Enantioselective synthesis of functionalized 2-oxo-cyclohexane carbonitriles. Access to a trioxane analogue of artemisinin

Tetrahedron Asymmetry

Volumn 8, Issue 13, 1997, Pages 2085-2088

  Hamzaoui, M ^a   Provot, O ^a   Gregoire F ^a   Riche, C ^a   Chiaroni, A ^a   Gay, F ^b   Moskowitz, H ^a   Mayrargue, J ^a  

^a CNRS   (France)

^b PITIÉ SALPÊTRIÈRE HOSPITAL   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ARTEMISININ DERIVATIVE; CYCLOHEXANONE DERIVATIVE;

ARTICLE; CHIRALITY; DRUG SYNTHESIS; ENANTIOMER; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IN VITRO STUDY; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL; REACTION ANALYSIS; STEREOCHEMISTRY; X RAY DIFFRACTION;

EID: 0030796609     PISSN: 09574166     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0957-4166(97)00238-3     Document Type: Article

References (20)

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13. 1, a=7.363(4), b=14.500(8), c=16.434(9), Z=4, 5085 measured reflections (-8
14. 8Z, 8E and 11Z, 11E isomers were easily separated by column chromatography on silicagel and then transformed separately.
15. Desmaële, D.; Zouhiri, F.; D'Angelo, J.; Tetrahedron: Asymmetry, 1994, 5, 1645-1648.
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18. This reaction is under study in view of others applications.
19. 4: C, 61.64; H, 7.56; N, 5.52. Found: C, 61.51; H, 7.66; N, 5.37.
20. All new compounds were characterised by satisfactory spectroscopic and elemental analysis.