Analysis of genetic linkage and somatic loss of heterozygosity in affected pairs of first-degree relatives

American Journal of Human Genetics

Volumn 61, Issue 2, 1997, Pages 418-422

  Rohde, K ^a   Teare, M D ^b   Santibanez Koref M ^c  

^a MAX DELBRÜCK CENTER FOR MOLECULAR MEDICINE   (Germany)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^c HAMMERSMITH HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; BREAST CANCER; CANCER SUSCEPTIBILITY; GENETIC RECOMBINATION; GENETIC SUSCEPTIBILITY; HETEROZYGOSITY LOSS; HUMAN; ONSET AGE; PENETRANCE; PRIORITY JOURNAL; RELATIVE;

EID: 0030799058     PISSN: 00029297     EISSN: None     Source Type: Journal    
DOI: 10.1086/514849     Document Type: Article

References (13)

1. Collins N, McManus R, Wooster R, Mangion J, Seal S, Lakhani SR, Ormiston O, et al (1995) Consistent loss of the wildtype allele in breast cancers from a family linked to the BRCA2 gene on chr13q12-13. Oncogene 10:1673-1675
2. Cornelis RS, Neuhausen SL, Johanson O, Kelsell D, Ponder BAJ, Tonin P, Hamann U, et al (1995) High allele loss rates at 17q12-q21 in breast and ovarian tumors from BRCA1-linked families. Genes Chromosom Cancer 13:203-210
3. Cottingham RW Jr, Idury RM, Schäffer AA (1993) Faster sequential genetic linkage computations. Am J Hum Genet 53:252-263
4. Easton DF, Bishop DT, Ford D, Crockford GP, The Breast Cancer Linkage Consortium (1993) Genetic linkage analysis in familial breast and ovarian cancer: results from 214 families. Am J Hum Genet 52:678-701
5. Lustbader ED, Rebbeck TR, Buetow KH (1995) Using loss of heterozygosity data in affected pedigree member linkage tests. Genet Epidemiol 12:339-350
6. Ott J (1989) Computer-simulation methods in human linkage analysis. Proc Natl Acad Sci USA 86:4175-4178
7. Rebbeck TR, Lustbader ED, Buetow KH (1994) Somatic allele loss in genetic linkage analysis of cancer. Genet Epidemiol 11:419-429
8. Rohde K, Teare MD, Scherneck S, Santibáñez Koref M (1995) A program using loss of constitutional heterozygosity data to ascertain the location of predisposing genes in cancer families. Hum Hered 45:337-345
9. Sato T, Tanigami A, Yamakawa K, Akiyama F, Kasumi F, Sakamoto G, Nakamura Y (1990) Allelotype of breast cancer: cumulative allele losses promote tumour progression in breast cancer. Cancer Res 50:7184-7189
10. Steichen-Gersdorf E, Gallion HH, Ford D, Girodet C, Easton DF, DiCioccio RA, Evans G, et al (1994) Familial site-specific ovarian cancer is linked to BRCA1 on 17q12-21. Am J Hum Genet 55:870-875
11. Teare MD, Rohde K, Santibáñez Koref M (1994) The use of loss of constitutional heterozygosity data to ascertain the location of predisposing genes in cancer families. J Med Genet 31:449-452
12. Varley JM, Thorncroft M, McGown A, Appelby J, Kelsey AM, Tricker KJ, Evans DGR, et al (1997) A detailed study of heterozygosity on chromosome 17 in tumours from Li-Fraumeni patients carrying a mutation to the TP53 gene. Oncogene 14:865-871
13. Weeks D, Ott J, Lathrop GM (1990) SLINK: a general simulation program for linkage analysis. Am J Hum Genet Suppl 47:A204