Oxytocin antagonist [1-D(CH2)5,Tyr(ME)2,Thr4,Tyr-NH29]ornithine vasotocin inhibits oxytocin-induced prostaglandin F(2α) release in late- pregnant cows

Biology of Reproduction

Volumn 57, Issue 2, 1997, Pages 436-441

  Fuchs, A R ^a   Fields, M J ^b   Chang, S M T ^b   Thatcher, W W ^b   Willard, C C ^c   Handel, R D ^c  

^a WEILL CORNELL MEDICAL COLLEGE   (United States)

^b UNIVERSITY OF FLORIDA   (United States)

^c TEXAS A AND M UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARGIPRESTOCIN; OXYTOCIN ANTAGONIST; PROSTAGLANDIN F2 ALPHA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; COW; DOSE RESPONSE; GENE EXPRESSION; NONHUMAN; PRIORITY JOURNAL; PROGESTERONE BLOOD LEVEL; PROSTAGLANDIN RELEASE; RECEPTOR AFFINITY; RECEPTOR BINDING; TOCOLYSIS; TREATMENT PLANNING; UTERUS CONTRACTILITY;

ANIMALS; CATTLE; CELL MEMBRANE; DINOPROST; ENDOMETRIUM; FEMALE; KINETICS; MYOMETRIUM; OXYTOCIN; PREGNANCY; PROGESTERONE; RECEPTORS, OXYTOCIN; VASOTOCIN;

ANIMALIA; BOVINAE;

EID: 0030807240     PISSN: 00063363     EISSN: None     Source Type: Journal    
DOI: 10.1095/biolreprod57.2.436     Document Type: Article

References (29)

1. Ivell R, Rust W, Einspanier A, Hartung S, Fields MJ, Fuchs A-R. Oxytocin and oxytocin receptor gene expression in the reproductive tract of the pregnant cow: rescue of luteal oxytocin production at term. Biol Reprod 1995; 51:551-558.
2. Fuchs A-R, Ivell R, Fields PA, Chang S-MT, Fields MJ. Oxytocin receptors in bovine cervix: distribution and gene expression during the estrous cycle. Biol Reprod 1996; 54:700-708.
3. Mironneau J. Effects of oxytocin on ionic currents underlying rhythmic activity and contraction in uterine smooth muscle. Pfluegers Arch 1976; 414A:460-483.
4. Fuchs A-R, Husslein P, Fuchs F. Oxytocin and the initiation of human parturition. II. Stimulation of prostaglandin production in human decidua by oxytocin. Am J Obstet Gynecol 1981; 141:694-699.
5. 2α from ovine endometrial tissue. Prostaglandins 1988; 35:535-548.
6. Manning M, Sawyer WH. Discovery, development, and some uses of vasopressin and oxytocin antagonists. J Lab Clin Med 1989; 114:617-632.
7. Chen DL, Chan WY, Manning M. Agonist and antagonist specificities of decidual prostaglandin releasing oxytocin receptors and myometrial uterotonic oxytocin receptors in pregnant rats. J Reprod Fertil 1994; 102:337-343.
8. Ivanisevic M, Behrens O, Helmer H, Demarest K, Fuchs A-R. Vasopressin receptors in human pregnant myometrium and decidua: interactions with oxytocin and vasopressin agonists and antagonists. Am J Obstet Gynecol 1989; 161:1637-1643.
9. 9]ornithine vasotocin, a selective oxytocin receptor ligand. Eur J Pharmacol 1987; 147:197-207.
10. 2α release in pregnant cows: influence of gestational age and oxytocin receptor concentrations. Biol Reprod 1996; 54:647-653.
11. Guilbault LA, Thatcher WW, Drost M, Hopkins SM. Source of F series prostaglandins during early postpartum period in cattle. Biol Reprod 1984; 31:879-887.
12. 2α of cows in response to recombinant interferon. J Dairy Sci 1995; 78:1921-1931.
13. Fuchs A-R, Behrens O, Helmer H, Liu H-C, Barros C-M, Fields MJ. Oxytocin and vasopressin receptors in bovine endometrium and myometrium during the estrous cycle and early pregnancy. Endocrinology 1990; 127:629-636.
14. Fuchs A-R, Helmer H, Behrens O, Liu H-C, Antonian L, Chang SM, Fields MJ, Oxytocin and bovine parturition: a steep rise in endometrial oxytocin receptors precedes onset of labor. Biol Reprod 1992; 47:937-944.
15. Kruszynski M, Lammek B, Manning M, Seto J, Haldar J, Sawyer WH. [1-β-Mercapto-β,β-cyclopentamethylene propionic acid),2-(Omethyl)tyrosine]arginine vasopressin and [1-β-mercapto-β,β-cyclopentamethylene propionic acid]arginine vasopressin. Two highly potent antagonists of the vasopressor response to arginine vasopressin. J Med Chem 1980; 23:364-368.
16. Melin P, Trojnar J, Johansson B, Vilhardt H, Åkerlund M. Synthetic antagonists of the myometrial response to oxytocin and vasopressin. J Endocrinol 1986; 111:125-131.
17. Ott L. An Introduction to Statistical Methods and Data Analysis. Bel mont, CA: Duxbury Press, a division of Wadsworth Publications; 1977.
18. Tallarida RJ, Murray RR. Pharmacological Calculations, 2nd Ed. New York: Springer-Verlag; 1987: 77-81.
19. Fuchs A-R, Behrens O, Helmer H, Barros CM, Fields MJ. Oxytocin and vasopressin receptors in cow uterus. In: Vilhardt H, Trojnar J, Thorn N (eds.), The Neurohypophysis. New Aspects of Morphology, Function and Regulation. Fourth Intl Conference, July 2-5, 1989; Copenhagen. Oxford: Oxford University Press; 1990: 142-144.
20. Manning M, Bankowski K, Olma A, Lammek B, Cheng LL, Klis WA, Seto J, Haldar J, Sawyer W. Solid phase synthesis of 16 potent (selective and nonselective) in vivo antagonists of oxytocin. J Med Chem 1989; 32:382-391.
21. Andersen LF, Lyndrup J, Åkerlund M, Melin P Oxytocin receptor blockade: a new principle in the treatment of preterm labor? Am J Perinatol 1989; 6:196-199.
22. Goodwin TM, Paul R, Silver H, Spellacy W, Parsons M, Chez R, Hayashi R, Valenzuela G, Creasy R, Merriman R. The effect of the oxytocin antagonist atosiban on preterm uterine activity in the human. Am J Obstet Gynecol 1994; 170:474-478.
23. 8]oxytocin on spontaneous nocturnal myometrial contractions. J Dev Physiol 1989; 12:225-232.
24. Fejgin MD, Pak SC, Warnell C, Flouret G, Parsons MT, Wilson L Jr. Oxytocin antagonist inhibitory effect on rat and baboon uterus may be overcome by prostaglandin. Am J Obstet Gynecol 1994; 171:1076-1080.
25. Gorewit RC, Wachs EA, Sagi R, Merrill WC. Current concepts on the role of oxytocin in milk ejection. J Dairy Sci 1983; 66:2236-2250.
26. 2α on the release of arachidonic acid. Prostaglandins 1979; 18:507-512.
27. Fuchs A-R. Oxytocin in animal parturition. In: Amico JA, Robinson AG (eds.), Oxytocin. Laboratory and Clinical Studies. Amsterdam, New York, Oxford: Exerpta Medica; 1985: 207-235.
28. 2α in spontaneous and oxytocin induced labor. Am J Obstet Gynecol 1983; 147:497-502.
29. 2α during the bovine peripartal period. Prostaglandins 1978; 16:111-118.