Ferrous-ascorbate complexes as carriers of nitric oxide

General Physiology and Biophysics

Volumn 16, Issue 1, 1997, Pages 91-95

  Kuropteva, Z V ^a   Kudryavtsev, M E ^a  

^a EMANUEL INSTITUTE OF BIOCHEMICAL PHYSICS   (Russian Federation)

Author keywords

Carriers; EDRF; Nitric oxide; Nitrosyl ferrous ascorbate complexes

Indexed keywords

DRUG CARRIER; ENDOTHELIUM DERIVED RELAXING FACTOR; FERROUS ASCORBATE; NITRIC OXIDE;

ABSORPTION SPECTROPHOTOMETRY; ARTICLE; BINDING AFFINITY; CHEMICAL BINDING; COMPLEX FORMATION; ELECTRON SPIN RESONANCE; OXIDATION; VASODILATATION;

ASCORBIC ACID; BIOLOGICAL TRANSPORT; ELECTRON SPIN RESONANCE SPECTROSCOPY; FERROUS COMPOUNDS; NITRIC OXIDE; REACTIVE OXYGEN SPECIES; SPECTROPHOTOMETRY, ULTRAVIOLET;

EID: 0030800302     PISSN: 02315882     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (17)

1. Beckman J. S. (1991): The double-edged role of nitric oxide in brain function and superoxide-mediated injury. J. Develop. Physiol. 15, 53-59
2. De Vente J., Bol J. G. M., Berkelmans H. S., Schipper J., Steinbusch H. M. W. (1990): Immunocytochemistry of cGMP in the cerebellum of immature, adult and aged rat: the involvement of nitric oxide. Eur. J. Neurosci. 2, 845-862
3. Drapier J.-C., Pellat C., Henry Y. (1991): Generation of EPR-detectable nitrosyl-iron complexes in tumor target cells cocultured with activated macrophages. J. Biol. Chem. 266, 10162-10167
4. Ignarro L. J. (1990): Biosynthesis and metabolism of endothelium-derived nitric oxide. Annu. Rev. Pharmacol. Toxicol. 30, 535-560
5. Kuropteva Z. V., Pastushenko O. N. (1985): Change in paramagnetic blood and liver complexes in animals under the influence of glyceryl trinitrate. Dokl. Acad. Sci. USSR 281, 189-191 (in Russian).
6. 31P-NMR study of metabolic changes in mouse tumor and liver after combined misonidazole and irradiation treatment. Appl. Magnet. Resonance 2, 495-510
7. Lancaster J. R., Hibbs J. B. (1990): EPR demonstration of iron-nitrosyl complex formation by cytotoxic activated macrophages. Proc. Natl. Acad. Sci. USA 87, 1223-1227
8. Moncada S., Higgs E. A. (Eds.) (1990): Nitric Oxide from L-arginine: A Bioregulatory System. Elsevier Science Publishers B. V.. Amsterdam
9. Moncada S., Radomski M. W.. Palmer R. M. J. (1988): Endothelium-derived relaxing factor: identification as nitric oxide and role in the control of vascular tone and platelet. function. Biochem. Pharmacol. 37, 245-249
10. Moncada S., Palmer R. M. J., Higgs E. A. (1989): Biosynthesis of nitric oxide from L-arginine. A pathway for regulation of cell function and communication. Biochem. Pharmacol. 38, 1709-1715
11. O'Connor K. J., Knowles K. D., Patel K. D., Palmer R. M. J.. Moncada S. (1990): Nitric oxide has proliferative as well as antiproliferative effects (Abstract). Arch. Pharm. Int. Ther. 305, 270
12. Palmer R. M. J., Ferrige A. G., Moncada S. (1987): Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor. Nature 327, 524-526
13. Palmer R. M. J., Ashton D. S., Moncada S. (1988): Vascular endothelial cells synthesize nitric oxide from L-arginine. Nature 333, 664-666
14. Shubin V. E., Kuropteva Z. V. (1983): EPR study of NO generation during reduction of nitrofurans and nitroimidazoles. 1. Hemoglobin solutions. Stud. Biophys. 97, 157-164
15. Stuehr D. J., Nathan C. F. (1989): Nitric oxide: a macrophage product responsible for cytostasis and respiratory inhibition in tumor target cells. J. Exp. Med. 169, 1543-1555
16. Vanin A. F. (1991): Endothelium-derived relaxing factor is a nitrosyl iron complex with thiol ligands (Hypothesis). FEBS Lett. 289, 1-3
17. Zhumabaeva T. T., Kudryavtsev M. E., Voronina S. S., Kuropteva Z. V. (1987): The influence of metronidazole and local tumor irradiation on paramagnetic metallo-complexes of liver and tumor tissues. Radiobiologiya 27, 384-389 (in Russian)