Excess glutamine exacerbates trinitrobenzenesulfonic acid-induced colitis in rats

Diseases of the Colon and Rectum

Volumn 40, Issue 10 SUPPL., 1997, Pages

  Shinozaki, Masaru ^a   Saito, Hideaki ^a   Muto, Tetsuichiro ^a  

^a UNIVERSITY OF TOKYO   (Japan)

Author keywords

Colitis; Crohn's disease; Elemental diet; Glutamine; Inflammatory bowel disease; Nutritional therapy

Indexed keywords

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; COLON BIOPSY; COLON ULCER; CROHN DISEASE; DISEASE COURSE; FEMALE; HISTOPATHOLOGY; NONHUMAN; PROTEIN INTAKE; RAT;

ANIMALS; COLITIS; COLON; CROHN DISEASE; FEMALE; FOOD, FORMULATED; GLUTAMINE; RATS; RATS, SPRAGUE-DAWLEY; TIME FACTORS; TRINITROBENZENESULFONIC ACID;

EID: 0030806057     PISSN: 00123706     EISSN: None     Source Type: Journal    
DOI: 10.1007/bf02062022     Document Type: Article

References (15)

1. Crohn BB, Berg AA. Right-side (regional) colitis. JAMA 1938;110:32-8.
2. Fleming SE, Fitch MD, DeVries S, Liu ML, Kight C. Nutrient utilization by cells isolated from rat jejunem, cecum, and colon. J Nutr 1991;121:869-78.
3. Seidman E, LeLeiko N, Ament M, et al. Nutritional issues in pediatric inflammatory bowel disease. J Pediatric Gastroenterol Nutr 1991;12:424-38.
4. Fischer CP, Bode BP, Abcouwer SF, Lukaszewicz GC, Souba WW. Hepatic uptake of glutamine and other amino acids during infection and inflammation. Shock 1995;3:315-22.
5. Fujita T, Sakurai K. Efficacy of glutamine-enriched enteral nutrition in an experimental model of mucosal ulcerative colitis. Br J Surg 1995;82:749-51.
6. Morris GP, Beck PL, Herridge MS, Depew WT, Szewczuk MR, Wallace JL. Hapten-induced model of chronic inflammation and ulceration in the rat colon. Gastroenterology 1989;96:795-803.
7. Klimberg VS, Salloum RM, Kasper M, et al. Oral glutamine accelerates healing of the small intestine and improves outcome after whole abdominal radiation. Arch Surg 1990;125:1040-5.
8. O'Dwyer ST, Scott T, Smith RJ, Wilmore DW. 5-Fluorouracil toxicity on small intestinal mucosa but not white blood cells is decreased by glutamine [abstract]. Clin Res 1987;35:A369.
9. Chapman MA, Grahn MF, Boyle MA, Hutton M, Rogers J, Williams NS. Butyrate oxidation is impaired in the colonic mucosa of sufferers of quiescent ulcerative colitis. Gut 1994;35:73-6.
10. Roediger WE. Utilization of nutrients by isolated epithelial cells of the rat colon. Gastroenterology 1982;83: 424-9.
11. Newsholme EA, Crabtree B, Ardawi MS. Glutamine metabolism in lymphocytes: its biochemical, physiological and clinical importance. Q J Exp Physiol 1985;70: 473-89.
12. Wu GY, Field CJ, Marliss EB. Glutamine and glucose metabolism in rat splenocytes and mesenteric lymph node lymphocytes. Am J Physiol 1991;260:E141-7.
13. Ardawi MS. Glutamine and glucose metabolism in human peripheral lymphocytes. Metabolism 1988;37: 99-103.
14. den Butter G, Lindell SL, Sumimoto R, Schilling MK, Southard JH, Belzer FO. Effect of glycine in dog and rat liver transplantation. Transplantation 1993;56:817-22.
15. Weinberg JM, Varani J, Johnson KJ, et al. Protection of human umbilical vein endothelial cells by glycine and structurally similar amino acids against calcium and hydrogen peroxide-induced lethal cell injury. Am J Pathol 1992;140:457-71.