Secondary polycythemia in male B6C3F1 mice with spontaneously occurring hepatocellular carcinomas

Toxicologic Pathology

Volumn 25, Issue 5, 1997, Pages 511-515

  Horinouchi, Akira ^a   Hayashi, Shim Mo ^a   Ando, Takao ^a   Nonoyama, Takashi ^a  

^a TAKEDA PHARMACEUTICAL COMPANY LIMITED   (Japan)

Author keywords

B6C3F1 mice; Erythropoietin; Hepatocellular carcinoma; Immunohistochemistry; Inclusion body; Polycythemia

Indexed keywords

ERYTHROPOIETIN;

ANIMAL TISSUE; ARTICLE; CARCINOGENICITY; CELL INCLUSION; CONTROLLED STUDY; ERYTHROCYTE COUNT; IMMUNOHISTOCHEMISTRY; LIVER CELL CARCINOMA; MALE; MOUSE; NONHUMAN; POLYCYTHEMIA; PRIORITY JOURNAL; PROTEIN SYNTHESIS; ROUGH ENDOPLASMIC RETICULUM;

ANIMALIA;

EID: 0030796339     PISSN: 01926233     EISSN: None     Source Type: Journal    
DOI: 10.1177/019262339702500514     Document Type: Article

References (29)

1. Bondurant MC and Koury MJ (1986). Anemia induces accumulation of erythropoietin mRNA in the kidney and liver. Mol. Cell Biol. 6: 2731-2733.
2. Bondurant MC, Koury MJ, and Semenza G (1991). Erythropoietin ontogeny and organ distribution in mice. Semin. Hematol. 28: 20-27.
3. Caro J, Zon LI, Silver R, Miller O, and Erslev AJ (1983). Erythopoietin in liver tissue extracts and liver purfusates from hypoxic rats. Am. J. Physiol. 244: E431-E434.
4. Castle, WB (1985). The polycythemias. In: Hematology, 4th ed., Becker WS (ed). The Massachusetts Institute of Technology Press, Cambridge, Massachusetts, pp. 305-321.
5. Chandra M and Frith CH (1992). Spontaneous neoplasmas in B6C3F1 mice. Taxicol. Lett. 60: 91-98.
6. Eckardt K-U, Ratclitte PJ, Tan CC, Bauer C and Kurtz, A (1992). Age dependent expression of the erythropoietin gene in rat liver and kidney. J. Clin. Invest. 89: 753-760.
7. Goldberg MA, Glass GA, Cunningham JM, and Bunn HF (1986). The regulated expression of erythropoietin by two human hepatoma cell lines. Proc. Natl. Acad. Sci. USA 84: 7972-7976.
8. Haseman JK, Huff JE, Rao GN, Arnold JE, Boorman GA, and McConnell, EE (1985). Neoplasm observed in untreated and corn oil gavage control groups of F344/N rats and (C57BL/6N X C3H/ HeN)F1 (B6C3F1) mice. JNCI 75: 975-984.
9. Hayashi S, Nonoyama T, and Miyajima H (1992). Spontaneous follicular center cell lymphomas of B cell origin in cataract mice. Jpn. J. Cancer Res. 83: 281-287.
10. Herkens C, Wolff M, Fandrey J, Schuler F, and Jelkmann W (1990). Immuno-cytochemical demonstration of erythropoietin in hypoxic human hepatoma cultures. Histochemistry 100: 303-309.
11. Horinouchi A, Hayashi S, Ando T, and Nonoyama T (1996). Polycythemia in hepatocellular carcinoma-bearing B6C3F1 mice. J. Toxicol. Pathol. 9: 233-240.
12. Horinouchi A, Takami K, Sekiguchi M, and Ando T (1996). Erythropoietin messenger RNA expression in the kidneys of mice with acute anemia. J. Toxicol. Pathol. 9: 51-56.
13. Kan YW, McFadzean AJS, Todd D, and Tso SC (1961). Further observations on polycythemia in hepatocellular carcinoma. Blood 18: 592-598.
14. Koury ST, Bondurant MC, and Koury MJ (1986). Localization of erythropoietin synthesizing cells in murine kidneys by in situ hybridization. Blood 71: 524-527.
15. Kurts A, Eckadrdt K-U, Pugh C, Corvol P, Fabbro D, and Ratcliffe P (1992). Phorbol ester inhibits erythropoietin production in human hepatoma cells (Hep G2). Am. J. Physiol. 253: C1204-C1210.
16. Lai P-H, Everett R, Wang F-F, Arakawa T, and Goldwasser E (1986). Structural characterization of humon erythropoietin. J. Biol. Chem. 261: 3116-3121.
17. Maronport RR, Haseman JK, Boorman GA, Eustis SE, Rao GN, and Huff JE (1987). Liver lesions in B6C3F1 mice: The National Toxicology Program, Experience and Position. Arch. Toxicol. (suppl. 10): 10-26.
18. McFadzean AJS, Todd D, and Tsang KC (1958). Polycythemia in primary carcinoma of the liver. Blood 13: 427-435.
19. Muzzillo DA, Hishino M, and Matsuyama M (1991). Ultrastructural cytochemistry of eosinophilic inclusions in the cells of hyperplastic nodules and hepatomas in mouse liver. Acta Pathol. Jpn. 41: 806-810.
20. Nakashima O, Sugihara S, Eguchi A, Taguchi J, Watanabe J, and Masamichi K (1992). Pathomorphologic study of pale bodies in hepatocellular carcinoma. Acta Pathol. Jpn. 42: 414-418.
21. Nemi CJ (1986). Clinical and laboratory evaluation of anemias and polycythemia. In: Shalm's Veterinary Hematology, 4th ed., Nemi CJ (ed). Lea & Febiger Press, Philadelphia, pp. 572-576.
22. Powell DJ, Friedman JM, Ouletter AJ, Krauter KS, and Darnell JE Jr (1984). Transcriptional and post-transcriptional control of specific messenger RNAs in adult and embryonic liver. J. Mol. Biol. 179: 21-35.
23. [SAS] Statistical Analysis Systems (1992). SAS Technical Report, SAS/STAT Software, Release 6.07. Statistical Analysis Systems Institute, Cary, North Carolina.
24. Scholtz H, Baier W, Ratcliffe P, Eckardt K, Zapf J, Kurtz A, and Bauer C (1992). Insulin-like growth factors decrease oxygen-regulated erythropoietin production by human hepatoma cells (Hep G2). Am. J. Physiol. 263: C474-C479.
25. Semenza GL, Trystman MD, Gearhart JD, and Antonarakis SE (1989). Polycythemia in transgenic mice expressing the human erythropoietin gene. Proc. Natl. Acad. Sci. USA 86: 2301-2305.
26. Snedecor GW and Cochran WG (1980). Statistical Methods, 7th ed. Iowa State University Press, Ames, Iowa.
27. Tamano S, Hagiwara A, Shibata M, Kurata Y, Fukushima S, and Ito N (1988). Spontaneous tumors in aging (C57BL/6N X C3H/ HeN)F1 (B6C3F1) mice. Toxicol. Pathol. 3: 321-326.
28. Tóth K, Somosy Z, Bence J, and Sugár J (1975). Study of globular bodies found in hepatomas of Swiss mice. Z. Krebsforsch 84: 67-73.
29. Zanjani ED, Poster J, Burlington H, Mann L, and Wasserman LR (1977). Liver as the primary site of erythropoietin formation in the fetus. J. Lab. Clin. Med. 89: 640-644.