G proteins and regulation of pyruvate dehydrogenase activity by insulin in human circulating lymphocytes

International Journal of Biochemistry and Cell Biology

Volumn 29, Issue 10, 1997, Pages 1207-1217

  Curto, Magda ^a   Piccinini, Marco ^a   Rabbone, Ivana ^a   Mioletti, Silvia ^a   Mostert, Michael ^a   Bruno, Renato ^a   Rinaudo, Maria T ^a  

^a UNIVERSITY OF TURIN   (Italy)

Author keywords

G proteins; Insulin; Pertussis toxin; Pyruvate dehydrogenase

Indexed keywords

GUANINE NUCLEOTIDE BINDING PROTEIN; INSULIN; PERTUSSIS TOXIN; PYRUVATE DEHYDROGENASE;

ARTICLE; CELL CULTURE; CONTROLLED STUDY; ENZYME ACTIVITY; GLUCOSE OXIDATION; HUMAN; HUMAN CELL; IN VITRO STUDY; LYMPHOCYTE; NORMAL HUMAN;

ADENOSINE DIPHOSPHATE RIBOSE; ADULT; CELL MEMBRANE; GTP-BINDING PROTEINS; HUMANS; HYPOGLYCEMIC AGENTS; INSULIN; MIDDLE AGED; PERTUSSIS TOXIN; PYRUVATE DEHYDROGENASE COMPLEX; T-LYMPHOCYTES; VIRULENCE FACTORS, BORDETELLA;

EID: 0030807779     PISSN: 13572725     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1357-2725(97)00049-6     Document Type: Article

References (50)

1. i protein in adipocytes from streptozocin-induced diabetic rats. Biochem. Soc. Symp. 56, 137-154.
2. Casey P. J. and Gilman A. G. (1988) G protein involvement in receptor-effector coupling. J. Biol. Chem. 263, 2577-2580.
3. Ciaraidi T. P. and Maisel A. (1989) Role of guanine nucleotide regulatory proteins in insulin stimulation of glucose transport in rat adipocytes. Influence of bacterial toxins. Biochem. J. 264, 389-396.
4. Curto M., Piccinini M., Bruno R., Mostert M. and Rinaudo M. T. (1988) Insulin modulation of pyruvate dehydrogenase in human circulating lymphocytes. Int. J. Biochem. 20, 1211-1217.
5. Curto M., Piccinini M., Cerutti F., Rabbone I., Mostert M., Sacchetti C., Bruno R. and Rinaudo M. T. (1992) The insulin signal and its effects on the pyruvate dehydrogenase complex in circulating lymphocytes of obese children. Int. J. Biochem. 24, 831-837.
6. Denton R. M. and Tavaré J. M. (1995) Does mitogen-activated-protein kinase have a role in insulin action? The cases for and against. Eur. J. Biochem. 227, 597-611.
7. Exton J. H. (1991) Some thoughts on the mechanism of action of insulin. Diabetes 40, 521-526.
8. i activity in diabetes. Nature 327, 229-232.
9. Gilman A. G. (1987) G proteins: transducers of receptor-generated signals. Annu. Rev. Biochem. 56, 615-649.
10. Goren H. J., Northup J. K. and Hollenberg M. D. (1985) Action of insulin modulated by pertussis toxin in rat adipocytes. Can. J. Physiol. Pharmacol. 63, 1017-1022.
11. i protein in adipocytes from streptozocin-induced diabetic rats. Diabetes 40, 88-94.
12. Hagg S. A., Taylor S. I. and Ruderman N. B. (1976) Glucose metabolism in perfused skeletal muscle. Pyruvate dehydrogenase activity in starvation, diabetes and exercise. Biochem. J. 158, 203-210.
13. Heyworth C. M., Grey A.-M., Wilson S. R., Hanski E. and Houslay M. D. (1986) The action of islet activating protein (pertussis toxin) on insulin's ability to inhibit adenylate cyclase and activate cyclic AMP phosphodiesterase in hepatocytes. Biochem. J. 235, 145-149.
14. i into pyruvate dehydrogenase phosphate in mitochondria from control and insulin-treated adipose tissue. Nature 264, 471-473.
15. Jarett I. and Kiechle F. (1984) Intracellular mediators of insulin action. Vitam. Horm. 41, 51-78.
16. Jarett L., Kiechle F. L., Popp D. A., Kotagal N. and Gavin J. R. (1980) Differences in the effect of insulin on the generation by adipocytes and IM-9 lymphocytes of a chemical mediator which stimulates the action of insulin on pyruvate dehydrogenase. Biochem. Biophys. Res. Commun. 96, 715-741.
17. Katada T. and Ui M. (1982) Direct modification of the membrane adenylate cyclase system by islet-activating protein due to ADP-ribosylation of a membrane protein. Proc. Natl. Acad. Sci. U.S.A. 79, 3129-3133.
18. Kaziro Y., Hiroshi I., Kozasa T., Nakafuku M. and Satoh T. (1991) Structure and function of signal-transducing GTP binding-proteins. Annu. Rev. Biochem. 60, 349-400.
19. Laemmli U. K. (1970) Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227, 680-685.
20. Lilley K., Zhang C, Villar-Palasi C., Lamer J. and Huang L. (1992) Insulin mediator stimulation of pyruvate dehydrogenase phosphatase. Arch. Biochem. Biophys. 296, 170-174.
21. Lowry O. H., Rosenbrough N. J., Farr A. L. and Randall R. J. (1951) Protein measurement with the Folin phenol reagent. J. Biol. Chem. 193, 265-275.
22. 3H-1 murine myocytes. J. Biol. Chem. 263, 6134-6141.
23. 3H-1 murine myocytes. J. Biol. Chem. 265, 16873-16879.
24. Mandarino L. J., Madar Z., Kolterman O. I., Bell J. M. and Olefsky L. J. (1986) Adipocyte glycogen synthase and pyruvate dehydrogenase in obese and type II diabetic subjects. Am. J. Physiol. 251, E489-E496.
25. Milligan G., Mullaney I. and McKenzie F. R. (1990) Specificity of interactions of receptors and effectors with GTP-binding proteins in native membranes. Biochem. Soc. Symp. 56, 21-34.
26. Moreno F. I., Mills L, Garcia-Sàinz J. A. and Fain J. N. (1983) Effects of pertussis toxin treatment on the metabolism of rat adipocytes. J. Biol. Chem. 258, 10938-10943.
27. iα2. Nature 379, 840-844.
28. i2-specific antisense RNA in vivo inhibits neonatal growth. Science 260, 991-995.
29. 41 subunits of guanine nucleotide-binding regulatory proteins from bovine brain. J. Biol. Chem. 263, 2020-2026.
30. Pizza M. G., Covacci A., Bartoloni A., Perugini M., Nencioni L., De Magistris M. T., Villa L., Nucci D., Manetti R., Bugnoli M., Giovannoni F., Olivieri R., Barbieri J., Sato H. and Rappuoli R. (1989) Mutants of pertussis toxin suitable for vaccine development. Science 246, 497-500.
31. Rinaudo M. T., Curto M., Bruno R., Marino C., Piccinini M., Cerutti F., Mostert M. and Sacchetti C. (1989) The behaviour of pyruvate dehydrogenase in circulating lymphocytes from diabetic children. Diabetologia 32, 245-248.
32. Rinaudo M. T., Curto M., Rabbone I., Piccinini M., Bruno R., Mioletti S. and Gamba S. (1994) Effect of sulfonylurea agents on pyruvate dehydrogenase activity in circulating lymphocytes of patients with non-insulin-dependent diabetes mellitus (NIDDM). J. Diab. Comp. 8, 221-225.
33. Robertson R. P., Seaquist E. R. and Walseth T. F. (1991) G proteins and modulation of insulin secretion. Diabetes 40, 1-6.
34. Rothenberg P. L. and Kahn C. R. (1988) Insulin inhibits pertussis toxin-catalyzed ADP-ribosylation of G-proteins. J. Biol. Chem. 263, 15546-15552.
35. Rutter G. A., Diggle T. A. and Denton R. M. (1992) Regulation of pyruvate dehydrogenase by insulin and polyamines within electropermeabilized fat-cells and isolated mitochondria. Biochem. J. 285, 435-439.
36. Saltiel A. R. (1990) Second messengers of insulin action. Diabetes Care 13, 244-256.
37. Saltiel A., Jacobs S., Siegel M. and Cuatrecasas P. (1981) Insulin stimulates the release from liver plasma membranes of a chemical modulator of pyruvate dehydrogenase. Biochem. Biophys. Res. Commun. 102, 1041-1047.
38. Seals J. R. and Czech M. P. (1981) Characterization of a pyruvate dehydrogenase activator released by adipocyte plasma membranes in response to insulin. J. Biol. Chem. 256, 2894-2899.
39. Seals J. R. and Jarett L. (1980) Activation of pyruvate dehydrogenase by direct addition of insulin to an isolated-plasma membrane/mitochondria mixture: evidence for generation of insulin's second messenger in a subcellular system. Proc. Natl. Acad. Sci. U.S.A. 77, 77-81.
40. Spiegel A. M. (1988) Guanine nucleotide binding proteins and signal transduction. Vitam. Horm. 44, 47-101.
41. Stansbie D., Denton R. M., Bridges B. J., Pask H. T. and Randle P. J. (1976) Regulation of pyruvate dehydrogenase and pyruvate dehydrogenase phosphate phosphatase activity in rat epididymal fat-pads. Biochem. J. 154, 225-236.
42. Strassheim D., Milligan G. and Houslay M. D. (1990) Diabetes abolishes the GTP-dependent, but not the receptor-dependent inhibitory function of the inhibitory guanine-nucleotide-binding regulatory protein (Gi) on adipocytes adenylate cyclase activity. Biochem. J. 266, 521-526.
43. Sternweis P. C. (1994) The active role of βγ in signal transduction. Curr. Opin. Cell Biol. 6, 198-203.
44. Tamura M., Nogimori K., Murai S., Yajima M., Ito K., Katada T., Ui M. and Ishii S. (1982) Subunit structure of islet-activating protein, pertussis toxin, in conformity with the A-B model. Biochemistry 21, 5516-5522.
45. Teague W. M., Pettit F. H., Wu T. L., Silberman S. R. and Reed L. J. (1982) Purification and properties of pyruvate dehydrogenase phosphatase from bovine heart and kidney. Biochemistry 21, 5585-5592.
46. Thomas A. P. and Denton R. M. (1986) Use of toluene permeabilized mitochondria to study the regulation of adipose tissue pyruvate dehydrogenase in situ. Biochem. J. 238, 93-101.
47. White M. F. and Kahn R. (1994) The insulin signaling system. J. Biol. Chem. 269, 1-4.
48. Wieland O. H. (1983) The mammalian pyruvate dehydrogenase complex: structure and regulation. Rev. Physiol. Biochem. Pharmacol. 96, 123-170.
49. Wieland O. H., Patzelt C. and Löffler G. (1972) Active and inactive forms of pyruvate dehydrogenase in rat liver. Effect of starvation and refeeding and of insulin treatment on pyruvate dehydrogenase interconversion. Eur. J. Biochem. 26, 426-433.
50. Wieland O. H., Siess E., Schulze-Wethmar F. H., Von Funcke H. G. and Winton B. (1971) Active and inactive forms of pyruvate dehydrogenase in rat heart and kidney. Effect of diabetes, fasting and refeeding on pyruvate dehydrogenase interconversion. Arch. Biochem. Biophys. 143, 593-601.