Chemoenzymatic synthesis and characterization of a new type of carbohydrate-based cationic antimicrobial agents

Bioorganic and Medicinal Chemistry Letters

Volumn 7, Issue 13, 1997, Pages 1645-1648

  Kirk, Ole ^a   Pedersen, Flemming D ^a   Fuglsang, Claus C ^a  

^a NOVO NORDISK A S   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIINFECTIVE AGENT; GLUCOPYRANOSIDE;

ANTIBACTERIAL ACTIVITY; ANTIFUNGAL ACTIVITY; ARTICLE; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; FUSARIUM OXYSPORUM; MICROCOCCUS LUTEUS; NONHUMAN; STRUCTURE ANALYSIS; VIBRIO ALGINOLYTICUS;

EID: 0030801392     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(97)00276-X     Document Type: Article

References (13)

1. (a) Cox, M. F. Surfactants, in Lange, K. F., Ed., Detergents and Cleaners; Carl Hanser Verlag: Munic, 1994; pp 43-90.
2. (b) Greek, B. F. Chem. Eng. News 1991, 25-52.
3. Rubingh, D. N. Surface-active Cationic Compounds in Detergency, in Cationic Surfactants, Rubingh, D. N.; Holland, P. M., Eds., Marcel Dekker, Inc.: New York, 1990; pp 469-507.
4. Boethling, R. S. Water Res. 1984, 18, 1061-1076.
5. Puchta, R.; Krings, P.; Sandkühler, P. Tenside Surf. Det. 1993, 30, 186-191.
6. Andresen, O.; Kirk, O. Prog. Biotechnol. 1995, 10, 343-351.
7. Adelhorst, K.; Björkling, F.; Godtfredsen S. E.; Kirk, O. Synthesis 1990, 111-115.
8. (a) Finkelstein, H. Ber. 1910, 43, 1528
9. (b) Conant, J. B.; Kimer, W. R. J. Am. Chem. Soc. 1924, 46, 323-256.
10. (a) Menschutkin, N. Z. Physik. Chem. 1890, 6, 41
11. (b) Jackson, E. L. J. Am. Chem. Soc. 1938, 60, 722-723.
12. 3)3), 3.25-3.9 (8H, m), 4.28 (m, 2H), 4.44 (0.3H, d, J=7.5 Hz, H-1β), 4.83 (0.7H, d, J=3.7 Hz, H-1α).
13. 7/ml). A sample (1.0 ml) was then added test substance at levels of 0, 10, 50, 100, 500, 1000, and 2000 ppm. The samples were allowed to incubate for 30 minutes before plating 10 μl samples on TY agar plates. Growth or nogrowth was established by visual inspection of the plates after 16 h incubation at 30 °C. To measure antifungal activity, a culture of Fusarium oxysporum was used. Wells were made in agar plates containing the fungal spores. 15 μl samples of solutions of the test substances in concentrations of 0, 100, 500, 2500, 7500 and 15000 ppm were added to each well. After incubation for 48 h at 26 °C clearing zones were visually observed as a measure of growth inhibition.