FK506 Enhances IL-13 Production by T Cells Activated through CD3/CD28

International Archives of Allergy and Immunology

Volumn 114, Issue 3, 1997, Pages 300-301

  Dumont, Francis J ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD28 ANTIGEN; CD3 ANTIGEN; IMMUNOGLOBULIN E; INTERLEUKIN 13; TACROLIMUS;

CONTROLLED STUDY; HUMAN; HUMAN CELL; IMMUNOGLOBULIN PRODUCTION; LETTER; PRIORITY JOURNAL; PROTEIN SYNTHESIS; T LYMPHOCYTE ACTIVATION;

ANTIGENS, CD28; ANTIGENS, CD3; ENZYME-LINKED IMMUNOSORBENT ASSAY; HUMANS; IMMUNOSUPPRESSIVE AGENTS; INTERLEUKIN-13; LYMPHOCYTE ACTIVATION; T-LYMPHOCYTES; TACROLIMUS; UP-REGULATION;

EID: 0030796322     PISSN: 10182438     EISSN: 14230097     Source Type: Journal    
DOI: 10.1159/000237684     Document Type: Article

References (6)

1. Kawamura N, Furaia H, Tame A, Kobayashi I, Ariga T, Okano M, Sakiyama Y: Extremely high serum level of IgE during immunosuppressive therapy: Paradoxical effect of cyclosporine A and tacrolimus. Int Arch Allergy Immunol 1997;1 12:422-424.
2. De Vries JE, Zurawski G: Immunoregulatory properties of IL-13: Its potential role in atopic disease. Int Arch Allergy Immunol 1995;106: 175-179.
3. Levy F, Kristofic C, Heusser C, Brinkmann V: Role of IL-13 in CD4 T cell dependent IgE production and atopy. Int Arch Allergy Immunol 1997;112:49-58.
4. Dumont FJ: Cyclosporin A and tacrolimus (FK-506). Immunosuppression through immu-nophilin-dependent inhibition of calcineurin function; in Lieberman R. Mukhcrjec A (eds): Principles of Drug Development in Transplantation and Autoimmunity. Austin, Landes, 1996. pp 175-205.
5. Pouw Kraan TCTM, Boeije LCM, Troon JTM, Rutschmann SK, Wijdcnes J, Aar-den LA: Human IL-13 production is negatively influenced by CD3 engagement. Enhancement of IL-13 production by cyclosporin A. J Immunol 1996;156:1818-1823.
6. Nusslein FI I, Weber G, Kaldcn JR: Synthetic glucocorticoids potentiate IgE synthesis. Allergy 1994:49:363-370.