Deleted form of hepatocyte growth factor (dHGF) increases the number of platelets in rats with liver cirrhosis

Liver

Volumn 17, Issue 4, 1997, Pages 192-197

  Masunaga, Hiroaki ^a   Fujise, Nobuaki ^a   Yamashita, Yasushi ^a   Shiota, Akira ^a   Yasuda, Hiroshi ^a   Higashio, Kanji ^a  

^a SNOW BRAND MILK PRODUCTS CO LTD   (Japan)

Author keywords

Hepatocellular dysfunction; HGF; Liver; Thrombocytopenia; Thrombopoiesis

Indexed keywords

CARBON TETRACHLORIDE; DIMETHYLNITROSAMINE; PHENOBARBITAL; SCATTER FACTOR;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; INTRAVENOUS DRUG ADMINISTRATION; LIVER CIRRHOSIS; MALE; NONHUMAN; RAT; THROMBOCYTE COUNT; THROMBOCYTOPENIA; THROMBOCYTOPOIESIS;

EID: 0030801788     PISSN: 01069543     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1600-0676.1997.tb00805.x     Document Type: Article

References (21)

1. GOHDA E, TSUBOUCHI H, NAKAYAMA H, et al. Human hepatocyte growth factor in plasma from patients with fulminant hepatic failure. Exp Cell Res 1986: 166: 139-150.
2. MIYAZAWA K, TSUBOUCHI H, NAKA D, et al. Molecular cloning and sequence analysis of cDNA for human hepatocyte growth factor. Biochem Biophys Res Commun 1989: 163: 967-973.
3. NAKAMURA T, NISHIZAWA T, HAGIYA M, et al. Molecular cloning and expression of human hepatocyte growth factor. Nature 1989: 342: 440-443.
4. HIGASHIO K, SHIMA N, GOTO M, et al. Identity of tumor cytotoxic factor from human fibroblasts and hepatocyte growth factor. Biochem Biophvs Res Commun 1990: 170: 397-404.
5. SHIMA N, NAGAO M, OGAKI F, TSUDA E, MURAKAMI A. HIGASHIO K. Tumor cytotoxic factor/hepatocyte growth factor from human fibroblasts: cloning of its cDNA, purification and characterization of recombinant protein. Biochem Biophys Res Commun 1991: 180: 1151-1158.
6. MATSUMOTO K, TAKEHARA T, INOUE H, HAGIYA M, SHIMIZU S, NAKAMURA T. Deletion of kringle domains or the N-terminal hairpin structure in hepatocyte growth factor results in marked decreases in related biological activities. Biochem Biophys Res Commun 1991: 181: 691-699.
7. SHIMA N, TSUDA E, GOTO M, et al. Hepatocyte growth factor and its variant with a deletion of five amino acids are distinguishable in their biological activity and tertiary structure Biochem Biophys Res Commun 1994: 200: 808-815.
8. TSUBOUCH H, HIRONO S, GOHDA E, et al. Clinical significance of human hepatocyte growth factor in blood from patients with fulminant hepatic failure. Hepatology 1989: 9: 875-881.
9. SHIMA N, HIGASHIO K, OGAKI H, OKABE K. ELISA for F-TCF (human hepatocyte growth factor/hHGF)/fibroblast-derived tumor cytotoxic factor antigen employing monoclonal antibodies and its application to patients with liver diseases. Gastroenterologia Jpn 1991: 26: 477-482.
10. MASUNAGA H, FUJISE N, SHIOTA A, YAMASHITA Y, YASUDA H, HIGASHIO K. Amelioration of disordered hepatic protein synthesis by the deleted form of hepatocyte growth factor in models of liver failure in rats. J Pharm Pharmacol 1996: 48: 876-879.
11. GREEN G, POLLER L, JEAN M, THOMSON M, DYMOCK I W. Association of abnormal fibrin polymerisation with severe liver disease. Gut 1977: 18: 909-912.
12. BOKS A L, BROMMER E J P, SCHALM S W, VANVLIET H H D M. Hemostasis and fibrinolysis in severe liver failure and their relation to hemorrhage. Hepatology 1986: 6: 79-86.
13. CARR J M. Disseminated intravascular coagulation in cirrhosis. Hepatology 1989: 10: 103-110.
14. SCMIDT K G, RASMUSSEN J W, BEKKER C, MADSEN P E R. Kinetics and in vivo distribution of 111-In-labelled autologous platelets in chronic hepatic disease: mechanism of thrombocytopenia. Scand J Haematol 1985: 34: 39-46.
15. TRIVEDI P, MOWAT A P. Carbon tetrachloride-induced hepatic fibrosis and cirrhosis in the developing rat: an experimental model of cirrhosis in childhood. Br J Exp Path 1983: 64: 25-33.
16. JÉZÉQUEL A M, MANCINI R, RINALDESI M L, MACARRI G, VENTURINI C, ORLANDI F. A morphological study of the early stages of hepatic fibrosis induced by low doses of dimethylnitrosamine in the rat. J Hepatol 1987: 5: 174-181.
17. NISHINO T, HISHA H, NISHINO N, ADACHI M, IKEHARA S. Hepatocyte growth factor as a hematopoietic regulator. Blood 1995: 85: 3093-3100.
18. BANU N, PRICE D J, LONDON R, et al. Modulation of megakaryocytopoiesis by human macrophage-stimulating protein, the ligand for the RON receptor. J Immunol 1996: 156: 2933-2940.
19. SAUVAGE F J, HASS P E, SPENCER S D, et al. Stimulation of megakaryocytopoiesis and thrombopoiesis by the c-Mpl ligand. Nature 1994: 369: 533-538.
20. SHIVDASANI R A, ROSENBLATT M F, ZUCKER-FRANKLIN D, et al. Transcription factor NF-E2 is required for platelet formation independent of the actions of thrombopoietin/ MGDF in megakaryocyte development. Cell 1995: 81: 695-704.
21. HINO M, NISHIZAWA Y, TAGAWA S, YAMANE T, MORII H, TATSUMI N. Constitutive expression of the thrombopoietin gene in a human hepatoma cell line. Biochem Biophys Res Commun 1995: 217: 475-481.