Open randomized study of cefepime versus piperacillin-gentamicin for treatment of febrile neutropenic cancer patients

Antimicrobial Agents and Chemotherapy

Volumn 41, Issue 8, 1997, Pages 1704-1708

  Yamamura, Deborah ^a   Gucalp, Rasim ^b   Carlisle, Penelope ^b   Cimino, Michael ^c,e   Roberts, Jeremy ^a   Rotstein, Coleman ^a,d  

^a MCMASTER UNIVERSITY   (Canada)

^b ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^c ROSWELL PARK CANCER INSTITUTE   (United States)

^d HENDERSON GENERAL HOSPITAL   (Canada)

^e CHILDREN S HOSPITAL OF BUFFALO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CEFEPIME; GENTAMICIN; PIPERACILLIN;

ADULT; AGED; ARTICLE; BACTEREMIA; BACTERIAL INFECTION; BACTERIUM CULTURE; BRONCHITIS; CANCER PATIENT; CELLULITIS; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG EFFICACY; DRUG SAFETY; FEMALE; FEVER; GASTROENTERITIS; GRAM NEGATIVE BACTERIUM; GRAM POSITIVE BACTERIUM; HUMAN; INTRAVENOUS DRUG ADMINISTRATION; MAJOR CLINICAL STUDY; MALE; NEPHROTOXICITY; NEUTROPENIA; PHARYNGITIS; PNEUMONIA; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SINUSITIS; STOMATITIS; SUPERINFECTION; URINARY TRACT INFECTION;

EID: 0030802949     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/aac.41.8.1704     Document Type: Article

References (27)

1. Body, G. P. 1984. Antibiotics in patients with neutropenia. Arch. Intern. Med. 144:1845-1851.
2. DePauw, B. E., S. C. Deresinski, R. Feld, E. F. Lane-Allman, and J. P. Donnelly. 1994 Ceftazidime compared with piperacillin and tobramycin for the empiric treatment of fever in neutropenic patients with cancer. Ann. Intern. Med. 120:834-844.
3. Eggiman, P., M. P. Glauser, M. Aoun, F. Meunier, and T. Calandra. 1993. Cefepime monotherapy for the empirical treatment of fever in granulocytopenic cancer patients. J. Antimicrob. Chemother. 32(Suppl. B):151-163.
4. Fuchs, P. C., R. N. Jones, A. L. Barry, and C. Thornsherry. 1986. Tentative disc diffusion susceptibility interpretive criteria for BMY-28142, a new cephalosporin. J. Clin. Microhiol. 23:634-636.
5. Gentry, L. O., and G. Rodriguez-Gomez. 1991. Randomized comparison of cefepime and ceftazidime for treatment of skin, surgical wound, and complicated urinary tract infections in hospitalized subjects. Antimicrob. Agents Chemother. 35:2371-2374.
6. Giuliano, M., M. Barza, N. V. Jacobus, and S. L. Gorbach. 1987. Effect of broad-spectrum parenteral antibiotics on composition of intestinal microflora of humans. Antimicrob. Agents Chemother. 31:202-206.
7. Hardin, T. C., and T. S. Jennings. 1994. Cefepime. Pharmacotherapy 14: 657-668.
8. Hughes, W. T., D. Armstrong, and G. P. Bodey, et al. 1990. Guidelines for the use of antimicrobial agents in neutropenic patients with unexplained fever: a statement by the Infectious Disease Society of America. J. Infect. Dis. 161: 381-396.
9. Huijgens, P. C., G. J. Ossenkoppele, and T. F. Weijers, et al. 1991. Imipenem-cilastatin for empirical therapy in neutropenic patients with fever: an open study in patients with hematologic malignancies. Eur. J. Haematol. 46:42-46.
10. Kieft, H., A. I. M. Hoepelman, M. Rozenherg-Arska, J. M. Branger, J. H. Voskuil, A. B. M. Geers, M. Kluyver, H. C. Hart, E. Poest-Clement, L. van Beugen, A. Struyvenberg, and J. Verhoef. 1993. Cefepime compared with ceftazidime as initial therapy for serious bacterial infections and sepsis syndrome. Antimicrob. Agents Chemother. 38:413-421.
11. Malik, I. A., Z. Abbas, and M. Karim. 1992. Randomized comparison of oral ciprofloxacin alone and with combination of parenteral antibiotics in neutropenic febrile patients. Lancet 339:1092-1096.
12. National Committee for Clinical Laboratory Standards. 1991. Performance standards for antimicrobial susceptibility testing: third informational supplement. M100-53. National Committee for Clinical Laboratory Standards, Villanova, Pa.
13. Neu, H. C., N. Chin, K. Jules, and P. Labthavikul. 1986. The activity of BMY 28142, a new broad spectrum B-lactamase stable cephalosporin. J. Antimicrob. Chemother. 17:441-452.
14. Nikaido, H., W. Liu, and E. Y. Rosenberg. 1990. Outer membrane permeability and β-lactamase stability of dipolar ionic cephalosporins containing methoxyimino substituents. Antimicrob. Agents Chemother. 34:337-342.
15. Pizzo, P. A. 1993. Management of fever in patients with cancer and treatment-induced neutropenia. N. Engl. J. Med. 328:1323-1332.
16. Pizzo, P. A., J. W. Hathorn, and J. Hiemenz, et al. 1986. A randomized trial comparing ceftazidime alone with combination antibiotic therapy in cancer patients with fever and neutropenia. N. Engl. J. Med. 315:552-558.
17. Rolston, K. V. I., P. Berkey, and G. P. Bodey, et al. 1992. A comparison of imipenem to ceftazidime with or without amikacin as empiric therapy in febrile neutropenic patients. Arch. Intern. Med. 152:283-291.
18. Rotstein, C., M. Cimino, K. Winkey, C. Cesari, and J. Fenner. 1988. Cefoperazone plus piperacillin versus mezlocillin plus tobramycin as empiric therapy for febrile episodes in neutropenic patients. Am. J. Med. 85(Suppl. 1A):36-43.
19. Rubin, M., J. W. Hathorn, D. Marshall, J. Gress, S. M. Steinberg, and P. A. Pizzo. 1988. Gram positive infections and the use of vancomycin in 550 episodes of fever and neutropenia. Ann. Intern. Med. 108:30-35.
20. Rubio, M., L. Palau, J. R. Vivas, E. del Potro, J. Diaz-Mediavilla, A. Alvarez, R. Martinez, and J. J. Picazo. 1994. Predominance of gram-positive microorganisms as a cause of septicemia in patients with hematological malignancies Infect. Control Hosp. Epidemiol. 15:101-104.
21. Sanders, C. C. 1993. Cefepime: the next generation? Clin. Infect. Dis. 17: 369-379.
22. Sanders, C. C., and W. E. Sanders, Jr. 1985. Microbial resistance to newer generation B-lactam antibiotics: clinical and laboratory implications. J. Infect. Dis. 151:399-406.
23. Sanders, J. W., N. R. Power, and R. D. Moore. 1991. Ceftazidime monotherapy for empiric therapy of febrile neutropenic patients: a meta-analysis. J. Infect. Dis. 164:907-916.
24. Schrank, J. H., Jr., J. W. Kelly, and C. K. McAllister. 1995. Randomized comparison of cefepime and ceftazidime for treatment of hospitalized patients with gram-negative bacteremia. Clin. Infect. Dis. 20:56-58.
25. Wade, J. C., S. C. Schimpff, K. A. Newman, and P. H. Wiernik. 1982. Staphylococcus epidermidis: an increasing cause of infection in patients with granulocytopenia. Ann. Intern. Med. 97:503-508.
26. Winston, D. J., C. V. Dudnick, M. Chapin, W. G. Ho, R. P. Gale, and W. J. Martin. 1983. Coagulase negative staphylococcal bacteremia in patients receiving immunosuppressive therapy. Arch. Intern. Med. 143:32-36.
27. Winston, D. J., W. G. Ho, D. A. Bruckner, and R. E. Champlin. 1991. Beta-lactam antibiotic therapy in febrile granulocytopenic patients: a randomized trial comparing cefoperazone plus piperacillin, ceftazidime plus piperacillin, and imipenem alone. Ann. Intern. Med. 115:849-839.