Increased thrombin generation in patients with chronic renal failure

International Journal of Clinical and Laboratory Research

Volumn 27, Issue 1, 1997, Pages 72-75

  Sagripanti, A ^a   Cozza, V ^a   Baicchi, U ^a   Camici, M ^a   Cupisti, A ^a   Barsotti, G ^a  

^a UNIVERSITY HOSPITAL OF PISA   (Italy)

Author keywords

Calcium nadroparin; Chronic uremia; Hypercoagulation; Prothrombin fragment 1 + 2

Indexed keywords

EID: 0030803438     PISSN: 09405437     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF02827247     Document Type: Article

References (24)

1. Larsson SO. On coagulation and fibrinolysis in uremic patients on maintenance hemodialysis. Acta Med Scand 1971; 189:453.
2. Panicucci F, Sagripanti A, Pinori E, Vispi M, Lecchini L, Barsotti G, Giovannetti S. Comprehensive study of haemostasis in chronic uraemia. Nephron 1983; 33:5.
3. Turney JH, Woods HF, Fewell MR, Weston MJ. Factor VIII complex in uraemia and effects of haemodialysis. BMJ 1981; 282:1653.
4. Tomura S, Nakamura Y, Deguchi F, Chida Y, Ohno Y, Kodama S, Hayashi T, Suzuki K, Marumo F. Plasma Von Willebrand factor and thrombomodulin as markers of vascular disorders in patients undergoing regular hemodialysis therapy. Thromb Res 1990; 58:413.
5. Vaziri ND, Shah GM, Winer RL, Gonzales E, Patel B, Alikhani S, Nguyen QX, Yamamoto J. Coagulation cascade, fibrinolytic system, antithrombin III, protein C and protein S in patients maintained on continuous ambulatory peritoneal dialysis. Thromb Res 1989; 53:173.
6. Sagripanti A, Barsotti G. Bleeding and thrombosis in chronic uremia. Nephron. In press.
7. Tomura S, Nakamura Y, Deguchi F, Ando R, Chida Y, Marumo F. Coagulation and fibrinolysis in patients with chronic renal failure undergoing conservative treatment. Thromb Res 1991; 64:81.
8. Sorensen PJ, Knudsen F, Nielsen AH, Dyerberg J. Protein C assays in uremia. Thromb Res 1989; 54:301.
9. Faioni EM, Franchi F, Krachmalnicoff A, Valsecchi C, Viganò GL, Remuzzi G, Mannucci PM. Low levels of the anticoagulant activity of protein C in patients with chronic renal insufficiency:an inhibitor of protein C is present in uremic plasma. Thromb Haemost 1991; 66:420.
10. Lai K, Yin JA, Yuen PMP, Li PKT. Effect of hemodialysis on protein C, protein S and antithrombin levels. Am J Kidney Dis 1991; 17:38.
11. Sagripanti A, Cupisti A, Baicchi U, Ferdeghini M, Morelli E, Barsotti G. Plasma parameters of the prothrombotic state in chronic uremia. Nephron 1993; 62:273.
12. Bauer KA, Rosenberg RD. The pathophysiology of the prethrombotic state in humans: insight gained from studies using markers of hemostatic system activation. Blood 1987; 70:343.
13. Pelzer H, Schwarz A, Stüber W. Determination of human prothrombin activation fragment 1+2 in plasma with an antibody against a synthetic peptide. Thromb Haemost 1991; 65:153.
14. Bruhn H, Conard J, Mannucci M, Monteagudo J, Pelzer H, Reverter JC, Samama M, Tripodi A, Wagner C. Multicentric evaluation of a new assay for prothrombin fragment 1+2 determination. Thromb Haemost 1992; 68:413.
15. Lindner A, Charra B, Sherrad DJ, Scribner BH. Accelerated atherosclerosis in prolonged maintenance hemodialysis. N Engl J Med 1974; 290:697.
16. Morelli E, Baldi R, Barsotti G, Ciardella F, Cupisti A, Dani L, Mantovanelli A, Giovannetti S. Combined therapy for selected chronic uremic patients:infrequent hemodialysis and nutritional management. Nephron 1987; 47:161.
17. Mannucci PM, Tripodi A, Bottazzo B, et al. Markers of procoagulant imbalance in patients with inherited thrombophilic syndromes. Thromb Haemost 1992; 67:200.
18. Estivals M, Pelzer H, Sie P, et al. Prothrombin fragment 1+2, thrombin-antithrombin III complexes and D-dimers in acute deep vein thrombosis' effects of heparin treatment. Br J Haematol 1991; 78:421.
19. Marongiu F, Sorano GG, Mameli G, et al. Thrombin activity and oral anticoagulant therapy: a further evaluation. Haemostasis 1990; 20:63.
20. Kario K, Matsuo T, Yamada T, Nakao K, Shimano C, Matsuo M. Factor VII hyperactivity in chronic dialysis patients. Thromb Res 1992; 67:105.
21. Weinstein MJ, Chute LE, Schmitt GW, Hamburger RH, Bauer KA, Troll JH, Janson P, Deykin D. Abnormal factor VIII coagulant antigen in patients with renal dysfunction and in those with disseminated intravascular coagulation. J Clin Invest 1985, 76:1406.
22. Erdem Y, Haznedaroglu IC, Kiraz S. Increased prothrombin fragment 1+2 concentrations in hemodialysis patients. Clin Nephrol 1996, 45:69.
23. Bauer KA, Weiss LM, Sparrow D, Vokonas PS, Rosenberg RD. Aging-associated changes in indices of thrombin generation and protein C activation in humans. J Clin Invest 1987; 80:1527.
24. Kario K, Matsuo T, Matsuo Miyako, Koide M, Yamada T, Nakamura S, Sakata T, Kato H, Miyata T Marked increase of activated factor VII in uremic patients. Thromb Haemost 1995; 73:763.