Insulin sensitivity, vascular reactivity, and clamp-induced vasodilatation in essential hypertension

Circulation

Volumn 96, Issue 3, 1997, Pages 849-855

  Natali, Andrea ^a,b   Taddei, Stefano ^a   Galvan, Alfredo Quiñones ^a   Camastra, Stefania ^a   Baldi, Simona ^a   Frascerra, Silvia ^a   Virdis, Agostino ^a   Sudano, Isabella ^a   Salvetti, Antonio ^a   Ferrannini, Ele ^a  

^a UNIVERSITY OF PISA   (Italy)

^b INSTITUTE OF CLINICAL PHYSIOLOGY   (Italy)

Author keywords

Acetylcholine; Hypertension; Insulin; Vasodilation

Indexed keywords

ACETYLCHOLINE; GLUCOSE; INSULIN; NITROPRUSSIDE SODIUM; NORADRENALIN;

ADRENERGIC ACTIVITY; ADULT; AGED; ARTICLE; BLOOD PRESSURE; BLOOD VESSEL REACTIVITY; CLINICAL ARTICLE; ESSENTIAL HYPERTENSION; FOREARM BLOOD FLOW; GLUCOSE METABOLISM; GLUCOSE TRANSPORT; HUMAN; INSULIN BLOOD LEVEL; INSULIN RESISTANCE; INSULIN SENSITIVITY; MALE; PRIORITY JOURNAL; VASCULAR RESISTANCE; VASODILATATION;

EID: 0030792915     PISSN: 00097322     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.CIR.96.3.849     Document Type: Article

References (37)

1. Ferrannini E, Buzzigoli G, Bonadonna R, Giorico MA, Oleggini M, Graziadei L, Pedrinelli R, Brandi L, Bevilacqua S. Insulin resistance in essential hypertension. N Engl J Med. 1987;317: 350-357.
2. Ferrannini E. The phenomenon of insulin resistance: its possible relevance to hypertensive disease. In: Laragh JH, Brenner BM, eds: Hypertension: Pathophysiology, Diagnosis, and Management. New York, NY: Raven Press; 1995:2281-2300.
3. Anderson EA, Hoffman RP, Balon TW, Sinkey CA, Mark AL. Hyperinsulinemia produces both sympathetic neural activation and vasodilation in normal humans. J Clin Invest. 1991;87:2246-2252.
4. Lembo G, Rendina V, Iaccarino G, Lamenza F, Volpe M, Trimarco B. Insulin reduces reflex forearm sympathetic vasoconstriction in healthy humans. Hypertension. 1993;21:1015-1019.
5. Sakai K, Imaizumi T, Masaki H, Takeshita A. Intra-arterial infusion of insulin attenuates vasoreactivity in human forearm. Hypertension. 1993;22:67-73.
6. Taddei S, Virdis A, Mattei P, Natali A, Ferrannini E, Salvetti A. Effect of insulin on acetylcholine-induced vasodilation in normal subjects and in patients with essential hypertension. Circulation. 1995;92:2911-2918.
7. Stout R. Effect of insulin on the proliferation of cultured primate arterial smooth muscle cells. Circ Res. 1975;36:319-327.
8. Berne C. Insulin resistance in hypertension - a relationship with consequences? J Int Med. 1991;229(suppl 2):65-73.
9. Baron AD, Steinberg HO, Chaker H, Learning R, Johnson A, Brechtel G. Insulin-mediated skeletal muscle vasodilatation contributes to both insulin sensitivity and responsiveness in lean humans. J Clin Invest. 1995;96:786-792.
10. Lillioja S, Young A, Culter C, Ivy J, Abbot W, Zawadzki J, Yki-Jarvinen H, Christin L, Secomb T, Bogardus C. Skeletal muscle capillary density and fiber type are possible determinants of in vivo insulin resistance in man. J Clin Invest. 1987;80:415-424.
11. Baron AD, Brechtel-Hook G, Johnson A, Hardin D. Skeletal muscle blood flow: a possible link between insulin resistance and blood pressure. Hypertension. 1993;21:129-135.
12. Taddei S, Virdis A, Mattei P, Ghiadoni L, Gennari A, Fasolo CB, Sudano I, Salvetti A. Aging and endothelial function in normotensive subjects and patients with essential hypertension. Circulation. 1995;91:1981-1987.
13. Baron AD, Laakso M, Brechtel G, Edelman SV. Mechanism of insulin resistance in insulin-dependent diabetes mellitus: a major role for reduced skeletal muscle blood flow. J Clin Endocrinol Metab. 1991;73:637-643.
14. Laakso M, Edelman SV, Brechtel G, Baron AD. Impaired insulin-mediated skeletal muscle blood flow in patients with NIDDM. Diabetes. 1992;41:1076-1083.
15. Johnstone MT, Creager SJ, Scales KM, Cusco JA, Lee BK, Creager MA. Impaired endothelium-dependent vasodilation in patients with insulin-dependent diabetes mellitus. Circulation. 1993;88: 2510-2516.
16. McVeigh GE, Brennan GM, Johnston GD, McDermott BJ, McGrath LT, Henry WR, Andrews JW, Hayes JR. Impaired endothelium-dependent and independent vasodilatation in patients with type 2 (non-insulin-dependent) diabetes mellitus. Diabetologia. 1992;35:771-776.
17. Utriainen T, Malmstrom R, Yki-Jarvinen H. Methodological aspects, dose-response characteristics and causes of interindividual variation in insulin stimulation of limb blood flow in normal subjects. Diabetologia. 1995;38:555-564.
18. Bianchi S, Bigazzi R, Quinones-Galvan A, Musceli E, Pecori N, Ciociaro D, Ferrannini E, Natali A. Insulin resistance and microalbuminuria in essential hypertension: sites and mechanism. Hypertension. 1995;26:789-795.
19. Laakso M, Edelman SV, Brechtel G, Baron AD. Decreased effect of insulin to stimulate skeletal muscle blood flow in obese man. J Clin Invest. 1990;85:1844-1852.
20. Hulthén U, Endre T, Mattiasson I, Berglund B. Insulin and forearm vasodilation in hypertension-prone men. Hypertension. 1995;25: 214-218.
21. Lembo G, Napoli R, Capaldo B, Rendina V, Iaccarino G, Volpe M, Trimarco B, Saccà L. Abnormal sympathetic overactivity evoked by insulin in the skeletal muscle of patients with essential hypertension. J Clin Invest. 1992;90:24-29.
22. Lembo G, Capaldo B, Rendina V, Iaccarino G, Napoli R, Guida R, Trimarco B, Saccà L. Acute noradrenergic activation induces insulin resistance in human skeletal muscle. Am J Physiol. 1994;29: E242-E247.
23. Devereux R. Detection of left ventricular hypertrophy by M-mode echocardiography: anatomic validation, standardization, and comparison to other methods. Hypertension. 1987;9(suppl II):II-19-II-26.
24. Furchgott RV, Zawadzki JV. The obligatory role of endothelial cells in the relaxation of smooth muscle by acetylcholine. Nature. 1980;288:373-376.
25. Shultz K, Shultz K, Shultz G. Sodium nitroprusside and other smooth muscle relaxants increase cyclic GMP levels in rats ductus deferents. Nature. 1977;265:750-751.
26. Agabiti R, Rizzoni D, Castellano M, Porteri E, Zulli R, Muiesan M, Bettoni G, Salvetti M, Muiesan P, Giulini S. Media:lumen ratio in human small resistance arteries is related to forearm minimal vascular resistance. J Hypertens. 1995;13:341-347.
27. Ferrannini E, Vichi S, Beck-Nielsen H, Laakso M, Paolisso G, Smith U. Insulin action and age. Diabetes. 1996;45:947-953.
28. Pollare T, Lithell H, Berne C. Insulin resistance is a characteristic of primary hypertension independent of obesity. Metabolism. 1990; 39:167-174.
29. Scherrer U, Randin D, Vollender P, Vollender L, Nicod P. Nitric oxide release accounts for insulin's vascular effects in humans. J Clin Invest. 1994;94:2511-2515.
30. Petrie J, Shinichiro U, Webb D, Elliott H, Connel J. Endothelial nitric oxide production and insulin sensitivity. Circulation. 1996;93: 1331-1333.
31. Sorensen K, Celermajer D, Georgakopulos D, Hatcher G, Betteridge D, Deanfield J. Impairment of endothelium-dependent dilatation is an early event in children with familial hypercholesterolemia and is related to the lipoprotein (a) level. J Clin Invest. 1994;93:50-55.
32. Quinones A, Santoro D, Natali A, Sampietro T, Boni C, Buzzigoli G, Ferrannini E. Insulin sensitivity in familial hypercholesterolemia. Metabolism. 1993;10:1359-1364.
33. Scherrer U, Vollenweider P, Randin D, Jequier E, Nicod P, Tappy L. Suppression of insulin-induced sympathetic activation and vaso-dilatation by dexamethasone in humans. Circulation. 1993;88: 388-394.
34. Weidman P, Beretta-Piccoli C, Trost B. Pressor factors and responsiveness in hypertension accompanying diabetes mellitus. Hypertension. 1985;7(suppl II):II-33-II-42.
35. Baron AD, Brechtel G, Johnson A, Fineberg N, Henry DP, Steinberg HO. Interactions between insulin and norepinephrine on blood pressure and insulin sensitivity. J Clin Invest. 1994;93: 2453-2462.
36. Amann F, Bolli P, Kiowski W, Buhler F. Enhanced alpha-adrencnoceptor mediated vasoconstriction in essential hypertension. Hypertension. 1981;3:1-119-1-123.
37. Steinberg H, Brechtel G, Johnson A, Fineberg N, Baron A. Insulin-mediated skeletal muscle vasodilatation is nitric oxide dependent: a novel action of insulin to increase nitric oxide release. J Clin Invest. 1994;94:1172-1179.