High-dose busulfan, melphalan, thiotepa and peripheral blood stem cell infusion for the treatment of metastatic breast cancer

Bone Marrow Transplantation

Volumn 19, Issue 12, 1997, Pages 1183-1189

  Bensinger, W I ^a,b   Schiffman, K S ^a   Holmberg, L ^a   Appelbaum, F R ^a,b   Maziarz, R ^a   Montgomery, P ^a   Ellis, E ^a   Rivkin, S ^a   Weiden, P ^a   Lilleby, K ^a   Rowley, S ^a,b   Petersdorf, S ^a   Klarnet, J P ^a   Nichols, W ^a   Hertler, A ^a   McCroskey, R ^a   Weaver, Ch ^c   Buckner, C D ^a,c  

^a Fred Hutchinson Cancer Research Center   (United States)

^b UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^c Response Oncology Inc   (United States)

Author keywords

Breast cancer; Busulfan; Melphalan; PBSC; Thiotepa

Indexed keywords

ANTINEOPLASTIC AGENT; BUSULFAN; GROWTH FACTOR; MELPHALAN; THIOTEPA;

ADULT; AGED; ARTICLE; ASPIRATION PNEUMONIA; BONE LESION; BREAST METASTASIS; CANCER SURVIVAL; CLINICAL TRIAL; CYTOMEGALOVIRUS INFECTION; DRUG EFFICACY; DRUG FATALITY; DRUG TOXICITY; FEMALE; GASTROINTESTINAL TOXICITY; HEMORRHAGIC CYSTITIS; HUMAN; HUMAN CELL; INTRAVENOUS DRUG ADMINISTRATION; MAJOR CLINICAL STUDY; MORTALITY; MULTICENTER STUDY; PERIPHERAL BLOOD STEM CELL; PNEUMONIA; PRIORITY JOURNAL; PROBABILITY; SOFT TISSUE DISEASE; STEM CELL TRANSPLANTATION; TREATMENT OUTCOME; VEIN OCCLUSION;

EID: 0030800390     PISSN: 02683369     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bmt.1700820     Document Type: Article

References (26)

1. Antman KH. Dose-intensive therapy in breast cancer. In: Armitage JO, Antman KH (eds). High-dose Cancer Therapy (Pharmacology, Hematopoietins, Stem Cells). Williams & Wilkins: Baltimore, 1992, pp 701-717.
2. Weaver C, Birch R, Schwartzberg L et al. High-dose chemotherapy and autologous stem cell transplantation for breast cancer. In: Buckner CD, Clift R (eds). Technical and Biological Components of Marrow Transplantation. Kluwer Academic Publishers: Boston, 1995, pp 59-85.
3. Antman K, Ayash L, Elias A et al. A phase II study of high-dose cyclophosphamide, thiotepa, and carboplatin with autologous marrow support in women with measurable advanced breast cancer responding to standard-dose therapy. J Clin Oncol 1992; 10: 102-110.
4. Kennedy MJ, Beveridge RA, Rowley SD et al. High-dose chemotherapy with reinfusion of purged autologous bone marrow following dose-intense induction as initial therapy for metastatic breast cancer. J Natl Cancer Inst 1991; 83: 920-926.
5. Peters WP, Shpall EJ, Jones RB et al. High-dose combination alkylating agents with bone marrow support as initial treatment for metastatic breast cancer. J Clin Oncol 1988; 6: 1368-1376.
6. Ayash LJ, Wheeler C, Fairclough D et al. Prognostic factors for prolonged progression-free survival with high-dose chemotherapy with autologous stem-cell support for advanced breast cancer. J Clin Oncol 1995; 13: 2043-2049.
7. Bezwoda WR, Seymour L, Dansey RD. High-dose chemotherapy with hematopoietic rescue as primary treatment for metastatic breast cancer: a randomized trial. J Clin Oncol 1995; 13: 2483-2489.
8. Weaver CH, West WH, Schwartzberg LS et al. Induction, mobilization of peripheral blood stem cells (PBSC), high-dose chemotherapy and PBSC infusion in patients with untreated stage IV breast cancer: outcomes by intent to treat analyses. Bone Marrow Transplant 1997; 19: 661-670.
9. Weaver CH, Bensinger WI, Appelbaum K et al. Phase I study of high-dose busulfan, melphalan, thiotepa with autologous stem cell support in patients with refractory malignancies. Bone Marrow Transplant 1994; 14: 813-819.
10. Lazarus HM, Reed MD, Spitzer TR et al. High-dose IV thiotepa and cryopreserved autologous bone marrow transplantation for therapy of refractory cancer. Cancer Treat Rep 1987; 71: 689-695.
11. Demirer T, Buckner CD, Appelbaum FR et al. High-dose busulfan and cyclophosphamide followed by autologous transplantation in patients with advanced breast cancer. Bone Marrow Transplant 1996; 17: 769-774.
12. Williams S, Gilewski T, Mick R et al. High dose consolidation therapy with autologous stem cell rescue in stage IV breast cancer: follow-up report. J Clin Oncol 1992; 10: 1743-1747.
13. Schiffman KS, Bensinger WI, Appelbaum FR et al. Phase II study of high-dose busulfan, melphalan and thiotepa with autologous peripheral blood stem cell support in patients with malignant disease. Bone Marrow Transplant 1996; 17: 943-950.
14. Bensinger WI, Singer J, Appelbaum F et al. Autologous transplantation with peripheral blood mononuclear cells collected after administration of recombinant granulocyte stimulating factor. Blood 1993; 81: 3158-3163.
15. Demirer T, Buckner CD, Lilleby K et al. Failure of a single cycle of high dose cyclophosphamide followed by intensive myeloablative therapy and autologous stem cell transplantation to improve outcome in relapsed disease. Cancer 1994; 74: 715-721.
16. Demirer T, Rowley S, Buckner CD et al. Peripheral blood stem-cell collections after paclitaxel, cyclophosphamide and recombinant human granulocyte colony-stimulating factor in patients with breast and ovarian cancer. J Clin Oncol 1995; 13: 1714-1719.
17. Demirer T, Buckner CD, Storer B et al. The effect of different chemotherapy regimens on peripheral blood stem cell collections in patients with breast cancer receiving granulocyte-colony stimulating factor. J Clin Oncol 1997; 15: 684-690.
18. Bensinger W, Appelbaum F, Rowley S et al. Factors that influence collection and engraftment of autologous peripheral-blood stem cells. J Clin Oncol 1995; 13: 2547-2555.
19. Rowley SD, Bensinger WI, Gooley TA et al. The effect of cell concentration on bone marrow and peripheral blood stem cell cryopreservation Blood 1994; 83: 2731-2736.
20. Bearman SI, Appelbaum FR, Buckner CD. Regimen-related toxicity in patients undergoing bone marrow transplantation. J Clin Oncol 1988; 6: 1562-1568.
21. Shuhart MC, McDonald GB. Gastrointestinal and hepatic complications. In: Forman SJ, Blume KG, Thomas ED (eds). Bone Marrow Transplantation. Blackwell Scientific: Boston, 1994, pp 454-481.
22. Crawford SW. Critical care and respiratory failure. In: Thomas ED, Forman SJ, Blume K (eds). Bone Marrow Transplantation. Chapter 37. Blackwell Scientific: Boston, 1994, pp 513-526.
23. Kaplan EL, Meier P. Nonparametric estimation from incomplete observations. J Am Stat Assoc 1958; 53: 457-481.
24. Dunphy FR, Spitzer G, Buzdar AU et al. Treatment of estrogen receptor-negative or hormonally refractory breast cancer with double high-dose chemotherapy intensification and bone marrow support. J Clin Oncol 1990; 8: 1207-1216.
25. Ayash LJ, Elias A, Wheeler C et al. Double dose-intensive chemotherapy with autologous marrow and peripheral-blood progenitor-cell support for metastatic breast cancer: a feasibility study. J Clin Oncol 1994; 12: 37-44.
26. Dunphy FR, Spitzer G, Fornoff JE et al. Factors predicting long-term survival for metastatic breast cancer patients treated with high-dose chemotherapy and bone marrow support (published erratum appears in Cancer 1994; 74: 773). Cancer 1994; 73: 2157-2167.