Noradrenergic alterations in Posttraumatic stress disorder

Annals of the New York Academy of Sciences

Volumn 821, Issue , 1997, Pages 125-141

  Southwick, Steven M ^a   Morgan III, C A ^a   Bremner, A Douglas ^a   Grillon, Christian G ^a   Krystal, John H ^a   Nagy, Linda M ^a   Charney, Dennis S ^a  

^a YALE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADRENALIN; ADRENERGIC RECEPTOR; NORADRENALIN; YOHIMBINE;

ADRENERGIC SYSTEM; ALERTNESS; BATTLE INJURY; BRAIN REGION; CLINICAL TRIAL; CONFERENCE PAPER; FAMILY; HUMAN; INTRAVENOUS DRUG ADMINISTRATION; LEARNING; LOCUS CERULEUS; MEMORY; NEUROBIOLOGY; NONHUMAN; NORADRENALIN BLOOD LEVEL; NORADRENALIN RELEASE; PANIC; POSITRON EMISSION TOMOGRAPHY; POSTTRAUMATIC STRESS DISORDER; SEROTONINERGIC NERVE CELL; SURVIVAL;

EID: 0030794675     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.1997.tb48274.x     Document Type: Conference Paper

References (115)

1. KARDINER, A. & H. SPIEGEL. 1947. The Traumatic Neuroses of War. Paul Hoeber. New York.
2. GRINKER, R. R. & J. P. SPIEGEL. 1945. Men Under Stress. Blakiston. Philadelphia, PA.
3. MEAKINS, J. C. & R. M. WILSON. 1918. The effect of certain sensory stimulation on the respiratory rate in cases of so-called "irritable heart." Heart 7: 17-22.
4. FRASER, F. & E. M. WILSON. 1918. The sympathetic nervous system and the "irritable heart of soldiers." Br. Med. J. 2: 27-29.
5. DOBBS, D. & W. P. WILSON. 1960. Observations on the persistence of neurosis. Dis. Nerv. Syst. 21: 40-46.
6. BRENDE, J. O. 1982. Electrodermal responses in post-traumatic syndromes. J. Nerv. Ment. Dis. 170: 352-361.
7. BLANCHARD, E. B. et al. 1986. A psychophysiological study of post traumatic stress disorders in Vietnam veterans. Behav. Res. Ther. 24: 645-652.
8. BLANCHARD, E. B. et al. 1991. Changes in plasma norepinephrine to combat-related stimuli among Vietnam veterans with posttraumatic stress disorder. J. Nerv. Ment. Dis. 179: 371-373.
9. MALLOY, P. F. et al. 1983. Validation of a multimethod assessment of posttraumatic stress disorder in Vietnam veterans. J. Consult. Clin. Psychol. 51: 488-494.
10. PALLMEYER, T. P. et al. 1986. The psychophysiology of combat-induced posttraumatic stress disorder in Vietnam veterans. Behav. Res. Ther. 24: 645-652.
11. PITMAN, R. K. et al. 1987. Psychophysiologic assessment of posttraumatic stress disorder imagery in Vietnam combat veterans. Arch. Gen. Psychiatry. 44: 970-975.
12. PITMAN, R. K. 1989. Posttraumatic stress disorder, hormone, and memory (editorial). Biol. Psychiatry 26: 221-223.
13. ORR, S. P. 1990. Psychophysiologic studies of post traumatic stress disorder. In Biological Assessment and Treatment of Post Traumatic Stress Disorder. E. L. Giller, Ed.: 135-160. American Psychiatric Press. Washington, DC.
14. ORR, S. P. 1993. Psychophysiological assessment of posttraumatic stress disorder imagery in World War II and Korean combat veterans. J. Abnorm. Psychol. 102: 152-159.
15. SHALEV, A. Y. 1993. Psychophysiologic assessment of traumatic imagery in Israeli civilian patients with posttraumatic stress disorders. Am. J. Psychiatry 150: 620-624.
16. PITMAN, R. K. et al. 1990. Psychophysiologic responses to combat imagery of Vietnam veterans with posttraumatic stress disorder versus other anxiety disorders. J. Abnorm. Psychol. 99: 49-54.
17. BLANCHARD, E. B. et al. 1991. The psychophysiology of motor vehicle accident related post-traumatic stress disorder. Biofeedback Self-Regul. 16: 116.
18. SOUTHWICK, S. M. et al. 1995. Clinical studies of neurotransmitter alterations in post-traumatic stress disorder. In Neurobiological and Clinical Consequences of Stress: From Normal Adaptation to PTSD. M. J. Friedman, D. S. Charney & A. Y. Deutch, Eds.: 335-349. Lippincott-Raven Publishers. Philadelphia, PA.
19. MASON, J. W. et al. 1995. Some approaches to the study of the clinical implications of thyroid alterations in post-traumatic stress disorder. In Neurobiological and Clinical Consequences of Stress: From Normal Adaptation to PTSD. M. J. Friedman, D. S. Charney & A. Y. Deutch, Eds.: 367-379. Lippincott-Raven Publishers. Philadelphia, PA.
20. YEHUDA, R. et al. 1995. Hypothalamic-pituitary-adrenal functioning in post-traumatic stress disorder: Expanding the concept of the stress response spectrum. In Neurobiological and Clinical Consequences of Stress: From Normal Adaptation to PTSD. M. J. Friedman, D. S. Charney & A. Y. Deutch, Eds.: 351-365. Lippincott-Raven Publishers. Philadelphia, PA.
21. CHARNEY, D. S. et al. 1993. Psychobiologic mechanisms of posttraumatic stress disorder. Arch. Gen. Psychiatry 50: 294-305.
22. ZIGMOND, M. J. et al. 1995. Neurochemical studies of central noradrenergic responses to acute and chronic stress: Implications for normal and abnormal behavior. In Neurobiological and Clinical Consequences of Stress: From Normal Adaptation to PTSD. M. J. Friedman, D. S. Charney & A. Y. Deutch, Eds.: 45-60. Lippincott-Raven Publishers. Philadelphia, PA.
23. IDA, Y. et al. 1985. Attenuating effect of diazepam on stress-induced increases in noradrenaline turnover in specific brain regions of rats: Antagonism by Ro15-1788. Life Sci. 37: 2491-2498.
24. TANAKA, M. et al. 1986. Involvement of brain noradrenaline and opioid peptides in emotional changes induced by stress in rats. In Emotions: Neural and Chemical Control. Y. Oomura, Ed.: 417. Scientific Societies Press. Tokyo, Japan.
25. TSUDA, A. & M. TANAKA. 1985. Differential changes in noradrenaline turnover in specific regions of rat brain produced by controllable and uncontrollable shocks. Behav. Neurosci. 99: 802-817.
26. ASTON-JONES, G. 1994. Locus coeruleus, stress, and post traumatic stress disorder: Neurobiological and clinical parallels. In Catecholamine Function in Post Traumatic Stress Disorder, Emerging Concepts. M. Murburg, Ed.: 17-62. American Psychiatric Press. Washington, DC.
27. REDMOND, D. E., JR. 1987. Studies of the nucleus locus coeruleus in monkeys and hypotheses for neuropsychopharmacology. In Psychopharmacology: The Third Generation of Progress. H. Y. Meltzer, Ed.: 967-975. Raven Press. New York.
28. REDMOND, D. E. & Y. H. HUANG. 1979. New evidence for a locus coeruleus norepinephrine connection with anxiety. Life Sci. 25: 2149-2162.
29. CHARNEY, D. S. et al. 1990. Noradrenergic dysregulation in panic disorder. In Neurobiology of Panic Disorders. J. C. Ballenger, Ed.: 91-105. Alan R. Liss. New York.
30. ABERCROMBIE, E. D. & B. L. JACOBS. 1987. Single-unit response of noradrenergic neurons in the locus coeruleus of freely moving cats. I. Acutely presented stressful and non-stressful stimuli. J. Neurosci. 7: 2837-2843.
31. ABERCROMBIE, E. D. & B. L. JACOBS. 1987. Single-unit response of noradrenergic neurons in the locus coeruleus of freely moving cats. II. Adaptation to chronically presented stressful stimuli. J. Neurosci. 7: 2844-2848.
32. RASMUSSEN, K. et al. 1986. Single unit activity of locus coeruleus neurons in the freely moving cat. I. During naturalistic behaviors and in response to simple and complex stimuli. Brain Res. 371: 324-334.
33. LEVINE, E. S. et al. 1990. Activity of cat locus coeruleus noradrenergic neurons during the defense reaction. Brain Res. 531: 189-195.
34. MCCULLOCH, J. & A. M. HARPER. 1979. Factors influencing the response of the cerebral circulation to phenylethylamine. Neurology 29: 201-207.
35. RAICHLE, M. E. et al. 1975. Central noradrenergic regulation of cerebral blood flow and vascular permeability. Proc. Natl. Acad. Sci. 72: 3726-3730.
36. LIANG, K. C. et al. 1990. Modulating effects of posttraining epinephrine on memory: Involvement of the amygdala noradrenergic system. Brain Res. 368: 125-133.
37. GALLAGHER, M. & B. S. KAPP. 1973. Manipulation of opiate activity in the amygdala alters memory processes. Life Sci. 23: 1973-1978.
38. GALLAGHER, M. et al. 1981. Aneuropharmacology of amygdaloid systems which contribute to learning and memory. In The Amygdaloid Complex. Y. Ben-Ari, Ed. Elsevier/ North Holland. Amsterdam.
39. MCGAUGH, J. L. et al. 1988. Memory-enhancing effects of posttraining naloxone: Involvement of β-noradrenergic influence in the amygdaloid complex. Brain Res. 446: 37-49.
40. INTROINI-COLLISON, I. B. et al. 1989. Memory-enhancement with intra-amygdala post-training naloxone is blocked by concurrent administration of propranolol. Brain Res. 476: 94-101.
41. SARA, S. J. & V. DEVAUGES. 1989. Idazoxan, an α-2 antagonist, facilitates memory retrieval in the rat. Behav. Neural Biol. 51: 401-411.
42. SARA, S. J. 1985. The locus-coeruleus and cognitive function: Attempts to relate noradrenergic enhancement of signal/noise in the brain. Physiol. Psychol. 13: 151-162.
43. PRINS, A. et al. 1995. Psychophysiological evidence for autonomic arousal and startle in traumatized adult populations. In Neurobiological and Clinical Consequences of Stress: From Normal Adaptation to PTSD. M. J. Friedman, D. S. Charney & A. Y. Deutch, Eds.: 291-314. Lippincott-Raven Publishers. Philadelphia, PA.
44. KOSTEN, T. R. et al. 1987. Sustained urinary norepinephrine and epinephrine elevation in post-traumatic stress disorder. Psychoneuroendocrinology 12: 13-20.
45. YEHUDA, R. et al. 1992. Urinary catecholamine excretion and severity of PTSD symptoms in Vietnam combat veterans. J. Nerv. Ment. Dis. 180: 321-325.
46. PITMAN, R. & S. ORR. 1990. Twenty-four hour urinary cortisol and catecholamine excretion in combat-related post-traumatic stress disorder. Biol. Psychiatry 27: 245-247.
47. DAVIDSON, L. M. & A. BAUM. 1986. Chronic stress and posttraumatic stress disorder. J. Consult. Clin. Psychol. 54: 303-308.
48. DEBELLIS, M. D. et al. 1994. Urinary catecholamine excretion in sexually abused girls. J. Am. Acad. Child Adolesc. Psychiatry 33: 320-327.
49. 2 adrenergic binding sites in post-traumatic stress disorder. Am. J. Psychiatry 144: 1511-1512.
50. PERRY, B. D. Neurobiological sequelae of childhood trauma: PTSD in children. In Catecholamine Function in Post-Traumatic Stress Disorder: Emerging Concepts. M. Murburg, Ed.: 131-158. APA Press. Washington, DC.
51. WEISS, R. T. et al. 1983. Platelet alpha 2 adrenoceptors in chronic congestive heart failure. Am. J. Cardiol. 52: 101-105.
52. 2-adrenergic binding sites in borderline personality disorder. Am. J. Psychiatry 147: 1014-1017.
53. PERRY, B. D. et al. 1990. Adrenergic receptor regulation in post-traumatic stress disorder. In Biological Assessment and Treatment of Post-Traumatic Stress Disorder. E. L. Ciller, Ed.: 87-114. APA Press. Washington, DC.
54. LERER, B. et al. 1987. Cyclic AMP signal transduction in post-traumatic stress disorder. Am. J. Psychiatry 144: 1324-1327.
55. LERER, B. et al. 1990. Platelet adenylate-cyclase and phospholipase C activity in posttraumatic stress disorder. Biol. Psychiatry 27: 735-744.
56. HAMMER, M. B. et al. 1990. Plasma dopamine and prolactin levels in PTSD. Biol. Psychiatry 27: 72A.
57. MCFALL, M. et al. 1990. Autonomic response to stress in Vietnam combat veterans with post-traumatic stress disorder. Biol. Psychiatry 27: 1165-1175.
58. BLANCHARD, E. B. et al. 1991. Changes in plasma norepinephrine to combat-related stimuli among Vietnam veterans with post traumatic stress disorder. J. Nerv. Ment. Dis. 179: 371-373.
59. DINAN, T. G. et al. 1990. A pilot study of neuroendocrine test battery in post traumatic stress. Biol. Psychiatry 28: 665-672.
60. HANSENNE M. et al. 1991. The clonidine test in post traumatic stress disorder. Am. J. Psychiatry 148: 810-811.
61. SOUTHWICK, S. M. et al. 1993. Abnormal noradrenergic function in posttraumatic stress disorder. Arch. Gen. Psychiatry 50: 266-274.
62. SCATTON, B. et al. 1980. Antidopamine properties of yohimbine. J. Pharmacol. Exp. Ther. 215: 494-499.
63. WINTER, J. C. & R. A. RABIN. 1992. Yohimbine as a serotonergic agent: Evidence for receptor binding and drug discrimination. J. Pharmacol. Exp. Ther. 263: 682-689.
64. PESKIND, E. R. et al. 1989. Yohimbine increases cerebrospinal fluid and plasma norepinephrine but not arginine vasopressin in humans. Neuroendocrinology 50: 286-291.
65. CHARNEY, D. S. et al. 1987. Neurobiological mechanisms of panic anxiety: Biochemical and behavioral correlates of yohimbine-induced panic attacks. Am. J. Psychiatry 144: 1030-1036.
66. GLAZER, W. M. et al. 1987. Noradrenergic function in schizophrenia. Arch. Gen. Psychiatry 44: 898-904.
67. 2-adrenergic receptor sensitivity in depression: The plasma MHPG, behavioral, and cardiovascular responses to yohimbine. Arch. Gen. Psychiatry 45: 718-726.
68. CHARNEY, D. S. et al. 1989. Noradrenergic function in generalized anxiety disorder: Effects of yohimbine in healthy subjects and patients with generalized anxiety disorder. Psychol. Res. 27: 173-182.
69. RASMUSSEN, S. A. et al. 1987. Effects of yohimbine in obsessive-compulsive disorder. Psychopharmacology (Berl.). 93: 308-313.
70. CHARNEY, D. S. et al. 1984. Noradrenergic function in panic anxiety: Effects of yohimbine in healthy subjects and patients with agoraphobia and panic disorder. Arch. Gen. Psychiatry 41: 751-763.
71. CHARNEY, D. S. et al. 1987. Neurobiological mechanisms of panic anxiety: Biochemical and behavioral correlates of yohimbine-induced panic attacks. Am. J. Psychiatry 144: 1030-1036.
72. GURGUIS, G. N. M. & T. W. UHDE. 1990. Plasma 3-methoxy-4-hydroxyphenylethylene glycol (MHPG) and growth hormone responses to yohimbine in panic disorder patients and normal controls. Psychoneuroendocrinology 15: 217-224.
73. MORGAN, C. A. et al. 1995. Yohimbine facilitated acoustic startle in combat veterans with post-traumatic stress disorder. 117: 466-471.
74. BROWN, J. S. et al. 1951. Conditioned fear as revealed by magnitude of startle response to an auditory stimulus. J. Exp. Psychol. 43: 317-328.
75. DAVIS, M. & B. ASTRACHAN. 1978. Conditioned fear and startle magnitude: Effects of different footshock or backshock intensities. J. Exp. Psychol. [Anim. Behav. Proc]. 4: 95-103.
76. COOK, E. W. et al. 1991. Emotional dysfunction and affective modulation of startle. J. Abnorm. Psychol. 100: 5-13.
77. GRILLON, C. et al. 1992. Fear potentiated startle in humans: Effects of anticipatory anxiety on the acoustic blink reflex. Psychophysiology. In press.
78. DAVIS, M. et al. 1979. Noradrenergic agonists and antagonists: Effects on conditioned fear as measured by the potentiated startle paradigm. Psychopharmacology 65: 111-118.
79. DAVIS, M. 1979. Diazepam and flurazepm: Effects on conditioned fear as measured by the potentiated startle paradigm Psychopharmacology 62: 1-7.
80. KEHNE, J. H. & M. DAVIS. 1985. Central noradrenergic involvement in yohimbine excitation of acoustic startle: Effects of DSP4 and 6-OHDA. Brain Res. 330: 32-41.
81. MORGAN C. A. et al. 1993. Yohimbine facilitated acoustic startle reflex in humans. Psychopharmacology 110: 342-346.
82. BREMNER, J. D. et al. 1997. PET measurement of cerebral metabolic correlates of yohimbine administration in combat related Posttraumatic Stress Disorder. Arch. Gen. Psychiatry 54: 246-254.
83. SAVAKI, H. E. et al. 1982. The central noradrenergic system in the rat: Metabolic mapping with alpha-adrenergic blocking agents. Brain Res. 234: 65-79.
84. INOUE, M. & M. MCHUGH. 1991. Pappius: The effect of alpha-adrenergic receptor blockers prazosin and yohimbine on cerebral metabolism and biogenic amine content of traumatized brain. J. Cereb. Blood Flow Metab. 11: 242-252.
85. SOUTHWICK, S. M. et al. 1997. Noradrenergic and serotonergic function in Posttraumatic Stress Disorder. Arch. Gen. Psychiatry. In press.
86. IRELAND, S. J. & M. B. TYERS. 1987. Pharmacological characterization of 5-hydroxytryptamine-induced depolarization of the rabbit isolated vagus nerve. Br. J. Pharmacol. 90: 229.
87. ROBERTSON, D. W. et al. 1991. MCPP but not TFMPP is an antagonist at cardiac 5-HT3 receptors. Life Sci. 50: 599-605.
88. 1B receptor ligands exist? Arch. Pharmacol. 339: 675-683.
89. SHEN, Y. et al. 1993. Molecular cloning and expression of a 5-hydroxytryptamine: receptor sybtype. J. Biol. Chem. 268: 18200-18204.
90. 2 receptors in interneurons. Synapse 9: 208-218.
91. 1C) receptors. J. Pharmacol. Exp. Ther. 2142: 552-557.
92. 2 activated interneuron. Brain Res. 506: 62-69.
93. CARVER, J. G. et al. 1993. The effects of 5-HT and m-chlorphenylpiperazine (m-CPP) on the efflux of [3-H]-5-HT from human perfused platelets. Br. J. Clin. Pharmacol. 35: 473-478.
94. HAMIK, A. & S. J. PEROUTKA. 1989. l-(m-chlorophenypiperazine interactions with neurotransmitter receptors in the human brain. Biol. Psychiatry 25: 569-575.
95. 1 recognition sites. J. Recept. Res. 8: 59-81.
96. ANISMAN, H. et al. 1979. Escape performance after inescapable shock in selectively bred lines of mice: Response maintenance and catecholamine activity. J. Comp. Physiol. Psychiatry 93: 229-241.
97. BERGER, B. et al. 1979. Genetically determined differences in noradrenergic input to the brain cortex: A histochemical and biochemical study in two inbred strains of mice. Neuroscience 4: 877-888.
98. 2 receptor responsiveness and decreased basal activity in spontaneously hypertensive rats. J. Neural Transm. 69: 71-83.
99. GAXIOLA, B. et al. 1984. Epinephrine-induced platelet aggregation. A twin study. Clin. Genet. 26: 543-548.
100. PROPPING, P. & W. FRIEDL. 1983. Genetic control of adrenergic receptors on human platelets. A twin study. Human Genet. 64: 105-109.
101. WIELAND, S. et al. 1986. Stock differences in the susceptibility of rats to learned helplessness training. Life Sci. 39: 937-944.
102. KENDLER, D. S. et al. 1993. Panic disorder in women: A population-based twin study. Psychol. Med. 23: 397-406.
103. NOYES, R. et al. 1986. Relationship between panic disorder and agoraphobia: A family study. Arch. Gen. Psychiatry 43: 227-232.
104. MARTIN, N. G. et al. 1988. Anxiety disorders an neuroticism: Are there genetic factors to panic? Acta Psychiatr. Scand. 77: 698-706.
105. DAVIDSON, J. et al. Familial psychiatric illness in chronic Posttraumatic Stress Disorder. Compr. Psychiatry 30: 339-345.
106. BRESLAU, N. et al. 1991. Traumatic events and posttraumatic stress disorder in an urban population of young adults. Arch. Gen. Psychiatry 48: 216-222.
107. IRWIN J. et al. 1986. Sensitization of norepinephrine activity following acute and chronic foot-shock. Brain Res. 379: 98-103.
108. KARMARCY, N. R. et al. 1984. Footshock treatment activates catecholamine synthesis in slices of mouse brain region. Brain Res. 290: 311-319.
109. MELIA, K. R. et al. 1991. Regulation of tyrosine hydroxylase (TH) in the locus coeruleus (LC) by corticotropin-releasing factor (CRF): Relation to stress and depression. Neurosci. Abstr. 16: 444.
110. NAGY et al. Genetic epidemiology of panic attacks and noradrenergic response in posttraumatic stress disorder: A family history study. J. Traumatic Stress. In press.
111. MURBURG, M. M. 1994. Catecholamine Function in Posttraumtic Stress Disorder: Emerging Concepts. American Psychiatric Press. Washington, DC.
112. POST, R. M. 1992. Transduction of psychosocial stress into the neurobiology of recurrent affect disorder. Am. J. Psychiatry 149: 999-1010.
113. MACTUTUS, C. F. et al. 1980. Extending the ACTH-induced memory reactivation in amnestic paradigm. Physiol. Behav. 24: 541-546.
114. STONE, W. S. et al. 1990. Amphetamine, epinephrine and glucose enhancement of memory retrieval. Psychobiology 18: 227-230.
115. KOLB, L. C. et al. 1984. Propranolol and clonidine in the treatment of the chronic posttraumatic stress disorders of war. In Posttraumatic Stress Disorder: Psychological and Biological Sequelae. B. A. van der Kolk, ed. American Psychiatric Press. Washington, DC.