Trihexyphenidyl treatment of clozapine-induced hypersalivation

International Clinical Psychopharmacology

Volumn 12, Issue 4, 1997, Pages 213-215

  Spivak, B ^a,b   Adlersberg, S ^a,b   Rosen, L ^a,b   Gonen, N ^a,b   Mester, R ^a,b   Weizman, A ^c  

^a NESS ZIONA MENTAL HEALTH CENTER   (Israel)

^b TEL AVIV UNIVERSITY   (Israel)

^c GEHA MENTAL HEALTH CENTER   (Israel)

Author keywords

Clozapine; Hypersalivation; Trihexyphenidyl

Indexed keywords

CHOLINERGIC RECEPTOR BLOCKING AGENT; CLOZAPINE; TRIHEXYPHENIDYL;

ADULT; ARTICLE; CLINICAL ARTICLE; DRUG EFFICACY; FEMALE; HUMAN; HYPERSALIVATION; MALE; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; RATING SCALE; SALIVATION; SCHIZOPHRENIA;

EID: 0030801683     PISSN: 02681315     EISSN: None     Source Type: Journal    
DOI: 10.1097/00004850-199707000-00005     Document Type: Article

References (13)

1. Baldessarini RJ, Huston-Lyons D, Campbell A, Marsh E and Cohen BM (1992) Do central antiadrenergic actions contribute to the atypical properties of clozapine. British Journal of Psychiatry, 160, 12-16.
2. Bymaster FP, Health I, Hendrix JC and Shannon HE (1993) Comparative behavioral and neurochemical activities of cholinergic antagonists in rats. Journal of Pharmacology and Experimental Therapeutics, 267, 16-24.
3. Copp PJ, Lament R and Tennent TG (1991) Amitriptyline in clozapine-induced sialorrhoea. British Journal of Psychiatry, 159, 166.
4. First MB, Spitzer RL, Gibbon M and Williams JBW (1994) Structured Clinical Interview for Axis I DSM-IV Disorders/Patient Version (SCID-I/P, Version 2.0). Biometric Research Department, New York State Psychiatric Institute, New York.
5. Goldberg TE and Weinberger DR (1994) The effect of clozapine on neurocognition: an overview. Journal of Clinical Psychiatry, 55, 88-90.
6. Grabowski J (1992) Clonidine treatment of clozapine-induced hypersalivation. Journal of Clinical Psychopharmacology, 12, 69-70.
7. Loenders B, Rampart M and Herman AG (1994) Effect of enantiomers of M3 antagonists on muscarinic receptors in rabbit trachea. Archives of Internal Pharmacodynamics and Therapeutics, 328, 225-234.
8. Mavridis M, Rogard M and Besson MJ (1995) Chronic blockade of muscarinic cholinergic receptors by systemic trihexyphenidyl (Artane) administration modulates but does not mediate the dopaminergic regulation of striatal prepropeptide messenger RNA expression. Neuroscience, 66, 37-53.
9. Patton HD (1989) The autonomic nervous system. In: Textbook of Physiology, 21st edn (Eds, HD Patton, AF Fuchs, B Hille, AM Scher and R Steiner), pp 737-743. WB Saunders Company, Philadelphia.
10. Safferman A, Liberman JA, Kane JM, Szymanski S and Kion B (1991) Update on the clinical efficacy and side effects of clozapine. Schizophrenia Bulletin, 17, 247-261.
11. Schuster P, Gabriel E, Kufferle B, Strobl G and Karobath M (1977) Reversal by physostigmine of clozapine induced delirium. Clinical Toxicology, 10, 427-441.
12. Shen A and Mitchelson F (1994) Characterization of the muscarine receptor subtype on sympathetic nerve endings in the rat caudal artery. European Journal of Pharmacology, 252, 167-172.
13. Wagstaff AJ and Bryson HM (1995) Clozapine: a review of its pharmacological properties and therapeutic use in patients with schizophrenia who are unresponsive to or intolerant of classical antipsychotic agents. Central Nervous System Drugs, 4, 370-400.