Inhibition of the action of nitric oxide prodrugs by pyocyanin: Mechanistic studies

Canadian Journal of Physiology and Pharmacology

Volumn 75, Issue 5, 1997, Pages 398-406

  Hussain, Aman S ^a   Bozinovski, Jovan ^a   Maurice, Donald H ^a   McLaughlin, Brian E ^a   Marks, Gerald S ^a   Brien, James F ^a   Nakatsu, Kanji ^a  

^a QUEEN S UNIVERSITY   (Canada)

Author keywords

Inhibitors; Methylene blue; Nitric oxide; Nitrovasodilators; Pyocyanin

Indexed keywords

CYCLIC GMP; GLYCERYL TRINITRATE; GUANYLATE CYCLASE; LINSIDOMINE; N ACETYL S NITROSOPENICILLAMINE; NITRIC OXIDE; PYOCYANINE;

ANIMAL TISSUE; AORTA; ARTICLE; CHEMOLUMINESCENCE; CONTROLLED STUDY; ENZYME ACTIVATION; IN VITRO STUDY; METABOLIC ACTIVATION; NONHUMAN; PRIORITY JOURNAL; RABBIT; VASODILATATION;

EID: 0030796957     PISSN: 00084212     EISSN: None     Source Type: Journal    
DOI: 10.1139/y97-062     Document Type: Article

References (35)

1. Adams, A.F., and Haslam, R.J. 1978. Factors affecting the activity of guanylate cyclase in lysates of human blood platelets. Biochem. J. 174(1): 23-35.
2. Beckman, J., and Tsai, J.-H. 1994. Reactions and diffusion of nitric oxide and peroxynitrite. Biochemist, 16: 8-14.
3. Bennett, B.M., McDonald, B.J., Nigam, R., and Simon, C.W. 1994. Biotransformation of organic nitrates and vascular smooth muscle function. Trends Pharmacol. Sci. 15: 245-249.
4. Bozinovski, J., Brien, J.F., Marks, G.S., and Nakatsu, K. 1994. Inhibition of nitrovasodilators by pyocyanin and methylene blue is dissociated from nitric oxide formation. Can. J. Physiol. Pharmacol. 72: 746-752.
5. Brien, J.F., McLaughlin, B.E., Breedon, B.E., Bennett, B.M., Nakatsu, K., and Marks, G.S. 1986. Biotransformation of glyceryl trinitrate occurs concurrently with relaxation of rabbit aorta. J. Pharmacol. Exp. Ther. 237: 608-613.
6. Brien, J.F., McLaughlin, B.E., Kobus, S.M., Kawamoto, J.H., Nakatsu, K., and Marks, G.S. 1988. Mechanism of glyceryl trinitrate induced vasodilation. I. Relationship between drug biotransformation, tissue cGMP elevation and relaxation of rabbit aorta. J. Pharmacol. Exp. Ther. 244: 322-327.
7. Brien, J.F., McLaughlin, B.E., Nakatsu, K., and Marks, G.S. 1991. Quantitation of nitric oxide formation from nitrovasodilator drugs by chemiluminescence analysis of headspace gas. J. Pharmacol. Methods, 25: 19-27.
8. Chung, S.J., and Fung, H.L. 1993. Relationship between nitroglycerin-induced vascular relaxation and nitric oxide production. Biochem. Pharmacol. 45(1): 157-163.
9. Diamond, J., and Holmes, T.J. 1975. Effects of potassium chloride and smooth muscle relaxants on tension and cyclic nucleotide levels in rat myometrium. Can. J. Physiol. Pharmacol. 53: 1099-1107.
10. Edwards, J.C., Ignarro, L.J., Hyman, A.L., and Kadowitz, P.J. 1984. Relaxation of intrapulmonary artery and vein by nitrogen oxide-containing vasodilators and cyclic GMP. J. Pharmacol. Exp. Ther. 228(1): 33-42.
11. Furchgott, R.F. 1988. Studies on relaxation of rabbit aorta by sodium nitrite. The basis for the proposal that the acid activatable inhibitory factor from bovine retractor penis is inorganic nitrite and the endothelium-derived relaxing factor is nitric oxide. In Mechanisms of vasodilation. Edited by P.M. VanHoutte. Raven Press, New York. pp. 401-414.
12. Furchgott, R.F., and Zawadzki, J.V. 1980. The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetykholine. Nature (London), 288: 373-376.
13. Gruetter, C.A., Gruetter, D.Y., Lyon, J.E., Kadowitz, P.J., and Ignarro, L.J. 1981. Relationship between cyclic guanosine 3′:5′-monophosphate formation and relaxation of coronary smooth muscle by glyceryl trinitrate, nitroprusside, nitrite and nitric oxide: Effects of methylene blue and methaemoglobin. J. Pharmacol. Exp. Ther. 219: 181-186.
14. Gryglewski, R.J., Zembowicz, A., Salvemini, D., Taylor, G.W., and Vane, J.R. 1992. Modulation of the pharmacological actions of nitrovasodilators by methylene blue and pyocyanin. Br. J. Pharmacol. 106: 838-845.
15. Hussain, A.S., Poklewska-Koziell, M., Brien, J.F., Marks, G.S., and Nakatsu, K. 1994. Nitric oxide release from glyceryl trinitrate by rabbit aortic strip: detection by rabbit taenia coli concurrent with vasorelaxation. Br. J. Pharmacol. 113: 1508-1514.
16. Hussain, A.S., Brien, J.F., Marks, G.S., and Nakatsu, K. 1996. Superoxide does not inhibit glyceryl trinitrate-rabbit aortic strip mediated relaxation of rabbit taenia coli: evidence against nitric oxide itself as the smooth muscle active metabolite? Drug Metab. Dispos. 24: 780-785.
17. Ignarro, L.J., Lippton, H., Edwards, J.C., Baricos, W.H., Hyman, A.L., Kadowitz, P.J., and Gruetter, C.A. 1981. Mechanism of vascular smooth muscle relaxation by organic nitrates, nitrites, nitroprusside, and nitric oxide: evidence for the involvement of S-nitrosothiols as active intermediates. J. Pharmacol. Exp. Ther. 218: 739-749.
18. Ignarro, L.J., Burke, T.M., Wood, K.S., Wolin, M.S., and Kadowitz, P.J. 1984. Association between cyclic GMP accumulation and acetylcholine-elicited relaxation of bovine intrapulmonary artery. J. Pharmacol. Exp. Ther. 228: 682-690.
19. Ignarro, L.J., Harbison, R.G., Wood, K.S., and Kadowitz, P.J. 1986. Dissimilarities between methylene blue and cyanide on relaxation and cyclic GMP formation in endothelium-intact intrapulmonary artery caused by nitrogen oxide-containing vasodilators and acetylcholine. J. Pharmacol. Exp. Ther. 236: 30-36.
20. Ignarro, L.J., Buga, G.M., Wood, K.S., Byrns, R.E, and Chaudhuri, G. 1987. Endothelium-derived relaxing factor produced and released from artery and vein is nitric oxide. Proc. Natl. Acad. Sci. U.S.A. 84: 9265-9267.
21. Katsuki, S., Arnold, W.P., and Murad, F. 1977. Effects of sodium nitroprusside, nitroglycerin, and sodium azide on levels of cyclic nucleotides and mechanical activity of various tissues. Adv. Cyclic Nucleotide Res. 3: 239-247.
22. Knight, M., Hartman, P.E., Hartman, Z., and Young, V.M. 1979. A new method of preparation of pyocyanin and demonstration of an unusual bacterial sensitivity. Anal. Biochem. 95: 19-23.
23. Layne, E. 1957. Spectrophotometric and turbidimetric methods for measuring proteins. In Methods in enzymology. III. Edited by S. Colowick and N. Kaplan. Academic Press, New York, pp. 447-454.
24. Lipton, S.A., Choi, Y.B., Pan, Z.H., Lei, S.Z., Chen, H.S., Sucher, N.J., Loscalzo, J., Singel, D.J., and Stamler, J.S. 1993. A redoxbased mechanism for the neuroprotective and neurodestructive effects of nitric oxide and related nitroso-compounds. Nature (London), 364: 626-632.
25. Liu, Z., Nakatsu, K., Brien, J.F., Beaton, E.D., Marks, G.S., and Maurice, D.H. 1993. Selective sequestration of nitric oxide by subcellular components of vascular smooth muscle and platelets: relationship to nitric oxide stimulation of the soluble guanylyl cyclase. Can. J. Physiol. Pharmacol. 71: 938-945.
26. Marczin, N., Ryan, U.S., and Catravas, J.D. 1992. Methylene blue inhibits nitrovasodilator- and endothelium-derived relaxing factor-induced cyclic GMP accumulation in cultured pulmonary arterial smooth muscle cells via generation of superoxide anion. J. Pharmacol. Exp. Ther. 263: 170-179.
27. Marks, G.S., McLaughlin, B.E., Nakatsu, K., and Brien, J.F. 1992. Direct evidence for nitric oxide formation from glyceryl trinitrate during incubation with intact bovine pulmonary artery. Can. J. Physiol. Pharmacol. 70: 308-311.
28. Marks, G.S., McLaughlin, B.E., Jimmo, S.L., Poklewska-Koziell, M., Brien, J.F., and Nakatsu, K. 1995. Time-dependent increase in nitric oxide formation concurrent with vasodilation induced by sodium nitroprusside, 3-morpholinosydnonimine, and S-nitroso-N-acetylpenicillamine but not by glyceryl trinitrate. Drug Metab. Dispos. 23: 1248-1252.
29. Mayer, B., Brunner, F., and Schmidt, K. 1993. Inhibition of nitric oxide synthesis by methylene blue. Biochem. Pharmacol. 45: 367-374.
30. Murad, F., Mittal, C.K., Arnold, W.P., Katsuki, S., and Kimura, H. 1978. Guanylate cyclase: activation by azide, nitro compounds, nitric oxide, and hydroxyl radical and inhibition by haemoglobin and myoglobin. Adv. Cyclic Nucleotide Res. 9: 145-158.
31. Palmer, R.M.J., Ferrige, A.G., and Moncada, S. 1987. Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor. Nature (London), 327: 524-525.
32. Vukomanovic, D.V., Zoutman, D., Stone, J., Nakatsu, K., and Marks, G.S. 1997. Electrospray mass spectrometric, spectrophotometric and electrochemical methods do not provide evidence for the binding of nitric oxide by pyocyanin at pH 7. Biochem. J. 322: 25-29.
33. Warren, J.B., Loi, R., Rendell, N.B., and Taylor, G.W. 1990. Nitric oxide is inactivated by the bacterial pigment pyocyanin. Biochem. J. 266: 921-923.
34. Wolin, M.S., Cherry, P.D., Rodenburg, J.M., Messina, E.J., and Kaley, G. 1990. Methylene blue inhibits vasodilation of skeletal muscle arterioles to acetylcholine and nitric oxide via the extracellular generation of superoxide anion. J. Pharmacol. Exp. Ther. 245: 872-876.
35. Zivin, J.A., and Bartko, J.J. 1976. Statistics for disinterested scientists. Life Sci. 18: 15-26.