Interferon-γ induced increases in intracellular calcium in T lymphocytes from patients with multiple sclerosis precede clinical exacerbations and detection of active lesions on MRI

Journal of Neurology Neurosurgery and Psychiatry

Volumn 63, Issue 3, 1997, Pages 339-345

  Martino, G ^a,b   Filippi, M ^b   Martinelli, V ^b   Brambilla, E ^a   Gobbi, C ^a   Comi, G ^b   Grimaldi, L M E ^a,b  

^a SAN RAFFAELE HOSPITAL   (Italy)

^b UNIVERSITY OF MILAN   (Italy)

Author keywords

Calcium; Interferon ; Lymphocytes; MRI; Multiple sclerosis

Indexed keywords

CALCIUM ION; GAMMA INTERFERON;

ADULT; ARTICLE; CALCIUM CELL LEVEL; CALCIUM TRANSPORT; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE ACTIVITY; EXCITABILITY; FEMALE; FLUOROMETRY; HUMAN; MALE; MULTIPLE SCLEROSIS; NUCLEAR MAGNETIC RESONANCE IMAGING; PATHOGENESIS; PERIPHERAL LYMPHOCYTE; PRIORITY JOURNAL; SPECTROSCOPY; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION;

EID: 0030798574     PISSN: 00223050     EISSN: None     Source Type: Journal    
DOI: 10.1136/jnnp.63.3.339     Document Type: Article

References (17)

1. Martin R, McFarland HF, McFarlin DE. Immunological aspects of demyelinating diseases. Annu Rev Immunol 1992;10:153-87.
2. Weinstock-Guttman B, Ransohoff RM, Kinkel RP, Rudick RA. The interferons: biological effects, mechanisms of action, and use in multiple sclerosis. Ann Neurol 1995;37: 7-15.
3. 2+ influx in T-lymphocytes from MS patients. Proc Natl Acad Sci USA 1994;91:4825-9.
4. Lewis RS, Cahalan MD. Potassium and calcium channels in lymphocytes. Annu Rev Immunol 1995;13:623-53.
5. 2+ influx in patients with relapsing-remitting multiple sclerosis. Neurology 1996;46:1416-21.
6. Martino G, Moiola L, Brambilla E, Clementi E, Grimaldi LME. γ-interferon induces T-lymphocyte proliferation in multiple sclerosis via a calcium-dependent mechanism. J Neuroimmunol 1995;62:169-76.
7. Poser CM, Paty DW, Scheinberg L, McDonald I, Davis FA, Ebers GC, et al. New diagnostic criteria for MS: guidelines for research protocols. Ann Neurol 1983;13:227-31.
8. Kurtzke JF. Rating neurological impairment in multiple sclerosis: an expanded disability scale (EDSS). Neurology 1983;33:1444-52.
9. 2+ indicators with greatly improved fluorescence properties. J Biol Chem 1985;260:3440-50.
10. 2+ influx: two independently regulated mechanisms of influx stimulation coexist in neurosecretory PC12 cells. J Biol Chem 1992;267:2164-72.
11. Hess SD, Oortgiesen M, Cahalan MD. Calcium oscillation in human T and natural killer cells depend upon membrane potential and calcium influx. J Immunol 1993;130:2620-33.
12. Deggle PJ. Time series. A biostatistical introduction. New York: Oxford University Press, 1990:202-20.
13. Cambi F, Lees MB, Williams RM, Macklin WB. Chronic experimental allergic encephalomyelitis produced by bovine proteolipid apoprotein: immunological studies in rabbits. Ann Neurol 1983;13:303-8.
14. Yoshimura T, Kunishita T, Sakai K, Endoh M, Namikawa T, Tabira T. Chronic experimental allergic enephalomyelitis in guinea pigs induced by proteolipid protein. J Neurol Sci 1985;69:47-58.
15. Massacesi L, Genain CP, Lee-Parritz D, Letvin NL, Canfield D, Hauser SL. Active and passively induced experimental autoimmune encephalomyelitis in common marmoset: a new model for multiple sclerosis. Ann Neurol 1995;37:519-30.
16. Rieckmann P, Albrecht BA, Kitze B, Weber T, Tumani H, Broocks A, et al. Tumor necrosis factor-α messenger RNA expression in patients with relapsing-remitting multiple sclerosis is associated with disease activity. Ann Neurol 1995;37:82-8.
17. Jacob CO. Tumor necrosis factor and interferon gamma: relevance for immune regulation and genetic predisposition to autoimmune disease. Semin Immunol 1992;4:147-54.