Stereoselective Pseudomonas cepacia lipase mediated synthesis of α-hydroxyamides

Tetrahedron Asymmetry

Volumn 8, Issue 15, 1997, Pages 2509-2512

  Adamczyk, Maciej ^a   Grote, Jonathan ^a   Rege, Sushil ^a  

^a ABBOTT DIAGNOSTICS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMIDE; TRIACYLGLYCEROL LIPASE;

AMIDATION; ARTICLE; BURKHOLDERIA CEPACIA; DRUG SYNTHESIS; ENANTIOMER; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; PARTIAL DRUG SYNTHESIS; PRIORITY JOURNAL; STEREOCHEMISTRY;

EID: 0030793169     PISSN: 09574166     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0957-4166(97)00270-X     Document Type: Article

References (26)

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22. For leading references: Garcia, M. J.; Rebolledo, F.; Gotor, V. Tetrahedron 1994, 23, 6935-6940; Puertas, S.; Brieva, R.; Redbollo, F.; Gotor, V. Tetrahedron 1993, 49, 4007-4014; Garcia, M. J.; Rebolledo, F.; Gotor, V. Tetrahedron: Asymmetry 1993, 4, 2199-210. Also, see Chamorro, C.; Gonzalez-Muniz, R.; Conde, S. Tetrahedron: Asymmetry 1995, 6, 2343-2352.
23. For leading references: Garcia, M. J.; Rebolledo, F.; Gotor, V. Tetrahedron 1994, 23, 6935-6940; Puertas, S.; Brieva, R.; Redbollo, F.; Gotor, V. Tetrahedron 1993, 49, 4007-4014; Garcia, M. J.; Rebolledo, F.; Gotor, V. Tetrahedron: Asymmetry 1993, 4, 2199-210. Also, see Chamorro, C.; Gonzalez-Muniz, R.; Conde, S. Tetrahedron: Asymmetry 1995, 6, 2343-2352.
24. For leading references: Garcia, M. J.; Rebolledo, F.; Gotor, V. Tetrahedron 1994, 23, 6935-6940; Puertas, S.; Brieva, R.; Redbollo, F.; Gotor, V. Tetrahedron 1993, 49, 4007-4014; Garcia, M. J.; Rebolledo, F.; Gotor, V. Tetrahedron: Asymmetry 1993, 4, 2199-210. Also, see Chamorro, C.; Gonzalez-Muniz, R.; Conde, S. Tetrahedron: Asymmetry 1995, 6, 2343-2352.
25. + at 270; chiral HPLC (see reference 23 for conditions) retention times 17.6 mins (S), 39.8 mins (R).
26. A Regis 250×4.6 mm Chiralcel OD column, eluted with 1%-2% iPrOH/hexanes for esters and 5% iPrOH/hexanes for amides, was employed.