Aspects of the pharmacokinetics of doxycycline given to healthy and pneumonic East African dwarf goats by intramuscular injection

Veterinary Research Communications

Volumn 21, Issue 6, 1997, Pages 453-462

  Ole Mapenay, I M ^a   Mitema, E S ^a   Maitho, T E ^a  

^a UNIVERSITY OF NAIROBI   (Kenya)

Author keywords

Doxycycline; Goats; Pharmacokinetics; Pneumonia; Treatment

Indexed keywords

DOXYCYCLINE; FENBENDAZOLE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BACTERIAL PNEUMONIA; CONTROLLED STUDY; DRUG ABSORPTION; DRUG BLOOD LEVEL; DRUG DISTRIBUTION; DRUG ELIMINATION; DRUG HALF LIFE; FEMALE; GOAT; INTRAMUSCULAR DRUG ADMINISTRATION; MALE; MANNHEIMIA HAEMOLYTICA; NONHUMAN; PHARMACOKINETICS;

AFRICA, EASTERN; ANIMALS; ANTI-BACTERIAL AGENTS; BODY TEMPERATURE; DOXYCYCLINE; FEMALE; GOAT DISEASES; GOATS; HALF-LIFE; INJECTIONS, INTRAMUSCULAR; MALE; MANNHEIMIA HAEMOLYTICA; METABOLIC CLEARANCE RATE; PASTEURELLA INFECTIONS; PNEUMONIA, BACTERIAL; REFERENCE VALUES;

ANIMALIA; BACILLUS CEREUS; BACTERIA (MICROORGANISMS); CAPRA HIRCUS; MANNHEIMIA HAEMOLYTICA; PASTEURELLA;

EID: 0030805111     PISSN: 01657380     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1005863520483     Document Type: Article

References (33)

1. Ames, J.R., Larson, V.L. and Stowe, C.M., 1983. Oxytetracycline concentrations in healthy and diseased cattle. American Journal of Veterinary Research, 44, 1354-1357
2. Anika, S.M., Nouws, J.F.M., Van Gogh, H., Nieuwenhuijis, J., Vree, T.B. and Van Miert, A.S.J.P.M., 1986a. Chemotherapy and pharmacokinetics of some antimicrobial agents in healthy dwarf goats and those infected with Ehrlichia phagocytophila (tick-borne fever). Research in Veterinary Science, 41, 386-390
3. Anika, S.M., Nouws, J.F.M., Vree, T.B. and Van Miert, A.S.J.P.A.M., 1986b. The efficacy and plasma disposition of chloramphenicol and spiramycin in tick borne fever infected dwarf goats. Journal of Veterinary Pharmacology and Therapeutics, 8, 433-435
4. Baggot, J.D., 1977. Principles of Drug Disposition in Domestic Animals, (W.B. Saunders, Philadelphia), 144-189
5. Baggot, J.D., 1980. Distribution of antimicrobial agents in normal and diseased animals. Journal of the American Veterinary Medical Association, 176, 1085-1090
6. Burrows, G.E., Barto, P.B. and Weeks, B.R., 1986. Chloramphenicol, lincomycin and oxytetracycline disposition in calves with experimental pneumonic pasteurellosis. Journal of Veterinary Pharmacology and Therapeutics, 9, 213-222
7. Clark, J.G., Adams, C.J. and Addis, D.G., 1976. Oxytetracycline blood serum levels in healthy, pneumonic and recovered cattle. Proceedings of the Annual Meeting of the American Association of Bovine Practice, 9, 142-147
8. Cunha, B.A., Sibley, C.M. and Ristuccia, A.M., 1982. Doxycycline. Therapeutic Drug Monitoring, 4, 115-135
9. Dornbush, A.C. and Abbey, A., 1972. Microbiological assay of the tetracyclines. In: F. Kavanagh (ed.), Analytical Microbiology, vol. II. (New York, Academic Press), 365-383
10. Dunne, A., 1985. JANA: a new iterative polyexponential curve stripping programme. Computer Methods. Programmes in Biomedicine, 20, 269-275
11. Groothius, D.G. and Van Miert, A.S.J.P.A.M., 1987. Salmonellosis in veal calves. Some therapeutic aspects. The Veterinary Quarterly, 9, 91-96
12. Immelman, A. and Dreyer, G., 1982. The use of doxycycline to control heart water in sheep. Journal of the South African Veterinary Association, 53, 23-24
13. Jha, V.K., Jayachandran, C., Singh, M.K. and Singh, S.D., 1989. Pharmacokinetic data on doxycycline and its distribution in different biological fluids in female goats. Veterinary Research Communications, 13, 11-16
14. Knoppert, N.W., Nijmeijer, S.M., Van Duin, C.T.M., Korstanje, C., Van Gogh, H. and Van Miert, A.S.J.P.A.M., 1988. Some pharmacokinetics data of aditoprim and trimethoprim in healthy and tickborne fever infected dwarf goats. Journal of Veterinary Pharmacology and Therapeutics, 11, 135-144
15. Koch-Wesser, J. and Sellers, E.M., 1976. Binding of drugs to serum albumin. Part 2. New England Journal of Medicine, 4, 526-531
16. Kramer, J., Carter, G.G., Arret, B., Wilner, J., Wright, W.W. and Kirshbaum, A., 1968. Antibiotic residues in milk, dairy products and animal tissues. Methods, reports and protocols FDA Rep., 344-837 (4008)
17. Kutler, K.L. and Simpson, J.E., 1978. Relative efficacy of two oxytetracycline formulations and doxycycline in the treatment of acute anaplasmosis in splenectomized calves. American Journal of Veterinary Research, 39, 347-349
18. Ladefoged, O., 1979. Pharmacokinetics of antipyrine and trimethoprim in pigs with endotoxin induced fever. Journal of Veterinary Pharmacology, 2, 209-214
19. Metzler, C.M. and Weiner, D.L., 1986. PC-NONLIN User's Guide, version VO2, (Statistical Consultants, Lexington, KY)
20. Nouws, J.F.M., Anika, S.M., Van Miert, A.S.J.P.A.M., Vree, T.B., Baakman, M. and Van Duin, C.T.M., 1986. Effects of tick-borne fever on the disposition of sulphadimidine and its metabolites in plasma of goats. Research in Veterinary Science, 40, 377-381
21. Ole-Mapenay, I.M., 1994. Effects of pneumonia on the pharmacokinetics of doxycycline in goats, (MSc thesis, University of Nairobi, Nairobi, Kenya)
22. Ole-Mapenay, I.M. and Mitema, E.S., 1995. Some pharmacokinetic parameters of doxycycline in East African goats after intramuscular administration of a long-acting formulation. Veterinary Research Communications, 19, 425-432
23. Pijpers, A., Van Klingeren, B., Schoevers, E.J., Verheijden, J.H.M. and Van Miert, A.S.J.P.A.M., 1989. In vitro activity of five tetracyclines and some other antimicrobial agents against four porcine respiratory tract pathogens. Journal of Veterinary Pharmacology and Therapeutics, 12, 267-276
24. Pijpers, A., Schoevers, E.J., Van Gogh, H., Van Leengoed, L.A.M.G., Visser, I.J.R., Van Miert, A.S.J.P.A.M. and Verheijden, J.H.M., 1990. The pharmacokinetics of oxytetracycline following intravenous administration in healthy and diseased pigs. Journal of Veterinary Pharmacology and Therapeutics, 13, 320-326
25. Riond, J.L. and Riviere, J.E., 1990. Pharmacokinetics and metabolic inertness of doxycycline in young pigs. American Journal of Veterinary Research, 51, 1271-1275
26. Riond, J.L., Tyczkowska, K. and Riviere, J.E., 1989. Pharmacokinetics and metabolic inertness of doxycycline in calves with mature and immature rumen function. American Journal of Veterinary Research, 50, 1329-1333
27. Shapiro, S.S. and Wilks, M.B., 1965. An analysis of variance test for normality. Biometrika, 52, 591-611
28. Steel, R.G.D. and Torrie, J.H., 1980. Principles and Procedures of Statistics. A Biometrical Approach, 2nd edn., (McGraw Hill, New York), 539-540
29. Van Gool, F., Santoul, C. and Raynaud, J.P., 1986. Caractéristiques pharmacocinétiques et bilan des essais cliniques pour le traitement ou la metaphylaxie des bronchopneumonies infectieuses des veaux boucherie par le Ronaxan. Proceedings of the 14th World Congress on Diseases in Cattle, (Rhone Merieux), 627-631
30. Van Leengoed, L.A.M.G., 1988. Pathogenic studies on Haemophilus pleuropneumoniae. (PhD thesis, University of Utrecht)
31. Van Miert, A.S.J.P.A.M., 1985. Fever and associated clinical haematologic and blood biochemical changes in the goat and other animal species. Veterinary Quarterly, 7, 200-216
32. Van Miert, A.S.J.P.A.M., 1990. Influence of febrile disease on the pharmacokinetics of veterinary drugs. Annales Recherches Vétérinaire, 21 (supplement 1), 11s-28s
33. Ziv, G. and Sulman, F.G., 1974. Analysis of pharmacokinetic properties of nine tetracycline analogues in dairy cows and ewes. American Journal of Veterinary Research, 35, 1197-1201