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Topotecan was approved by the FDA for marketing to treat ovarian cancer on May 29, 1996
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Topotecan was approved by the FDA for marketing to treat ovarian cancer on May 29, 1996.
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3
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0343967649
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Irinotecan was approved by the FDA for marketing to treat colorectal cancer on June 14, 1996
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Irinotecan was approved by the FDA for marketing to treat colorectal cancer on June 14, 1996.
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4
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(e) D. H. Comins, H. Hong, J. K. Saha, and G. Jianhua, J. Org. Chem. 1994, 59, 5120.
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D.L. Comins, M.F. Baefsky, and H. Hong, J. Am. Chem. Soc. 1992, 114, 10971.
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23
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0010372638
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For a recent review see: R. Grigg, V. Sridharan, P. Stevenson, S. Sukirthalingam, and T. Worakun, Tetrahedron 1990, 46, 4003.
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24
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4444276636
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For a recent review see: H. C. Kolb, M. S. VanNieuwenhze, and K. B. Sharpless, Chem. Rev. 1994, 94, 2483.
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25
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0342661592
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manuscript in preparation
-
For some recent results on the intramoleular Heck reaction (cf. 9 to 10) see: D. D. Bankston, F. G. Fang, and S. Xie, J. Org. Chem., manuscript in preparation.
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J. Org. Chem.
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31
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0028321956
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At the time we implemented this solution, no reports on the Mitsunobu reaction of pyridones had appeared in the literature. Subsequently, Comins has published a study on the Mitsonubu reaction of pyridones and the application of this reaction to the synthesis of 1: (a) D. L. Comins and G. Jianhua, Tetrahedron Lett. 1994, 35, 2819.
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32
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0027978935
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See also reference 15e
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(b) D. L. Comins, H. Hong, and G. Jianhua, Tetrahedron Lett. 1994, 35, 5331. See also reference 15e.
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Heck, R.F.1
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34
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37049095646
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For a nickel-mediated cyclization of a chloroaromatic system see: M. Mori, S. Kudo, and Y. Ban, J. Chem. Soc., Perkin Trans. I 1979, 771.
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35
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0028054343
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A similar strategy for palladium removal has been developed in the synthesis of the angiotensin II receptor antagonist losartan: R. D. Larsen, A. O. King, C. Y. Chen, E. G. Gorley, B. S. Foster, F. E. Roberts, C. Yang, D. R. Lieberman, R. A. Reamer, D. M. Tschaen, T. R. Verhoeven, P. J. Reider, Y. S. Lo, L. T. Rossano, A. S. Brookes, D. Meloni, J. R. Moore, and J. F. Arnett, J. Org. Chem. 1994, 59, 6391.
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Tschaen, D.M.10
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Lo, Y.S.13
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Brookes, A.S.15
Meloni, D.16
Moore, J.R.17
Arnett, J.F.18
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36
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0343967643
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note
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The biological activity of this compound will be reported elsewhere.
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