Effect of N-nitrosodiethylamine on lipid peroxidation and antioxidant enzymes in rat liver mitochondria: Protective role of antioxidants

Bulletin of Environmental Contamination and Toxicology

Volumn 59, Issue 2, 1997, Pages 254-260

  Bansal, A K ^a   Bhatnagar, D ^b   Soni, G L ^c  

^a GOVERNMENT MEDICAL COLLEGE   (India)

^b DEVI AHILYA UNIVERSITY   (India)

^c PUNJAB AGRICULTURAL UNIVERSITY   (India)

Author keywords

[No Author keywords available]

Indexed keywords

1 CHLORO 2,4 DINITROBENZENE; ANTIOXIDANT; ASCORBIC ACID; BENZOIC ACID; CATALASE; CUMENE HYDROPEROXIDE; DIETHYLNITROSAMINE; EDETIC ACID; FREE RADICAL; GLUTATHIONE PEROXIDASE; GLUTATHIONE REDUCTASE; GLUTATHIONE TRANSFERASE; MALONALDEHYDE; SUCCINIC ACID; SUPEROXIDE DISMUTASE; THIOBARBITURIC ACID;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; LIPID PEROXIDATION; LIVER MITOCHONDRION; MALE; NONHUMAN; OXIDATIVE STRESS; PHOTOLYSIS; RAT;

ANIMALS; ANTI-ULCER AGENTS; ANTIOXIDANTS; ASCORBIC ACID; CARCINOGENS; CATALASE; DIETHYLNITROSAMINE; DRUG INTERACTIONS; FREE RADICALS; GLUTATHIONE; GLUTATHIONE PEROXIDASE; GLUTATHIONE REDUCTASE; GLUTATHIONE TRANSFERASE; LIPID PEROXIDATION; MALE; MALONDIALDEHYDE; MITOCHONDRIA, LIVER; RATS; RATS, WISTAR; SUCCINIC ACID; SUPEROXIDE DISMUTASE; THIOBARBITURATES; VITAMIN E;

ANIMALIA;

EID: 0030808358     PISSN: 00074861     EISSN: None     Source Type: Journal    
DOI: 10.1007/s001289900472     Document Type: Article

References (24)

1. Aebi HE (1983) Catalase. In: Bergmeyer HU (ed) Methods in Enzymatic Analysis, Vol 3. Academic Press, New York, p 276-286
2. Bartsch H, Hietanen E, Malaveille C (1989) Carcinogenic nitrosamines:Free radical aspects of their action. Free Radic Biol Med 7:637-644
3. Bindoli A (1988) Lipid peroxidation in mitochondria. Free Radic Biol Med 5:247-261
4. Boitier E, Meradboudia M, Guguenguillouzo C, Defer N, Ceballospicot I, Leroux JP, Marsac C (1995) Impairment of the mitochondrial respiratory chain activity in diethylnitrosamine-induced rat hepatomas-possible involvement of oxygen free radicals. Cancer Res 55:3028-3035
5. Carlberg I, Mannervik B (1985) Glutathione reductase. Meth Enzymol 113:484-490
6. Cavallini L, Valente M, Bindoli A (1984) On the mechanism of inhibition of lipid peroxidation by manganese. Inorg Chim Acta 91:117-120
7. Daum G (1985) Lipids of mitochondria. Biochim Biophys Acta 882:1-42
8. Frei B, England L, Ames BN (1989) Ascorbate is an outstanding antioxidant in human blood plasma. Proc Natl Acad Sci USA 86:6377-6381
9. Gutteridge JMC, Richmond R, Halliwell B (1979) Inhibition of the iron-catalyzed formation of hydroxyl radicals from superoxide and of lipid peroxidation by desferrioxamine. Biochem J 184:469-472
10. Habig WH, Pabst MJ, Jakoby WB (1974) Glutathione S-transferases: The first enzymatic step in mercapturic acid formation. J Bio Chem 249:7130-7139
11. Halliwell B, Gutteridge JMC, Cross CE (1992) Free radicals, antioxidants and human disease: where are we now? J Lab Clin Med 119:598-620
12. Lowry OH, Rosenbrough NJ, Farr AL, Randall RJ (1951) Protein measurement with Folin-phenol reagent. J Biol Chem 193:265-275
13. Magee PN, Barnes JM (1956) The production of malignant primary hepatic tumours in the rat by feeding dimethylnitrosamine. Br J Cancer 10:114-122
14. Marklund S, Marklund G (1974) Involvement of the superoxide anion radical in the autooxidation of pyrogallol and a convenient assay for superoxide dismutase. Eur J Biochem 47:469-474
15. Meszaros L, Tihanyi K, Horvath I (1982) Mitochondrial substrate oxidation-dependent protection against lipid peroxidation. Biochim Biophys Acta 713:675-677
16. Morehouse LA, Thomas CE, Aust SD (1984) Superoxide generation by NADPH-cytochrome P-450 reductase The effect of iron chelators and the role of superoxide in microsomal lipid peroxidation. Arch Biochem Biophys 232: 366-377
17. Mustafa MG (1974) Augmentation of mitochondrial oxidation in lung tissue during recovery of animal from ozone exposure. Arch Biochem Biophys 165:531-538
18. Ohkawa H, Ohishi N, Yagi K (1979) Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biochem 95:351-358
19. Paglia DE, Valentine WN (1967) Studies on the quantitative characterization of erythrocyte glutathione peroxidase. J Lab Clin Med 70:158-169
20. Scanlan RA (1983) Formation and occurence of nitrosamines in food. Can Res (Suppl) 43:2435s-2440s
21. Sies H (1991) Oxidative stress, oxidants and antioxidants Academic Press, New York
22. Song PJ, Hu JF (1988) N-nitrosamines in Chinese foods. Fd Chem Toxicol 26:205-208
23. Sottocasa GL (1976) The isolation of mitochondria and their membranes. In: Maddy AH (ed) Biochemical Analysis of Membranes. John Wiley, New York, p 55-78
24. Szabados GY, Tretter L, Horvath I (1989) Lipid peroxidation in liver and ehrlich ascites cell mitochondria Free Rad Res Commun 7:161-170