Transport of L-arginine and the nitric oxide inhibitor N(G)-monomethyl-L-arginine in human erythrocytes in chronic renal failure

Clinical Science

Volumn 93, Issue 1, 1997, Pages 57-64

  Mendes Ribeiro, A C ^a   Hanssen, H ^a   Kiessling, K ^a   Roberts, N B ^b   Mann, G E ^c   Ellory, J C ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b ROYAL LIVERPOOL UNIVERSITY HOSPITAL   (United Kingdom)

^c KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

Arginine transport; Dialysis; Erythrocytes; N(G) monomethyl L arginine transport; Uraemia

Indexed keywords

ALANINE; ARGININE; CITRULLINE; LEUCINE; LYSINE; N(G) METHYLARGININE; N(G) NITROARGININE; NITRIC OXIDE SYNTHASE INHIBITOR; ORNITHINE;

ADULT; AMINO ACID BLOOD LEVEL; AMINO ACID TRANSPORT; ARTICLE; CATION TRANSPORT; CELL LEVEL; CHRONIC KIDNEY FAILURE; CLINICAL ARTICLE; CONTROLLED STUDY; ERYTHROCYTE; FEMALE; HEMODIALYSIS; HUMAN; HUMAN CELL; INTRACELLULAR FLUID; ISOTOPE LABELING; MALE; MEMBRANE TRANSPORT; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; SMOOTH MUSCLE FIBER; UREMIA; VASCULAR ENDOTHELIUM;

EID: 0030800295     PISSN: 01435221     EISSN: None     Source Type: Journal    
DOI: 10.1042/cs0930057     Document Type: Article

References (27)

1. Moncada S, Palmer RMJ, Higgs A. Nitric oxide: physiology, pathophysiology and pharmacology. Pharmacol Rev 1991; 43: 109-42.
2. Hecker M, Mulsch A, Bassenge E, Forstermann U, Busse R. Subcellular localisation and characterization of nitric oxide synthase(s) in endothelial cells: physiological implications. Biochem J 1994; 299: 247-52.
3. Murad F, Mittal CK, Arnold WP, Katsuki S, Kimura H. Guanylate cyclase: activation by azide, nitro compounds, nitric oxide and hydroxyl radical and inhibition by haemoglobin and myoglobin. Adv Cyclic Nucleotide Res 1978; 9: 145-58.
4. Knowles RG, Moncada S. Nitric oxide synthases in mammals. Biochem J 1994; 298: 249-58.
5. MacAllister RJ, Fickling SA, Whitley GSJ, Vallance P. Metabolism of methylarginines by human vasculature: implications for the regulation of nitric oxide synthesis. Br J Pharmacol 1994; 112: 43-8.
6. Noris M, Benigni A, Boccardo P, et al. Enhanced nitric oxide synthesis in uraemia: implications for platelet dysfunction and dialysis hypotension. Kidney Int 1993; 44: 445-50.
7. Herbelin A, Nguyen AT, Zingraff J, Urena P, Descamps-Latscha B. Influence of uraemia and hemodialysis on circulating interleukin-1 and tumor necrosis factor. Kidney Int 1990; 37: 116-25.
8. Yoshizumi M, Perrella MA, Burnett JC, Lee M. Tumor necrosis factor downregulates an endothelial nitric oxide synthase mRNA by shortening its half-life. Circ Res 1993; 73: 205-9.
9. Mendes Ribeiro AC, Roberts NB, Lane C, Yacoob M, Ellory JC. Accumulation of the nitric oxide antagonist N-monomethyl-L-arginine in end stage renal failure patients on regular haemodialysis. Exp Physiol 1996; 81: 475-81.
10. Fervenza FC, Hendry BM, Ellory JC. Effects of dialysis and transplantation on red cell Na pump function in renal failure. Nephron 1989; 53: 121-8.
11. Fervenza FC, Harvey CM, Hendry BM, Ellory JC. Increased lysine transport capacity in erythrocytes from patients with chronic renal failure. Clin Sci 1989; 76: 419-22.
12. Fervenza FC, Meredith D, Ellory JC, Hendry BM. Abnormal erythrocyte choline transport in patients with chronic renal failure. Clin Sci 1991; 80: 137-41.
13. Peuchant E, Motta C, Salles C, Clerc M. A compensatory mechanism improving red cell membrane fluidity in hemodialysed patients. Clin Chim Acta 1990; 190: 57-66.
14. Vanholder RC, Ringoir SM. Adequacy of dialysis: a critical analysis. Kidney Int 1992; 42: 540-8.
15. Welt LG, Sachs JR, McManus TJ. An ion transplant defect from uremic patients. Trans Assoc Am Phys 1964; 77: 169-81.
16. Cotton JR, Woodward T, Knochel JP. Correlation of uremia cellular injury with a protein-restricted amino acid-supplemented diet. Am J Kidney Dis 1985; 5: 233-6.
17. Deves R, Angelo S, Chavez P. N-Ethylmaleimide discriminates between two lysine transport systems in human erythrocytes. J Physiol (London) 1993; 468: 753-66.
18. Mendes Ribeiro AC, Kiessling K, Luo LY, Mann GE, Ellory JC. N-Monomethyl-L-arginine (L-NMMA) transport in red cells from uraemic patients. J Physiol (London) 1995; 487P: 98P.
19. Krupka RM, Deves R. Kinetics of inhibition of transport systems. Int Rev Cytol 1983; 84: 303-52.
20. Peek K, Roberts NB, Taylor WH. Urinary amino acids: determination of the orthophthalaldehyde derivatives by reverse phase HPLC. Ann Clin Biochem 1988; 25 (Suppl.): 70-3S.
21. Bogle RG, Coade SB, Moncada S, Pearson JD, Mann GE. Bradykinin and ATP stimulate L-arginine uptake and nitric oxide release in vascular endothelial cells. Biochim Biophys Acta 1991; 180: 926-32.
22. Bogle RG, Baydoun AR, Pearson JD, Mann GE. L-Arginine transport is increased in macrophages generating nitric oxide. Biochem J 1992; 284: 15-18.
23. Bogle RG, Baydoun AR, Pearson JD, Mann GE. Regulation of L-arginine transport and nitric oxide release in superfused porcine aortic endothelial cells. J Physiol (London) 1996; 490.1: 229-41.
24. Bogle RG, Moncada S, Pearson JD, Mann GE. Identification of inhibitors of nitric oxide synthase that do not interact with the endothelial cell L-arginine transporter. Br J Pharmacol 1992; 105: 768-70.
25. Chen S, Boyd CAR. Regulation of rat alveolar macrophage nitric oxide (NO) production by cationic amino acid transport. J Physiol (London) 1995; 482P: 44P.
26. Carr SJ, Layward E, Bevington A, Hattersley J, Walls J. Plasma amino acid profile in the elderly with increasing uraemia. Nephron 1994; 66: 228-30.
27. Silva AD, Blythe WB, Welt LG. Arginase activity of human erythrocyte ghosts in uremia. Biomedicine 1975; 23: 307-9.