Pharmacokinetics of flumequine in sheep after intravenous and intramuscular administration: Bioavailability and tissue residue studies

Journal of Veterinary Pharmacology and Therapeutics

Volumn 20, Issue 4, 1997, Pages 249-257

  Delmas, J M ^a   Chapel, A M ^a   Gaudin, V ^a   Sanders, P ^a  

^a Healthy Pigs Production and Experimentation Section   (France)

Author keywords

[No Author keywords available]

Indexed keywords

DRUG METABOLITE; FLUMEQUINE;

ADIPOSE TISSUE; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BIOAVAILABILITY; CONTROLLED STUDY; DOSE RESPONSE; DRUG BLOOD LEVEL; DRUG DETERMINATION; DRUG DISTRIBUTION; DRUG EXCRETION; DRUG HALF LIFE; DRUG TISSUE LEVEL; FEMALE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; INTRAMUSCULAR DRUG ADMINISTRATION; INTRAVENOUS DRUG ADMINISTRATION; KIDNEY; LIVER; MALE; MUSCLE; NONHUMAN; PRIORITY JOURNAL; SHEEP;

ANIMALIA; OVIS ARIES;

EID: 0030801114     PISSN: 01407783     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2885.1997.00067.x     Document Type: Article

References (21)

1. Anonymous (1993) Décision de la commission du 14 avril 1993 arrêtant les méthodes à utiliser pour la recherche de résidus de substances à effet hormonal et de substances à effest thyréostatiques. Journal OfficieI des Communautés, Décision 93/256/CEE. L118/64.
2. Fiserova-Bergerova, V. (1995) Extrapolation of physiological parameters for physiologically based simulation models. Toxicology Letters, 79, 77-86.
3. Gibaldi, M. & Perrier, D. (1975) Pharmacokinetics (Vol. 1). In Drugs and the Pharmaceutical Sciences, Marcel Dekker, New York, USA.
4. Harrison, L.I., Schuppan, D., Rohlfing, S.R., Hansen, A.R., Hansen, C.S., Funk, M.L., Collins, S.H. & Ober, R.E. (1984) Determination of flumequine and a hydroxy metabolite in biological fluids by High-Pressure Liquid Chromatographic, fluorimetric and microbiological methods. Antimicrobial Agents and Chemotherapy. 25, 301-305.
5. Harrison, L.I., Schuppan, D., Rohlfing, S.R., Hansen, A.R., Gerster, J.F., Hansen, C.S., Funk, M.L. & Ober, R.E. (1986) Disposition of radiolabeled flumequine in rat and dog. Drug Metabolism and Disposition, 14, 555-558.
6. Houpert, P., Combrisson, H., Le Nain, S., Autefage, A. & Toutain, P.L. (19931 Intra- vs intermuscular injections in swine. Veterinary Research, 24, 278-285.
7. Labaune, J.P. (1984) Pharmacocinétique: Principes fondamentaux. pp. 291-315. Masson, Paris, France.
8. Lam, F.C., Hung, C.T. & Perrier, D.G. (1985) Estimation of variance for harmonic mean half-lives. Journal of Pharmaceutical Sciences, 74, 229-231.
9. Meijer, B.A., Ceyssens, K.G.F., de Jong, W.Th. & de Grève, I.J.A.C. (1994) Unavailability of flumequine after semisimultaneous administration to veal calves. Pharmaceutical Research, 11, 117-121.
10. Mevius, D.J., Breukink, H.J., Guelen, P.J.M., Jansen, T. & De Greve, B. (1990) Pharmacokinetics, metabolism and renal clearance of flumequine in veal calves. Journal of Veterinary Pharmacology and Therapeutics, 13, 159-169.
11. Mevius, D.J., Breukink, H.J., van Miert, A.S.J.P.A.M., Kessels, B.G.F., Jobse, A.S. & Smit, J.A.H. (1991) Effects of experimentally induced Pasteurella haemolytica infection in dairy calves on the pharmacokinetics of flumequine. Journal of Veterinary Pharmacology and Therapeutics, 14, 174-184.
12. Moutafchieva, R., Nouws, J.F.M., Keukens, H.J., Kan, C.A., Beek, W.M.J., Streutjens, E. & Hoogenboom, L.A.P. (1994) The effect of comedication with sodium salicylate on plasma disposition, metabolism and tissue distribution of flumequine in broilers. Proceedings of the 6th international congress EAVPT (Edinburgh) Ed. P. Lees. 78-79. Blackwell Scientific Publications, Oxford.
13. Romvary, A., Sandor, G., Csiko, G.Y. & Lkehel, J. (1994) Residue studies in poultry skin and fat. Proceedings of the 6th international congress EAVPT (Edinburgh) Ed. P. Lees. 784-785. Blackwell Scientific Publications, Oxford.
14. Schuppan, D., Harrison, L.I., Rohlfing, S.R., Miller, H.L., Funk, M.L., Hansen, C.S. & Ober, R.E. (1985) Plasma and urine levels of flumequine and 7-hydroxyflumequine following single and multiple oral dosing. Journal of Antimicrobial Chemotherapy, 15, 337-343.
15. Shah, V.P., Midha, K.K., Dighnat, S., McGilveray, I.J., Skelly, J.P., Yacobi, A., Layloff, T., Viswanathan, C.T., Cook, E., McDowall, R.D., Pittman, K.A. & Spector, S. (1992) Analytical methods validation: Bioavailability, bioequivalence and pharmacokinetic studies. Journal of American Official Association of Chemistry, 75, 19A-26A.
16. Testa, B. & Jenner, P. (1976) Chemical and Biochemical aspect. In Drug metabolism, pp. 117-184. Marcel Dekker, New York, USA.
17. Vree, T.B., van Ewijk-Beneken Kolmer, E.W.J. & Nouws, J.F.M. (1992) Direct-gradient high-performance liquid chromatographic analysis and preliminary pharmacokinetics of flumequine and flumequine acyl glucuronide in humans: effect of probenecid. Journal of Chromatography, 579, 131-141.
18. Witkamp, R.F., Yun, H.I., Van't Klooster, G.A.E., Van Mosel, J.F., Ensink, J.M., Noordhoek, J. & Van Miert, A.S.J.P.A.M. (1992) Comparative aspects and sexual differentiation of sulfamethazine plasma elimination and metabolite formation. Studies in rats, rabbits, dwarf goats and cattle. American Journal of Veterinary Research, 53, 1830-1835.
19. Yamaoka, K., Terumichi, N. & Uno, T. (1978a) Application of Akaike's information criterion (AIC) in the evaluation of linear pharmacokinetic equations. Journal of Pharmacokinetics and Biopharmaceutics, 6, 165-175.
20. Yamaoka, K., Terumichi, N. & Uno, T. (1978a) Statistical moments in pharmacokinetics. Journal of Pharmacokinetics and Biopharmaceutics, 6, 547-558.
21. Ziv, G., Soback, S., Bor, A. & Kurtz, B. (1986) Clinical pharmacokinetics of flumequine in calves. Journal of Veterinary Pharmacology and Therapeutics, 9, 171-182.