyatis R, Remmers EF, Roberts AB, Yocum DE, Sporn MB, Wilder RL: Anchorage-independent growth of synoviocytes from arthritic and normal joints: stimulation by exogenous platelet derived growth factor and inhibition by transforming growth factor-beta and retinoids. J Clin Invest 83:1267-1276, 1989
5. Brinckerhoff CE, Harris ED Jr: Survival of rheumatoid synovium implanted into nude mice. Am J Pathol 103:411-419, 1981
6. Moodie SA, Willumsen BM, Weber MJ, Wolfman A: Complexes of Ras.GTP with Raf-1 and mitogen activated protein kinase kinase. Science 260:1658-1661, 1993
7. Bourne HR, Sanders DA, McCormick F: The GTPase superfamily: conserved structure and molecular mechanism. Nature 349: 117-127, 1991
8. Bos JL: The ras gene family and human carcinogenesis. Mutat Res 195:255-271, 1988
9. Barbacid M: Ras oncogenes: their role in neoplasm. Eur J Clin Invest 20:225-235, 1990
10. Roivainen A, Isomäki P, Nikkari S, Saario R, Vuori K, Toivanen P: Oncogene expression in synovial fluid cells in reactive and early rheumatoid arthritis: a brief report. Br J Rheumatol 34:805-808, 1995
11. Roivainen A, Söderström K-O, Pirilä L, Aro H, Kortekangas P, Merilahti-Palo R, Yli-Jama T, Toivanen A, Toivanen P: Oncoprotein expression in human synovial tissue: an immunohistochemical study of different types of arthritis. Br J Rheumatol 35:933-942, 1996
12. Roivainen A, Jalava J, Pirilä L, Yli-Jama T, Toivanen P: H-ras oncogene point mutations in arthritic synovium (abstract). Arthritis Rheum 39 (suppl 9):S192, 1996
13. Arnett FC, Edworthy SM, Bloch DA, McShane DJ, Fries JF, Cooper NS, Healey LA, Kaplan SR, Liang MH, Luthra HS, Medsger TA Jr, Mitchell DM, Neustadt DH, Pinals RS, Schaller JG, Sharp JT, Wilder RL, Hunder GG: The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum 31:315-324, 1988
14. Altman R: Classification of disease: osteoarthritis. Semin Arthritis Rheum 20:40-47, 1991
15. Reddy EP, Reynolds RK, Santos E, Barbacid M: A point mutation is responsible for the acquisition of transforming properties by the T24 human bladder carcinoma oncogene. Nature 300:149-152, 1982
16. Capon DJ, Seeburg PH, McGrath JP, Hayflick JS, Edman U, Levinson AD, Goeddel DV: Activation of Ki-ras2 gene in human colon and lung carcinomas by two different point mutations. Nature 304:507-513, 1983
17. Tainsky M, Cooper CS, Giovanetta BC, Woude GFV: An activated rasN gene: detected in late but not early passage human PA1 teratocarcinoma cells. Science 225:643-645, 1984
18. Bos JL, Vries MV, Jansen AM, Veeneman GH, van Boom JH, van der Eb AJ: Three different mutations in codon 61 of the human N-ras gene detected by synthetic oligonucleotide hybridization. Nucleic Acid Res 12:155-163, 1984
19. Chirgwin JM, Przybyla AE, McDonald RJ, Rutter WJ: Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease. Biochemistry 18:5294-5299, 1979
20. Saiki RK, Gelefand DH, Stoffel S, Scharf SJ, Higuchi R, Horn GT, Mullis KB, Erlich HA: Primer-directed enzymatic amplification of DNA with a thermostable DNA polymerase. Science 239:487-491, 1988
21. Padua RA, Carter G, Hughes D, Gow J, Farr C, Oscier D, McCormick F, Jacobs A: Ras mutations in myelodysplasia detected by amplification, oligonucleotide hybridization and transformation. Leukemia 2:503-510, 1988
22. Oncogene Science: 1994 Research Products Catalog. Uniondale, NY, Oncogene Science, Inc., 1994
23. Case JP, Lafyatis R, Remmers EF, Kumkumian GK, Wilder RL: Transin/stromelysin expression in rheumatoid synovium. Am J Pathol 135:1055-1064, 1989
24. Trabandt A, Aicher WK, Gay RE, Sukhatme VP, Nilson-Hamilton M, Hamilton RT, Mcghee JR, Fassbender HG, Gay S: Expression of the collagenolytic and ras-induced cysteine proteinase cathepsin L and proliferation-associated oncogenes in synovial cells of MRL/I mice and patients with rheumatoid arthritis. Matrix 10: 349-361, 1990
25. Anders M, Krohn K, Kröger H, Huser H, Sparmann M, Meissner A, Gombert W: Proto-oncogene expression in cultured synovial fibroblasts of patients with rheumatoid arthritis. Mol Cell Probes 5:207-213, 1991
26. Trabandt A, Aicher WK, Gay RE, Sukhatme VP, Fassbender HG, Gay S: Spontaneous expression of immediately-early response genes c-fos and egr-1 in collagenase-producing rheumatoid synovial fibroblasts. Rheumatol Int 12:53-59, 1992
27. Ritchlin C, Dwyer E, Bucala R, Winchester R: Sustained and distinctive patterns of gene activation in synovial fibroblasts and whole synovial tissue obtained from inflammatory synovitis. Scand J Immunol 40:292-298, 1994
28. Kinne RW, Boehm S, Iftner T, Aigner T, Vornehm S, Weseloh G, Bravo R, Emmrich F, Kroczek RA: Synovial fibroblast-like cells strongly express jun-B and c-fos proto-oncogenes in rheumatoid-and osteoarthritis. Scand J Rheumatol 24:121-125, 1995
29. Leren TP, Rødingen OK, Røsby O, Solberg K, Berg K: Screening for point mutations by semi-automated DNA sequencing using Sequenase® and magnetic beads. Biotechniques 14:618-623, 1993
30. Tanaka K, Wood DR, Lin BK, Khalili M, Tamanoi F, Cannon JF: A dominant activating mutation in the effector region of RAS abolishes IRA2 sensitivity. Mol Cell Biol 12:631-637, 1992
31. Santos E, Nebreda AR: Structural and functional properties of ras proteins. FASEB J 3:2151-2163, 1989
32. Barbacid M: Ras genes. Annu Rev Biochem 56:779-827, 1987
33. Reynolds SH, Stowers SJ, Patterson RM, Maronpot RR, Aaronson SA, Anderson MW: Activated oncogenes in B6C3F1 mouse liver tumors: implications for risk assessment. Science 237:1309-1316, 1987
34. Sloan SR, Newcomb EW, Pellicer A: Neutron radiation can activate K-ras via a point mutation in codon 146 and induces a different spectrum of ras mutations than does gamma radiation. Mol Cell Biol 10:405-408, 1990
35. Quilliam LA, Zhong S, Rabun KM, Carpenter JW, South TL, Der CJ, Campbell-Burk S: Biological and structural characterization of a Ras transforming mutation at the phenylalanine-156 residue, which is conserved in all members of the Ras superfamily. Proc Natl Acad Sci U S A 92:1272-1276, 1995
36. Howe LR, Leevers SJ, Gomez N, Nakielny S, Cohen P, Marshall CJ: Activation of the MAP kinase pathway by the protein kinase raf. Cell 71:335-342, 1992
37. Wasylyk C, Wasylyk B, Heidecker G, Huleihel M, Rapp UR: Expression of Raf oncogenes activates the PEA1 transcription factor motif. Mol Cell Biol 9:2247-2250, 1989
38. Pankov R, Umezawa A, Maki R, Der CJ, Hauser CA, Oshima R: Oncogene activation of human keratin 18 transcription via the Ras signal transduction pathway. Proc Natl Acad Sci U S A 91:873-877, 1994
39. Liang P, Averboukh L, Zhu W, Pardee AB: Ras activation of genes: Mob-1 as a model. Proc Natl Acad Sci U S A 91:12515-12519, 1994
40. Mangues R, Symmans WF, Lu S, Schwartz S, Pellicer A: Activated N-ras oncogene and N-ras proto-oncogene act through the same pathway for in vivo tumorigenesis. Oncogene 13:1053-1063, 1996