An unusual case of severe combined immunodeficiency with hypereosinophilia

Journal of Internal Medicine

Volumn 242, Issue 3, 1997, Pages 267-269

  Dams, E Th M ^a   Mascart Lemone, F ^b   Schandene L ^b   Van Der Meer, J W M ^a  

^a RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^b ERASME HOSPITAL   (Belgium)

Author keywords

Hypereosinophilia; Immunodeficiency; Interferon gamma; Omenn's syndrome

Indexed keywords

CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 2; INTERLEUKIN 4; INTERLEUKIN 5;

ADULT; ARTICLE; CASE REPORT; COMBINED IMMUNODEFICIENCY; HUMAN; HYPEREOSINOPHILIA; IMMUNOPATHOLOGY; IMMUNOTHERAPY; MALE; PRIORITY JOURNAL;

EID: 0030801160     PISSN: 09546820     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2796.1997.00199.x     Document Type: Article

References (11)

1. Omenn GS. Familial reticuloendotheliosis with eosinophilia. New Engl J Med 1965; 273: 427-32.
2. Businco L, Di Fazio A, Grazia Ziruolo M, Boner AL, Valletta EA, Ruco LP et al. Clinical and immunological findings in four infants with Omenn's syndrome: a form of severe combined immunodeficiency with phenotypically normal T cells, elevated IgE, and eosinophilia. Clin Immunol Immunopathol 1987; 44: 123-33.
3. De Saint-Basile G, le Deist F, de Villartay J-P, Cerf-Bensussan N, Journet O, Brousse N et al. Restricted heterogeneity of T lymphocytes in combined immunodeficiency with hypereosinophilia (Omenn's syndrome). J Clin Invest 1991; 87: 1352-9.
4. Robinson DS, Qutayba H, Sun Y, Tsicopoulos A, Barkans J, Bentley AM et al. Predominant Th2-like bronchoalveolar T-lymphocyte population in atopic asthma. New Engl J Med 1992; 326: 298-304.
5. Cogan E, Schandené L, Crusiaux A, Cochaux P, Velu T, Goldman M. Brief report: clonal proliferation of type 2 helper T cells in a man with the hypereosinophilic syndrome. New Engl J Med 1994; 330: 535-8.
6. Schandené L, Ferster A, Mascart-Lemone F, Crusiaux A, Gérard C, Marchant A et al. T helper type 2-like cells and therapeutic effects of interferon-γ combined immunodeficiency with hypereosinophilia (Omenn's syndrome). Eur J Immunol 1993; 23: 56-60.
7. Scott P. IFN gamma modulates the early development of Th1 and Th2 responses in a murine model of cutaneous leishmaniasis. J Immunol 1991; 147: 3149-55.
8. Melamed I, Cohen A, Roifman CM. Expansion of CD3 CD4 CD8 T cell population expressing high levels of IL-5 in Omenn's syndrome. Clin Exp Immunol 1994; 95: 14-21.
9. Rousset F, Robert J, Andary M, Bonnin J-P, Souillet G, Chrétien I et al. Shifts in interleukin-4 and interferon-γ production by T cells of patients with elevated IgE levels and the modulatory effects of these lymphokines on spontaneous IgE synthesis. J Allergy Clin Immunol 1991; 87: 58-69.
10. Paganelli R, Capobianchi MR, Ensoli B, D'Offizi GP, Facchini J, Dianzani F, Aiuti F. Evidence that defective gamma interferon production in patients with primary immunodeficiencies is due to intrinsic incompetence of lymphocytes. Clin Exp Immunol 1988; 72: 124-9.
11. Eibl MM, Wolf HM. Primary immunodeficiency disorders. Pathogenesis and treatment. Clin Immunother 1996; 5: 137-60.