Assessment of dose proportionality, absolute bioavailability, and immunogenicity response of CTLA4Ig (BMS-188667), a novel immunosuppressive agent, following subcutaneous and intravenous administration to rats

Pharmaceutical Research

Volumn 14, Issue 7, 1997, Pages 911-916

  Srinivas, Nuggehally R ^a   Shyu, Wen Chyi ^a   Weiner, Russell S ^a   Warner, Garvin ^b   Comereski, Charles ^b   Tay, Lee K ^a   Greene, Douglas S ^a   Barbhaiya, Rashmi H ^a  

^a BRISTOL MYERS SQUIBB   (United States)

^b BRISTOL MYERS SQUIBB COMPANY   (United States)

Author keywords

CTLA4Ig; Immunogenicity; Intravenous; Pharmacokinetics; Rats; Subcutaneous

Indexed keywords

CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; IMMUNOSUPPRESSIVE AGENT;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRUG BIOAVAILABILITY; FEMALE; IMMUNOGENICITY; INTRAVENOUS DRUG ADMINISTRATION; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SUBCUTANEOUS DRUG ADMINISTRATION;

ANIMALS; ANTIBODIES; ANTIGENS, CD; ANTIGENS, DIFFERENTIATION; AREA UNDER CURVE; BIOLOGICAL AVAILABILITY; FEMALE; IMMUNOCONJUGATES; IMMUNOSUPPRESSIVE AGENTS; INJECTIONS, INTRAVENOUS; INJECTIONS, SUBCUTANEOUS; MALE; RATS; RATS, SPRAGUE-DAWLEY; RECOMBINANT FUSION PROTEINS;

EID: 0030805029     PISSN: 07248741     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1012156001831     Document Type: Article

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