Imidazole and triazole substituted ether phospholipids: Potent antitumor agents

Bioorganic and Medicinal Chemistry Letters

Volumn 7, Issue 18, 1997, Pages 2379-2382

  Nair, Haridasan K ^a   Peterson, Andrew C ^a   Yazdi, Parvin T ^a   Franzmair, Rudolf ^a  

^a Clarion Pharmaceuticals   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; ETHER PHOSPHOLIPID; IMIDAZOLE DERIVATIVE; PHOSPHOLIPID DERIVATIVE; TRIAZOLE DERIVATIVE;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IN VITRO STUDY; TUMOR CELL LINE;

EID: 0030799727     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(97)00433-2     Document Type: Article

References (19)

1. (a) Houlihan, W. J.; Lohmeyer, M.; Workman, P.; Cheon, S. H. Med. Res. Rev. 1995, 15, 157.
2. (b) Lohmeyer, M.; Bitman, R. Drugs of the Future 1994, 19, 1021.
3. (c) Brachwitz, H.; Vollgraf, C. Pharmac. Ther. 1995, 66, 39.
4. (d) Andreesen, R. Prog. Biochem. Pharmacol. 1988, 22, 118.
5. Arnold, D.; Weltzien, H. U.; Westpal, O. Liebigs Ann. Chem. 1967, 709, 234.
6. (a) Meyer, K. L.; Schwendner, S. W.; Counsell, R. E. J. Med. Chem. 1989, 32, 2142.
7. (b) Plotzke, K. P.; Haradhira, T.; Stancato, L.; Olken, N. M.; Skinner, S.; Gross, M. D.; Wahl, R. L.; Counsell, R. E. Nucl. Med. Biol. 1992, 19, 765.
8. (c) Plotzke, K. P.; Fisher, S. J.; Wahl, R. L.; Olken, N. M.; Skinner, S.; Gross, M. D.; Counsell, R. E. J. Nucl. Med. 1993, 34, 787.
9. (d) Rampy, M. A.; Chou, T. S.; Pinchuk, A. N.; Skinner, R. W. S.; Gross, M. D.; Fisher, S.; Wahl, R.; Counsell, R. E. Nucl. Med. Biol. 1995, 19, 765.
10. (a) Bauchlinger, M.; Dresp, J.; Schmid, E.; Berdel, W. E. Mutatation Res. 1983, 121, 225.
11. (b) Kling, M. T.; Echardt, K.; Gocke, E.; Wild, D.; Berdel, W. E.; Munder, P. G. Cancer Lett. 1981, 12, 217.
12. (a) Brachwitz, H.; Langen, P.; Otto, J.; Schmidt, J. J. Prakt. Chem. 1979, 321, 775.
13. (b) Hirth, G.; Banner, R. Helv. Chim. Acta 1982, 65, 1059.
14. Heymans, F.; Michel, E.; Borrel, M.; Wichrowski, B.; Godfroid, J.; Convert, O.; Coeffier, E.; Tence, M.; Benveniste, J. Biochem. Biophys. Acta 1981, 666, 230.
15. Hermetter, A.; Paltauf, F. Chem. Phys. Lipids 1981, 29, 191.
16. Chandrakumar, N. S.; Hajdu, J. J. Org. Chem. 1983, 48, 1197.
17. 4OH, 65+25+5 v/v/v].
18. Skehan, P.; Storeng, R.; Scudiero, D.; Monks, A.; McMahon, J.; Vistica, D.; Warren, J. T.; Bokesch, H.; Kenney, S.; Boyd, M. R. J. Natl. Cancer Inst. 1990, 82, 1107.
19. Unpublished work of Dr. P.T. Yazdi, Clarion Pharmaceuticals, Inc.