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Volumn 122, Issue 1-2, 1997, Pages 11-21

Evidence for mitochondrial metabolism of 7,12-dimethylbenz(a)anthracene in porcine ovaries: Comparison with microsomal metabolism

Author keywords

7,12 dimethylbenz(a)anthracene; Cytochrome P450; Mitochondria; Ovary; Porcine

Indexed keywords

7,12 DIMETHYLBENZ[A]ANTHRACENE; ALPHA NAPHTHOFLAVONE; ANDROSTENEDIONE; CHOLESTEROL; CYTOCHROME P450; ELLIPTICINE; ENZYME; ESTRADIOL; INDOMETACIN; MARKER; PROGESTERONE; RADIOISOTOPE; TESTOSTERONE;

EID: 0030805805     PISSN: 0300483X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0300-483X(97)00074-7     Document Type: Article
Times cited : (10)

References (40)
  • 1
    • 0017565666 scopus 로고
    • Characterization of cytochrome oxidase purified from rat liver
    • Ades, I.Z., Cascarano, J., 1977. Characterization of cytochrome oxidase purified from rat liver. J. Bioenerg. Biomembr. 9, 237-253.
    • (1977) J. Bioenerg. Biomembr. , vol.9 , pp. 237-253
    • Ades, I.Z.1    Cascarano, J.2
  • 2
    • 0023631006 scopus 로고
    • Mechanisms of regulation of rat ovarian 7,12-dimethylbenz(a)anthracene hydroxylase
    • Bengtsson, M., Dong, Y., Mattisson, R.D., Rydström, J., 1987. Mechanisms of regulation of rat ovarian 7,12-dimethylbenz(a)anthracene hydroxylase. Chem-Biol. Interact. 63, 15-27.
    • (1987) Chem-Biol. Interact. , vol.63 , pp. 15-27
    • Bengtsson, M.1    Dong, Y.2    Mattisson, R.D.3    Rydström, J.4
  • 3
    • 0025341751 scopus 로고
    • On the identity of xenobiotic metabolizing form(s) of cytochrome P450 in endocrine organs
    • Bengtsson, M., Hallberg, E., Georgellis, A., Rydström, J., 1990. On the identity of xenobiotic metabolizing form(s) of cytochrome P450 in endocrine organs. Cancer Lett. 52, 235-241.
    • (1990) Cancer Lett. , vol.52 , pp. 235-241
    • Bengtsson, M.1    Hallberg, E.2    Georgellis, A.3    Rydström, J.4
  • 4
    • 0024264603 scopus 로고
    • Metabolism of 7,12-dimethylbenz(a)anthracene by different types of cells in the human ovary
    • Bengtsson, M., Hamberger, L., Rydström, J., 1988. Metabolism of 7,12-dimethylbenz(a)anthracene by different types of cells in the human ovary. Xenobiotica 18, 1255-1262.
    • (1988) Xenobiotica , vol.18 , pp. 1255-1262
    • Bengtsson, M.1    Hamberger, L.2    Rydström, J.3
  • 5
    • 0343342803 scopus 로고
    • Regulation and role of aryl hydrocarbon hydroxylase in rat adrenal and gonads
    • Hietanen, E., Laitinen, M., Hänninen, O. (Eds.), Elsevier, Amsterdam
    • Bengtsson, M., Montelius, J., Hallberg, E., Mankowitz, L., Rydström, J., 1982. Regulation and role of aryl hydrocarbon hydroxylase in rat adrenal and gonads. In: Hietanen, E., Laitinen, M., Hänninen, O. (Eds.), Developments in Biochemistry Vol. 23. Elsevier, Amsterdam, pp. 653-656.
    • (1982) Developments in Biochemistry , vol.23 , pp. 653-656
    • Bengtsson, M.1    Montelius, J.2    Hallberg, E.3    Mankowitz, L.4    Rydström, J.5
  • 6
    • 0020677606 scopus 로고
    • Metabolism of polycyclic aromatic hydrocarbons in the rat ovary. Comparison with metabolism in adrenal and liver tissue
    • Bengtsson, M., Montelius, J., Mankowitz, L., Rydström, J., 1983. Metabolism of polycyclic aromatic hydrocarbons in the rat ovary. Comparison with metabolism in adrenal and liver tissue. Biochem. Pharmacol. 32, 129-136.
    • (1983) Biochem. Pharmacol. , vol.32 , pp. 129-136
    • Bengtsson, M.1    Montelius, J.2    Mankowitz, L.3    Rydström, J.4
  • 7
    • 0020530858 scopus 로고
    • Regulation of Carcinogen Metabolism in the Rat Ovary by the Estrus Cycle and Gonadotropin
    • Bengtsson, M., Rydström, J., 1983. Regulation of Carcinogen Metabolism in the Rat Ovary by the Estrus Cycle and Gonadotropin. Science 219, 1437-1438.
    • (1983) Science , vol.219 , pp. 1437-1438
    • Bengtsson, M.1    Rydström, J.2
  • 8
    • 0029077901 scopus 로고
    • Brain mitochondrial cytochrome P450: Xenobiotic metabolism, presence of multiple forms and their selective inducibility
    • Bhagwat, S.V., Boyd, M.R., Ravindranath, V., 1995. Brain mitochondrial cytochrome P450: Xenobiotic metabolism, presence of multiple forms and their selective inducibility. Arch. Biochem. Biophys. 320, 73-83.
    • (1995) Arch. Biochem. Biophys. , vol.320 , pp. 73-83
    • Bhagwat, S.V.1    Boyd, M.R.2    Ravindranath, V.3
  • 9
    • 0029009343 scopus 로고
    • Identification of a rat adrenal cytochrome P450 active in polycyclic hydrocarbon metabolism as rat CYP 1B1
    • Bhattacharyya, K.K., Brake, P.B., Eltom, S.E., Otto, S.A., Jefcoate, C.R., 1995. Identification of a rat adrenal cytochrome P450 active in polycyclic hydrocarbon metabolism as rat CYP 1B1. J. Biol. Chem. 270, 11595-11602.
    • (1995) J. Biol. Chem. , vol.270 , pp. 11595-11602
    • Bhattacharyya, K.K.1    Brake, P.B.2    Eltom, S.E.3    Otto, S.A.4    Jefcoate, C.R.5
  • 10
    • 0019168050 scopus 로고
    • Biotransformation and bioactivation of 7,12-dimethylbenz(a)anthracene (7,12-DMBA)
    • DiGiovanni, J., Juchau, M.R., 1980. Biotransformation and bioactivation of 7,12-dimethylbenz(a)anthracene (7,12-DMBA). Drug Metabol. Rev. 11, 61-101.
    • (1980) Drug Metabol. Rev. , vol.11 , pp. 61-101
    • DiGiovanni, J.1    Juchau, M.R.2
  • 11
    • 0023156272 scopus 로고
    • Evidence for a free-radical-dependent metabolism of 7,12-dimethylbenz(a)anthracene in rat testis
    • Georgellis, A., Montelius, J., Rydström, J., 1987. Evidence for a free-radical-dependent metabolism of 7,12-dimethylbenz(a)anthracene in rat testis. Toxicol. Appl. Pharmacol. 87, 141-154.
    • (1987) Toxicol. Appl. Pharmacol. , vol.87 , pp. 141-154
    • Georgellis, A.1    Montelius, J.2    Rydström, J.3
  • 12
    • 0028023649 scopus 로고
    • Steroidogenic cytochrome P450 enzyme messenger ribonucleic acids and follicular fluid steroids in individual follicles during preovulatoric maturation in the pig
    • Guthrie, H.D., Barber, J.A., Leighton, J.K., Hammond, J.M., 1987. Steroidogenic cytochrome P450 enzyme messenger ribonucleic acids and follicular fluid steroids in individual follicles during preovulatoric maturation in the pig. Biol. Reprod. 51, 465-471.
    • (1987) Biol. Reprod. , vol.51 , pp. 465-471
    • Guthrie, H.D.1    Barber, J.A.2    Leighton, J.K.3    Hammond, J.M.4
  • 13
    • 0025036585 scopus 로고
    • Influence of effectors of prostaglandin metabolism on the toxicity induced by 7-hydroxymethyl-12-methylbenz(a)anthracene in cultured rat adrenal cells
    • Hallberg, E., Rydström, J., 1990. Influence of effectors of prostaglandin metabolism on the toxicity induced by 7-hydroxymethyl-12-methylbenz(a)anthracene in cultured rat adrenal cells. Xenobiotica 20, 1311-1318.
    • (1990) Xenobiotica , vol.20 , pp. 1311-1318
    • Hallberg, E.1    Rydström, J.2
  • 14
    • 33645859262 scopus 로고
    • Selective adrenal necrosis and apoplexy induced by 7,12-dimethylbenz(a)anthracene
    • Huggins, C., Morii, S., 1961. Selective adrenal necrosis and apoplexy induced by 7,12-dimethylbenz(a)anthracene. J. Exptl. Med. 114, 741-760.
    • (1961) J. Exptl. Med. , vol.114 , pp. 741-760
    • Huggins, C.1    Morii, S.2
  • 16
    • 0027493771 scopus 로고
    • Molecular cloning, expression, and enzymatic characterization of the rat kidney cytochrome P-450 arachidonic acid epoxygenase
    • Karara, A., Makita, K., Jacobson, H.R., Falck, J.R., Guengerich, F.P., Dubois, R.N., Capdevila, J.H., 1993. Molecular cloning, expression, and enzymatic characterization of the rat kidney cytochrome P-450 arachidonic acid epoxygenase. J. Biol. Chem. 268, 13565-13570.
    • (1993) J. Biol. Chem. , vol.268 , pp. 13565-13570
    • Karara, A.1    Makita, K.2    Jacobson, H.R.3    Falck, J.R.4    Guengerich, F.P.5    Dubois, R.N.6    Capdevila, J.H.7
  • 17
    • 0018972027 scopus 로고
    • Purification and characterization of mitochondrial cytochrome P-450 associated with cholesterol side chain cleavage from bovine Corpus Luteum
    • Kashiwagi, K., Dafeldecker, W.P., Salhanick, H.A., 1980. Purification and characterization of mitochondrial cytochrome P-450 associated with cholesterol side chain cleavage from bovine Corpus Luteum. J. Biol. Chem. 255, 2606-2611.
    • (1980) J. Biol. Chem. , vol.255 , pp. 2606-2611
    • Kashiwagi, K.1    Dafeldecker, W.P.2    Salhanick, H.A.3
  • 18
    • 0029081540 scopus 로고
    • Novel involvement of mitochondrial steroid hydroxylase P450 ell in xenobiotic metabolism
    • Lund, B.-O., Lund, J., 1995. Novel involvement of mitochondrial steroid hydroxylase P450 ell in xenobiotic metabolism. J. Biol. Chem. 270, 20895-20897.
    • (1995) J. Biol. Chem. , vol.270 , pp. 20895-20897
    • Lund, B.-O.1    Lund, J.2
  • 19
    • 0021879451 scopus 로고
    • Properties of cytosolic epoxide hydrolase purified from the liver of untreated and clofibrate-treated mice. Characterization of optimal assay conditions, substrate specificity and effects of modulators on the catalytical activity
    • Meijer, J., DePierre, J.W., 1985. Properties of cytosolic epoxide hydrolase purified from the liver of untreated and clofibrate-treated mice. Characterization of optimal assay conditions, substrate specificity and effects of modulators on the catalytical activity. Eur. J. Biochem. 150, 7-16.
    • (1985) Eur. J. Biochem. , vol.150 , pp. 7-16
    • Meijer, J.1    Depierre, J.W.2
  • 21
    • 0020067646 scopus 로고
    • Metabolism of polycyclic aromatic hydrocarbons and covalent binding of metabolites to protein in rat adrenal gland
    • Montelius, J., Papadopoulos, D., Bengtsson, M., Rydström, J., 1982. Metabolism of polycyclic aromatic hydrocarbons and covalent binding of metabolites to protein in rat adrenal gland. Cancer Res. 42, 1479-1486.
    • (1982) Cancer Res. , vol.42 , pp. 1479-1486
    • Montelius, J.1    Papadopoulos, D.2    Bengtsson, M.3    Rydström, J.4
  • 23
    • 0026485625 scopus 로고
    • Polycyclic aromatic hydrocarbon metabolism in rat adrenal, ovary and testes microsomes is catalyzed by the same novel cytochrome P450 (P450RAP)
    • Otto, S., Bhattacharyya, K.K., Jefcoate, C.R., 1992. Polycyclic aromatic hydrocarbon metabolism in rat adrenal, ovary and testes microsomes is catalyzed by the same novel cytochrome P450 (P450RAP). Endocrinology 131, 3067-3076.
    • (1992) Endocrinology , vol.131 , pp. 3067-3076
    • Otto, S.1    Bhattacharyya, K.K.2    Jefcoate, C.R.3
  • 24
    • 0026018303 scopus 로고
    • A novel adrenocorticotropin-inducible cytochrome P-450 from rat adrenal microsomes catalyzes polycyclic aromatic hydrocarbon metabolism
    • Otto, S., Marcus, C., Pidgeon, C., Jefcoate, C.R., 1991. A novel adrenocorticotropin-inducible cytochrome P-450 from rat adrenal microsomes catalyzes polycyclic aromatic hydrocarbon metabolism. Endocrinology 129, 970-982.
    • (1991) Endocrinology , vol.129 , pp. 970-982
    • Otto, S.1    Marcus, C.2    Pidgeon, C.3    Jefcoate, C.R.4
  • 25
    • 0020494654 scopus 로고
    • In vitro synthesis of monoamine oxidase of rat liver outer mitochondrial membrane
    • Sagara, Y., Ito, A., 1982. In vitro synthesis of monoamine oxidase of rat liver outer mitochondrial membrane. Biochem. Biophys. Res. Commun. 109, 1102-1107.
    • (1982) Biochem. Biophys. Res. Commun. , vol.109 , pp. 1102-1107
    • Sagara, Y.1    Ito, A.2
  • 26
    • 0026347345 scopus 로고
    • Constitutive and inducible forms of cytochrome P450 from hepatic mitochondria
    • Waterman, M.R., Johnson, E.F. (Eds.), Academic Press, San Diego
    • Shayiq, R.M., Addaya, S., Avadhani, N.G., 1991. Constitutive and inducible forms of cytochrome P450 from hepatic mitochondria. In: Waterman, M.R., Johnson, E.F. (Eds.), Methods Enzymol 206. Academic Press, San Diego, pp. 587-594.
    • (1991) Methods Enzymol , vol.206 , pp. 587-594
    • Shayiq, R.M.1    Addaya, S.2    Avadhani, N.G.3
  • 27
    • 0028111994 scopus 로고
    • cDNa cloning, sequence analysis, and induction by aryl hydrocarbons of a murine cytochrome P450 gene, Cyp1b1
    • Shen, Z., Liu, J., Wells, R.L., Elkind, M.M., 1994. cDNA cloning, sequence analysis, and induction by aryl hydrocarbons of a murine cytochrome P450 gene, Cyp1b1. DNA Cell Biol. 13, 763-769.
    • (1994) DNA Cell Biol. , vol.13 , pp. 763-769
    • Shen, Z.1    Liu, J.2    Wells, R.L.3    Elkind, M.M.4
  • 28
    • 0018449722 scopus 로고
    • Cholesterol side-chain cleavage, cytochrome P450, and the control of steroidogenesis
    • Simpson, E.R., 1979. Cholesterol side-chain cleavage, cytochrome P450, and the control of steroidogenesis. Mol. Cell Endocr. 13, 213-227.
    • (1979) Mol. Cell Endocr. , vol.13 , pp. 213-227
    • Simpson, E.R.1
  • 29
    • 0018087378 scopus 로고
    • Metabolism of benzo(a)pyrene to reactive intermediate(s) via prostaglandin biosynthesis
    • Sivarajah, K., Andersson, M.W., Eling, T.E., 1978. Metabolism of benzo(a)pyrene to reactive intermediate(s) via prostaglandin biosynthesis. Life Sci. 23, 2571-2578.
    • (1978) Life Sci. , vol.23 , pp. 2571-2578
    • Sivarajah, K.1    Andersson, M.W.2    Eling, T.E.3
  • 31
    • 0028574698 scopus 로고
    • The effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on estrogen metabolism in MCF-7 breast cancer cells: Evidence for induction of a novel 17β-estradiol 4-hydroxylase
    • Spink, D.C., Hayes, C.L., Young, N.R., Christou, M., Sutter, T.R., Jefcoate, C.R., Gierthy, J.F., 1995. The effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on estrogen metabolism in MCF-7 breast cancer cells: Evidence for induction of a novel 17β-estradiol 4-hydroxylase. J. Steroid Biochem. Mol. Biol. 51, 251-258.
    • (1995) J. Steroid Biochem. Mol. Biol. , vol.51 , pp. 251-258
    • Spink, D.C.1    Hayes, C.L.2    Young, N.R.3    Christou, M.4    Sutter, T.R.5    Jefcoate, C.R.6    Gierthy, J.F.7
  • 33
    • 0028276386 scopus 로고
    • Complete cDNa sequence of a human dioxin-inducible mRNa identifies a new gene subfamily of cytochrome P450 that maps to chromosome 2
    • Sutter, T.R., Tang, Y.M., Hayes, C.L., Wo, Y.P., Jab, E.W., Li, X., Yin, H., Cody, C.W., Greenlee, W.F., 1994. Complete cDNA sequence of a human dioxin-inducible mRNA identifies a new gene subfamily of cytochrome P450 that maps to chromosome 2. J. Biol. Chem. 269, 13092-13099.
    • (1994) J. Biol. Chem. , vol.269 , pp. 13092-13099
    • Sutter, T.R.1    Tang, Y.M.2    Hayes, C.L.3    Wo, Y.P.4    Jab, E.W.5    Li, X.6    Yin, H.7    Cody, C.W.8    Greenlee, W.F.9
  • 34
    • 0017668828 scopus 로고
    • Radioactive assay for aryl hydrocarbon hydroxylase. Improved method and biological importance
    • van Cantfort, J., DeGraeve, J., Gielen, J.E., 1977. Radioactive assay for aryl hydrocarbon hydroxylase. Improved method and biological importance. Biochem. Biophys. Res. Commun. 79, 505-512.
    • (1977) Biochem. Biophys. Res. Commun. , vol.79 , pp. 505-512
    • Van Cantfort, J.1    DeGraeve, J.2    Gielen, J.E.3
  • 35
    • 0029048701 scopus 로고
    • Rat CYP1B1: An adrenal cytochrome P450 that exhibits sex dependent expression in livers and kidneys of TCDD-treated animals
    • Walker, N.J., Gastel, J.A., Costa, L.T., Clark, G.C., Lucier, G.W., Sutter, T.R., 1995. Rat CYP1B1: an adrenal cytochrome P450 that exhibits sex dependent expression in livers and kidneys of TCDD-treated animals. Carcinogenesis 16, 1319-1327.
    • (1995) Carcinogenesis , vol.16 , pp. 1319-1327
    • Walker, N.J.1    Gastel, J.A.2    Costa, L.T.3    Clark, G.C.4    Lucier, G.W.5    Sutter, T.R.6
  • 36
    • 0026324284 scopus 로고
    • P450-catalyzed steroid hydroxylation: Assay and product identification by thin-layer chromatography
    • Waterman, M.R., Johnson, E.F. (Eds.), Academic Press, San Diego
    • Waxman, J.D., 1991. P450-catalyzed steroid hydroxylation: assay and product identification by thin-layer chromatography. In: Waterman, M.R., Johnson, E.F. (Eds.), Methods Enzymol. 206. Academic Press, San Diego, pp. 462-476.
    • (1991) Methods Enzymol. , vol.206 , pp. 462-476
    • Waxman, J.D.1
  • 37
    • 0015055235 scopus 로고
    • Aryl hydrocarbon (benzo(a)pyrene) hydroxylase in microsomes from rat tissue: Differential inhibiton and stimulation by benzoflavones and organic solvents
    • Wiebel, F.J., Leutz, J.C., Diamond, L., Gelboin, H.V., 1971. Aryl hydrocarbon (benzo(a)pyrene) hydroxylase in microsomes from rat tissue: Differential inhibiton and stimulation by benzoflavones and organic solvents. Arch. Biochem. Biophys. 144, 78-86.
    • (1971) Arch. Biochem. Biophys. , vol.144 , pp. 78-86
    • Wiebel, F.J.1    Leutz, J.C.2    Diamond, L.3    Gelboin, H.V.4
  • 38
    • 0026450658 scopus 로고
    • Morphometric assessment of the murine ovarian toxicity of 7,12-dimethylbenz(a)anthracene
    • Weitzman, G.A., Miller, M.M., London, S.N., Mattison, D.R., 1992. Morphometric assessment of the murine ovarian toxicity of 7,12-dimethylbenz(a)anthracene. Reprod. Toxicol. 6, 137-141.
    • (1992) Reprod. Toxicol. , vol.6 , pp. 137-141
    • Weitzman, G.A.1    Miller, M.M.2    London, S.N.3    Mattison, D.R.4
  • 39
    • 0027236945 scopus 로고
    • Differential expression of cytochrome P450 2C24 transcripts in rat kidney and prostate: Evidence of alternative and possibly trans splicing events
    • Zaphiropoulos, P.G., 1993. Differential expression of cytochrome P450 2C24 transcripts in rat kidney and prostate: Evidence of alternative and possibly trans splicing events. Biochem. Biophys. Res. Commun. 192, 778-786.
    • (1993) Biochem. Biophys. Res. Commun. , vol.192 , pp. 778-786
    • Zaphiropoulos, P.G.1
  • 40
    • 0029165723 scopus 로고
    • Cytochrome P450 genes expressed in porcine ovaries: Identification of novel forms, evidence for gene conversion, and evolutionary relationships
    • Zaphiropoulos, P.G., Skantz, A., Eliasson, M., Bengtsson Ahlberg, M., 1995. Cytochrome P450 genes expressed in porcine ovaries: Identification of novel forms, evidence for gene conversion, and evolutionary relationships. Biochem. Biophys. Res. Commun. 212, 433-441.
    • (1995) Biochem. Biophys. Res. Commun. , vol.212 , pp. 433-441
    • Zaphiropoulos, P.G.1    Skantz, A.2    Eliasson, M.3    Bengtsson Ahlberg, M.4


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