메뉴 건너뛰기




Volumn 66, Issue 2, 1997, Pages 229-244

Expression of human p140trk receptors in p140trk-deficient, PC12/endothelial cells results in nerve growth factor-induced signal transduction and DNA synthesis

Author keywords

Differentiation; DNA synthesis; Fibroblast growth factor; K 252a; Nerve growth factor; Overexpression; P140(trk); PC12 endothelial hybrid cells; Proliferation; Receptor; Signal transduction; Staurosporine; Transfection; Tyrosine kinase

Indexed keywords

DNA; MYELIN BASIC PROTEIN; NERVE GROWTH FACTOR; NEUROTROPHIN; PROTEIN TYROSINE KINASE; RECEPTOR PROTEIN; THYMIDINE; TRITON X 100; TRYPSIN; TYROSINE;

EID: 0030795343     PISSN: 07302312     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-4644(19970801)66:2<229::AID-JCB10>3.0.CO;2-C     Document Type: Article
Times cited : (30)

References (49)
  • 2
    • 0027183950 scopus 로고
    • Differential expression of nerve growth factor receptors leads to altered binding affinity and neurotrophin responsiveness
    • Benedetti M, Levi A, Chao MV (1993): Differential expression of nerve growth factor receptors leads to altered binding affinity and neurotrophin responsiveness. Proc Natl Acad Sci U S A 90:7859-7863.
    • (1993) Proc Natl Acad Sci U S A , vol.90 , pp. 7859-7863
    • Benedetti, M.1    Levi, A.2    Chao, M.V.3
  • 3
    • 0026512998 scopus 로고
    • K-252a inhibits nerve growth factor-induced trk proto-oncogene tyrosine phosphorylation and kinase activity
    • Berg MM, Sternberg DW, Parada LF, Chao MV (1992): K-252a inhibits nerve growth factor-induced trk proto-oncogene tyrosine phosphorylation and kinase activity. J Biol Chem 267:13-16.
    • (1992) J Biol Chem , vol.267 , pp. 13-16
    • Berg, M.M.1    Sternberg, D.W.2    Parada, L.F.3    Chao, M.V.4
  • 4
    • 0024987175 scopus 로고
    • Nerve growth factor and the issue of mitosis in the nervous system
    • Black IB, Dicicco-Bloom E, Dreyfus CF (1987): Nerve growth factor and the issue of mitosis in the nervous system. Curr Top Dev Biol 24:161-192.
    • (1987) Curr Top Dev Biol , vol.24 , pp. 161-192
    • Black, I.B.1    Dicicco-Bloom, E.2    Dreyfus, C.F.3
  • 5
    • 0026019918 scopus 로고
    • Tissue localization of nerve growth factor and nerve growth factor receptors
    • Bothwell M (1991): Tissue localization of nerve growth factor and nerve growth factor receptors. Curr Top Microbiol Immunol 165:55-70.
    • (1991) Curr Top Microbiol Immunol , vol.165 , pp. 55-70
    • Bothwell, M.1
  • 6
    • 0020358150 scopus 로고
    • Nerve growth factor has both mitogenic and anti-mitogenic activity
    • Burstein DE, Greene LA (1982): Nerve growth factor has both mitogenic and anti-mitogenic activity. Dev Biol 94: 477-482.
    • (1982) Dev Biol , vol.94 , pp. 477-482
    • Burstein, D.E.1    Greene, L.A.2
  • 7
    • 0026730310 scopus 로고
    • Neurotrophin receptors: A window into neuronal differentiation
    • Chao MV (1992): Neurotrophin receptors: A window into neuronal differentiation. Neuron 9:583-593.
    • (1992) Neuron , vol.9 , pp. 583-593
    • Chao, M.V.1
  • 8
    • 0028519237 scopus 로고
    • Induction of nerve growth factor responsiveness in C6-2B glioma cells by expression of trkA proto-oncogene
    • Colangelo AM, Fink DW Jr, Rabin SJ, Mocchetti I (1994): Induction of nerve growth factor responsiveness in C6-2B glioma cells by expression of trkA proto-oncogene. Glia 12:117-127.
    • (1994) Glia , vol.12 , pp. 117-127
    • Colangelo, A.M.1    Fink Jr., D.W.2    Rabin, S.J.3    Mocchetti, I.4
  • 10
    • 0029569114 scopus 로고
    • Cip/waf1 in NIH3T3 cells expressing trkA
    • Cip/waf1 in NIH3T3 cells expressing trkA. J Biol Chem 270:30841-30844.
    • (1995) J Biol Chem , vol.270 , pp. 30841-30844
    • Decker, S.J.1
  • 11
    • 0022542457 scopus 로고
    • PC12 cell mutants that possess low- but not high-affinity nerve growth factor receptors neither respond to nor internalize nerve growth factor
    • Green SH, Rydel RE, Connolly JL, Greene LA (1986): PC12 cell mutants that possess low-but not high-affinity nerve growth factor receptors neither respond to nor internalize nerve growth factor. J Cell Biol 102:830-843.
    • (1986) J Cell Biol , vol.102 , pp. 830-843
    • Green, S.H.1    Rydel, R.E.2    Connolly, J.L.3    Greene, L.A.4
  • 12
    • 0028808732 scopus 로고
    • Early events in neurotrophin signalling via trk and p75 receptors
    • Greene LA, Kaplan DR (1995): Early events in neurotrophin signalling via trk and p75 receptors. Curr Opin Neurobiol 5:579-587.
    • (1995) Curr Opin Neurobiol , vol.5 , pp. 579-587
    • Greene, L.A.1    Kaplan, D.R.2
  • 13
    • 0027265719 scopus 로고
    • Insulin-like growth factor-binding protein modulates the growth response to insulin-like growth factor I by human gastric cancer cell
    • Guo YS, Beauchamp RD, Jin GF, Townsend CM, Tompson JC (1993): Insulin-like growth factor-binding protein modulates the growth response to insulin-like growth factor I by human gastric cancer cell. Gastroenterology 104:1595-1604.
    • (1993) Gastroenterology , vol.104 , pp. 1595-1604
    • Guo, Y.S.1    Beauchamp, R.D.2    Jin, G.F.3    Townsend, C.M.4    Tompson, J.C.5
  • 14
    • 0026468503 scopus 로고
    • Overexpression of the trk tyrosine kinase rapidly accelerates nerve growth factor-induced differentiation
    • Hempstead B, Rabin SJ, Kaplan L, Reid S, Parada LF, Kaplan DR (1992): Overexpression of the trk tyrosine kinase rapidly accelerates nerve growth factor-induced differentiation. Neuron 9:883-896.
    • (1992) Neuron , vol.9 , pp. 883-896
    • Hempstead, B.1    Rabin, S.J.2    Kaplan, L.3    Reid, S.4    Parada, L.F.5    Kaplan, D.R.6
  • 15
    • 0019366764 scopus 로고
    • Nerve growth factor-induced alteration in the response of PC12 pheochromocytoma cells to epidermal growth factor
    • Huff K, End D, Guroff G (1981): Nerve growth factor-induced alteration in the response of PC12 pheochromocytoma cells to epidermal growth factor. J Cell Biol 88: 189-198.
    • (1981) J Cell Biol , vol.88 , pp. 189-198
    • Huff, K.1    End, D.2    Guroff, G.3
  • 17
    • 0027170791 scopus 로고
    • Characterization, sequence and expression of the murine S100 beta gene
    • Jiang H, Shah S, Hilt DC (1993): Characterization, sequence and expression of the murine S100 beta gene. J Biol Chem 268:20502-20511.
    • (1993) J Biol Chem , vol.268 , pp. 20502-20511
    • Jiang, H.1    Shah, S.2    Hilt, D.C.3
  • 19
    • 0027050178 scopus 로고
    • Nerve growth factor mediates signal transduction through trk homodimer receptors
    • Jing S, Tapley P, Barbacid M (1992): Nerve growth factor mediates signal transduction through trk homodimer receptors. Neuron 9:1067-1079.
    • (1992) Neuron , vol.9 , pp. 1067-1079
    • Jing, S.1    Tapley, P.2    Barbacid, M.3
  • 20
    • 0028115022 scopus 로고
    • Neurotrophin signal transduction by the trk receptor
    • Kaplan DR, Stephens RM (1994): Neurotrophin signal transduction by the trk receptor. J Neurobiol 25:1404-1417.
    • (1994) J Neurobiol , vol.25 , pp. 1404-1417
    • Kaplan, D.R.1    Stephens, R.M.2
  • 21
    • 0023932758 scopus 로고
    • Internalization of nerve growth factor by PC12 cells. A description of cellular pools
    • Kasaian MT, Neet KE (1988): Internalization of nerve growth factor by PC12 cells. A description of cellular pools. J Biol Chem 263:5083-5090.
    • (1988) J Biol Chem , vol.263 , pp. 5083-5090
    • Kasaian, M.T.1    Neet, K.E.2
  • 22
    • 0025857391 scopus 로고
    • The trk proto-oncogene encodes a receptor for nerve growth factor
    • Klein R, Jing S, Nanduri V, O'Rourke E, Barbacid M (1991): The trk proto-oncogene encodes a receptor for nerve growth factor. Cell 65:189-197.
    • (1991) Cell , vol.65 , pp. 189-197
    • Klein, R.1    Jing, S.2    Nanduri, V.3    O'Rourke, E.4    Barbacid, M.5
  • 24
    • 0023267658 scopus 로고
    • Long-term heterologous down-regulation of EGF receptors in PC12 by NGF
    • Lazarovici P, Dickens G, Kuzuya H, Guroff G (1987): Long-term heterologous down-regulation of EGF receptors in PC12 by NGF. J Cell Biol 104:1611-1621.
    • (1987) J Cell Biol , vol.104 , pp. 1611-1621
    • Lazarovici, P.1    Dickens, G.2    Kuzuya, H.3    Guroff, G.4
  • 27
    • 0027263736 scopus 로고
    • Transfection with trk restores slow NGF binding, efficient NGF uptake and multiple NGF responses to NGF-nonresponsive PC12 cell mutants
    • Loeb DM, Greene LA (1993): Transfection with trk restores slow NGF binding, efficient NGF uptake and multiple NGF responses to NGF-nonresponsive PC12 cell mutants. J Neurosci 13:2919-2929.
    • (1993) J Neurosci , vol.13 , pp. 2919-2929
    • Loeb, D.M.1    Greene, L.A.2
  • 28
    • 0026091934 scopus 로고
    • The trk proto-oncogene rescues NGF responsiveness in mutant NGF-nonresponsive PC12 cell lines
    • Loeb DM, Maragos J, Martin-Zanca D, Chao MV, Parada LF, Greene LA (1991): The trk proto-oncogene rescues NGF responsiveness in mutant NGF-nonresponsive PC12 cell lines. Cell 66:961-966.
    • (1991) Cell , vol.66 , pp. 961-966
    • Loeb, D.M.1    Maragos, J.2    Martin-Zanca, D.3    Chao, M.V.4    Parada, L.F.5    Greene, L.A.6
  • 29
    • 0028245830 scopus 로고
    • A trkA point mutation affecting interaction with PLCγ abolishes NGF-promoted peripherin induction but not neurite outgrowth
    • Loeb DM, Stephens RM, Copeland T, Kaplan DR, Greene LA (1994): A trkA point mutation affecting interaction with PLCγ abolishes NGF-promoted peripherin induction but not neurite outgrowth. J Biol Chem 269:8901-8910.
    • (1994) J Biol Chem , vol.269 , pp. 8901-8910
    • Loeb, D.M.1    Stephens, R.M.2    Copeland, T.3    Kaplan, D.R.4    Greene, L.A.5
  • 31
    • 0027428516 scopus 로고
    • Expression of trkA cDNA in neuroblastoma mediates differentiation in vitro and in vivo
    • Matsushima H, Bogenmann E (1993): Expression of trkA cDNA in neuroblastoma mediates differentiation in vitro and in vivo. Mol Cell Biol 13:7447-7456.
    • (1993) Mol Cell Biol , vol.13 , pp. 7447-7456
    • Matsushima, H.1    Bogenmann, E.2
  • 32
    • 0026561025 scopus 로고
    • The rat trk protooncogene product exhibits properties characteristic of the slow nerve growth factor receptor
    • Meakin SO, Suter U, Drinkwater CC, Welcher AA, Shooter EM (1992): The rat trk protooncogene product exhibits properties characteristic of the slow nerve growth factor receptor. Proc Natl Acad Sci U S A 89:2374-2378.
    • (1992) Proc Natl Acad Sci U S A , vol.89 , pp. 2374-2378
    • Meakin, S.O.1    Suter, U.2    Drinkwater, C.C.3    Welcher, A.A.4    Shooter, E.M.5
  • 33
    • 0027374486 scopus 로고
    • Identification of trk binding sites for SHC and phosphatidylinositol 3′-kinase and formation of a multimeric signalling complex
    • Obermeier A, Lammers R, Wiesmuller KH, Jung G, Schlessinger J, Ulrich A (1993): Identification of trk binding sites for SHC and phosphatidylinositol 3′-kinase and formation of a multimeric signalling complex. J Biol Chem 268:22963-22966.
    • (1993) J Biol Chem , vol.268 , pp. 22963-22966
    • Obermeier, A.1    Lammers, R.2    Wiesmuller, K.H.3    Jung, G.4    Schlessinger, J.5    Ulrich, A.6
  • 34
    • 0026684676 scopus 로고
    • Inhibition of the cellular actions of nerve growth factor by staurosporine and K-252a results from the attenuation of the activity of the trk tyrosine kinase
    • Ohmichi M, Decker SJ, Pang L, Saltiel AR (1992): Inhibition of the cellular actions of nerve growth factor by staurosporine and K-252a results from the attenuation of the activity of the trk tyrosine kinase. Biochemistry 31:4034-4039.
    • (1992) Biochemistry , vol.31 , pp. 4034-4039
    • Ohmichi, M.1    Decker, S.J.2    Pang, L.3    Saltiel, A.R.4
  • 35
    • 0027209064 scopus 로고
    • The tyrosine kinase inhibitor tyrphostin blocks the cellular actions of nerve growth factor
    • Ohmichi M, Pang L, Ribon V, Gazit A, Levitzki A, Saltiel AR (1993): The tyrosine kinase inhibitor tyrphostin blocks the cellular actions of nerve growth factor. Biochemistry 32:4650-4658.
    • (1993) Biochemistry , vol.32 , pp. 4650-4658
    • Ohmichi, M.1    Pang, L.2    Ribon, V.3    Gazit, A.4    Levitzki, A.5    Saltiel, A.R.6
  • 36
    • 0026733002 scopus 로고
    • ras activity and consequent prolonged erk activity
    • ras activity and consequent prolonged erk activity. Neuron 9:705-717.
    • (1992) Neuron , vol.9 , pp. 705-717
    • Qui, M.S.1    Green, S.H.2
  • 37
    • 0027395119 scopus 로고
    • SNT, a differentiation-specific target of neurotrophic factor-induced tyrosine kinase activity in neurons and PC12 cells
    • Rabin SJ, Cleghon V, Kaplan DR (1993): SNT, a differentiation-specific target of neurotrophic factor-induced tyrosine kinase activity in neurons and PC12 cells. Mol Cell Biol 13:2203-2213.
    • (1993) Mol Cell Biol , vol.13 , pp. 2203-2213
    • Rabin, S.J.1    Cleghon, V.2    Kaplan, D.R.3
  • 38
    • 0027093254 scopus 로고
    • Staurosporine-induced neunte outgrowth in PC12 cells is independent of protein kinase C inhibition
    • Rasouly D, Rahamim E, Lester D, Matsuda Y, Lazarovici P (1992): Staurosporine-induced neunte outgrowth in PC12 cells is independent of protein kinase C inhibition. Mol Pharmacol 42:35-43.
    • (1992) Mol Pharmacol , vol.42 , pp. 35-43
    • Rasouly, D.1    Rahamim, E.2    Lester, D.3    Matsuda, Y.4    Lazarovici, P.5
  • 40
    • 0001477595 scopus 로고
    • cAMP analogs promote survival and neurite outgrowth in cultures of rat sympathetic and sensory neurons independently of nerve growth factor
    • Rydel RE, Greene LA (1988): cAMP analogs promote survival and neurite outgrowth in cultures of rat sympathetic and sensory neurons independently of nerve growth factor. Proc Natl Acad Sci U S A 85:1257-1261.
    • (1988) Proc Natl Acad Sci U S A , vol.85 , pp. 1257-1261
    • Rydel, R.E.1    Greene, L.A.2
  • 41
    • 0028199799 scopus 로고
    • Trk receptors use redundant signal transduction pathways involving SHC and PLCγ1 to mediate NGF responses
    • Stephens RM, Loeb DM, Copeland TD, Pawson T, Greene LA, Kaplan DR (1994): Trk receptors use redundant signal transduction pathways involving SHC and PLCγ1 to mediate NGF responses. Neuron 12:691-705.
    • (1994) Neuron , vol.12 , pp. 691-705
    • Stephens, R.M.1    Loeb, D.M.2    Copeland, T.D.3    Pawson, T.4    Greene, L.A.5    Kaplan, D.R.6
  • 42
    • 0030042812 scopus 로고    scopus 로고
    • Nerve growth factor-stimulated nuclear S6 kinase in PC12 cells
    • Tang T, Hirata Y, Whalin M, Guroff G (1996): Nerve growth factor-stimulated nuclear S6 kinase in PC12 cells. J Neurochem 66:1198-1206.
    • (1996) J Neurochem , vol.66 , pp. 1198-1206
    • Tang, T.1    Hirata, Y.2    Whalin, M.3    Guroff, G.4
  • 43
    • 0025877704 scopus 로고
    • The changing scene of neurotrophic factors
    • Thoenen H (1991): The changing scene of neurotrophic factors. Trends Neurosci 14:165-170.
    • (1991) Trends Neurosci , vol.14 , pp. 165-170
    • Thoenen, H.1
  • 44
    • 0027410490 scopus 로고
    • Nerve growth factor is a potent inducer of proliferation and neuronal differentiation for adult rat chromaffin cells in vitro
    • Tischler AS, Riseberg JC, Hardenbrook MA, Cherington V (1993): Nerve growth factor is a potent inducer of proliferation and neuronal differentiation for adult rat chromaffin cells in vitro. J Neurosci 13:1533-1542.
    • (1993) J Neurosci , vol.13 , pp. 1533-1542
    • Tischler, A.S.1    Riseberg, J.C.2    Hardenbrook, M.A.3    Cherington, V.4
  • 45
    • 0023784240 scopus 로고
    • Decreased levels of nerve growth factor receptor in dexamethasone-treated PC12 cells
    • Tocco MD, Contreras ML, Koizumi S, Dickens G, Guroff G (1988): Decreased levels of nerve growth factor receptor in dexamethasone-treated PC12 cells. J Neurosci Res 20:411-419.
    • (1988) J Neurosci Res , vol.20 , pp. 411-419
    • Tocco, M.D.1    Contreras, M.L.2    Koizumi, S.3    Dickens, G.4    Guroff, G.5
  • 46
    • 0026486878 scopus 로고
    • Sustained activation of the mitogen-activated protein (MAP) kinase cascade may be required for differentiation of PC12 cells
    • Traverse S, Gomez N, Paterson H, Marshall C, Cohn P (1992): Sustained activation of the mitogen-activated protein (MAP) kinase cascade may be required for differentiation of PC12 cells. Biochem J 288:351-355.
    • (1992) Biochem J , vol.288 , pp. 351-355
    • Traverse, S.1    Gomez, N.2    Paterson, H.3    Marshall, C.4    Cohn, P.5
  • 47
    • 0021101196 scopus 로고
    • Conversion of nerve growth factor complexes to a slowly dissociating, Triton X-100 insoluble state by anti-nerve growth factor antibodies
    • Vale RD, Shooter EM (1983): Conversion of nerve growth factor complexes to a slowly dissociating, Triton X-100 insoluble state by anti-nerve growth factor antibodies. Biochemistry 22:5022-5028.
    • (1983) Biochemistry , vol.22 , pp. 5022-5028
    • Vale, R.D.1    Shooter, E.M.2
  • 49
    • 0028287101 scopus 로고
    • Expression of trkA confers neuronlike responsiveness to nerve growth factor on an immortalized hypothalamic cell line
    • Zhou J, Holtzman DM, Weiner RI, Mobley WC (1994): Expression of trkA confers neuronlike responsiveness to nerve growth factor on an immortalized hypothalamic cell line. Proc Natl Acad Sci U S A 91:3824-3828.
    • (1994) Proc Natl Acad Sci U S A , vol.91 , pp. 3824-3828
    • Zhou, J.1    Holtzman, D.M.2    Weiner, R.I.3    Mobley, W.C.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.