Mechanism of atrioventricular nodal facilitation in the rabbit heart: Role of the distal AV node

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 272, Issue 6 41-6, 1997, Pages

  Fahy, Gerard J ^a   Efimov, Igor ^a   Cheng, Yuanna ^a   Kidwell, Gregory A ^a   Van Wagoner, David ^a   Tchou, Patrick J ^a   Mazgalev, Todor ^a  

^a LERNER RESEARCH INSTITUTE   (United States)

Author keywords

Atrioventricular nodal physiology; Intrinsic atrioventricular nodal properties; Microelectrode recording; Pacing protocol; Preexcitation

Indexed keywords

ACTION POTENTIAL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ELECTROGRAPHY; FEMALE; HEART ATRIOVENTRICULAR NODE; HEART ATRIUM; HEART PACING; HIS BUNDLE; MALE; MICROELECTRODE; NONHUMAN; PRIORITY JOURNAL; RABBIT;

EID: 0030792563     PISSN: 03636135     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpheart.1997.272.6.h2815     Document Type: Article

References (20)

1. Billette, J. Preceding His-atrial interval as a determinant of atrioventricular nodal conduction time in the human and rabbit heart. Am. J. Cardiol. 38: 889-896, 1976.
2. Billette, J. Atrioventricular nodal activation during periodic premature stimulation of the atrium. Am. J. Physiol. 252 (Heart Circ. Physiol. 21): H163-H177, 1987.
3. Billette, J., and R. Metayer. Origin, domain, and dynamics of rate-induced variations of functional refractory period in rabbit atrioventricular node. Circ. Res. 65: 164-175, 1989.
4. Billette, J., and S. Nattel. Dynamic behavior of the atrioventricular node: a functional model of interaction between recovery, facilitation, and fatigue. J. Cardiovasc. Electrophysiol. 5: 90-102, 1994.
5. Cheng, J., and M. N. Levy. Feedback mechanisms and dynamics of atrioventricular node propagation. Ann. NY Acad. Sci. 591: 1-10, 1990.
6. Fahy, G. J., and G. A. Kidwell. Effects of beta-adrenergic blockade on facilitated antegrade conduction in the human atrioventricular node (Abstract). Pacing Clin. Electrophysiol. 18: 839, 1995.
7. Fahy, G. J., and G. A. Kidwell. Facilitated conduction in human atrioventricular node: fact or artifact? (Abstract). J. Am. Coll. Cardiol. 27: 122A, 1996.
8. Heethaar, R. M., J. J. D. van der Gon, and F. L. Meijler. Mathematical model of AV conduction in the rat heart. Cardiovasc. Res. 105-114, 1973.
9. Keim, S., T. Mazgalev, R. Kinn, K. Rist, and P. Tchou. Facilitation of anterograde conduction following preconditioning impulses in the human atrioventricular node (Abstract). J. Am. Coll. Cardiol. 21: 282A, 1993.
10. Kidwell, G. A., and G. J. Fahy. Effects of facilitation on AV nodal fast and slow pathways (Abstract). J. Am. Coll. Cardiol. 25: 254A, 1995.
11. Kokubun, S., M. Nishimura, A. Noma, and H. Irisawa. Membrane currents in the rabbit atrioventricular node cell. Pflügers Arch. 393: 15-22, 1982.
12. Lehmann, M. H., R. T. Steinman, M. D. Meissner, and C. D. Schuger. Quantitating AV nodal function: has A1-A2 outlived its usefulness? Pacing Clin. Electrophysiol. 13: 1674-1677, 1990.
13. Levy, M. N., P. H. Martin, H. Zieske, and D. Adler. Role of positive feedback in the atrioventricular nodal Wenckebach phenomenon. Circ. Res. 34: 697-710, 1974.
14. Lewis, T., and A. M. Master. Observations upon conduction in the mammalian heart. AV conduction. Heart 12: 209-269, 1925.
15. Liu, Y., W. Zeng, M. Delmar, and J. Jalife. Ionic mechanisms of electrotonic inhibition and concealed conduction in rabbit atrioventricular nodal myocytes. Circulation 88: 1634-1646, 1993.
16. Mazgalev, T., Y. Cheng, I. Efimov, and P. Tchou. Effects of 2,3-butanedione monoxime on the AV conduction in isolated heart (Abstract). Circulation 92: 1432, 1995.
17. Mazgalev, T., L. S. Dreifus, J. Bianchi, and E. L. Michelson. Atrioventricular nodal conduction during atrial fibrillation in rabbit heart. Am. J. Physiol. 243 (Heart Circ. Physiol. 12): H754-H760, 1982.
18. Meijler, F. L., and M. J. Janse. Morphology and electrophysiology of the mammalian atrioventricular node. Physiol. Rev. 68: 608-647, 1988.
19. Mendez, C., and G. K. Moe. Some characteristics of transmembrane potentials of AV nodal cells during propagation of premature beats. Circ. Res. 19: 933-1010, 1966.
20. Merideth, J., C. Mendez, W. J. Mueller, and G. K. Moe. Electrical excitability of atrioventricular nodal cells. Circ. Res. 23: 69-85, 1968.