HI/Acetic acid reduction of peracetylated N-acetyl neuraminic acid esters to stereoselectively provide α-2-deoxy-2-hydrido derivatives

Tetrahedron Letters

Volumn 38, Issue 34, 1997, Pages 5921-5924

  Gervay, Jacquelyn ^a   Gregar, Travis Q ^a  

^a University of Arizona   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

N ACETYLNEURAMINIC ACID DERIVATIVE;

ARTICLE; DRUG SYNTHESIS; IN VITRO STUDY; REACTION ANALYSIS; REDUCTION; STEREOCHEMISTRY; THERMODYNAMICS;

EID: 0030797389     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4039(97)01323-3     Document Type: Article

References (15)

1. th ACS National Meeting, San Francisco, CA April 1997, CARB 0067.
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11. Gervay, J.; Hadd, M.J. J. Org. Chem. submitted.
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13. 12: 678.1048; found: 678.1046.
14. Care must be taken as this reaction is extremely exothermic.
15. Compound 5 was purified using flash column chromatography (7:3 bexzene:acetone).