Effect of 2,4-dinitrophenol on the hypometabolic response to hypoxia of conscious adult rats

Journal of Applied Physiology

Volumn 83, Issue 2, 1997, Pages 537-542

  Saiki, Chikako ^a,b   Mortola, Jacopo P ^a  

^a MCGILL UNIVERSITY   (Canada)

^b NIPPON DENTAL UNIVERSITY   (Japan)

Author keywords

Cellular hypoxia; Hypoxic ventilatory response; Oxidative phosphorylation; Oxygen consumption; Uncoupling agents

Indexed keywords

2,4 DINITROPHENOL; OXYGEN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BODY TEMPERATURE; CONTROLLED STUDY; HYPOTENSION; HYPOXIA; MALE; METABOLIC DISORDER; NONHUMAN; OXIDATIVE PHOSPHORYLATION; OXYGEN CONSUMPTION; PRIORITY JOURNAL; RAT; SYSTEMIC VASCULAR RESISTANCE; WAKEFULNESS;

EID: 0030796186     PISSN: 87507587     EISSN: None     Source Type: Journal    
DOI: 10.1152/jappl.1997.83.2.537     Document Type: Article

References (33)

1. Brody, T. M. The uncoupling of oxidative phosphorylation as a mechanism of drug action. Pharmacol. Rev. 7: 335-363, 1955.
2. Cain, S. M., and C. K. Chapler. Circulatory responses to 2,4-dinitrophenol in dog limb during normoxia and hypoxia. J. Appl. Physiol. 59: 698-705, 1985.
3. Cameron, M. A. M. The action of nitrophenols on the metabolic rate of rats. Br. J. Pharmacol. 13: 25-29, 1958.
4. Dempsey, J. A., H. V. Forster, and D. M. Ainsworth. Regulation of hyperpnea, hyperventilation, and respiratory muscle recruitment during exercise. In: Regulation of Breathing (2nd ed.), edited by J. A. Dempsey and A. I. Pack. New York: Dekker, 1995, vol. 79, chapt. 24, p. 1065-1134. (Lung Biol. Health Dis. Ser.)
5. Frappell, P. B., A. Dotta, and J. P. Mortola. Metabolism during normoxia, hyperoxia, and recovery in newborn rats. Can. J. Physiol. Pharmacol. 70: 408-411, 1992.
6. Frappell, P., C. Lanthier, R. V. Baudinette, and J. P. Mortola. Metabolism and ventilation in acute hypoxia: a comparative analysis in small mammalian species. Am. J. Physiol. 262 (Regulatory Integrative Comp. Physiol. 31): R1040-R1046, 1992.
7. Gautier, H., M. Bonora, S. Ben M'Barek, and J. D. Sinclair. Effects of hypoxia and cold acclimation on thermoregulation in the rat. J. Appl. Physiol. 71: 1355-1363, 1991.
8. Gonzalez, N. C., K. Perry, Y. Moue, R. L. Clancy, and J. Piiper. Pulmonary gas exchange during hypoxic exercise in the rat. Respir. Physiol. 96: 111-125, 1994.
9. Gonzalez, N. C., A. Sokari, and R. L. Clancy. Maximum oxygen uptake and arterial blood oxygenation during hypoxic exercise in rats. J. Appl. Physiol. 71: 1041-1049, 1991.
10. Heller, S. L., M. H. Brooke, K. K. Kaiser, and R. Choski. 2,4-Dinitrophenol, muscle biopsy, and McArdle's disease. Neurology 38: 15-19, 1988.
11. Hershenson, M. B., P. P. O'Rourke, D. A. Christakis, B. J. Coopes, and R. K. Crone. Oxygen extraction in lamb skeletal muscle. Pediatr. Res. 28: 101-105, 1990.
12. Hill, J. R. The oxygen consumption of new-born and adult mammals. Its dependence on the oxygen tension in the inspired air and on the environmental temperature. J. Physiol. (Lond.) 149: 346-373, 1959.
13. 2 uptake increased by 2:4-dinitrophenol. Respir. Physiol. 6: 187-201, 1969.
14. Jones, D. P. Cellular energetics and biochemistry of hypoxia. In: Tissue Oxygen Deprivation: From Molecular to Integrated Function, edited by G. G. Haddad and G. Lister. New York: Dekker, 1996, p. 25-50.
15. Kuwahira, I., N. C. Gonzalez, N. Heisler, and J. Piiper. Changes in regional blood flow distribution and oxygen supply during hypoxia in conscious rats. J. Appl. Physiol. 74: 211-214, 1993.
16. Levine, S. Role of tissue hypermetabolism in stimulation of ventilation by dinitrophenol. J. Appl. Physiol. 43: 72-74, 1977.
17. Levine, S. Role of peripheral tissue receptors in stimulation of ventilation by 2,4-dinitrophenol. J. Appl. Physiol. 47: 1066-1073, 1979.
18. Levine, S., and W. E. Huckabee. Ventilatory response to drug-induced hypermetabolism. J. Appl. Physiol. 38: 827-833, 1975.
19. Liang, C.-S., and W. B. Hood, Jr. Afferent neural pathway in the regulation of cardiopulmonary responses to tissue hypermetabolism. Circ. Res. 38: 209-214, 1976.
20. Millhorn, D. E., F. L. Eldridge, and T. G. Waldrop. Effects of salicylate and 2,4-dinitrophenol on respiration and metabolism. J. Appl. Physiol. 53: 925-929, 1982.
21. Mortola, J. P., and A. Dotta. Effects of hypoxia and ambient temperature on gaseous metabolism of newborn rats. Am. J. Physiol. 263 (Regulatory Integrative Comp. Physiol. 32): R267-R272, 1992.
22. Mortola, J. P., and H. Gautier. Interaction between metabolism and ventilation: effects of respiratory gases and temperature. In: Regulation of Breathing (2nd ed.), edited by J. A. Dempsey and A. I. Pack. New York: Dekker, 1995, vol. 79, p. 1011-1064. (Lung Biol. Health Dis. Ser.)
23. Mortola, J. P., and T. Piazza. Breathing pattern in rats with chronic section of the superior laryngeal nerves. Respir. Physiol. 70: 51-62, 1987.
24. Mortola, J. P., R. Rezzonico, and C. Lanthier. Ventilation and oxygen consumption during acute hypoxia in newborn mammals: a comparative analysis. Respir. Physiol. 78: 31-43, 1989.
25. Mortola, J. P., and C. Saiki. Ventilatory response to hypoxia in rats: gender differences. Respir. Physiol. 106: 21-34, 1996.
26. Obeso, A., L. Almaraz, and C. Gonzalez. Effects of cyanide and uncouplers on chemoreceptors activity and ATP content of the cat carotid body. Brain Res. 481: 250-257, 1989.
27. Ohtake, P. J, and D. B. Jennings. Ventilation is stimulated by small reductions in arterial pressure in the awake dog. J. Appl. Physiol. 73: 1549-1557, 1992.
28. 2 production, body temperature, and ventilation in hypoxic newborn cats and dogs before and afterbody warming. Pediatr. Res. 30: 165-169, 1991.
29. Prabhakar, N. R., J. Mitra, E. M. Adams, and N. S. Cherniack. Involvement of ventral medullary surface in respiratory responses induced by 2,4-dinitrophenol. J. Appl. Physiol. 66: 598-605, 1989.
30. Rohlicek, C. V., C. Saiki, T. Matsuoka, and J. P. Mortola. Cardiovascular and respiratory consequences of body warming during hypoxia in conscious newborn cats. Pediatr. Res. 40: 1-5, 1996.
31. Saiki, C., T. Matsuoka, and J. P. Mortola. Metabolic-ventilatory interaction in conscious rats: effect of hypoxia and ambient temperature. J. Appl. Physiol. 76: 1594-1599, 1994.
32. Schaeffer, J. I., and G. G. Haddad. Ventilatory response to moderate and severe hypoxia in adult dogs: role of endorphins. J. Appl. Physiol. 65: 1383-1388, 1988.
33. Williams, T. F., R. W. Winters, J. R. Clapp, W. Hollander, Jr., and L. G. Welt. Effects of 2,4-dinitrophenol on respiration in the dog. Am. J. Physiol. 193: 181-188, 1958.