Effects of methylprednisolone on hemodynamics and β-adrenergic receptor signaling in rabbits with acute left ventricular failure

Heart and Vessels

Volumn 12, Issue 2, 1997, Pages 84-91

  Nishimura, Hiroshi ^a   Yoshikawa, Tsutomu ^a   Kobayashi, Natsuki ^a   Anzai, Toshihisa ^a   Nagami, Keiichi ^a   Handa, Shunnosuke ^b   Ogawa, Satoshi ^a  

^a KEIO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b TOKAI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Aortic regurgitation; Catecholamine; Corticosteroids; Heart failure; adrenergic receptor

Indexed keywords

ADENYLATE CYCLASE; BETA ADRENERGIC RECEPTOR; CATECHOLAMINE; CORTICOSTEROID; ISOPRENALINE; METHYLPREDNISOLONE; NORADRENALIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; AORTA VALVE REGURGITATION; ARTICLE; CONGESTIVE HEART FAILURE; CONTROLLED STUDY; DIASTOLIC BLOOD PRESSURE; ENZYME ACTIVITY; FEMALE; HEART LEFT VENTRICLE ENDDIASTOLIC VOLUME; HEART LEFT VENTRICLE FAILURE; HEART LEFT VENTRICLE OVERLOAD; HEART MUSCLE; HEART OUTPUT; HEMODYNAMICS; HYPOTENSION; INTRAVENOUS DRUG ADMINISTRATION; NONHUMAN; PRIORITY JOURNAL; RABBIT; RECEPTOR DENSITY; SIGNAL TRANSDUCTION;

EID: 0030800752     PISSN: 09108327     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF02820871     Document Type: Article

References (35)

1. Feldman MD, Copelas L, Gwathmey JK, Phillips P, Warren SE, Schoen FJ, Grossman W, Morgan JP (1987) Deficient production of cyclic AMP: pharmacologic evidence of an important cause of contractile dysfunction in patients with end-stage heart failure. Circulation 75:331-339
2. Unverferth DV, Blandford M, Kates RE (1980) Tolerance to dobutamine after a 72-hour continuous infusion. Am J Med 69:262-266
3. Bristow MR, Minobe W, Rasmussen R, Larrabee P, Skerl L, Klein JW, Anderson FL, Murray J, Mestroni L, Karwande SV, Fowler M, Ginsburg R (1992) β-Adrenergic neuroeffector abnormalities in the failing human heart are produced by local rather than systemic mechanisms. J Clin Invest 89:803-815
4. Bristow MR, Ginsburg R, Minobe W, Cubicciotti RS, Sageman WS, Lurie K, Billingham ME, Harrison DC, Stinson EB (1982) Decreased catecholamine sensitivity and beta-adrenergic-receptor density in failing human hearts. N Engl J Med 307:205-211
5. Milano CA, Allen LF, Rockman HA, Dolber PC, McMinn TR, Chien KR, Johnson TD, Bond RA, Lefkowitz RJ (1994) Enhanced myocardial function in transgenic mice overexpressing the β2-adrenergic receptor. Science 264:582-586
6. Besse JC, Bass AD (1966) Potentiation by hydrocortisone of response to catecholamines in vascular smooth muscle. J Pharmacol Exp Ther 154:224-238
7. Kalsner S (1969) Steroid potentiation of responses to sympathomimetic amines in aortic strips. Br J Pharmacol 36:582-593
8. Kaumann AJ (1972) Potentiation of the effects of isoprenaline and noradrenaline by hydrocortisone in cat heart muscle. Naunyn-Schmiedeberg's Arch Pharmacol 273:134-153
9. Logsdon PJ, Middleton E Jr, Coffey RG (1972) Stimulation of leukocyte adenyl cyclase by hydrocortisone and isoproterenol in asthmatic and nonasthmatic subjects. J Allergy Clin Immunol 50:45-56
10. Mano K, Akbarzadeh A, Townley RG (1979) Effect of hydrocortisone on beta-adrenergic receptors in lung membranes. Life Sci 25:1925-1930
11. Fraser CM, Venter C (1980) The synthesis of β-adrenergic receptors in cultured human lung cells: induction by glucocorticoids. Biochem Biophys Res Commun 94:390-397
12. Cheng JB, Goldfien A, Ballard PL, Roberts JM (1980) Glucocorticoids increase pulmonary β-adrenergic receptors in fetal rabbit. Endocrinology 107:1646-1648
13. Marone G, Lichtenstein L, Plaut M (1980) Hydrocortisone and human lymphocytes: increases in cyclic adenosine 3′, 5′-monophosphate and potentiation of adenylate cyclase-activating agents. J Pharmacol Exp Ther 215:469-478
14. Davies AO, Lefkowitz RJ (1980) Corticosteroid-induced differential regulation of β-adrenergic receptors in circulating human polymorphonuclear leukocytes and mononuclear leukocytes. J Clin Endocrinol Metab 51:599-605
15. Davies AO, Lefkowitz RJ (1981) Agonist-promoted high affinity state of the β-adrenergic receptor in human neutrophils: modulation by corticosteroids. J Clin Endocrinol Metab 53:703-708
16. Davies AO, Lefkowitz RJ (1983) In vitro desensitization of beta-adrenergic receptors in human neutrophils. J Clin Invest 71:565-571
17. Saito T, Takanashi M, Gallagher E, Fuse A, Suzaki S, Inagaki O, Yamada K, Ogawa R (1995) Corticosteroid effect on early beta-adrenergic downregulation during circulatory shock. Intens Care Med 21:204-210
18. Wainai Y, Kusuhara M, Yamada T, Yoshikawa T, Suzuki M, Hori S, Handa S, Yoshinaga K, Yamaguchi K (1990) Atrial natriuretic peptide secretion in rabbits with aortic regurgitation. Res Exp Med 190:13-18
19. Wainai Y (1991) Adaptive mechanisms of the aorta and left ventricle to volume overloading following aortic regurgitation in rabbits. Cardiovasc Res 25:463-467
20. Sugiyama S, Hayashi K, Hanaki Y, Taki K, Ozawa T (1991) Effect of methylprednisolone on recovery of β-adrenergic desensitization in rat hearts. Arzneim-Forsch/Drug Res 41:439-443
21. Taylor RB, Reid R, Kendle KE, Geddes C, Curle PF (1983) Assay procedures for the determination of biogenic amines and their metabolites in rat hypothalamus using ion-pairing reversed-phase high-performance liquid chromatography. J Chromatogr 277:101-114
22. Yoshikawa T, Handa S, Yamada T, Wainai Y, Suzuki M, Tani M, Nakamura Y (1993) Sequential changes in sympatho-neuronal regulation and contractile function following aortic regurgitation in rabbit heart. Eur Heart J 14:1404-1409
23. Yoshikawa T, Handa S, Suzuki M, Nagami K (1994) Abnormalities in sympathoneuronal regulation are localized to failing myocardium in rabbit heart. J Am Coll Cardiol 24:210-215
24. Yoshikawa T, Handa S, Nagami K, Suzuki M, Wainai Y, Minami T, Suzuki K, Kitazawa S (1995) Effect of the angiotensin-converting enzyme inhibitor alacepril on ventricular function and beta-adrenoceptor number in rabbits with aortic regurgitation. Jpn Heart J 36:91-100
25. Peterson GL (1977) A simplification of protein assay method of Lowry et al. which is more generally applicable. Anal Biochem 83:346-356
26. Scatchard G (1949) The attractions of proteins for small molecules and ions. Ann NY Acad Sci 51:660-672
27. Abe M, Yamazaki N, Suzuki Y, Kobayashi A, Ohta H (1984) Effects of palmitoyl carnitine in Na,K-ATPase and adenylate cyclase activity of canine myocardial sarcolemma. J Mol Cell Cardiol 16:239-245
28. Steiner AL, Parker CW, Kipnis DM (1972) Radioimmunoassay for cyclic nucleotide. J Biol Chem 247:1106-1113
29. Lai E, Rosen OM, Rubin CS (1982) Dexamethasone regulates the β-adrenergic receptor subtype expressed by 3T3-L1 preadipocytes and adipocytes. J Biol Chem 257:6691-6696
30. Zhong H, Minneman KP (1993) Close reciprocal regulation of β1- and β2-adrenergic receptors by dexamethasone in C6 glioma cells: effects on catecholamine responsiveness. Mol Pharmacol 44:1085-1093
31. Tseng YT, Tucker MA, Kashiwai KT, Waschek JA, Padbury JF (1995) Regulation of β1-adrenoceptors by glucocorticoids and thyroid hormones in fetal sheep. Eur J Pharmacol 289:353-359
32. Anzai T, Yoshikawa T, Baba A, Nishimura H, Shiraki H, Nagami K, Suzuki M, Wainai Y, Ogawa S (1996) Myocardial sympathetic denervation prevents chamber-specific alteration of beta-adrenergic transmembrane signaling in rabbits with heart failure. J Am Coll Cardiol 28:1314-1322
33. Collins S, Caron MG, Lefkowitz RJ (1988) β2-Adrenergic receptors in hamster smooth muscle cells are transcriptionally regulated by glucocorticoids. J Biol Chem 263:9067-9070
34. Hadcock JR, Malbon CG (1988) Regulation of β-adrenergic receptors by "permissive" hormones: glucocorticoids increase steady-state levels of receptor mRNA. Proc Natl Acad Sci USA 85:8415-8419
35. Taylor WT Jr, Self TH (1976) Mineralocorticoid activity of methylprednisolone. Am J Hosp Pharm 33:526-528