HLA-B27 Transgenic Rats: AnimaL Model of Human HLA-B27-Associated Disorders

Toxicologic Pathology

Volumn 25, Issue 4, 1997, Pages 407-408

  O'neill, T P ^a  

^a ARMED FORCES INSTITUTE OF PATHOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HLA B27 ANTIGEN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIGEN EXPRESSION; ARTICLE; CHRONIC ARTHRITIS; CHRONIC INFLAMMATION; HISTOPATHOLOGY; HLA SYSTEM; MAJOR HISTOCOMPATIBILITY COMPLEX; NONHUMAN; PRIORITY JOURNAL; RAT; TRANSGENIC MOUSE;

ANIMALS; ANIMALS, GENETICALLY MODIFIED; BETA 2-MICROGLOBULIN; CHRONIC DISEASE; COLORECTAL NEOPLASMS; DISEASE MODELS, ANIMAL; FEMALE; GENE TRANSFER TECHNIQUES; HLA-B27 ANTIGEN; HUMANS; MALE; RATS; RATS, INBRED F344; RATS, INBRED LEW; RATS, SPRAGUE-DAWLEY; SPONDYLITIS, ANKYLOSING;

ANIMALIA; MUS MUSCULUS;

EID: 0030804877     PISSN: 01926233     EISSN: None     Source Type: Journal    
DOI: 10.1177/019262339702500411     Document Type: Article

References (8)

1. Breban M., Fernandez-Sueiro JL, Richardson JA, Havdavand RR, Maika SD, Hammer RE, and Taurog JD (1996). T cells, but not thymic exposure to HLA-B27, are required for the inflammatory disease of HLA-B27 transgenic rats. J. Immunol. 156: 794-803.
2. Breban M., Hammer RE, Richardson JA, and Taurog JD (1993). Transfer of the inflammatory disease of HLA-B27 transgenic rats by bone marrow engraftment. J. Exp. Med. 178: 1607-1616.
3. Cotran RS, Kumar V, and Robbins SL (eds) (1994). Pathologic Basis of Disease. W. B. Saunders, Philadelphia, pp. 1253–1254.
4. Hammer RE, Maika SD, Richardson JA, Tang J., and Taurog JD (1990). Spontaneous inflammatory disease in transgenic rats expressing HLA-B27 and human β2m: An animal model of HLA-B27-associated human disorders. Cell 63: 1099-1112.
5. Hammer RE, Richardson JA, Simmons WA, White AL, Breban M., and Taurog JD (1995). High prevalence of colorectal cancer in HLA-B27 transgenic F344 rats with chronic inflammatory bowel disease. J. Invest. Med. 43: 262-268.
6. Taurog JD, Lowen L., Forman J., and Hammer RE (1988). HLA-B27 in inbred and noninbred transgenic mice. Cell surface expression and recognition as an alloantigen in the absence of human β2-microglobulin. J. Immunol. 141: 4020-4023.
7. Taurog JD, Maika SD, Simmons WA, Breban M., and Hammer RE (1993). Susceptability to inflammatory disease in HLA-B27 transgenic rats correlates with level of B27 expression. J. Immunol. 150: 4168-4178.
8. Yanagisawa H., Richardson JA, Taurog JD, and Hammer RE (1995). Characterization of psoriasiform and alopecic skin lesions in HLA-B27 transgenic rats. Am. J. Pathol. 147: 955-964.