Neuropeptide FF in the VTA blocks the analgesic effects of both intra- VTA morphine and exposure to stress

Brain Research

Volumn 758, Issue 1-2, 1997, Pages 250-254

  Altier, Nadège ^a   Stewart, Jane ^a  

^a and Applied Physiology   (Canada)

Author keywords

Analgesia; Dopamine; Footshock stress; Formalin test; Neuropeptide FF; Opioids; Ventral tegmental area

Indexed keywords

17 METHYLNALTREXONE BROMIDE; DOPAMINE; DRUG VEHICLE; FORMALDEHYDE; MORPHINE; NEUROPEPTIDE FF; OPIATE ANTAGONIST;

ANALGESIA; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; INTRACEREBROVENTRICULAR DRUG ADMINISTRATION; MALE; NONHUMAN; PAIN; PAIN ASSESSMENT; PRIORITY JOURNAL; RAT; SHOCK; STRESS; SUBCUTANEOUS DRUG ADMINISTRATION; VENTRAL TEGMENTUM;

ANALGESICS, OPIOID; ANIMALS; MALE; MORPHINE; NARCOTIC ANTAGONISTS; OLIGOPEPTIDES; PAIN; PAIN MEASUREMENT; RATS; RATS, WISTAR; STRESS; VENTRAL TEGMENTAL AREA;

EID: 0030792598     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(97)00333-8     Document Type: Article

References (32)

1. F.V. Abbott, Studies on Morphine Analgesia in an Animal Model of Tonic Pain, Ph.D. thesis, McGill University, Montreal, Quebec, Canada, 1981.
2. F.V. Abbott, K.B.J. Franklin, R.J. Ludwick, R. Melzack, Apparent lack of tolerance in the formalin test suggests different mechanisms for morphine analgesia in different types of pain, Pharmacol. Biochem. Behav. 15 (1981) 637-640.
3. F.V. Abbott, R. Melzack, B.F. Leber, Morphine analgesia and tolerance in the tail-flick and formalin tests: dose-response relationships, Pharmacol. Biochem. Behav. 17 (1982) 1213-1219.
4. M. Allard, S. Geoffre, P. Legendre, J.D. Vincent, G. Simmonet, Characterization of rat spinal cord receptors to FLFQPQRFamide, a mammalian morphine-modulating peptide: a binding study, Brain Res. 500 (1989) 169-176.
5. M. Allard, J.M. Zajac, G. Simmonet, Autoradiographic distribution of receptors to FLFQPQRFamide, a morphine-modulating peptide, in rat central nervous system, Neuroscience 49 (1992) 101-106.
6. N. Altier, J. Stewart, Opioid receptors in the ventral tegmental area contribute to stress-induced analgesia in the formalin test for tonic pain. Brain Res. 718 (1996) 203-206.
7. P.B.S. Clarke, K.B.J. Franklin, Infusions of 6-hydroxydopamine into the nucleus accumbens abolish the analgesic effect of amphetamine but not of morphine in the formalin test, Brain Res. 580 (1992) 106-110.
8. M.S. Fanselow, Shock-induced analgesia on the formalin test: effects of shock severity, naloxone, hypophysectomy, and associated variables, Behav. Neurosci. 98 (1984) 79-95.
9. K.B.J. Franklin, Analgesia and the neural substrate of reward, Neurosci. Biobehav: Rev. 13 (1989) 149-154.
10. H. Isbell, N.B. Wikler, N.B. Eddy, J.L. Wilson, C.F. Moran, Tolerance and addiction liability of 6-dimethylanino-4-4-diphenyl-hepatanone-3 (methadon), J. Am. Med. Assoc. 135 (1947) 888-894.
11. E.M. Joyce, G.F. Koob, R. Strecker, S.D. Iversen, F.E. Bloom, The behavioral effects of enkephalin analogues injected into the ventral tegmental area and globus pallidus, Brain Res. 221 (1981) 359-370.
12. P.W. Kalivas, R. Richardson-Carlson, Endogeneous enkephalin modulation of dopamine neurons in the ventral tegmental area, Am. J. Physiol. 258 (1986) 243-249.
13. M. Kavaliers, Inhibitory influences of mammalian FMRFamide (Phe-Met-Arg-Phe-amide)-related peptides on nociception and morphine- and stress-induced analgesia in mice, Neurosci. Lett. 115 (1990) 307-312.
14. 2-related peptides augments morphine and stress-induced analgesia in mice, Peptides, 10 (1989) 741-745.
15. L. Kivipelto, E.A. Majane, H.-Y.T. Yang, P. Panula, Immunohistochemical distribution and partial characterization of FLFQPQRFamidelike peptides in central nervous system of rats, J. Comp. Neurol. 286 (1989) 269-287.
16. J.R. Lake, M.V. Hammond, R.C. Shaddox, L.M. Hunsicker, H.-Y.T. Yang, D.H. Malin, IgG from neuropeptide FF antiserum reverses morphine tolerance in the rat, Neurosci. Lett. 132 (1991) 29-32.
17. D.H. Malin, J.R. Lake, D.E. Fowler, M.V. Hammond, S.L. Brown, J.E. Leyva, P.E. Prasco, T.M. Dougherty, FMRF-NH2-like mammalian peptide precipitates opiate-withdrawal syndrome in the rat, Peptides 11 (1990) 277-280.
18. 2-like mammalian octapeptide: possible role in opiate dependence and abstinence, Peptides 11 (1990) 969-972.
19. B.H. Manning, M.J. Morgan, K.B.J. Franklin, Morphine analgesia in the formalin test: evidence for forebrain and midbrain sites of action, Neuroscience 63 (1994) 289-294.
20. N. Marco, L. Stinus, M. Allard, M. Le Moal, G. Simmonet, Neuropeptide FLFQPQRFAMIDE receptors within the ventral mesencephalon and dopaminergic terminal areas: localization and functional antiopioid involvement, Neuroscience 64 (1995) 1035-1044.
21. B.K. Matthies, K.B.J. Franklin, Formalin pain is expressed in decerebrate rats but not attenuated by morphine, Pain 51 (1992) 199-206.
22. R. Melzack, The tragedy of needless pain, Sci. Am. 262 (1990) 27-33.
23. M.J. Morgan, Opioid-Dopamine Interactions in Analgesia in the Formalin Test, Doct. Diss., McGill University, Montreal, Quebec, Canada, 1990.
24. M.J. Morgan, K.B.J. Franklin, 6-hydroxydopamine lesions of the ventral tegmentum abolish ( + ) amphetamine and morphine analgesia in the formalin test but not the tail flick test, Brain Res. 519 (1990) 144-149.
25. M.J. Morgan, K.B.J. Franklin, Dopamine receptor subtypes and formalin test analgesia, Pharmacol. Biochem. Behav. 40 (1991) 317-322.
26. B.M. Mount, I. Ajemian, J.F. Scott, Use of the Brompton mixture in treating the chronic pain of malignant disease, Can. Med. Assoc. J. 115 (1976) 122-124.
27. P. Oberling, L. Stinus, M. Le Moal, G. Simmonet, Biphasic effect on nociception and antiopiate activity of the neuropeptide FF (FLFQPQRFamide) in the rat, Peptides 14 (1993) 919-924.
28. G. Paxinos and C. Watson, The Rat Brain in Stereotaxic Coordinates, Academic Press, Orlando, FL, 1986.
29. R.B. Rothman, A review of the role of anti-opioid peptides in morphine tolerance and dependence, Synapse 12 (1992) 129-138.
30. R.G. Twycross, Clinical experience with diamorphine in advanced malignant disease, Int. J. Clin. Pharmacol. 9 (1974) 184-198.
31. R.G. Twycross, Relief of pain. In C.M. Saunders (Ed.), The Management of Terminal Disease, Edward Arnold, London, UK, 1978, pp. 65-98.
32. H.-Y.T. Yang, W. Fratta, E.A. Majane, E. Costa, Isolation, sequencing, synthesis and pharmacological characterization of two brain neuropeptides that modulate the action of morphine, Proc. Natl. Acad. Sci. USA 82 (1985) 7757-7761.