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Volumn 816, Issue , 1997, Pages 177-193

The polycystic ovary syndrome. Pathogenesis, metabolic implications, and therapeutic approach

Author keywords

[No Author keywords available]

Indexed keywords

ANDROGEN; ANTIANDROGEN; INSULIN; ORAL CONTRACEPTIVE AGENT;

EID: 0030806344     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.1997.tb52142.x     Document Type: Conference Paper
Times cited : (4)

References (89)
  • 2
    • 0023879442 scopus 로고
    • Polycystic ovaries - A common finding in normal women
    • POLSON, D. W., J. WADSWORTH, J. ADAMS & S. FRANKS. 1988. Polycystic ovaries - A common finding in normal women. Lancet 870-872.
    • (1988) Lancet , pp. 870-872
    • Polson, D.W.1    Wadsworth, J.2    Adams, J.3    Franks, S.4
  • 4
    • 0018362651 scopus 로고
    • Pituitary tumors associated with hyperprolactinemia and polycystic ovary disease
    • FUTTERWEIT, W., & D. T. KRIEGER. 1979. Pituitary tumors associated with hyperprolactinemia and polycystic ovary disease. Fertil. Steril. 31: 608-613.
    • (1979) Fertil. Steril. , vol.31 , pp. 608-613
    • Futterweit, W.1    Krieger, D.T.2
  • 5
    • 0023786193 scopus 로고
    • Screening for 21-hydroxylase deficiency among hirsutise women: Lack of utility of the adrenocorticotropin hormone test
    • Dewailly, D., M. C. Vantyghem, C. Lemaire, F. Duffose, A. Racadot & P. Fossati. 1988. Screening for 21-hydroxylase deficiency among hirsutise women: Lack of utility of the adrenocorticotropin hormone test. Fertil. Steril. 50: 228-232.
    • (1988) Fertil. Steril. , vol.50 , pp. 228-232
    • Dewailly, D.1    Vantyghem, M.C.2    Lemaire, C.3    Duffose, F.4    Racadot, A.5    Fossati, P.6
  • 6
    • 0025951575 scopus 로고
    • Is the inappropriate gonadotropin secretion of patients with polycystic ovary syndrome similar to that of patients with adult-onset congenital adrenal hyperplasia?
    • LEVIN, J. H., E. CARMINA & R. A. LOBO. 1991. Is the inappropriate gonadotropin secretion of patients with polycystic ovary syndrome similar to that of patients with adult-onset congenital adrenal hyperplasia? Fertil. Steril. 56: 635-640.
    • (1991) Fertil. Steril. , vol.56 , pp. 635-640
    • Levin, J.H.1    Carmina, E.2    Lobo, R.A.3
  • 7
    • 0024361382 scopus 로고
    • Polycystic ovary syndrome: A changing perspective
    • FRANKS, S. 1989. Polycystic ovary syndrome: A changing perspective. Clin. Endocrinol. 31: 87-120.
    • (1989) Clin. Endocrinol. , vol.31 , pp. 87-120
    • Franks, S.1
  • 8
    • 0024542647 scopus 로고
    • Heterogeneity of the polycystic ovary syndrome
    • CONWAY, G. S., J. W. HONOUR & H. S. JACOBS. 1989. Heterogeneity of the polycystic ovary syndrome. Clin. Endocrinol. 30: 459-470.
    • (1989) Clin. Endocrinol. , vol.30 , pp. 459-470
    • Conway, G.S.1    Honour, J.W.2    Jacobs, H.S.3
  • 9
    • 0027984865 scopus 로고
    • A prospective study of the prevalence of clear-cut endocrine disorders and polycystic ovaries in 350 patients with hirsutism or androgenic alopecia
    • ODriscoll, J. B., H. Mamtora, J. Higginson, A. Pollock, J. Kane & D. C. Anderson. 1994. A prospective study of the prevalence of clear-cut endocrine disorders and polycystic ovaries in 350 patients with hirsutism or androgenic alopecia. Clin. Endocrinol. 41: 231-236.
    • (1994) Clin. Endocrinol. , vol.41 , pp. 231-236
    • Odriscoll, J.B.1    Mamtora, H.2    Higginson, J.3    Pollock, A.4    Kane, J.5    Anderson, D.C.6
  • 10
    • 0023277586 scopus 로고
    • Hirsutism, polycystic ovarian disease and ovarian 17-ketosteroid reductase deficiency
    • PANG, S., B. SOFTNESS, W. SWEENEY & M. I. NEW. 1987. Hirsutism, polycystic ovarian disease and ovarian 17-ketosteroid reductase deficiency. N. Engl. J. Med. 316: 1295-1301.
    • (1987) N. Engl. J. Med. , vol.316 , pp. 1295-1301
    • Pang, S.1    Softness, B.2    Sweeney, W.3    New, M.I.4
  • 11
    • 0026708726 scopus 로고
    • How common are polycystic ovaries in normal women and what is their significance for the fertility of the population?
    • CLAYTON, R. N., V. OGDEN, J. HODGKINSON, L. WORSWICK, D. A. RODIN, S. DYER & T. W. MEADE. 1992. How common are polycystic ovaries in normal women and what is their significance for the fertility of the population? Clin. Endocrinol. 37: 127-134.
    • (1992) Clin. Endocrinol. , vol.37 , pp. 127-134
    • Clayton, R.N.1    Ogden, V.2    Hodgkinson, J.3    Worswick, L.4    Rodin, D.A.5    Dyer, S.6    Meade, T.W.7
  • 12
    • 0023848926 scopus 로고
    • Episodic pulsative secretion of FSH, LH, prolactin, oestradiol, oestrone and LH circadian variations in polycystic ovary syndrome
    • VENTUROLI, S., E. PORU, R. FABBRI, O. MAGRINI, L. GAMMI, R. PARADISI, M. FORACCI, et al. 1988. Episodic pulsative secretion of FSH, LH, prolactin, oestradiol, oestrone and LH circadian variations in polycystic ovary syndrome. Clin. Endocrinol. 28: 93-107.
    • (1988) Clin. Endocrinol. , vol.28 , pp. 93-107
    • Venturoli, S.1    Poru, E.2    Fabbri, R.3    Magrini, O.4    Gammi, L.5    Paradisi, R.6    Foracci, M.7
  • 13
    • 0025914152 scopus 로고
    • Reduction of gonadotropin-releasing hormone pulse frequency is associated with subsequent selective follicle-stimulating hormone secretion in women with polycystic ovarian disease
    • CHRISTMAN, G. M., J. F. RANDOLPH, R. P. KELCH & J. C. MARSHALL. 1991. Reduction of gonadotropin-releasing hormone pulse frequency is associated with subsequent selective follicle-stimulating hormone secretion in women with polycystic ovarian disease. J. Clin. Endocrinol. Metab. 72: 1278-1285.
    • (1991) J. Clin. Endocrinol. Metab. , vol.72 , pp. 1278-1285
    • Christman, G.M.1    Randolph, J.F.2    Kelch, R.P.3    Marshall, J.C.4
  • 14
    • 0023574450 scopus 로고
    • Changing pituitary reactivity to follicle-stimulating hormone and luteinizing hormone-releasing hormone after induced ovulatory cycles and after anovulation in patients with polycystic ovarian disease
    • BLANKSTEIN, J., J. RABINOVICI, M. GOLDENBERG, J. SHALEY, A. MEHTA, D. M. SERR & S. MASHIACH. 1987. Changing pituitary reactivity to follicle-stimulating hormone and luteinizing hormone-releasing hormone after induced ovulatory cycles and after anovulation in patients with polycystic ovarian disease. J. Clin. Endocrinol. Metab. 65: 1164-1167.
    • (1987) J. Clin. Endocrinol. Metab. , vol.65 , pp. 1164-1167
    • Blankstein, J.1    Rabinovici, J.2    Goldenberg, M.3    Shaley, J.4    Mehta, A.5    Serr, D.M.6    Mashiach, S.7
  • 15
    • 0021261713 scopus 로고
    • Evidence for decreased endogenous dopamine and opoid inhibitory influences on LH secretion in polycystic ovary syndrome
    • CUMMING, D. C., R. L. REID, M. E. QUIGLEY, R. W. REBAR & S. S. C. YEN. 1984. Evidence for decreased endogenous dopamine and opoid inhibitory influences on LH secretion in polycystic ovary syndrome. Clin. Endocrinol. 20: 643-648.
    • (1984) Clin. Endocrinol. , vol.20 , pp. 643-648
    • Cumming, D.C.1    Reid, R.L.2    Quigley, M.E.3    Rebar, R.W.4    Yen, S.S.C.5
  • 16
    • 0022412840 scopus 로고
    • Central opioid activity in polycystic ovary syndrome with and without dopaminergic modulation
    • BARNES, R. & R. A. LOBO. 1985. Central opioid activity in polycystic ovary syndrome with and without dopaminergic modulation. J. Clin. Endocrinol. Metab. 61: 779-782.
    • (1985) J. Clin. Endocrinol. Metab. , vol.61 , pp. 779-782
    • Barnes, R.1    Lobo, R.A.2
  • 18
    • 0023864662 scopus 로고
    • Current concepts: Pathogenesis and treatment of polycystic ovary syndrome
    • MCKENNA, T. J. 1988. Current concepts: Pathogenesis and treatment of polycystic ovary syndrome. N. Engl. J. Med. 318: 558-562.
    • (1988) N. Engl. J. Med. , vol.318 , pp. 558-562
    • Mckenna, T.J.1
  • 19
    • 34547388923 scopus 로고
    • Enhanced disparity of gonadotropin secretion by estrone in women with polycystic ovarian disease
    • CHANG, R. J., F. P. MANFDEL, J. K. LU & H. L. JUDD. 1982. Enhanced disparity of gonadotropin secretion by estrone in women with polycystic ovarian disease. J. Clin. Endocrinol. Metab. 60: 773-778.
    • (1982) J. Clin. Endocrinol. Metab. , vol.60 , pp. 773-778
    • Chang, R.J.1    Manfdel, F.P.2    Lu, J.K.3    Judd, H.L.4
  • 20
    • 0021951006 scopus 로고
    • The effects of the aromatase inhibitor delta-testosterone on gonadotropin release and steroid metabolism in polycystic ovarian disease
    • DUNAIF, A., C. LOONGCOPE, J. CANICK, T. BADGER & W. F. CROWLY, JR. 1985. The effects of the aromatase inhibitor delta-testosterone on gonadotropin release and steroid metabolism in polycystic ovarian disease. J. Clin. Endocrinol. Metab. 60: 773-780.
    • (1985) J. Clin. Endocrinol. Metab. , vol.60 , pp. 773-780
    • Dunaif, A.1    Loongcope, C.2    Canick, J.3    Badger, T.4    Crowly Jr., W.F.5
  • 21
    • 0017259117 scopus 로고
    • Strength-duration characteristics of estrogen effects on gonadotropin response to gonadotropin-releasing hormone in women
    • YOUNG, J. R. & R. B. JAFFE. 1976. Strength-duration characteristics of estrogen effects on gonadotropin response to gonadotropin-releasing hormone in women. J. Clin. Endocrinol. Metab. 42: 432-442.
    • (1976) J. Clin. Endocrinol. Metab. , vol.42 , pp. 432-442
    • Young, J.R.1    Jaffe, R.B.2
  • 22
    • 34547387827 scopus 로고
    • Congenital adrenal hyperplasia and reproductive function in females
    • C. Flamigni, S. Venruroli & J. Givens, Eds.: Year Book Medical Publishers. Chicago
    • ROSENFIELD, R. L. 1985. Congenital adrenal hyperplasia and reproductive function in females. In Adolescence in Females. C. Flamigni, S. Venruroli & J. Givens, Eds.: 373-387. Year Book Medical Publishers. Chicago.
    • (1985) Adolescence in Females , pp. 373-387
    • Rosenfield, R.L.1
  • 23
    • 0022995743 scopus 로고
    • Acute modulation of the hypothalamic-pituitary axis by intravenous testosterone in normal women
    • SERAFINI, P., P. D. SILLV, R. J. PAULSEN, M. EKIND-HERNANDEZ & R. A. LOBO. 1986. Acute modulation of the hypothalamic-pituitary axis by intravenous testosterone in normal women. Am. J. Obstet. Gynecol. 155: 1288-1292.
    • (1986) Am. J. Obstet. Gynecol. , vol.155 , pp. 1288-1292
    • Serafini, P.1    Sillv, P.D.2    Paulsen, R.J.3    Ekind-Hernandez, M.4    Lobo, R.A.5
  • 24
    • 0022596436 scopus 로고
    • Do androgens directly regulate gonadotropin secretion in the polycystic ovary syndrome?
    • DUNAIF, A. 1986. Do androgens directly regulate gonadotropin secretion in the polycystic ovary syndrome? J. Clin. Endocrinol. Metab. 63: 215-221.
    • (1986) J. Clin. Endocrinol. Metab. , vol.63 , pp. 215-221
    • Dunaif, A.1
  • 27
    • 0000806773 scopus 로고
    • New data on follicle cells hi polycystic ovaries: A proposed mechanism for the genesis of cystic follicles
    • ERICKSON, G. F. & S. S. C. YEN. 1984. New data on follicle cells hi polycystic ovaries: A proposed mechanism for the genesis of cystic follicles. Semin. Reprod. Endocrinol. 2: 231.
    • (1984) Semin. Reprod. Endocrinol. , vol.2 , pp. 231
    • Erickson, G.F.1    Yen, S.S.C.2
  • 28
    • 0022478980 scopus 로고
    • An analysis of follicle development and ovum maturation
    • ERICKSON, G. 1986. An analysis of follicle development and ovum maturation. Ser. Reprod. Endocrinol. 4: 233-254.
    • (1986) Ser. Reprod. Endocrinol. , vol.4 , pp. 233-254
    • Erickson, G.1
  • 29
    • 0012253262 scopus 로고
    • Hyperprolactinemia and polycystic ovarian disease
    • W. Futterwit, Ed.: Springer-Verlag. New York
    • FUTTERWEIT, W. 1984. Hyperprolactinemia and polycystic ovarian disease. In Polycystic Ovarian Disease. W. Futterwit, Ed.: 97-111. Springer-Verlag. New York.
    • (1984) Polycystic Ovarian Disease , pp. 97-111
    • Futterweit, W.1
  • 30
    • 0022085050 scopus 로고
    • The ovarian androgen producing cells: A review of structure/function relationships
    • ERICKSON, G. F., D. A. MAGOFFIN, C. A. DYER & C. HOFEDITZ. 1985. The ovarian androgen producing cells: A review of structure/function relationships. Endocrinol. Rev. 6: 371-399.
    • (1985) Endocrinol. Rev. , vol.6 , pp. 371-399
    • Erickson, G.F.1    Magoffin, D.A.2    Dyer, C.A.3    Hofeditz, C.4
  • 31
    • 0023120674 scopus 로고
    • The distribution of oestradiol in plasma in relation to uterine cross-sectional area in women with polycystic or multifollicular ovaries
    • POLSON, D. W., S. FRANKS, M. J. REED, R. W. CHENG, J. ADAMS & V. H. JAMES. 1987. The distribution of oestradiol in plasma in relation to uterine cross-sectional area in women with polycystic or multifollicular ovaries. Clin. Endocrinol. 26: 581-588.
    • (1987) Clin. Endocrinol. , vol.26 , pp. 581-588
    • Polson, D.W.1    Franks, S.2    Reed, M.J.3    Cheng, R.W.4    Adams, J.5    James, V.H.6
  • 32
    • 0002700339 scopus 로고
    • Folliculogenesis in polycystic ovary syndrome
    • A. Dunaif, J. Givens, F. Haseltine & G. Merrlan, Eds. Blackwell Scientific. Cambridge, MA.
    • ERICKSON, G. F. 1992. Folliculogenesis in polycystic ovary syndrome. In Current Issues in Endocrinology and Metabolism: Polycystic Ovary Syndrome. A. Dunaif, J. Givens, F. Haseltine & G. Merrlan, Eds. Blackwell Scientific. Cambridge, MA.
    • (1992) Current Issues in Endocrinology and Metabolism: Polycystic Ovary Syndrome
    • Erickson, G.F.1
  • 33
    • 0024446256 scopus 로고
    • Insulin-like growth factor 1 regulates aromatase activity in human granulosa and granulosa luteal cells
    • ERICKSON, G. F., V. G. GARZO & D. A. MAGOFFIN. 1989. Insulin-like growth factor 1 regulates aromatase activity in human granulosa and granulosa luteal cells. J. Clin. Endocrinol. Metab. 69: 716-724.
    • (1989) J. Clin. Endocrinol. Metab. , vol.69 , pp. 716-724
    • Erickson, G.F.1    Garzo, V.G.2    Magoffin, D.A.3
  • 34
    • 0018672003 scopus 로고
    • Functional studies of aromase activity in human granulosa cells from normal and polycystic ovaries
    • ERICKSON, G. F., A. J. HSUEH, M. E. QUIGLLEY, R. W. RADAR & S. S. YEN. 1979. Functional studies of aromase activity in human granulosa cells from normal and polycystic ovaries. J. Clin. Endocrinol. Metab. 49: 514-519.
    • (1979) J. Clin. Endocrinol. Metab. , vol.49 , pp. 514-519
    • Erickson, G.F.1    Hsueh, A.J.2    Quiglley, M.E.3    Radar, R.W.4    Yen, S.S.5
  • 35
    • 0025930591 scopus 로고
    • Polycystic ovary syndrome: Interaction of follicle stimulating hormone and polypeptide growth factors in oestradiol production by human granulosa cells
    • FRANKS, S. & H. D. MASON. 1991. Polycystic ovary syndrome: Interaction of follicle stimulating hormone and polypeptide growth factors in oestradiol production by human granulosa cells. J. Steroid Biochem. Mol. Biol. 40: 405-409.
    • (1991) J. Steroid Biochem. Mol. Biol. , vol.40 , pp. 405-409
    • Franks, S.1    Mason, H.D.2
  • 36
    • 0028298216 scopus 로고
    • A syndrome of female pseudohermaphroditism, hypergonadotropic hypogonadism, and multicystic ovaries associated with missense mutations in the gene encoding aromatase (P450)
    • CONTE, F. A., M. M. GRUMBACH, Y. ITO, C. R. FISHER & E. R. SIMPSON. 1994. A syndrome of female pseudohermaphroditism, hypergonadotropic hypogonadism, and multicystic ovaries associated with missense mutations in the gene encoding aromatase (P450). J. Clin. Endocrinol. Metab. 78: 1287-1292.
    • (1994) J. Clin. Endocrinol. Metab. , vol.78 , pp. 1287-1292
    • Conte, F.A.1    Grumbach, M.M.2    Ito, Y.3    Fisher, C.R.4    Simpson, E.R.5
  • 37
    • 0018601195 scopus 로고
    • The precursors of endometrial carcinoma
    • SHERMAN, A. I. & S. BROWN. 1979. The precursors of endometrial carcinoma. Am. J. Obstet. Gynecol. 135: 947-956.
    • (1979) Am. J. Obstet. Gynecol. , vol.135 , pp. 947-956
    • Sherman, A.I.1    Brown, S.2
  • 38
    • 0018742466 scopus 로고
    • Effects of exogenous testosterone on ovarian weight, follicular morphology and intraovarian progesterone concentration in estrogen-primed hypophysectomised immature female rats
    • HILLIER, S. G. & G. T. Ross. 1979. Effects of exogenous testosterone on ovarian weight, follicular morphology and intraovarian progesterone concentration in estrogen-primed hypophysectomised immature female rats. Bil. Reprod. 20: 61-68.
    • (1979) Bil. Reprod. , vol.20 , pp. 61-68
    • Hillier, S.G.1    Ross, G.T.2
  • 39
    • 34547387863 scopus 로고
    • On the action of intraovarian injection of androgen on follicle and corpus luteum maturation in women
    • HUFFMAN, F. & C. MEGER. 1965. On the action of intraovarian injection of androgen on follicle and corpus luteum maturation in women. Geburst. Frauenheik. 25: 1132-1137.
    • (1965) Geburst. Frauenheik. , vol.25 , pp. 1132-1137
    • Huffman, F.1    Meger, C.2
  • 40
    • 0023277586 scopus 로고
    • Hirsutism, polycystic ovarian disease and ovarian 17-ketosteroid reductase deficiency
    • PANG, S., B. SOFTNESS, W. SWEENEY & M. I. NEW. 1987. Hirsutism, polycystic ovarian disease and ovarian 17-ketosteroid reductase deficiency. N. Engl. J. Med. 316: 1295-1301.
    • (1987) N. Engl. J. Med. , vol.316 , pp. 1295-1301
    • Pang, S.1    Softness, B.2    Sweeney, W.3    New, M.I.4
  • 41
    • 0026378756 scopus 로고
    • Structure and expression of a new complementary DNA encoding the almost exclusive 3b-hydroxysteroid dehydrogenase/D5-D4 isomerase in human adrenals and gonads
    • RHEAUME, E., Y. LACHANCE, H-F. ZHAO, N. BRETON, M. DUMONT, Y. DE LAUNOIT, C. TRUDEL, V. LUU-THE, J. SIMARD & F. LABRIE. 1991. Structure and expression of a new complementary DNA encoding the almost exclusive 3b-hydroxysteroid dehydrogenase/D5-D4 isomerase in human adrenals and gonads. Mol. Endocrinol. 5: 1147-1157.
    • (1991) Mol. Endocrinol. , vol.5 , pp. 1147-1157
    • Rheaume, E.1    Lachance, Y.2    Zhao, H.-F.3    Breton, N.4    Dumont, M.5    De Launoit, Y.6    Trudel, C.7    Luu-The, V.8    Simard, J.9    Labrie, F.10
  • 42
    • 0025195368 scopus 로고
    • Dysregulation of cytochrome P450c 17 alpha as the case of polycystic ovarian syndrome
    • ROSEFIELD, R. L., R. B. BARNES, J. F. CARA & A. W. LUCKY. 1990. Dysregulation of cytochrome P450c 17 alpha as the case of polycystic ovarian syndrome. Fertil. Steril. 53: 785-791.
    • (1990) Fertil. Steril. , vol.53 , pp. 785-791
    • Rosefield, R.L.1    Barnes, R.B.2    Cara, J.F.3    Lucky, A.W.4
  • 43
    • 0028938872 scopus 로고
    • Gonadotropin and gonadal steroid response to a dose of long-acting agonist of gonadotropin releasing hormone in ovulatory and anovulatory women with polycystic ovary syndrome
    • WHITE, D., A. LEIGH, C. WILSON, A. DONALSON & C. FRANKS. 1995. Gonadotropin and gonadal steroid response to a dose of long-acting agonist of gonadotropin releasing hormone in ovulatory and anovulatory women with polycystic ovary syndrome. Clin. Endocrinol. 42: 475-481.
    • (1995) Clin. Endocrinol. , vol.42 , pp. 475-481
    • White, D.1    Leigh, A.2    Wilson, C.3    Donalson, A.4    Franks, C.5
  • 44
    • 0022578632 scopus 로고
    • Hormonal regulation of P450 scc(20- 22-desmolase) and P450c17(17α-hydroxylase/17,20-lyase) in cultures human granulosa cell
    • VOUTILAINEN, R., J. TAPANAINEN, B-C. CHUNG, K. J. MATTESON & W. L. MILLER. 1986. Hormonal regulation of P450 scc(20- 22-desmolase) and P450c17(17α-hydroxylase/17,20-lyase) in cultures human granulosa cell. J. Clin. Endocrinol. Metab. 63: 202-207.
    • (1986) J. Clin. Endocrinol. Metab. , vol.63 , pp. 202-207
    • Voutilainen, R.1    Tapanainen, J.2    Chung, B.-C.3    Matteson, K.J.4    Miller, W.L.5
  • 45
    • 0026664328 scopus 로고
    • Detection of functional ovarian hyperandrogenism in women with androgen excess
    • EHRMANN, D. A., R. L. ROSENFIELD, R. BARNES, D. F. BRIGELL & Z. SHEIKH. 1992. Detection of functional ovarian hyperandrogenism in women with androgen excess. N. Engl. J. Med. 327: 157-162.
    • (1992) N. Engl. J. Med. , vol.327 , pp. 157-162
    • Ehrmann, D.A.1    Rosenfield, R.L.2    Barnes, R.3    Brigell, D.F.4    Sheikh, Z.5
  • 46
    • 0028588696 scopus 로고
    • Studies of the nature of 17-hydroxyprogesterone hyperresponsiveness to gonadotropin releasing hormone agonist challenge in functional ovarian hyperandrogenism
    • ROSENFILD, R. L., R. B. BARNES & D. A. EHRMANN. 1994. Studies of the nature of 17-hydroxyprogesterone hyperresponsiveness to gonadotropin releasing hormone agonist challenge in functional ovarian hyperandrogenism. J. Clin. Endocrinol. Metab. 79: 1686-1692.
    • (1994) J. Clin. Endocrinol. Metab. , vol.79 , pp. 1686-1692
    • Rosenfild, R.L.1    Barnes, R.B.2    Ehrmann, D.A.3
  • 47
    • 0028588696 scopus 로고
    • Studies of the nature of 17-hydroxyprogesterone hyperresponsiveness to gonadotropin releasing hormone agonist challenge in functional ovarian hyperandrogenism
    • ROSENFILD, R. L., R. B. BARNES & D. A. EHRMAN. 1994. Studies of the nature of 17-hydroxyprogesterone hyperresponsiveness to gonadotropin releasing hormone agonist challenge in functional ovarian hyperandrogenism. J. Clin. Endocrinol. Metab. 79: 1686-1692.
    • (1994) J. Clin. Endocrinol. Metab. , vol.79 , pp. 1686-1692
    • Rosenfild, R.L.1    Barnes, R.B.2    Ehrman, D.A.3
  • 48
    • 0028029753 scopus 로고
    • Hypersecretion of androstenedione by isolated cells from polycystic ovaries
    • GILING-SMITH, C., D. S. WILIS, R. W. BEARD & S. FRANKS. 1994. Hypersecretion of androstenedione by isolated cells from polycystic ovaries. J. Clin. Endocrinol. Metab. 79: 1158-1165.
    • (1994) J. Clin. Endocrinol. Metab. , vol.79 , pp. 1158-1165
    • Giling-Smith, C.1    Wilis, D.S.2    Beard, R.W.3    Franks, S.4
  • 49
    • 0024542647 scopus 로고
    • Heterogeneity of the polycystic ovary syndrome
    • CONWAY, G. S., J. W. HONOUR & H. S. JACOBS. 1989. Heterogeneity of the polycystic ovary syndrome. Clin. Endocrinol. 30: 459-470.
    • (1989) Clin. Endocrinol. , vol.30 , pp. 459-470
    • Conway, G.S.1    Honour, J.W.2    Jacobs, H.S.3
  • 50
    • 0025887469 scopus 로고
    • Hirsutism in polycystic ovary syndrome: Current concepts
    • LOBO, R. A. 1991. Hirsutism in polycystic ovary syndrome: Current concepts. Clin. Obstet. Gynecol. 34: 817-826.
    • (1991) Clin. Obstet. Gynecol. , vol.34 , pp. 817-826
    • Lobo, R.A.1
  • 51
    • 0014082786 scopus 로고
    • Testosterone and androstenedione blood production rates in normal women and women with idiopathic hirsutism or polycystic ovaries
    • BARDIN, C. W. & M. B. LIPSETT. 1967. Testosterone and androstenedione blood production rates in normal women and women with idiopathic hirsutism or polycystic ovaries. J. Clin. Invest. 46: 891-902.
    • (1967) J. Clin. Invest. , vol.46 , pp. 891-902
    • Bardin, C.W.1    Lipsett, M.B.2
  • 52
    • 0016008573 scopus 로고
    • Sex-hormone-binding-globulin
    • ADERSON, D. C. 1974. Sex-hormone-binding-globulin. Clin. Endocrinol. 3: 69-96.
    • (1974) Clin. Endocrinol. , vol.3 , pp. 69-96
    • Aderson, D.C.1
  • 53
    • 0026040768 scopus 로고
    • Pathophysiology of sex hormone binding globulin (SHBG): Relation to insulin
    • PUGEAT, M., J. C. CRAVE, M. ELMIDANI, et al. 1991. Pathophysiology of sex hormone binding globulin (SHBG): Relation to insulin. J. Steroid Biochem. Mol. Biol. 40: 841-849.
    • (1991) J. Steroid Biochem. Mol. Biol. , vol.40 , pp. 841-849
    • Pugeat, M.1    Crave, J.C.2    Elmidani, M.3
  • 54
    • 0018906734 scopus 로고
    • Correlation of hyperandrogenism with hyperinsulism in polycystic ovarian disease
    • BURGEN, G. A., J. R. GIVENS & A. E. KITABCHI. 1980. Correlation of hyperandrogenism with hyperinsulism in polycystic ovarian disease. J. Clin. Endocrinol. Metab. 50: 113-116.
    • (1980) J. Clin. Endocrinol. Metab. , vol.50 , pp. 113-116
    • Burgen, G.A.1    Givens, J.R.2    Kitabchi, A.E.3
  • 55
    • 0027255435 scopus 로고
    • Insulin resistance in polycystic ovarian syndrome
    • DUNAIF, A. 1993. Insulin resistance in polycystic ovarian syndrome. Ann. N.Y. Acad. Sci. 687: 60-64.
    • (1993) Ann. N.Y. Acad. Sci. , vol.687 , pp. 60-64
    • Dunaif, A.1
  • 56
    • 0027532914 scopus 로고
    • Global estimates or prevalence of diabetes mellitus and impaired glucose tolerance in adults
    • KING, H. & M. REWERS. 1993. Global estimates or prevalence of diabetes mellitus and impaired glucose tolerance in adults. Diabetes Care 16: 157-177.
    • (1993) Diabetes Care , vol.16 , pp. 157-177
    • King, H.1    Rewers, M.2
  • 57
    • 0023573935 scopus 로고
    • Prevalence of diabetes and impaired glucose tolerance and plasma glucose levels in U.S. population aged 20-74 yr
    • HARRIS, M. I., W. C. HADDEN, W. C. KWOLER & P. H. BENNETT. 1987. Prevalence of diabetes and impaired glucose tolerance and plasma glucose levels in U.S. population aged 20-74 yr. Diabetes 36: 523-534.
    • (1987) Diabetes , vol.36 , pp. 523-534
    • Harris, M.I.1    Hadden, W.C.2    Kwoler, W.C.3    Bennett, P.H.4
  • 58
    • 0023189131 scopus 로고
    • Characterization of groups of hyperandrogenic women with acanthosis nigricans, impaired glucose tolerance and/or hyperinsulinemia
    • DUNAIF, A., M. GRAF, J. MANDELI, V. LAUMAS &; A. DOBJANSKI. 1987. Characterization of groups of hyperandrogenic women with acanthosis nigricans, impaired glucose tolerance and/or hyperinsulinemia. J. Endocrinol. Metab. 65: 499-507.
    • (1987) J. Endocrinol. Metab. , vol.65 , pp. 499-507
    • Dunaif, A.1    Graf, M.2    Mandeli, J.3    Laumas, V.4    Dobjanski, A.5
  • 59
    • 0024437305 scopus 로고
    • Profound peripheral insulin resistance, independentn of obesity, in the polycystic ovary syndrome
    • DUNAIF, A., W. FUTTERWEIT, K. R. SEGAL & A. DOBRJANSKY. 1989. Profound peripheral insulin resistance, independentn of obesity, in the polycystic ovary syndrome. Diabetes 38: 1165-1174.
    • (1989) Diabetes , vol.38 , pp. 1165-1174
    • Dunaif, A.1    Futterweit, W.2    Segal, K.R.3    Dobrjansky, A.4
  • 62
    • 0018520840 scopus 로고
    • Glucose clamp technique: A method for quantifying insulin secretion and resistance
    • DE FRONZO, R. A., J. D. TOBIN & R. ANDRES. 1979. Glucose clamp technique: A method for quantifying insulin secretion and resistance. Am. J. Physiol. 237: E214-223.
    • (1979) Am. J. Physiol. , vol.237
    • De Fronzo, R.A.1    Tobin, J.D.2    Andres, R.3
  • 63
    • 34547389637 scopus 로고
    • Polycystic ovary syndrome: A model of primary defect of insulin action
    • First and second Department of Medicine, University of Athens Medical School, Greece. Abstract No. 834. Anaheim, CA
    • DIAMANTI-KANDARAKIS, E., A. MIRTRAKOU, D. PLATANISSIOTIS, G. SPINA, E. DYTELIS, S. PAPTIS. (Sponsor: S. Nader). 1994. Polycystic ovary syndrome: A model of primary defect of insulin action. First and second Department of Medicine, University of Athens Medical School, Greece. Abstract No. 834. 76th Annual Meeting Endocrine Society, Anaheim, CA.
    • (1994) 76th Annual Meeting Endocrine Society
    • Diamanti-Kandarakis, E.1    Mirtrakou, A.2    Platanissiotis, D.3    Spina, G.4    Dytelis, E.5    Paptis, S.6    Nader, S.7
  • 64
    • 0029880488 scopus 로고    scopus 로고
    • b-Cell dysfunction independent of obesity and glucose intolerance in the polycystic ovary syndrome
    • DUNAIF, A. & D. FINEGOOD. 1996. b-Cell dysfunction independent of obesity and glucose intolerance in the polycystic ovary syndrome. J. Clin. Endocrinol. Metab. 81: 3.942-3.947.
    • (1996) J. Clin. Endocrinol. Metab. , vol.81
    • Dunaif, A.1    Finegood, D.2
  • 65
    • 85047696604 scopus 로고
    • Polycystic ovary syndrome as a form of functional ovarian hyperandrogenism due to dysregulation of androgen secretion
    • ERRHMAN, D. A., R. B. BARNES & R. L. ROSENFILD. 1995. Polycystic ovary syndrome as a form of functional ovarian hyperandrogenism due to dysregulation of androgen secretion. Endoc. Rev. 16: 322-353.
    • (1995) Endoc. Rev. , vol.16 , pp. 322-353
    • Errhman, D.A.1    Barnes, R.B.2    Rosenfild, R.L.3
  • 67
    • 0027450302 scopus 로고
    • Insulin resistance in polycystic ovary syndrome: Decreased expression of GLUT-4 glucose transporters in adipocytes
    • ROSENBAUM, D., R. S. HABER & A. DUNAIF. 1993. Insulin resistance in polycystic ovary syndrome: Decreased expression of GLUT-4 glucose transporters in adipocytes. Am. J. Physiol. 264: 197-202.
    • (1993) Am. J. Physiol. , vol.264 , pp. 197-202
    • Rosenbaum, D.1    Haber, R.S.2    Dunaif, A.3
  • 68
    • 0029119085 scopus 로고
    • Excessive insulin receptor serine phosphorylation in cultured fibroblasts and in skeletal muscle: A potential mechanism for insulin resistance in the polycystic ovary syndrome
    • DUNAIF, A., J. XIA, C-B. BOOK, E. SCHENKER & Z. TANG. 1995. Excessive insulin receptor serine phosphorylation in cultured fibroblasts and in skeletal muscle: A potential mechanism for insulin resistance in the polycystic ovary syndrome. J. Clin. Invest. 96: 801-810.
    • (1995) J. Clin. Invest. , vol.96 , pp. 801-810
    • Dunaif, A.1    Xia, J.2    Book, C.-B.3    Schenker, E.4    Tang, Z.5
  • 70
    • 0024381472 scopus 로고
    • Suppression of serum insulin by diazoxide reduces testosterone levels in obese women with polycystic ovary syndrome
    • NESTLER, J. E., C. O. BARLASCINI, D. W. MATT, et al. 1989. Suppression of serum insulin by diazoxide reduces testosterone levels in obese women with polycystic ovary syndrome. J. Clin. Endocrinol. Metab. 68: 1027.
    • (1989) J. Clin. Endocrinol. Metab. , vol.68 , pp. 1027
    • Nestler, J.E.1    Barlascini, C.O.2    Matt, D.W.3
  • 71
    • 0028315971 scopus 로고
    • Metformin therapy in polycystic ovary syndrome reduces hyperinsulinemia, insulin resistance, hyperandrogenemia and systolic blood pressure, while facilitating normal menses and pregnancy
    • VELAZGUEZ, E. M., S. MENTOZA, T. HAMER, F. SOSA & C. J. GLUECK. 1994. Metformin therapy in polycystic ovary syndrome reduces hyperinsulinemia, insulin resistance, hyperandrogenemia and systolic blood pressure, while facilitating normal menses and pregnancy. Metabolism 43: 647-654.
    • (1994) Metabolism , vol.43 , pp. 647-654
    • Velazguez, E.M.1    Mentoza, S.2    Hamer, T.3    Sosa, F.4    Glueck, C.J.5
  • 72
    • 0025359669 scopus 로고
    • Suppression of hyperandrogenism does not improve peripheral of hepatic insulin resistance in the polycystic ovary syndrome
    • DUNAIF, A., G. GREEN, W. FUTTERWEIT & A. DOBRJANSKY. 1990. Suppression of hyperandrogenism does not improve peripheral of hepatic insulin resistance in the polycystic ovary syndrome. J. Clin. Endocrinol. Metab. 70: 699-704.
    • (1990) J. Clin. Endocrinol. Metab. , vol.70 , pp. 699-704
    • Dunaif, A.1    Green, G.2    Futterweit, W.3    Dobrjansky, A.4
  • 75
    • 0345477236 scopus 로고
    • Effects of insulin on ovarian steroidogenesis
    • A. Dunaif, J. H. Givens, F. P. Haseline, et al., Eds. Blackwell Scientific. Cambridge, MA
    • BARBIERI, R. L. 1992. Effects of insulin on ovarian steroidogenesis. In Polycystic Ovary Syndrome. A. Dunaif, J. H. Givens, F. P. Haseline, et al., Eds. Blackwell Scientific. Cambridge, MA.
    • (1992) Polycystic Ovary Syndrome
    • Barbieri, R.L.1
  • 76
    • 0027218635 scopus 로고
    • Intraovarian regulation: The proposed role of insulin-like growth factors
    • ADASHI, E. Y. 1993. Intraovarian regulation: The proposed role of insulin-like growth factors. Ann. N.Y. Acad. Sci. 687: 10-12.
    • (1993) Ann. N.Y. Acad. Sci. , vol.687 , pp. 10-12
    • Adashi, E.Y.1
  • 77
    • 0002875363 scopus 로고
    • Effects of insulin on steroidogenesis in vivo
    • A. Dunaif, J. R. Givens, F. P. Halestine, G. R. Merriam, Eds.: Blackwell Scientific. Oxford, England
    • NESTLER, J. E., J. N. CLORE & W. G. BLACKARD. 1992. Effects of insulin on steroidogenesis in vivo. In Polycystic Ovary Syndrome. A. Dunaif, J. R. Givens, F. P. Halestine, G. R. Merriam, Eds.: 265-278. Blackwell Scientific. Oxford, England.
    • (1992) Polycystic Ovary Syndrome , pp. 265-278
    • Nestler, J.E.1    Clore, J.N.2    Blackard, W.G.3
  • 79
    • 0027196489 scopus 로고
    • Evidence for a single gene effect causing polycystic ovaries and male pattern baldness
    • CAREY, A. H., K. L. CHAN, F. SHORT, D. WHITE, R. WILLIAMSON & S. FRANKS. 1993. Evidence for a single gene effect causing polycystic ovaries and male pattern baldness. Clin. Endocrinol. 38: 653-658.
    • (1993) Clin. Endocrinol. , vol.38 , pp. 653-658
    • Carey, A.H.1    Chan, K.L.2    Short, F.3    White, D.4    Williamson, R.5    Franks, S.6
  • 81
    • 0028786656 scopus 로고
    • Serine phosphorylation of human P450c17 increase 17,20 lyase activity: Implications for adrenarche and polycystic ovary syndrome
    • ZHANG, L., H. RODRIGUEZ, S. OHNO, et al. 1995. Serine phosphorylation of human P450c17 increase 17,20 lyase activity: Implications for adrenarche and polycystic ovary syndrome. Proc. Natl. Acad. Sci. USA 92: 10619-10623.
    • (1995) Proc. Natl. Acad. Sci. USA , vol.92 , pp. 10619-10623
    • Zhang, L.1    Rodriguez, H.2    Ohno, S.3
  • 82
    • 0023727845 scopus 로고
    • Effects of cyproterone acetate plus ethinylestradiol low dose on plasma androgens and lipids in mildly hirsute or acneic young women
    • VERMULEN, A. & R. RUBENS. 1988. Effects of cyproterone acetate plus ethinylestradiol low dose on plasma androgens and lipids in mildly hirsute or acneic young women. Contraception (USA) 38: 419-428.
    • (1988) Contraception (USA) , vol.38 , pp. 419-428
    • Vermulen, A.1    Rubens, R.2
  • 83
    • 0024565357 scopus 로고
    • Spironolactone is an effective and well tolerated systemic antiandrogen therapy for hirsute women
    • EARTH, J. H., C. A. CHERRY, F. WOJNAROWSKA & R. P. DAWER. 1989. Spironolactone is an effective and well tolerated systemic antiandrogen therapy for hirsute women. J. Clin. Endocrinol. Metab. 68: 966-970.
    • (1989) J. Clin. Endocrinol. Metab. , vol.68 , pp. 966-970
    • Earth, J.H.1    Cherry, C.A.2    Wojnarowska, F.3    Dawer, R.P.4
  • 84
    • 0028140279 scopus 로고
    • Comparison of flutamide and Spironolactone in the treatment of hirsutism: A randomized controlled trial
    • CUSAN, L., J. L. DUPOND, R. R. GOMEZ, TREMBLAY & F. LABRIE. 1994. Comparison of flutamide and Spironolactone in the treatment of hirsutism: A randomized controlled trial. Fertil. Steril. 61: 281-287.
    • (1994) Fertil. Steril. , vol.61 , pp. 281-287
    • Cusan, L.1    Dupond, J.L.2    Gomez, R.R.3    Tremblay4    Labrie, F.5
  • 85
    • 0022491765 scopus 로고
    • Clomiphene citrate-induced ovulation: Aclinical update
    • ADASHI, E. Y. 1986. Clomiphene citrate-induced ovulation: Aclinical update. Semin. Reprod. Endocrinol. 4: 255-275.
    • (1986) Semin. Reprod. Endocrinol. , vol.4 , pp. 255-275
    • Adashi, E.Y.1
  • 86
    • 0026607265 scopus 로고
    • Treatment of insulin-resistant mice with oral antidiabetic agent pioglitazone: Evaluation of liver GLUT2 and prosphoenolpyruvate carboxykinase expression
    • HOFMAN, C. A., C. W. EDWARDS III, R. M. HILMAN & J. R. COLCA. 1992. Treatment of insulin-resistant mice with oral antidiabetic agent pioglitazone: Evaluation of liver GLUT2 and prosphoenolpyruvate carboxykinase expression. Endocrinology 130: 735-740.
    • (1992) Endocrinology , vol.130 , pp. 735-740
    • Hofman, C.A.1    Edwards III, C.W.2    Hilman, R.M.3    Colca, J.R.4
  • 87
    • 0026543775 scopus 로고
    • Improvement in endocrine and ovarian function during dietary treatment of obese women with polycystic ovary syndrome
    • KIDDY, D. S., D. HAMILTON FAIRLEY, A. BUSH, F. SHORT, V. ANYAKOU, M. J. REED & S. FRANKS. 1992. Improvement in endocrine and ovarian function during dietary treatment of obese women with polycystic ovary syndrome. Clin. Endocrinol. 36: 105-111.
    • (1992) Clin. Endocrinol. , vol.36 , pp. 105-111
    • Kiddy, D.S.1    Hamilton Fairley, D.2    Bush, A.3    Short, F.4    Anyakou, V.5    Reed, M.J.6    Franks, S.7
  • 88
    • 13844300199 scopus 로고
    • Androgenic disorders of women: Diagnostic and therapeutic decision making
    • GEOFFREY, P. R. 1995. Androgenic disorders of women: Diagnostic and therapeutic decision making. Am. J. Med. Assoc. 98: 120-129s.
    • (1995) Am. J. Med. Assoc. , vol.98
    • Geoffrey, P.R.1


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