-
1
-
-
0018888058
-
Hypolipidaemic hepatic peroxisome proliferators form a novel class of chemical carcinogens
-
J.K. Reddy, D.L. Azarnoff, C.E. Hignite, Hypolipidaemic hepatic peroxisome proliferators form a novel class of chemical carcinogens, Nature 283 (1980) 397-398.
-
(1980)
Nature
, vol.283
, pp. 397-398
-
-
Reddy, J.K.1
Azarnoff, D.L.2
Hignite, C.E.3
-
2
-
-
0023887949
-
Chemically induced proliferation of peroxisomes: Implications for risk assessment
-
W.T. Stott, Chemically induced proliferation of peroxisomes: implications for risk assessment. Regul. Toxicol. Pharmacol. 8 (1988) 125-159.
-
(1988)
Regul. Toxicol. Pharmacol.
, vol.8
, pp. 125-159
-
-
Stott, W.T.1
-
3
-
-
0028172089
-
Mechanistically-based human hazard assessment of peroxisome proliferator-induced hepatocarcinogenesis
-
J. Ashby, A. Brady, C.R. Elcombe, B.M. Elliott, J. Ishmael, J. Odum, J.D. Tugwood, S. Kettle, I.F.H. Purchase, Mechanistically-based human hazard assessment of peroxisome proliferator-induced hepatocarcinogenesis, Hum. Experim. Toxicol. 13 (1994) S1-S117.
-
(1994)
Hum. Experim. Toxicol.
, vol.13
-
-
Ashby, J.1
Brady, A.2
Elcombe, C.R.3
Elliott, B.M.4
Ishmael, J.5
Odum, J.6
Tugwood, J.D.7
Kettle, S.8
Purchase, I.F.H.9
-
4
-
-
0027476494
-
Genotoxic effects of selected peroxisome proliferators
-
H. Reisenbichler, P.M. Eckl, Genotoxic effects of selected peroxisome proliferators, Mutat. Res. 286 (1993) 135-144.
-
(1993)
Mutat. Res.
, vol.286
, pp. 135-144
-
-
Reisenbichler, H.1
Eckl, P.M.2
-
5
-
-
0027526347
-
Induction of sister chromatide exchange and micronuclei in primary cultures of rat and human hepatocytes by the peroxisome proliferator, Wy-14643
-
J.-J. Hwang, M.T.S. Hsia, R.L. Jirtle, Induction of sister chromatide exchange and micronuclei in primary cultures of rat and human hepatocytes by the peroxisome proliferator, Wy-14643, Mutat. Res. 286 (1993) 123-133.
-
(1993)
Mutat. Res.
, vol.286
, pp. 123-133
-
-
Hwang, J.-J.1
Hsia, M.T.S.2
Jirtle, R.L.3
-
6
-
-
0028987876
-
Mechanisms of hepatocarcinogenicity of peroxisome proliferating drugs and chemicals
-
B.G. Lake, Mechanisms of hepatocarcinogenicity of peroxisome proliferating drugs and chemicals, Annu. Rev. Pharmacol. Toxicol. 35 (1995) 483-507.
-
(1995)
Annu. Rev. Pharmacol. Toxicol.
, vol.35
, pp. 483-507
-
-
Lake, B.G.1
-
7
-
-
0018345144
-
Mitogenic and carcinogenic effects of a hypolipidemic peroxisome proliferator. [4-chloro-6-(2,3-xylidino)-2-pyrimidinylthio]acetic acid (Wy-14, 643), in rat and mouse liver
-
J.K. Reddy, M.S. Rao, D.L. Azarnoff, S. Sell, Mitogenic and carcinogenic effects of a hypolipidemic peroxisome proliferator. [4-chloro-6-(2,3-xylidino)-2-pyrimidinylthio]acetic acid (Wy-14, 643), in rat and mouse liver, Cancer Res. 39 (1979) 152-161.
-
(1979)
Cancer Res.
, vol.39
, pp. 152-161
-
-
Reddy, J.K.1
Rao, M.S.2
Azarnoff, D.L.3
Sell, S.4
-
8
-
-
0026578966
-
Nuclear receptors and chemical carcinogenesis
-
S. Green, Nuclear receptors and chemical carcinogenesis, Trends Pharmacol. Sci. 13 (1992) 251-255.
-
(1992)
Trends Pharmacol. Sci.
, vol.13
, pp. 251-255
-
-
Green, S.1
-
9
-
-
0027517501
-
Glutathione S-transfcrase isoenzyme patterns in different subtypes of enzyme-altered rat liver oci treated with the peroxisome proliferator nafenopin or with phenobarbital
-
B. Grasl-Kraupp, T. Waldhor, W. Huber, R. Schulte-Hermann, Glutathione S-transfcrase isoenzyme patterns in different subtypes of enzyme-altered rat liver oci treated with the peroxisome proliferator nafenopin or with phenobarbital, Carcinogenesis 14 (1993) 2407-2412.
-
(1993)
Carcinogenesis
, vol.14
, pp. 2407-2412
-
-
Grasl-Kraupp, B.1
Waldhor, T.2
Huber, W.3
Schulte-Hermann, R.4
-
10
-
-
0024364826
-
Perfluorodecanoic acid decreases the enzyme activity and the amount of glutathione S-transferases proteins and mRNAs in vivo
-
H. Schramm, T. Friedberg, L.W. Robertson, F. Oesch, W. Kissel, Perfluorodecanoic acid decreases the enzyme activity and the amount of glutathione S-transferases proteins and mRNAs in vivo, Chem.-Biol. Interact. 70 (1989) 127-143.
-
(1989)
Chem.-Biol. Interact.
, vol.70
, pp. 127-143
-
-
Schramm, H.1
Friedberg, T.2
Robertson, L.W.3
Oesch, F.4
Kissel, W.5
-
11
-
-
0022497284
-
Inhibition of liver glutathione s-transferase activity in rats by hypolipidemic drugs related or unrelated to clofibrate
-
A. Foliot, D. Touchard, L. Mallet, Inhibition of liver glutathione S-transferase activity in rats by hypolipidemic drugs related or unrelated to clofibrate, Biochem. Pharmacol. 35 (1986) 1685-1690.
-
(1986)
Biochem. Pharmacol.
, vol.35
, pp. 1685-1690
-
-
Foliot, A.1
Touchard, D.2
Mallet, L.3
-
12
-
-
0023219418
-
Induction of xenobiotic-metabolizing enzymes and peroxisome proliferation in rat liver caused by dietary exposure to di(2-ethylhexyl)phosphate
-
B. Lundgren, J.W. De Pierre, Induction of xenobiotic-metabolizing enzymes and peroxisome proliferation in rat liver caused by dietary exposure to di(2-ethylhexyl)phosphate, Xenobiotica 17 (1987) 585-593.
-
(1987)
Xenobiotica
, vol.17
, pp. 585-593
-
-
Lundgren, B.1
De Pierre, J.W.2
-
13
-
-
0025004340
-
Relationship between hepatic peroxisome proliferation and 8-hydroxydeoxyguanosine formation in liver dna of rats following long-term exposure to three peroxisome proliferators: Di(2-ethylhexyl) phthalate, aluminium clofibrate and simfibrate
-
A. Takagi, K. Sai, T. Umemura, R. Hasegawa, Y. Kurokawa, Relationship between hepatic peroxisome proliferation and 8-hydroxydeoxyguanosine formation in liver DNA of rats following long-term exposure to three peroxisome proliferators: di(2-ethylhexyl) phthalate, aluminium clofibrate and simfibrate, Cancer Lett. 53 (1990) 33-38.
-
(1990)
Cancer Lett.
, vol.53
, pp. 33-38
-
-
Takagi, A.1
Sai, K.2
Umemura, T.3
Hasegawa, R.4
Kurokawa, Y.5
-
14
-
-
0025317542
-
No measurable increase in thymidine glycol or 8-hydroxydeoxyguanosine in liver DNA of rats treated with nafenopin or choline-devoid low methionine diet
-
M.E. Hegi, D. Ulrich, P. Sagelsdorff, C. Richter, W.K. Lutz, No measurable increase in thymidine glycol or 8-hydroxydeoxyguanosine in liver DNA of rats treated with nafenopin or choline-devoid low methionine diet, Mutat. Res. 238 (1990) 325-329.
-
(1990)
Mutat. Res.
, vol.238
, pp. 325-329
-
-
Hegi, M.E.1
Ulrich, D.2
Sagelsdorff, P.3
Richter, C.4
Lutz, W.K.5
-
15
-
-
0023142244
-
Cell cycle-dependent initiation of hepatocarcinogenesis in rats by methyl(acetoxymethyl)nitrosamine
-
W.K. Kaufmann, J.M. Rice, M.L. Wenk, D. Devor, D.G. Kaufmann. Cell cycle-dependent initiation of hepatocarcinogenesis in rats by methyl(acetoxymethyl)nitrosamine, Cancer Res. 47 (1987) 1263-1266.
-
(1987)
Cancer Res.
, vol.47
, pp. 1263-1266
-
-
Kaufmann, W.K.1
Rice, J.M.2
Wenk, M.L.3
Devor, D.4
Kaufmann, D.G.5
-
16
-
-
0029068505
-
Enhancement by peroxisome proliferators of the susceptibility to DNA damage in the liver of male F344 rats
-
F. Hayashi, H. Tamura, T. Watanabe, T. Suga, Enhancement by peroxisome proliferators of the susceptibility to DNA damage in the liver of male F344 rats. Cancer Lett. 92 (1995) 87-90.
-
(1995)
Cancer Lett.
, vol.92
, pp. 87-90
-
-
Hayashi, F.1
Tamura, H.2
Watanabe, T.3
Suga, T.4
-
17
-
-
0023897866
-
Chlorophenoxyacid herbicides induce microsomal cytochrome P-450IVA1 (P-452) in rat liver
-
M.A. Bacher, G.G. Gibson, Chlorophenoxyacid herbicides induce microsomal cytochrome P-450IVA1 (P-452) in rat liver, Chem.-Biol. Interact. 65 (1988) 145-156.
-
(1988)
Chem.-Biol. Interact.
, vol.65
, pp. 145-156
-
-
Bacher, M.A.1
Gibson, G.G.2
-
18
-
-
0025738537
-
Comparison of Cytochrome P450 isoenzyme profiles in rat liver and hepatocyte cultures. The effects of model inducers on apoproteins and biotransformation activities
-
H.M. Wortelboer, C.A. de Kruif, A.A.J. van Iersel, H.E. Falke, J. Noordhoek, B.J. Blaauboer, Comparison of Cytochrome P450 isoenzyme profiles in rat liver and hepatocyte cultures. The effects of model inducers on apoproteins and biotransformation activities, Biochem. Pharmacol. 42 (1991) 381-390.
-
(1991)
Biochem. Pharmacol.
, vol.42
, pp. 381-390
-
-
Wortelboer, H.M.1
De Kruif, C.A.2
Van Iersel, A.A.J.3
Falke, H.E.4
Noordhoek, J.5
Blaauboer, B.J.6
-
19
-
-
0027174822
-
Activation of the anti-cancer drug ifosphamide by rat liver microsomal P450 enzymes
-
G.F. Weber, D.J. Waxman, Activation of the anti-cancer drug ifosphamide by rat liver microsomal P450 enzymes, Biochem. Pharmacol. 45 (1993) 1685-1694.
-
(1993)
Biochem. Pharmacol.
, vol.45
, pp. 1685-1694
-
-
Weber, G.F.1
Waxman, D.J.2
-
20
-
-
0026730908
-
The peroxisome proliferator-activated receptor mediates the induction of CYP4A6, a cytochrome P-450 fatty acid w-hydroxylase, by clofibric acid
-
A.S. Muerhoff, K.J. Griffin, E.F. Johnson, The peroxisome proliferator-activated receptor mediates the induction of CYP4A6, a cytochrome P-450 fatty acid w-hydroxylase, by clofibric acid, J. Biol. Chem. 267 (1992) 19051-19053.
-
(1992)
J. Biol. Chem.
, vol.267
, pp. 19051-19053
-
-
Muerhoff, A.S.1
Griffin, K.J.2
Johnson, E.F.3
-
21
-
-
0030273048
-
Differential effect of peroxisome proliferators on rat glutathione S-transferase isoenzymes
-
I. Voskoboinik, J.T. Ahokas, R. Drew, Differential effect of peroxisome proliferators on rat glutathione S-transferase isoenzymes, Tox. Lett. 87 (1996) 147-155.
-
(1996)
Tox. Lett.
, vol.87
, pp. 147-155
-
-
Voskoboinik, I.1
Ahokas, J.T.2
Drew, R.3
-
22
-
-
0023125992
-
DNA synthesis, mitotic index, drug-metabolising systems and cytogenetic analysis in regenerating rat liver
-
A.M. Rossi, M. Romano, L. Zaccaro, R. Pulci, M. Salmona, DNA synthesis, mitotic index, drug-metabolising systems and cytogenetic analysis in regenerating rat liver, Mutat. Res. 182 (1987) 75-82.
-
(1987)
Mutat. Res.
, vol.182
, pp. 75-82
-
-
Rossi, A.M.1
Romano, M.2
Zaccaro, L.3
Pulci, R.4
Salmona, M.5
-
23
-
-
0019453058
-
Role of glutathione in the metabolism-dependent toxicity and chemotherapy of cyclophosphamide
-
H.L. Gurtoo, J.H. Hipkens, S.D. Sharma, Role of glutathione in the metabolism-dependent toxicity and chemotherapy of cyclophosphamide, Cancer Res. 411 (1981) 3584-3591.
-
(1981)
Cancer Res.
, vol.411
, pp. 3584-3591
-
-
Gurtoo, H.L.1
Hipkens, J.H.2
Sharma, S.D.3
-
24
-
-
0016326528
-
Effects of cyclophosphamide on somatic cell chromosomes in rats
-
H.G. Payne, L.W. Nelson, J.H. Weikel, Effects of cyclophosphamide on somatic cell chromosomes in rats, Tox. Appl. Pharm. 30 (1974) 360-368.
-
(1974)
Tox. Appl. Pharm.
, vol.30
, pp. 360-368
-
-
Payne, H.G.1
Nelson, L.W.2
Weikel, J.H.3
-
25
-
-
0021205298
-
Metabolism and binding of cyclophosphamide and its metabolite acrolein to rat hepatic microsomal cytochrome P-450
-
A.J. Marinello, S.K. Bansal, B. Paul, P.L. Koser, J. Love, R.F. Struck, H.L. Gurtoo, Metabolism and binding of cyclophosphamide and its metabolite acrolein to rat hepatic microsomal cytochrome P-450, Cancer Res. 44 (1984) 4615-4621.
-
(1984)
Cancer Res.
, vol.44
, pp. 4615-4621
-
-
Marinello, A.J.1
Bansal, S.K.2
Paul, B.3
Koser, P.L.4
Love, J.5
Struck, R.F.6
Gurtoo, H.L.7
-
26
-
-
0342395892
-
Principles of drug modulation applied to glutathione S-transferase
-
K.D. Tew, C.B. Pickett, T.J. Mantle, B. Mannervik, J.D. Hayes (Eds.), CRC Press, Boca Raton
-
S. Ranganathan, P.J. Ciaccio, K.D. Tew, Principles of drug modulation applied to glutathione S-transferase, in: K.D. Tew, C.B. Pickett, T.J. Mantle, B. Mannervik, J.D. Hayes (Eds.), Structure and function of glutathione S-transferases, CRC Press, Boca Raton, 1993, pp. 249-256.
-
(1993)
Structure and Function of Glutathione S-transferases
, pp. 249-256
-
-
Ranganathan, S.1
Ciaccio, P.J.2
Tew, K.D.3
-
27
-
-
0027294025
-
Mechanism of trichloroethylene-induced elevation of individual serum bile acids
-
C. Bai, N. Stacey, Mechanism of trichloroethylene-induced elevation of individual serum bile acids, Tox. Appl. Pharm. 121 (1993) 296-302.
-
(1993)
Tox. Appl. Pharm.
, vol.121
, pp. 296-302
-
-
Bai, C.1
Stacey, N.2
-
28
-
-
0014645531
-
High yield preparation of of isolated rat liver parenchymal cells: A biochemical and structural studies
-
M. Berry, D. Friend, High yield preparation of of isolated rat liver parenchymal cells: A biochemical and structural studies, J. Cell Biol. 43 (1969) 506-520.
-
(1969)
J. Cell Biol.
, vol.43
, pp. 506-520
-
-
Berry, M.1
Friend, D.2
-
29
-
-
0024473632
-
An in vitro micronucleus assay for determining the radiosensitivity of hepatocytes
-
T. Alati, P. Eckl, R.L. Jirtle, An in vitro micronucleus assay for determining the radiosensitivity of hepatocytes, Radiat. Res. 119 (1989) 562-568.
-
(1989)
Radiat. Res.
, vol.119
, pp. 562-568
-
-
Alati, T.1
Eckl, P.2
Jirtle, R.L.3
-
30
-
-
0018170362
-
A simple and sensitive assay of 7-ethoxycoumarin deethylation
-
A. Aitio, A simple and sensitive assay of 7-ethoxycoumarin deethylation, Analyt. Biochem. 85 (1978) 488-491.
-
(1978)
Analyt. Biochem.
, vol.85
, pp. 488-491
-
-
Aitio, A.1
-
31
-
-
0016275313
-
Glutathione S-transferase - The first enzymatic step in mercapturic acid formation
-
W.H. Habig, MJ. Pabst, W.B. Jakoby, Glutathione S-transferase - the first enzymatic step in mercapturic acid formation, J. Biol. Chem. 249 (1974) 7130-7139.
-
(1974)
J. Biol. Chem.
, vol.249
, pp. 7130-7139
-
-
Habig, W.H.1
Pabst, M.J.2
Jakoby, W.B.3
-
32
-
-
0019742075
-
Assay of peroxisomal betta-oxidation of fatty acids
-
P.B. Lazarow, Assay of peroxisomal betta-oxidation of fatty acids, Methods Enzym. 72 (1981) 315-317.
-
(1981)
Methods Enzym.
, vol.72
, pp. 315-317
-
-
Lazarow, P.B.1
-
33
-
-
71849104860
-
Protein measurement with the folin phenol reagent
-
O.H. Lowry, N. Rosebrough, A. Farr, R. Randall, Protein measurement with the folin phenol reagent, J. Biol. Chem. 193 (1951) 265-275.
-
(1951)
J. Biol. Chem.
, vol.193
, pp. 265-275
-
-
Lowry, O.H.1
Rosebrough, N.2
Farr, A.3
Randall, R.4
-
34
-
-
0026049559
-
The inhibition of glutathione S-transferases: Mechanisms, toxic consequences and therapeutic benefits
-
P.J. van Bladeren, B. van Ommen, The inhibition of glutathione S-transferases: mechanisms, toxic consequences and therapeutic benefits, Pharmac. Ther. 51 (1991) 35-46.
-
(1991)
Pharmac. Ther.
, vol.51
, pp. 35-46
-
-
Van Bladeren, P.J.1
Van Ommen, B.2
-
35
-
-
0015009543
-
Effects of chemotherapeutic agents on normal mouse bone marrow growth in vitro
-
C.H. Brown, P.P. Carbone, Effects of chemotherapeutic agents on normal mouse bone marrow growth in vitro, Cancer Res. 31 (1971) 185-190.
-
(1971)
Cancer Res.
, vol.31
, pp. 185-190
-
-
Brown, C.H.1
Carbone, P.P.2
-
36
-
-
0014993435
-
On haematotoxic effects due to cyclophosphamide dosage in rats
-
W. Werner, M. Haller, V. Hoepfner, J. Kuechler, J. Ziervogel, On haematotoxic effects due to cyclophosphamide dosage in rats, Exp Path. 5 (1971) 123-127.
-
(1971)
Exp Path.
, vol.5
, pp. 123-127
-
-
Werner, W.1
Haller, M.2
Hoepfner, V.3
Kuechler, J.4
Ziervogel, J.5
-
37
-
-
0003965089
-
-
Charles C. Thomas Publisher, Springfield
-
D.L. Hill, A review of cyclophosphamide, Charles C. Thomas Publisher, Springfield, 1975, pp. 113-119.
-
(1975)
A Review of Cyclophosphamide
, pp. 113-119
-
-
Hill, D.L.1
-
38
-
-
0015293479
-
A correlation between cyclophosphamide induced leukopenia in mice and the presence of alkylating metabolites
-
F.D. Hayes, R.D. Short, J.E. Gibson, A correlation between cyclophosphamide induced leukopenia in mice and the presence of alkylating metabolites, Proc. Soc. Exp. Biol. Med. 139 (1972) 417-421.
-
(1972)
Proc. Soc. Exp. Biol. Med.
, vol.139
, pp. 417-421
-
-
Hayes, F.D.1
Short, R.D.2
Gibson, J.E.3
-
39
-
-
0023939084
-
Inhibition of rat liver glutathione s-transferase isoenzymes by acrolein
-
T.R. Stott, R.E. Kirsch, Inhibition of rat liver glutathione S-transferase isoenzymes by acrolein, Biochem. Internat. 16 (1988) 439-442.
-
(1988)
Biochem. Internat.
, vol.16
, pp. 439-442
-
-
Stott, T.R.1
Kirsch, R.E.2
-
40
-
-
0026642955
-
Mitogenesis, micronuclei, and carcinogenesis in the rat liver: Some basic inconsistencies
-
J. Ashby, P.A. Lefevre, Mitogenesis, micronuclei, and carcinogenesis in the rat liver: Some basic inconsistencies, Envir. Molec. Mutagen. 20 (1992) 29-38.
-
(1992)
Envir. Molec. Mutagen.
, vol.20
, pp. 29-38
-
-
Ashby, J.1
Lefevre, P.A.2
-
41
-
-
0025348696
-
Studies on the hyperplastic responsiveness of binucleated rat hepatocytes
-
J.A. Styles, A. Bybee, N.R. Pritchard, M.D. Kelly, Studies on the hyperplastic responsiveness of binucleated rat hepatocytes, Carcinogenesis 11 (1990) 1149-1152.
-
(1990)
Carcinogenesis
, vol.11
, pp. 1149-1152
-
-
Styles, J.A.1
Bybee, A.2
Pritchard, N.R.3
Kelly, M.D.4
-
42
-
-
0024788261
-
Zonal heterogeneity of peroxisome proliferation and morphology in rat liver after gemfibrozil treatment
-
K. Gorgas, S.K. Krisans, Zonal heterogeneity of peroxisome proliferation and morphology in rat liver after gemfibrozil treatment, J. Lipid Res. 30 (1989) 1859-1875.
-
(1989)
J. Lipid Res.
, vol.30
, pp. 1859-1875
-
-
Gorgas, K.1
Krisans, S.K.2
-
43
-
-
0025793398
-
Testing for induction of DNA synthesis in human hepatocyte primary cultures by rat liver tumor promoters
-
W. Parzefall, E. Erber, R. Sedivy, R. Schulte-Hermann, Testing for induction of DNA synthesis in human hepatocyte primary cultures by rat liver tumor promoters. Cancer Res. 51 (1991) 1143-1147.
-
(1991)
Cancer Res.
, vol.51
, pp. 1143-1147
-
-
Parzefall, W.1
Erber, E.2
Sedivy, R.3
Schulte-Hermann, R.4
-
44
-
-
0025116858
-
Acute hyperplasia and peroxisome proliferation induced by methylclofenapate: A species comparison and implications for liver carcinogenesis
-
J.A. Styles, M.D. Kelly, N.R. Pritchard, C.R. Elcombe, Acute hyperplasia and peroxisome proliferation induced by methylclofenapate: a species comparison and implications for liver carcinogenesis, Mouse Liver Carcinogenesis: Mechanisms and Species Comparisons, 1990, pp. 385-393.
-
(1990)
Mouse Liver Carcinogenesis: Mechanisms and Species Comparisons
, pp. 385-393
-
-
Styles, J.A.1
Kelly, M.D.2
Pritchard, N.R.3
Elcombe, C.R.4
|