Familial streptomycin ototoxicity in a South African family: A mitochondrial disorder

Journal of Medical Genetics

Volumn 34, Issue 11, 1997, Pages 904-906

  Gardner, Jessica C ^a   Goliath, Rene ^a   Viljoen, Denis ^a   Sellars, Scan ^a   Cortopassi, Gino ^b   Hutchin, Tim ^b   Greenberg, Jacquie ^a   Beighton, Peter ^a  

^a UNIVERSITY OF CAPE TOWN   (South Africa)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Deafness; Mitochondria; Ototoxicity; Streptomycin

Indexed keywords

AMINOGLYCOSIDE ANTIBIOTIC AGENT; GENTAMICIN; KANAMYCIN; MITOCHONDRIAL DNA; NEOMYCIN; STREPTOMYCIN; TOBRAMYCIN;

ADULT; ARTICLE; CLINICAL ARTICLE; FEMALE; GENETIC COUNSELING; HUMAN; MALE; OTOTOXICITY; PERCEPTION DEAFNESS; POINT MUTATION; PRIORITY JOURNAL; SOUTH AFRICA; TUBERCULOSIS;

EID: 0030806576     PISSN: 00222593     EISSN: None     Source Type: Journal    
DOI: 10.1136/jmg.34.11.904     Document Type: Article

References (10)

1. Sellars S, Brighton P. Childhood deafness in Southern Africa: an aetiological survey of 3064 deaf children. J Laryngol Oral 1983;97:885-9.
2. Viljoen DL, Sellars SL, Beighton P. Familial aggregation of streptomycin ototoxicity: autosomal dominant inheritance? J Med Genet 1983;20:357-60.
3. Hu DN, Qiu WQ, Wu BT, et al. Genetic aspects of antibiotic induced deafness: mitochondrial inheritance. J Med Genet 1991;28:79-83.
4. Prezant TR, Agapian JV, Bohlman MC, et al. Mitochondrial ribosomal RNA mutation associated with both antibiotic-induced and non-syndromic deafness. Nat Genet 1993;4: 289-93.
5. Higaski K. Unique inheritance of streptomycin-induced deafness. Clin Genet 1989;35:433-6.
6. Jaber L, Shohat M, Bu X, et al. Sensorineural deafness inherited as a tissue-specific mitochondrial disorder. J Med Genet 1992;29:86-90.
7. Hutchin T, Haworth I, Higashi K, et al. A molecular basis for human hypersensitivity to aminoglycoside antibiotics. Nucleic Acids Res 1993;21:4174-9.
8. Cortopassi G, Hutchin T. A molecular and cellular hypothesis for aminoglycoside-induced deafness. Hearing Res 1994;78:27-30.
9. Matthijs G, Claes S, Longo-Mbenza B, Cassiman JJ. Non-syndromic deafness associated with a mutation and a polymorphism in the mitochondrial 12S ribosomal RNA gene in a large Zairean pedigree. Eur J Hum Genet 1996;4: 46-51.
10. Hutchin TP, Cortopassi GA. Multiple origins of a mitochondrial mutation conferring deafness. Genetics 1997;145:771-6.