Pulmonary cell kinetics and morphometry after ozone exposure: Day versus night and dose response in rats

American Journal of Physiology - Lung Cellular and Molecular Physiology

Volumn 272, Issue 6 16-6, 1997, Pages

  Witschi, Hanspeter ^a   Espiritu, Imelda ^a   Pinkerton, Kent E ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Bronchiole alveolar junction; Centriacinar region; Cumulative labeling indexes; Nasal passages

Indexed keywords

OZONE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRONCHIOLE; CELL KINETICS; CONTROLLED STUDY; LABELING INDEX; LUNG ALVEOLUS CELL; MALE; MORPHOMETRICS; NIGHT; NONHUMAN; NOSE MUCOSA; PRIORITY JOURNAL; RAT; SUNLIGHT; TRACHEA;

EID: 0030797379     PISSN: 10400605     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajplung.1997.272.6.l1152     Document Type: Article

References (30)

1. Adamson, I. Y., and D. H. Bowden. The type 2 cell as progenitor of alveolar epithelial regeneration. A cytodynamic study in mice after exposure to oxygen. Lab. Invest. 30: 35-42, 1974.
2. Bennett, H. S., A. D. Wyrick, S. W. Lee, and J. H. McNeil. Science and art in preparing tissue embedded in plastic for light microscopy, with particular reference to glycol methacrylate, glass knives and simple stains. Stain Technol. 51: 71-79, 1976.
3. Bowden, D. H., and I. Y. Adamson. Endothelial regeneration as a marker of the differential vascular responses in oxygen-induced pulmonary edema. Lab. Invest. 30: 350-357, 1974.
4. Catalano, P. J., L. Y. Chang, J. R. Harkema, D. A. Kaden, J. A. Last, P. W. Mellick, W. C. Parks, K. E. Pinkerton, B. Radhakrishnamurthy, and L. M. Ryan. Consequences of prolonged inhalation of ozone on F344/N rats: collaborative studies. Part XI: Integrative Summary. Res. Rep. Health Eff. Inst. 65: 1-54, 1995.
5. Costa, D. L., J. S. Tepper, J. R. Lehman, M. F. Weber, D. W. Winsett, G. E. Hatch, and R. B. Devlin. Strain as a factor in the magnitude and time course of response to acute ozone (O3): a study of lung dysfunction and injury in Wistar, Fischer and Sprague-Dawley rats (Abstract). Am. Rev. Respir. Dis. 145: A96, 1992.
6. Costa, D. L., J. S. Tepper, and J. A. Raub. Interpretations and limitations of pulmonary function testing in small laboratory animals. In: Comparative Biology of the Normal Lung: Treatise on Pulmonary Toxicology, edited by R. A. Parent. Boca Raton, FL: CRC, 1991, vol. 1, p. 367-399.
7. Dungworth, D. L. Noncarcinogenic responses of the respiratory tract to inhaled toxicants. In: Concepts in Inhalation Toxicology, edited by R. O. McClellan and R. F. Henderson. New York: Hemisphere, 1989, p. 273-298.
8. Evans, M. J., N. P. Dekker, L. J. Cabral-Anderson, and G. Freeman. Quantitation of damage to the alveolar epithelium by means of type 2 cell proliferation. Am. Rev. Respir. Dis. 118: 787-790, 1978.
9. Evans, M. J., L. V. Johnson, R. J. Stephens, and G. Freeman. Cell renewal in the lungs of rats exposed to low levels of ozone. Exp. Mol. Pathol. 24: 70-83, 1976.
10. Gelzleichter, T. R., H. Witschi, and J. A. Last. Concentration-response relationships of rat lungs to exposure to oxidant air pollutants: a critical test of Haber's Law for ozone and nitrogen dioxide. Toxicol. Appl. Pharmacol. 112: 73-80, 1992.
11. Haschek, W. M., K. M. Reiser, A. J. Klein-Szanto, J. P. Kehrer, L. H. Smith, J. A. Last, and H. P. Witschi. Potentiation of butylated hydroxytoluene-induced acute lung damage by oxygen. Cell kinetics and collagen metabolism. Am. Rev. Respir. Dis. 127: 28-34, 1983.
12. Henderson, R. F. Bronchoalveolar lavage: a tool for assessing the health status of the lung. In: Concepts in Inhalation Toxicology, edited by R. O. McClellan and R. F. Henderson. Washington, DC: Hemisphere, 1988, p. 415-444.
13. Henderson, R. F., J. R. Harkema, J. A. Hotchkiss, D. G. Burt, and C. H. Hobbs. Rat strain and substrain differences in response to ozone (Abstract). Am. Rev. Respir. Dis. 147: A483, 1993.
14. Henderson, R. F., J. A. Hotchkiss, I. Y. Chang, B. R. Scott, and J. R. Harkema. Effect of cumulative exposure on nasal response to ozone. Toxicol. Appl. Pharmacol. 119: 59-65, 1993.
15. Hotchkiss, J. A., J. R. Harkema, and R. E. Henderson. Effect of cumulative ozone exposure on ozone-induced nasal epithelial hyperplasia and secretory metaplasia in rats. Exp. Lung Res. 15: 589-600, 1991.
16. Johnson, N. F., J. A. Hotchkiss, J. R. Harkema, and R. F. Henderson. Proliferative responses of rat nasal epithelia to ozone. Toxicol. Appl. Pharmacol. 103: 143-155, 1990.
17. Koren, H. S., R. B. Devlin, D. E. Graham, R. Mann, M. P. McGee, D. H. Horstman, W. J. Kozumbo, S. Becker, D. E. House, W. F. McDonnell, and P. A. Bromberg. Ozone-induced inflammation in the lower airways of human subjects. Am. Rev. Respir. Dis. 139: 407-415, 1989.
18. Lee, C., P. Rajini, K. E. Pinkerton, and H. P. Witschi. Correlation between cumulative labeling indices measured in the terminal bronchioles and in the centriacinar region in the lungs of rats exposed to oxidant air pollutants. Toxicol. Lett. 80: 25-28, 1995.
19. Lippmann, M. Ozone. In: Environmental Toxicants. Human Exposures and Their Health Effects, edited by M. Lippmann. New York: Reinhold, 1992, p. 465-519.
20. Pinkerton, K. E., D. E. Dodge, J. Cederdahl-Demmler, V. J. Wong, J. Peake, C. J. Haselton, P. W. Mellick, G. Singh, and C. G. Plopper. Differentiated bronchiolar epithelium in alveolar ducts of rats exposed to ozone for 20 months. Am. J. Pathol. 142: 947-956, 1993.
21. Pinkerton, K. E., R. H. Mercer, C. G. Plopper, and J. D. Crapo. Distribution of injury and microdosimetry of ozone in the ventilatory unit of the rat. J. Appl. Physiol. 73: 817-824, 1992.
22. Plopper, C. G., X. Duan, A. R. Buckpitt, and K. E. Pinkerton. Dose-dependent tolerance to ozone. IV. Site-specific elevation in antioxidant enzymes in the lungs of rats exposed for 90 days or 20 months. Toxicol. Appl. Pharmacol. 127: 124-131, 1994.
23. Rajini, P., T. R. Gelzleichter, J. A. Last, and H. Witschi. Airway epithelial labeling index as an indicator of ozone induced lung injury. Toxicology 83: 159-168, 1993.
24. Rajini, P., T. R. Gelzleichter, J. A. Last, and H. Witschi. Alveolar and airway cell kinetics in the lungs of rats exposed to nitrogen dioxide, ozone, and a combination of the two gases. Toxicol. Appl. Pharmacol. 121: 186-192, 1993.
25. Rajini, P., and H. P. Witschi. Cumulative labeling indices in epithelial cell populations of the respiratory tract after exposure to ozone at low concentrations. Toxicol. Appl. Pharmacol. 130: 32-40, 1995.
26. Sherwin, R. P., and V. Richters. Centriacinar (CAR) disease in the lungs of young adults: a preliminary report. In: Tropospheric Ozone and the Evironment, edited by R. L. Berlund, D. R. Lawson, and D. J. McKee. Pittsburgh, PA: Air and Waste Management Association, 1991, p. 178-196.
27. Van Bree, L., M. Marra, and P. J. A. Rombout. Differences in pulmonary biochemical and inflammatory responses of rats and guinea pigs resulting from daytime or nighttime single and repeated exposure to ozone. Toxicol. Appl. Pharmacol. 116: 209-216, 1992.
28. Van Bree, L., P. J. A. Rombout, I. M. C. M. Rietjens, J. A. M. A. Dormans, and M. Marra. Pathobiological effects in rat lung related to episodic ozone exposure. In: Atmospheric Ozone Research and its Policy Implications, edited by T. Schneider, S. D. Lee, G. J. R. Wolters, and L. D. Grant. New York: Elsevier, 1989, p. 723-732.
29. Weibel, E. R. Stereological Methods. Practical Methods for Biological Morphometry. London: Academic, 1979, vol. 1.
30. Young, J. T. Histopathological examination of the rat nasal cavity. Fundam. Appl. Toxicol. 1: 309-312, 1981.