메뉴 건너뛰기




Volumn 139, Issue 7, 1997, Pages 589-599

Molecular pathogenesis of astrocytoma and glioblastoma multiforme

Author keywords

Brain neoplasm; Cell cycle; Molecular biology; Oncogene; Tumour suppressor gene; Tumourigenesis

Indexed keywords

ASTROCYTOMA; BRAIN TUMOR; CARCINOGENESIS; CELL CYCLE; CHROMOSOME; GENE AMPLIFICATION; GLIOBLASTOMA; HUMAN; MOLECULAR BIOLOGY; ONCOGENE; PATHOGENESIS; PRIORITY JOURNAL; REVIEW; TUMOR SUPPRESSOR GENE;

EID: 0030802366     PISSN: 00016268     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF01411992     Document Type: Review
Times cited : (16)

References (88)
  • 4
    • 0023857965 scopus 로고
    • Specific chromosomal abnormalities in malignant human gliomas
    • Bigner SH, Mark J, Burger PC, et al (1988) Specific chromosomal abnormalities in malignant human gliomas. Cancer Res 88: 405-411
    • (1988) Cancer Res , vol.88 , pp. 405-411
    • Bigner, S.H.1    Mark, J.2    Burger, P.C.3
  • 5
    • 0023194301 scopus 로고
    • Relationship between gene amplification and chromosomal deviations in malignant human gliomas
    • Bigner SH, Wong AJ, Mark J, et al (1987) Relationship between gene amplification and chromosomal deviations in malignant human gliomas. Cancer Genet Cytogenet 29: 165-170
    • (1987) Cancer Genet Cytogenet , vol.29 , pp. 165-170
    • Bigner, S.H.1    Wong, A.J.2    Mark, J.3
  • 6
    • 0023145547 scopus 로고
    • The molecular genetics of cancer
    • Bishop JM (1987) The molecular genetics of cancer. Science 235: 305-311
    • (1987) Science , vol.235 , pp. 305-311
    • Bishop, J.M.1
  • 7
    • 0029397307 scopus 로고
    • The p53 gene and its role in human brain tumours
    • Bögler O, Su Huang HJ, Kleihues P, Cavanee W (1995) The p53 gene and its role in human brain tumours. Glia 15: 308-327
    • (1995) Glia , vol.15 , pp. 308-327
    • Bögler, O.1    Su Huang, H.J.2    Kleihues, P.3    Cavanee, W.4
  • 8
    • 0025611503 scopus 로고
    • Genetic mechanisms of tumour suppression by the human p53 gene
    • Chen P-L, Chen Y, Bookstein R, Lee W-H (1990) Genetic mechanisms of tumour suppression by the human p53 gene. Science 250: 1576-1580
    • (1990) Science , vol.250 , pp. 1576-1580
    • Chen, P.-L.1    Chen, Y.2    Bookstein, R.3    Lee, W.-H.4
  • 9
    • 0025935859 scopus 로고
    • p53 mutation and chromosome 17p deletion in human astrocytomas
    • Chung RY, Whaley J, Kley N (1991) p53 mutation and chromosome 17p deletion in human astrocytomas. Genes Chrom Cancer 3: 323-331
    • (1991) Genes Chrom Cancer , vol.3 , pp. 323-331
    • Chung, R.Y.1    Whaley, J.2    Kley, N.3
  • 10
    • 0029398189 scopus 로고
    • Gene amplification in human gliomas
    • Collins VP (1995) Gene amplification in human gliomas. Glia 15: 289-296
    • (1995) Glia , vol.15 , pp. 289-296
    • Collins, V.P.1
  • 11
    • 0029967152 scopus 로고    scopus 로고
    • Silencing of p16/CDKN2 expression in human gliomas by methylation and chromatin condensation
    • Costello JF, Berger MS, Huang HS, Cavanee WK (1996) Silencing of p16/CDKN2 expression in human gliomas by methylation and chromatin condensation. Cancer Res 56 (10): 2405-2010
    • (1996) Cancer Res , vol.56 , Issue.10 , pp. 2405-12010
    • Costello, J.F.1    Berger, M.S.2    Huang, H.S.3    Cavanee, W.K.4
  • 13
    • 0023937038 scopus 로고
    • Cell kinetics of human brain tumours: In vivo study with bromodeoxyuridine and flow cytometry
    • Danova M, Riccardi A, Gaetani P, et al (1988) Cell kinetics of human brain tumours: in vivo study with bromodeoxyuridine and flow cytometry. Eur J Cancer Clin Oncol 24: 873-880
    • (1988) Eur J Cancer Clin Oncol , vol.24 , pp. 873-880
    • Danova, M.1    Riccardi, A.2    Gaetani, P.3
  • 15
    • 0023700236 scopus 로고
    • Grading of astrocytomas: A simple and reproducible method
    • Daumas-Duport C, Scheithauer B, O'Fallon J, Kelly P (1988) Grading of astrocytomas: a simple and reproducible method. Cancer 62: 2152-2165
    • (1988) Cancer , vol.62 , pp. 2152-2165
    • Daumas-Duport, C.1    Scheithauer, B.2    O'Fallon, J.3    Kelly, P.4
  • 16
    • 0028885029 scopus 로고
    • Distribution of epidermal growth factor receptor gen amplification in brain tumours and correlation to prognosis
    • Diedrich U, Lucius J, Baron E, Behnke J, Pabst B, Zoll B (1995) Distribution of epidermal growth factor receptor gen amplification in brain tumours and correlation to prognosis. J Neurol 242: 683-688
    • (1995) J Neurol , vol.242 , pp. 683-688
    • Diedrich, U.1    Lucius, J.2    Baron, E.3    Behnke, J.4    Pabst, B.5    Zoll, B.6
  • 19
    • 0023218023 scopus 로고
    • Cancer genes: Rare combinants instead of activated oncogenes
    • Duesberg PH (1987) Cancer genes: rare combinants instead of activated oncogenes (review). Proc Natl Acad Sci USA 84: 2117-2134
    • (1987) Proc Natl Acad Sci USA , vol.84 , pp. 2117-2134
    • Duesberg, P.H.1
  • 21
    • 0029054187 scopus 로고
    • Molecular cytogenetic quantitation of gains and losses of genetic material from human gliomas
    • Feuerstein BG, Mohapatra G (1995) Molecular cytogenetic quantitation of gains and losses of genetic material from human gliomas. J Neurooncol 24: 47-55
    • (1995) J Neurooncol , vol.24 , pp. 47-55
    • Feuerstein, B.G.1    Mohapatra, G.2
  • 23
    • 0026517069 scopus 로고
    • p53 mutations in human malignant gliomas: Comparison of loss of heterozygosity with mutation frequency
    • Frankel R, Bayonna W, Koslow M, Newcomb E (1992) p53 mutations in human malignant gliomas: comparison of loss of heterozygosity with mutation frequency. Cancer Res 52: 1427-1433
    • (1992) Cancer Res , vol.52 , pp. 1427-1433
    • Frankel, R.1    Bayonna, W.2    Koslow, M.3    Newcomb, E.4
  • 24
    • 0026480293 scopus 로고
    • Cancer risks from germline p53 mutations
    • Frebourg T, Friend S (1992) Cancer risks from germline p53 mutations. J Clin Invest 90: 1637-1641
    • (1992) J Clin Invest , vol.90 , pp. 1637-1641
    • Frebourg, T.1    Friend, S.2
  • 28
    • 0028071555 scopus 로고
    • Mutations of the p53 tumour-suppressor gene: Clues to cancer etiology and molecular pathogenesis
    • Greenblatt MS, Bennett WP, Hollstein M, Harris CC (1994) Mutations of the p53 tumour-suppressor gene: clues to cancer etiology and molecular pathogenesis. Cancer Res 54: 4655-4678
    • (1994) Cancer Res , vol.54 , pp. 4655-4678
    • Greenblatt, M.S.1    Bennett, W.P.2    Hollstein, M.3    Harris, C.C.4
  • 29
    • 0023584218 scopus 로고
    • Genetics of cancer predisposition
    • Hansen MF, Cavanee WK (1987) Genetics of cancer predisposition. Cancer Res 47: 5518-5527
    • (1987) Cancer Res , vol.47 , pp. 5518-5527
    • Hansen, M.F.1    Cavanee, W.K.2
  • 31
    • 0029838878 scopus 로고    scopus 로고
    • Visual mapping by high resolution FISH
    • Heiskanen M, Peltonen L, Palotie A (1996) Visual mapping by high resolution FISH. TIG 12 (10: 379-382
    • (1996) TIG , vol.12 , Issue.10 , pp. 379-382
    • Heiskanen, M.1    Peltonen, L.2    Palotie, A.3
  • 32
    • 0022655932 scopus 로고
    • A human osteosarcome cell line secretes a growth factor structurally related to a homodimer of PDGF A-chains
    • Heldin CH, Johnsson A, Wennergren S, Wernstedt C, Betzholtz C, Westermark B (1986) A human osteosarcome cell line secretes a growth factor structurally related to a homodimer of PDGF A-chains. Nature 319: 511-514
    • (1986) Nature , vol.319 , pp. 511-514
    • Heldin, C.H.1    Johnsson, A.2    Wennergren, S.3    Wernstedt, C.4    Betzholtz, C.5    Westermark, B.6
  • 33
    • 0023817997 scopus 로고
    • Amplification of the epidermal growth factor receptor gene in biopsy specimens from human intracranial tumours
    • Helseth E, Unsgaard G, Dalen A, Fure H, Skandsen T, Odegaard A, Vik R (1988) Amplification of the epidermal growth factor receptor gene in biopsy specimens from human intracranial tumours. Br J Neurosurg 2: 217-255
    • (1988) Br J Neurosurg , vol.2 , pp. 217-255
    • Helseth, E.1    Unsgaard, G.2    Dalen, A.3    Fure, H.4    Skandsen, T.5    Odegaard, A.6    Vik, R.7
  • 35
    • 0025618980 scopus 로고
    • Mutant p53-DNA clones from human colon carcinomas cooperate with ras in transforming primary rat cells: A comparison of the "hot spot" mutant phenotypes
    • Hinds PW, Finlay CA, Quartin RS, Baker SJ, Fearon ER, Vogelstein B, Levine AJ (1990) Mutant p53-DNA clones from human colon carcinomas cooperate with ras in transforming primary rat cells: a comparison of the "hot spot" mutant phenotypes. Cell Growth Differ 1: 571-580
    • (1990) Cell Growth Differ , vol.1 , pp. 571-580
    • Hinds, P.W.1    Finlay, C.A.2    Quartin, R.S.3    Baker, S.J.4    Fearon, E.R.5    Vogelstein, B.6    Levine, A.J.7
  • 36
    • 0025265724 scopus 로고
    • Increased expression of mutant forms of p53 oncogene in primary lung cancer
    • Iggo R, Gatter K, Bartek J, Lane D, Harris AL (1990) Increased expression of mutant forms of p53 oncogene in primary lung cancer. Lancet 335: 675-679
    • (1990) Lancet , vol.335 , pp. 675-679
    • Iggo, R.1    Gatter, K.2    Bartek, J.3    Lane, D.4    Harris, A.L.5
  • 41
    • 8544278569 scopus 로고
    • Oncogenes and tumour suppressor genes
    • Klein G (1988) Oncogenes and tumour suppressor genes. Rev Oncol 1: 427-437
    • (1988) Rev Oncol , vol.1 , pp. 427-437
    • Klein, G.1
  • 42
    • 0015043748 scopus 로고
    • Mutation and cancer: Statistical study of retinoblastoma
    • Knudson AG (1971) Mutation and cancer: statistical study of retinoblastoma. Proc Natl Acad Sci USA 68: 820-823
    • (1971) Proc Natl Acad Sci USA , vol.68 , pp. 820-823
    • Knudson, A.G.1
  • 43
    • 0025876591 scopus 로고
    • The p53 tumour suppressor gene
    • Levine AJ, Momand J, Finlay C (1991) The p53 tumour suppressor gene. Nature 351: 453-456
    • (1991) Nature , vol.351 , pp. 453-456
    • Levine, A.J.1    Momand, J.2    Finlay, C.3
  • 47
    • 0023904523 scopus 로고
    • Selective amplification of the cytoplasmic domain of the epidermal growth factor receptor gene in glioblastoma multiforme
    • Malden LT, Novak U, Kaye A, Burgess AW (1988) Selective amplification of the cytoplasmic domain of the epidermal growth factor receptor gene in glioblastoma multiforme. Cancer Res 48: 2711-2714
    • (1988) Cancer Res , vol.48 , pp. 2711-2714
    • Malden, L.T.1    Novak, U.2    Kaye, A.3    Burgess, A.W.4
  • 48
    • 0023738138 scopus 로고
    • Molecular biology of brain tumours
    • McDonald JD, Dohrman GJ (1988) Molecular biology of brain tumours. Neurosurgery 23(5): 537-544
    • (1988) Neurosurgery , vol.23 , Issue.5 , pp. 537-544
    • McDonald, J.D.1    Dohrman, G.J.2
  • 50
    • 0025868284 scopus 로고
    • Identification of a germ-line mutation in the p53 gene in a patient with an intracranial ependymoma
    • Metzger A, Sheffield V, Duyk G, Danheshvar L, Edwards M, Cogen P (1991) Identification of a germ-line mutation in the p53 gene in a patient with an intracranial ependymoma. Proc Natl Acad Sci USA 88: 7825-7829
    • (1991) Proc Natl Acad Sci USA , vol.88 , pp. 7825-7829
    • Metzger, A.1    Sheffield, V.2    Duyk, G.3    Danheshvar, L.4    Edwards, M.5    Cogen, P.6
  • 51
    • 8544271257 scopus 로고
    • The expression and structure of p53 Gene products in cultured glioma cells
    • Tabuchi K (ed) Springer, Berlin Heidelberg New York Tokyo
    • Mineta T, Fukuyama K, Shiraishi T, et al (1991) The expression and structure of p53 Gene products in cultured glioma cells. In: Tabuchi K (ed) Biological aspects of human brain tumours. Springer, Berlin Heidelberg New York Tokyo
    • (1991) Biological Aspects of Human Brain Tumours
    • Mineta, T.1    Fukuyama, K.2    Shiraishi, T.3
  • 52
    • 0026649648 scopus 로고
    • The mdm2 oncogene product forms a complex with the p53 protein and inhibits p53 mediated trans-activation
    • Momand J, Zambetti GP, Olson DC, George DL, Levine AJ (1992) The mdm2 oncogene product forms a complex with the p53 protein and inhibits p53 mediated trans-activation. Cell 69: 1237-1245
    • (1992) Cell , vol.69 , pp. 1237-1245
    • Momand, J.1    Zambetti, G.P.2    Olson, D.C.3    George, D.L.4    Levine, A.J.5
  • 53
    • 0019638515 scopus 로고
    • Growth of purified astrocytes in a chemically defined medium
    • Morrison RS, de Villis J (1981) Growth of purified astrocytes in a chemically defined medium. Proc Natl Acad Sci USA 78: 7205-7209
    • (1981) Proc Natl Acad Sci USA , vol.78 , pp. 7205-7209
    • Morrison, R.S.1    De Villis, J.2
  • 54
    • 0025214980 scopus 로고
    • Basic fibroblast growth factor-like activity and receptors are expressed in a human glioma cell line
    • Morrison RS, Gross JL, Herbin WF (1990) Basic fibroblast growth factor-like activity and receptors are expressed in a human glioma cell line. Cancer Res 50: 2524-2529
    • (1990) Cancer Res , vol.50 , pp. 2524-2529
    • Morrison, R.S.1    Gross, J.L.2    Herbin, W.F.3
  • 55
    • 0021332973 scopus 로고
    • Retinoblastoma: Clues to human oncogenesis
    • Murphree AL, Benedict WF (1984) Retinoblastoma: clues to human oncogenesis. Science 223: 1028-1033
    • (1984) Science , vol.223 , pp. 1028-1033
    • Murphree, A.L.1    Benedict, W.F.2
  • 56
    • 0007356587 scopus 로고
    • Expression of messanger RNAs for PDGF and TGF and their receptors in human malignant gliomas
    • Nister M, Libermann TA, Betzholtz C (1988) Expression of messanger RNAs for PDGF and TGF and their receptors in human malignant gliomas. Cancer Res 48: 3908-3910
    • (1988) Cancer Res , vol.48 , pp. 3908-3910
    • Nister, M.1    Libermann, T.A.2    Betzholtz, C.3
  • 57
    • 0026464014 scopus 로고
    • Mapping of the shortest region of overlap of deletions of the short arm of chromosome 9 associated with human neoplasia
    • Olopade O, Bohlander S, Pomykala H, Maltepe E, Van Melle E, Le Beau M, Diaz M (1992) Mapping of the shortest region of overlap of deletions of the short arm of chromosome 9 associated with human neoplasia. Genomics 14: 437-443
    • (1992) Genomics , vol.14 , pp. 437-443
    • Olopade, O.1    Bohlander, S.2    Pomykala, H.3    Maltepe, E.4    Van Melle, E.5    Le Beau, M.6    Diaz, M.7
  • 58
    • 0031016446 scopus 로고    scopus 로고
    • Inhibition of epidermal growth factor receptor-associated tyrosine kinase blocks glioblastoma invasion in the brain
    • Penar PL, Khoshyomn S, Bhushan A, Tritton TR (1997) Inhibition of epidermal growth factor receptor-associated tyrosine kinase blocks glioblastoma invasion in the brain. Neurosurgery 40: 141-151
    • (1997) Neurosurgery , vol.40 , pp. 141-151
    • Penar, P.L.1    Khoshyomn, S.2    Bhushan, A.3    Tritton, T.R.4
  • 60
    • 0027196974 scopus 로고
    • Amplification and overexpression of the MDM2 gene in a subset of human malignant gliomas without p53 mutations
    • Reifenberger G, Liu L, Ichimura K, Schmidt EE, Collins VP (1993) Amplification and overexpression of the MDM2 gene in a subset of human malignant gliomas without p53 mutations. Cancer Res 53: 2736-2739
    • (1993) Cancer Res , vol.53 , pp. 2736-2739
    • Reifenberger, G.1    Liu, L.2    Ichimura, K.3    Schmidt, E.E.4    Collins, V.P.5
  • 62
    • 0023521410 scopus 로고    scopus 로고
    • Rev JA, Bello MJ, de Campos JM, Kusak ME, Ramos C, Benitez J (1987) Chromosomal patterns in human malignant astrocytomas. Cancer Genet Cytogenet 29 (2): 201-223 CaGCG 29: 223
    • CaGCG , vol.29 , pp. 223
  • 63
    • 0028954148 scopus 로고
    • Region-specific loss of heterozygosity on chromosome 19 is related to the morphologic type of human glioma
    • Ritland SR, Vinod G, Jenkins RB (1995) Region-specific loss of heterozygosity on chromosome 19 is related to the morphologic type of human glioma. Genes Chrom Cancer 12: 277-287
    • (1995) Genes Chrom Cancer , vol.12 , pp. 277-287
    • Ritland, S.R.1    Vinod, G.2    Jenkins, R.B.3
  • 64
    • 0025000381 scopus 로고
    • Growth factor induced gene-expression: The ups and downs of c-fos regulation
    • Rivera VM, Greenberg ME (1990) Growth factor induced gene-expression: the ups and downs of c-fos regulation. New Biol 2: 751-758
    • (1990) New Biol , vol.2 , pp. 751-758
    • Rivera, V.M.1    Greenberg, M.E.2
  • 65
    • 0024654697 scopus 로고
    • Immunohistochemical study of transforming growth factor expression in benign and malignant gliomas
    • Samuels V, Barrett JM, Bockman S, et al (1989) Immunohistochemical study of transforming growth factor expression in benign and malignant gliomas. Am J Pathol 134: 895-902
    • (1989) Am J Pathol , vol.134 , pp. 895-902
    • Samuels, V.1    Barrett, J.M.2    Bockman, S.3
  • 66
    • 0029964091 scopus 로고    scopus 로고
    • Patterns of epidermal growth factor receptor amplification in malignant gliomas
    • Sauter G, Maeda T, Waldman FM, Davis RL, Feuerstein BG (1996) Patterns of epidermal growth factor receptor amplification in malignant gliomas. Am J Pathol 148(4): 1047-1053
    • (1996) Am J Pathol , vol.148 , Issue.4 , pp. 1047-1053
    • Sauter, G.1    Maeda, T.2    Waldman, F.M.3    Davis, R.L.4    Feuerstein, B.G.5
  • 67
    • 0024276817 scopus 로고
    • The epidermal growth factor receptor as a multifunctional allosteric protein
    • Schlessinger J (1988) The epidermal growth factor receptor as a multifunctional allosteric protein. Biochemistry 27: 3119-3123
    • (1988) Biochemistry , vol.27 , pp. 3119-3123
    • Schlessinger, J.1
  • 68
    • 0028652269 scopus 로고
    • CDKN2 (p16/MTS1) gene deletion or CDK4 amplification occurs in the majority of glioblastomas
    • Schmidt EE, Ichimura K, Reifenberger G, Collins VP (1994) CDKN2 (p16/MTS1) gene deletion or CDK4 amplification occurs in the majority of glioblastomas. Cancer Res 54: 6321-6324
    • (1994) Cancer Res , vol.54 , pp. 6321-6324
    • Schmidt, E.E.1    Ichimura, K.2    Reifenberger, G.3    Collins, V.P.4
  • 71
    • 0017250977 scopus 로고
    • DNA related to the transforming gene(s) of avian sarcoma viruses is present in normal avian DNA
    • Stehelin D, Varmus HE, Bishop JM (1976) DNA related to the transforming gene(s) of avian sarcoma viruses is present in normal avian DNA. Nature 260: 170-173
    • (1976) Nature , vol.260 , pp. 170-173
    • Stehelin, D.1    Varmus, H.E.2    Bishop, J.M.3
  • 72
    • 0030056824 scopus 로고    scopus 로고
    • Alterations of retinoblastoma, p53, p16 (CDKN2), and p15 genes in human astrocytomas
    • Tsuzuki T, Tsunoda S, Sakaki T, Konishi N, Hiasa Y, Nakamura M (1996) Alterations of retinoblastoma, p53, p16 (CDKN2), and p15 genes in human astrocytomas. Cancer 78 (2): 287-293
    • (1996) Cancer , vol.78 , Issue.2 , pp. 287-293
    • Tsuzuki, T.1    Tsunoda, S.2    Sakaki, T.3    Konishi, N.4    Hiasa, Y.5    Nakamura, M.6
  • 73
    • 0030070484 scopus 로고    scopus 로고
    • CDKN2/P16 or RB alterations occur in the majority of glioblastomas and are inversely correlated
    • Ueki K, Ono Y, Henson JW, Efird JT, von Deimling A, Louis DN (1996) CDKN2/P16 or RB alterations occur in the majority of glioblastomas and are inversely correlated. Cancer Res 56 (1): 150-153
    • (1996) Cancer Res , vol.56 , Issue.1 , pp. 150-153
    • Ueki, K.1    Ono, Y.2    Henson, J.W.3    Efird, J.T.4    Von Deimling, A.5    Louis, D.N.6
  • 74
    • 0025343230 scopus 로고
    • Signal transduction by receptors with tyrosine kinase activity
    • Ullrich A, Schlessinger J (1990) Signal transduction by receptors with tyrosine kinase activity. Cell 61: 203-212
    • (1990) Cell , vol.61 , pp. 203-212
    • Ullrich, A.1    Schlessinger, J.2
  • 77
    • 0028672464 scopus 로고
    • Instability of short tandem repeats in human gliomas
    • Van de Kelft EJZ, Verlooy J (1994) Instability of short tandem repeats in human gliomas. J Neurosurg Sci 38: 203-208
    • (1994) J Neurosurg Sci , vol.38 , pp. 203-208
    • Van De Kelft, E.J.Z.1    Verlooy, J.2
  • 80
    • 0026669469 scopus 로고
    • p53 function and dysfunction
    • Vogelstein B, Kinzler K (1992) p53 function and dysfunction. Cell 70: 523-526
    • (1992) Cell , vol.70 , pp. 523-526
    • Vogelstein, B.1    Kinzler, K.2
  • 81
    • 0029397626 scopus 로고
    • Molecular pathways in the formation of gliomas
    • von Deimling AHR, Louis DN, Wiestler OD (1995) Molecular pathways in the formation of gliomas. Glia 15: 328-338
    • (1995) Glia , vol.15 , pp. 328-338
    • Von Deimling, A.H.R.1    Louis, D.N.2    Wiestler, O.D.3
  • 84
    • 0024350129 scopus 로고
    • Growth factor biology and oncogene activation in human gliomas and their implications for specific therapeutic concepts
    • Westphal M, Herrmann H-D (1989) Growth factor biology and oncogene activation in human gliomas and their implications for specific therapeutic concepts. Neurosurgery 25: 681-694
    • (1989) Neurosurgery , vol.25 , pp. 681-694
    • Westphal, M.1    Herrmann, H.-D.2
  • 85
    • 0023429079 scopus 로고
    • Increased expression of the epidermal growth factor receptor gene in malignant gliomas is invariably associated with gene amplification
    • Wong AJ, Bigner SH, Kinzler KW, Hamilton SR, Vogelstein B (1987) Increased expression of the epidermal growth factor receptor gene in malignant gliomas is invariably associated with gene amplification. Proc Natl Acad Sci USA 84: 6899-6903
    • (1987) Proc Natl Acad Sci USA , vol.84 , pp. 6899-6903
    • Wong, A.J.1    Bigner, S.H.2    Kinzler, K.W.3    Hamilton, S.R.4    Vogelstein, B.5
  • 86
    • 0028004727 scopus 로고
    • Two independent amplification events on chromosome 7 in glioma: Amplification of the EGFR gene and amplification of the oncogene MET
    • Wullich B, Sattler HP, Fischer U, Meese E (1994) Two independent amplification events on chromosome 7 in glioma: amplification of the EGFR gene and amplification of the oncogene MET. Anticancer Res 14: 577-579
    • (1994) Anticancer Res , vol.14 , pp. 577-579
    • Wullich, B.1    Sattler, H.P.2    Fischer, U.3    Meese, E.4
  • 88
    • 0022472735 scopus 로고
    • Monoclonal antibody analysis of p53 expression in normal and transformed cells
    • Yewdell JW, Gannon JV, Lane DP (1986) Monoclonal antibody analysis of p53 expression in normal and transformed cells. J Virol 59: 444-452
    • (1986) J Virol , vol.59 , pp. 444-452
    • Yewdell, J.W.1    Gannon, J.V.2    Lane, D.P.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.