Epidemiology and molecular biology of Barrett's adenocarcinoma

Seminars in Surgical Oncology

Volumn 13, Issue 4, 1997, Pages 270-280

  Altorki, Nasser K ^a   Oliveria, Susan ^b   Schrump, David S ^c  

^a WEILL CORNELL MEDICAL CENTER   (United States)

^b STRANG CANCER PREVENTION CENTER   (United States)

^c UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

Author keywords

Adenocarcinoma; Barrett esophagus; Cell cycle; Chromosome abnormalities; Esophageal neoplasms; Gene expression; Incidence; Mucous membrane; p53 genes; Precancerous conditions; Prevalence; Protein p53 genetics; Risk factors; Tumor suppressor genes

Indexed keywords

BARRETT ESOPHAGUS; CANCER EPIDEMIOLOGY; CANCER INCIDENCE; CANCER RISK; EARLY DIAGNOSIS; ESOPHAGUS CARCINOMA; GASTROESOPHAGEAL REFLUX; HELICOBACTER PYLORI; HETEROZYGOSITY LOSS; HUMAN; MALIGNANT TRANSFORMATION; MOLECULAR BIOLOGY; OCCULT CANCER; PREVALENCE; PRIORITY JOURNAL; REVIEW; RISK FACTOR; TUMOR SUPPRESSOR GENE;

ADENOCARCINOMA; ADOLESCENT; ADULT; AGE DISTRIBUTION; AGED; BARRETT ESOPHAGUS; CHILD; CHILD, PRESCHOOL; ESOPHAGEAL NEOPLASMS; FEMALE; HUMANS; INCIDENCE; INFANT; MALE; MIDDLE AGED; MOLECULAR BIOLOGY; RISK FACTORS; SEX DISTRIBUTION; SURVIVAL RATE; UNITED STATES;

EID: 0030792055     PISSN: 87560437     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1098-2388(199707/08)13:4<270::AID-SSU9>3.0.CO;2-2     Document Type: Review

References (189)

1. Barrett NR: Chronic peptic ulcer of the oesophagus and "oesophagitis." Br J Surg 1950;38:175-182.
2. Iascone C, DeMeester TR, Little AG, Skinner DB: Barrett's esophagus Functional assessment, proposed pathogenesis, and surgical therapy. Arch Surg 1983:118 543-549
3. Flook D, Stoddard CJ: Gastro-oesophageal reflux (GOR) in patients with oesophagitis or a columnar-lined (Barrett's) oesophagus. [Abstract] Gut 1983;24:1007A.
4. Phillips RW, Wong RK: Barrett's esophagus. Natural history, incidence, etiology, and complications. [Review] Gastroenterol Clin North Am 1991;20:791-816.
5. Skinner DB, Walther BC, Riddell RH, et al: Barrett's esophagus. Comparison of benign and malignant cases. Ann Surg 1983; 198:554-565.
6. Dent J, Bremner CG, Collen MJ, et al: Barrett's oesophagus. [Review] J Gastroenterol Hepatol 1991;6:1-22.
7. Gottfried MR, McClave SA, Boyce HW: Incomplete intestinal metaplasia in the diagnosis of columnar lined esophagus (Barrett's esophagus). Am J Clin Pathol 1989;92:741-746.
8. Rothman KJ: Measures of disease frequency. In "Modern epidemiology." Boston: Little, Brown, 1986:23-34.
9. Naef AP, Savary M, Ozzello L: Columnar-lined lower esophagus: an acquired lesion with malignant prediposition. J Thorac Cardiovasc Surg 1975;70:826-835.
10. Burbige EJ, Radigan JJ: Characteristics of the columnar-cell lined (Barrett's) esophagus. Gastrointest Endosc 1979;25:133-136.
11. Rothery GA, Patterson JE, Stoddard CJ, Day DW: Histological and histochemical changes in the columnar lined (Barrett's) oesophagus. Gut 1986;27:1062-1068.
12. Cooper BT, Barbezat GO: Barrett's oesophagus: a clinical study of 52 patients. Q J Med 1987;62:97-108.
13. Ovaska J, Miettinen M, Kivilaakso E: Adenocarcinoma arising in Barrett's esophagus. Dig Dis Sci 1989;34:1336-1339.
14. Herlihy KJ, Orlando RC, Bryson JC, et al: Barrett's esophagus: clinical, endoscopic, histologic, manometric, and electrical potential difference characteristics. Gastroenterology 1984;86:436-443.
15. Snyder JD, Goldman H: Barrett's esophagus in children and young adults. Frequent association with mental retardation [see comments]. Dig Dis Sci 1990;35:1185-1189.
16. Starnes VA, Adkins RB, Ballinger JF, Sawyers JL: Barrett's esophagus. A surgical entity. Arch Surg 1984;19:563-567.
17. Sarr MG, Hamilton SR, Marrone GC, Cameron JL: Barrett's esophagus: its prevalence and association with adenocarcinoma in patients with symptoms of gastroesophageal reflux. Am J Surg 1985;149:187-193.
18. Gilchrist AM, Levine MS, Carr RF, et al: Barrett's esophagus: diagnosis by double-contrast esophagography. AJR. Am J Roentgenol 1988;150:97-102.
19. Winters C Jr, Spurling TJ, Chobanian SJ, et al: Barrett's esophagus. A prevalent, occult complication of gastroesophageal reflux disease. Gastroenterology 1987;92:118-124.
20. Mann NS, Tsai MF, Nair PK: Barrett's esophagus in patients with symptomatic reflux esophagitis [see coments]. Am J Gastroenterol 1989;84:1494-1496.
21. Dahms BB, Rothstein FC: Barrett's esophagus in children: a consequence of chronic gastroesophageal reflux. Gastroenterology 1984;86:318-323.
22. Cooper JE, Spitz L, Wilkins BM Barrett's esophagus in children: a histologic and histochemical study of 11 cases. J Pediatr Surg 1987;22:191-196.
23. Schnell T, Sontag S, Wanner J, et al: Endoscopic screening for Barrett's esophagus (BE), esophageal adenocarcinoma (AdCa) and other mucosal changes in ambulatory subjects with symptomatic gastroesophageal reflux (GER). [Abstract]. Gastroenterology 1985;88:1576.
24. Howden CW, Vasudeva R, Cardona F, Holt S: Prevalence of esophagitis. [letter; comment] Dig Dis Sci 1992;37:1469-1470.
25. Schnell T, Sontag S, Miller T, et al: Are there identifiable risk factors (RF) for the presence of Barrett's esophagus (BE) in patients (PTS) with gastroesophageal reflux (GER)? [Abstract]. Gastroenterology 1991,100:A156.
26. Thier JS: Morphology of the epithelium of the distal esophagus in patients with midesophageal peptic strictures. Gastroenterology 1970;58:444-461.
27. Spechler SJ, Sperber H, Doos WG, Schimmel EM: The prevalence of Barrett's esophagus in patients with chronic peptic esophageal strictures. Dig Dis Sci 1983;28:769-774.
28. Cameron AJ, Zinsmeister AR, Ballard DJ, Carney JA: Prevalence of columnar-lined (Barrett's) esophagus. A comparison of population-based clinical and autopsy findings [see comments]. Gastroenterology 1990,99:918-922.
29. Cameron AJ, Lomboy CT: Barrett's esophagus: age, prevalence and extent of columnar epithelium [see comments]. Gastroenterology 1992;103:1241-1245.
30. Dees J, Van Blankenstein M, Frenkel M: Adenocarcinoma in Barrett's esophagus: a report of 13 cases. [Abstract] Gastroenterology 1978;74:1119.
31. Bonelli L: Barrett's esophagus: results of a multicentric survey. Gruppo Operativo per lo Studio delle Precancerosi Esofagee (GOSPE). Endoscopy 1993;25:652-654, (It.).
32. De la Pava S, Pickren JW. Adler RH: Ectopic gastric mucosa of the esophagus - a study on histogenesis. NY State J Med 1964;65:1831-1835.
33. Postlethwait RW, Musser AW: Changes in the esophagus in 1,000 autopsy specimens. J Thorac Cardiovasc Surg 1974;68:953-956.
34. Allison PR, Johnstone AS: The oesophagus lined with gastric mucous membrane. Thorax 1953;8:87-101.
35. Hall C, Hoie J, Langmark F: Adenocarcinoma in Barrett's oesophagus. Two case reports and discussion. Scand J Thorac Cardiovasc Surg 1982;16:107-109.
36. Carrie A: Adenocarcinoma of the upper end of the oesophagus arising from ectopic gastric epithelium. Br J Surg 1950;37:474.
37. McDonald GB, Brand DL, Thorning DR: Multiple adenomatous neoplasms arising in columnar-lined (Barrett's) esophagus. Gastroenterology 1977;72:1317-1321.
38. Berenson MM, Riddell RH, Skinner DB, Freston JW: Malignant transformation of esophageal columnar epithelium. Cancer 1978;41:554-561.
39. Lortat-Jacob JL, Maillard JN, Richard CA, et al: Primary esophageal adenocarcinoma: report of 16 cases. Surgery 1968;64:535-543.
40. Morson BC, Belcher JR: Adenocarcinoma of the oesophagus and ectopic gastric mucosa. Br J Cancer 1952;6:127-130.
41. Menguy R: On the malignant potential of acquired short esophagus. Arch Surg 1979;114:260-263.
42. Shafer RB: Adenocarcinoma in Barrett's columnar-lined esophagus. Arch Surg 1971;103:411-413.
43. Borrie J, Goldwater L: Columnar cell-lined esophagus: assessment of etiology and treatment: a 22-year experience. J Thorac Cardiovasc Surg 1976;71:825-834.
44. Hawe A, Payne WS, Weiland LH, Fontana RS: Adenocarcinoma in the columnar epithelial lined lower (Barrett) oesophagus. Thorax 1973;28:511-514.
45. Messian RA, Hermos JA, Robbins AH, et al: Barrett's esophagus. Clinical review of 26 cases. Am J Gastroenterol 1978;69:458-466.
46. Bremner CG: Benign strictures of the esophagus. [Review] Curr Probl Surg 1982;19:401-489.
47. Ransom JM, Patel GK, Clift SA, et al: Extended and limited types of Barrett's esophagus in the adult. Ann Thorac Surg 1982;33:19-27.
48. Radigan LR, Glover JL, Shipley FE, Shoemaker RE: Barrett esophagus. Arch Surg 1977;112:486-491.
49. Williamson WA, Ellis FH Jr, Gibb SP, et al: Barrett's esophagus. Prevalence and incidence of adenocarcinoma. Arch Intern Med 1991;151:2212-2216.
50. Harle IA, Finley RJ, Belsheim M, et al: Management of adenocarcinoma in a columnar-lined esophagus. Ann Thorac Surg 1985;40:330-336.
51. Cameron AJ, Ott BJ, Payne WS: The incidence of adenocarcinoma in columnar-lined (Barrett's) esophagus. N Engl J Med 1985;313:857-859
52. Stemmer EA, Adams WE: The incidence of carcinoma at the esophagogastric junction in short esophagus. Arch Surg 1960;81:771-780.
53. Robbins AH, Hermos JA, Schimmel EM, et al: The columnar-lined esophagus - analysis of 26 cases. Radiology 1977;123:1-7.
54. Spechler SJ, Robbins AH, Rubins HB, et al: Adenocarcinoma and Barrett's esophagus. An overrated risk? Gastroenterology 1984;87:927-933.
55. Sprung DJ, Ellis FH Jr, Gibb SP: Incidence of adenocarcinoma in Barrett's esophagus. [Abstract] Am J Gastroenterol 1984;79:817.
56. Miros M, Kerlin P, Walker N: Only patients with dysplasia progress to adenocarcinoma in Barrett's oesophagus. [see comments] Gut 1991;32:1441-1446.
57. McCallum RW, Polepalle S, Davenport K, et al: Progress report on ACG Barrett's esophagus study. [Abstract] Am J Gastroenterol 1990;85:51A.
58. Saubier EC, Gouillat C, Samaniego C, et al: Adenocarcinoma in columnar-lined Barrett's esophagus. Analysis of 13 esophagectomies. Am J Surg 1985;150:365-369.
59. Achkar E, Carey W: The cost of surveillance for adenocarcinoma complicating Barrett's esophagus. Am J Gastroenterol 1988; 83:291-294.
60. Moghissi K, Sharpe DA, Pender D: Adenocarcinoma and Barrett's oesophagus. A clinico-pathological study. Eur J Cardiothorac Surg 1993;7:126-132.
61. Haggitt RC, Dean PJ: Adenocarcinoma in Barrett's epithelium. In Spechler SJ, Goyal RK (eds): "Barrett's esophagus: pathophysiology, diagnosis, and management." New York: Elsevier, 1985:153-166.
62. Haggitt RC, Tryzelaar J, Ellis FH, Colcher H: Adenocarcinoma complicating columnar epithelium-lined (Barrett's) esophagus. Am J Clin Pathol 1978;70:1-5.
63. Hamilton SR, Smith RR, Cameron JL: Prevalence and characteristics of Barrett esophagus in patients with adenocarcinoma of the esophagus or esophagogastric junction. Hum Pathol 1988;19:942-948.
64. Van der Veen AH, Dees J, Blankensteijn JD, Van Blankenstein M: Adenocarcinoma in Barrett's oesophagus: an overrated risk. Gut 1989;30:14-18.
65. Watson RG, Porter KG, Sloan JM: Incidence of adenocarcinoma in Barrett's oesophagus and an evaluation of endoscopic surveillance. Eur J Gastroenterol Hepatol 1991;3:159-162.
66. Sampliner RE, Kogan FJ, Morgan TR, et al: Progression - regression of Barrett's esophagus. [Abstract] Gastroenterology 1985;88:1567.
67. Savary M, Miller G: Frequency and importance of endobrachyesophagus in reflux disease. In Siewert JR, Holscher AH (eds): "Diseases of the esophagus." Berlin: Springer-Verlag, 1988:529-536.
68. Robertson CS, Mayberry JF, Nicholson DA, et al: Value of endoscopic surveillance in the detection of neoplastic change in Barrett's oesophagus. Br J Surg 1988;75:760-763.
69. Hameeteman W, Tytgat GN, Houthoff HJ, van den Tweel JG: Barrett's esophagus, development of dysplasia and adenocarcinoma [see comments]. Gastroenterology 1989;96:1249-1256.
70. Skinner DB: The incidence of cancer in Barrett's esophagus varies according to series. In Giuli R, McCallum RW (eds): "Benign lesions of the esophagus and cancer: answers to 210 questions." New York: Springer-Verlag, 1989:764-765.
71. Polepalle SC, McCallum RW: Barrett's esophagus. Current assessment and future perspectives. [Review] Gastroenterol Clin North Am 1990;19:733-744.
72. Iftikhar SY, James PD, Steele RJ, et al: Length of Barrett's oesophagus: an important factor in the development of dysplasia and adenocarcinoma. [see comments] Gut 1992; 33:1155-1158.
73. Ollyo JB, Lang F, Fontolliet C, et al: Barrett's oesophagus: surveillance follow-up by oesophagoscopy, colonoscopy or panendoscopy? [Abstract] Gastroenterology 1990;98:100A.
74. Sontag SJ, Schnell TG, Chejfec G, et al: Barrett's oesophagus and colonic tumours. Lancet 1985;1(8435):946-949.
75. Robertson DA, Ayres RC, Smith CL: Screening for colonic cancer in patients with Barrett's oesophagus. BMJ 1989;298:650.
76. Tripp MR, Sampliner RE, Kogan FJ, Morgan TR: Colorectal neoplasms and Barrett's esophagus. Am J Gastroenterol 1986;81:1063-1064.
77. Lyons MF, Tsuchida AM, Schlepp GE: Is colonic neoplasia associated with Barrett's esophagus? [Abstract] Am J Gastroenterol 1990;85:1221A.
78. Rothstein RI, Smith RE, Power GC: Barrett's esophagus and colonic neoplasia. [Abstract] Gastroenterology 100:150A. 1991.
79. Barrett's oesophagus and colon cancer. [letter] Lancet 1987; 2(8567):1084-1085.
80. Ramage JK, Hall J, Williams JG: Barrett's oesophagus. [letter] Lancet 1987;2(8563):851.
81. Achkar JP, Post AB, Achkar E, Carey WD: Risk of extraesophageal malignancy in patients with adenocarcinoma arising in Barrett's esophagus. Am J Gastroenterol 1995;90:39-43.
82. Post AB, Achkar E, Carey WD: Prevalence of colonic neoplasia in patients with Barrett's esophagus. Am J Gastroenterol 1993; 88.877-880.
83. Schneider A, Sampliner RE, Garewal HS: Extra-esophageal malignancy in patients with Barrett's esophagus. [Abstract] Gastroenterology 1988;94:410A.
84. Menke-Pluymers MB, Hop WC, Dees J, et al: Risk factors for the development of an adenocarcinoma in columnar-lined (Barrett) esophagus. Cancer 1993;72:1155-1158.
85. Kabat GC, Ng SK, Wynder EL: Tobacco, alcohol intake, and diet in relation to adenocarcinoma of the esophagus and gastric cardia. Cancer Causes Control 1993;4:123-132.
86. Decarli A, Liati P, Negri E, et al: Vitamin A and other dietary factors in the etiology of esophageal cancer. Nutr Cancer 1987;10: 29-37.
87. Pottern LM, Morris LE, Blot WJ, et al: Esophageal cancer among black men in Washington, D.C. I. Alcohol, tobacco and other risk factors. J Natl Cancer Inst 1981;67:777-783.
88. Yu MC, Garabrant DH, Peters JM, Mack TM: Tobacco, alcohol, diet, occupation, and carcinoma of the esophagus. Cancer Res 1988;48.3843-3848.
89. Graham S, Marshall J, Haughey B, et al: Nutritional epidemiology of cancer of the esophagus. Am J Epidemiol 131:454-467, 1990.
90. Gray MR, Donnelly RJ, Kingsnorth AN: The role of smoking and alcohol in metaplasia and cancer risk in Barrett's columnar lined oesophagus. Gut 1993;34:727-731.
91. Vaughan TL, Davis S, Kristal A, Thomas DB: Obesity, alcohol, and tobacco as risk factors for cancers of the esophagus and gastric cardia: adenocarcinoma versus squamous cell carcinoma. Cancer Epidemiol Biomarkers Prev 1995;4:85-92.
92. Brown LM, Silverman DT, Pottern LM, et al: Adenocarcinoma of the esophagus and esophagogastric junction in white men in the United States: alcohol, tobacco, and socioeconomic factors. Cancer Causes Control 1994;5:333-340.
93. Schnell TG, Sontag SJ, Chejfec G: Adenocarcinomas arising in tongues or short segments of Barrett's esophagus. Dig Dis Sci 1992;37:137-143.
94. Pera M, Cameron AJ, Trastek VF, et al: Increasing incidence of adenocarcinoma of the esophagus and esophagogastric junction. Gastroenterology 1993;104:510-513.
95. Thompson JJ, Zinsser KR, Enterline HT: Barrett's metaplasia and adenocarcinoma of the esophagus and gastroesophageal junction. Hum Pathol 1983;14:42-61.
96. Kalish RJ, Clancy PE, Orringer MB, Appleman HD: Clinical, epidemiologic, and morphologic comparison between adenocarcinomas arising in Barrett's esophageal mucosa and in the gastric cardia. Gastroenterology 1984;86:461-467.
97. Lomboy CT, Pera M, Cameron AJ, et al: Adenocarcinoma of the esophagus and esophagogastric junction are both associated with Barrett's epithelium. [Abstract] Gastroenterology 1992,102:373A.
98. Naef AP, Savary M: Conservative operations for peptic esophagitis with stenosis in columnar-lined lower esophagus. Ann Thorac Surg 1972;13:543-551.
99. Burgess JN, Payne WS, Andersen HA, et al: Barrett esophagus: the columnar-epithelial-lined lower esophagus. Mayo Clin Proc 46.728-734, 1971.
100. Barrett's esophagus: epidemiological and clinical results of a multicentric survey. Gruppo Operativo per lo Studio delle Precancerosi Esofagee (GOSPE). Int J Cancer 1991;48:364-368.
101. Hassall E, Weinstein WM, Ament ME: Barrett's esophagus in childhood. Gastroenterology 1985;89:1331-1337.
102. Rosenberg JC, Fromm D: Barrett's esophagus as a premalignant lesion. In DeVita VT Jr, Hellman S, Rosenberg SA (eds): "Cancer Prevention 1993." Philadelphia: Lippincott. 1993:1-11.
103. Rosenberg JC, Budev H, Edwards RC, et al: Analysis of adenocarcinoma in Barrett's esophasus utilizing a staging system. Cancer 1985;55.1353-1360.
104. Smith RR, Hamilton SR, Boitnott JK, Rogers EL: The spectrum of carcinoma arising in Barrett's esophagus. A clinicopathologic study of 26 patients. Am J Surg Pathol 1984;8:563-573.
105. Rogers EL, Goldkind SF, Iseri OA, et al: Adenocarcinoma of the lower esophagus. A disease primarily of white men with Barrett's esophagus. J Clin Gastroenterol 1986;8:613-618.
106. Levi F, Ollyo JB, LaVecchia C, et al: The consumption of tobacco, alcohol and the risk of adenocarcinoma in Barrett's esophagus. Int J Cancer 1990;45:852-854.
107. Collins BJ, Abbott M, Thomas RJ, et al: Clinical profile in Barrett's esophagus: who should be screened for cancer? Hepatogastroenterology 1991;38:341-344.
108. Ziegler RG, Morris LE, Blot WJ, et al: Esophageal cancer among black men in Washington, D.C. II. Role of nutrition. J Natl Cancer Inst 1981;67:1199-1206.
109. Mettlin C, Graham S, Priore R, et al: Diet and cancer of the esophagus. Nutr Cancer 1981;2:143-147.
110. Brown LM, Swanson CA, Gridley G, et al: Adenocarcinoma of the esophagus: role of obesity and diet. [comment in: J Natl Cancer Inst 1995;87:847-848] J Natl Cancer Inst 1995;87:104-109.
111. Jochem VJ, Fuerst PA, Fromkes JJ: Familial Barrett's esophagus associated with adenocarcinoma. Gastroenterology 1992;102 (4 Pt 1):1400-1402.
112. Crabb DW, Berk MA, Hall TR, et al: Familial gastroesophageal reflux and development of Barrett's esophagus. Ann Intern Med 1985;103:52-54.
113. Eng C, Spechler SJ, Ruben R, Li FP: Familial Barrett esophagus and adenocarcinoma of the gastroesophageal junction. [published erratum appears in Cancer Epidemiol Biomarkers Prev 1993;2:505] Cancer Epidemiol Biomarkers Prev 1993;2: 397-399.
114. Gelfand MD: Barrett esophagus in sexagenarian identical twins. J Clin Gastroenterol 1983;5:251-253.
115. Fahmy N, King JF: Barrett's esophagus: an acquired condition with genetic predisposition. [comment in: Am J Gastroenterol 1994;89:287] Am J Gastroenterol 1993;88:1262-1265.
116. Everhart CW Jr, Holtzapple PG, Humphries TJ: Occurrence of Barrett's esophagus in three members of the same family: first report of familial incidence. [Abstract] Gastroenterology 1978; 74:1032A.
117. Prior A, Whorwell PJ: Familial Barrett's oesophagus? Hepatogastroenterology 1986;33:86-87.
118. Sartori S, Nielsen I, Indelli M, et al: Barrett esophagus after chemotherapy with cyclophosphamide, methotrexate, and 5-fluorouracil (CMF): an iatrogenic injury? [comment in: Ann Intern Med 1991;114:243-244; Ann Intern Med 1991;114.913] Ann Intern Med 1991;114:210-211.
119. Dahms BB, Greco MA, Strandjord SE, Rothstein FC: Barrett's esophagus in three children after antileukemia chemotherapy. Cancer 1987;60:2896-2900.
120. Spechler SJ: Barrett esophagus: a sequela of chemotherapy [editorial] [comment in: Ann Intern Med 1991;114:210-211] Ann Intern Med 1991;114:243-244.
121. Peters FT, Sleijfer DT, Van Imhoff GW, Kleibeuker JH: Is chemotherapy associated with development of Barrett's esophagus? Dig Dis Sci 1993;38:923-926.
122. Paull G, Yardley JH: Gastric and esophageal Campylobacter pylori in patients with Barrett's esophagus. Gastroenterology 1988;95:216-218.
123. Talley NJ, Cameron AJ, Shorter RG, et al: Campylobacter pylori and Barrett's esophagus. Mayo Clin Proc 1988;63:1176-1180.
124. Borhan-Manesh F, Farnum JB: Study of Helicobacter pylori colonization of patches of heterotopic gastric mucosa (HGM) at the upper esophagus. Dig Dis Sci 1993;38:142-146.
125. Ferreres J, Fernandez F, Vives AR, et al. Helicobacter pylori in Barrett's esophagus. Histol Histopathol 1991;6:403-408.
126. Loffeld RJ, Ten Tije BJ, Arends JW: Prevalence and significance of Helicobacter pylori in patients with Barrett's esophagus. Am J Gastroenterol 1992;87:1598-1600.
127. Blaser MJ, Perez-Perez GI, Lindenbaum J, et al. Rev Infect Dis 1991;13 (8 Suppl):704S-708S.
128. Helicobacter pylori in Barrett's oesophagus. Gruppo Operativo per lo Studio delle Precancerosi Esofagee (GOSPE). Histopathology 1991;18:568-570.
129. Hazell SL, Carrick J, Lee A: Campylobacter pylori can infect the oesophagus when gastric tissue is present. [Abstract] Gastroenterology 1988;94:178.
130. Talley R, Weinstein WM, Marin-Sorensen M, et al. Campylobacter pylori colonization of Barrett's esophagus. [Abstract] Gastroenterology 1984;94:454.
131. Walker SJ, Birch PJ, Stewart M, et al: Patterns of colonisation of Campylobacter pylori in the oesophasus, stomach and duodenum. Gut 1989;30:1334-1338.
132. Houck JA, Lucas JG: Absence of Campylobacter-like organisms in Barrett's esophagus. Arch Pathol Lab Med 1989;113:470-472.
133. Kalogeropoulos NK, Whitehead R: Campylobacter-like organisms and Candida in peptic ulcers and similar lesions of the upper gastrointestinal tract, a study of 247 cases. J Clin Pathol 1988;41: 1093-1098.
134. De Giacomo C, Fiocca R, Villani L, et al: Barrett's ulcer and Campylobacter-like organisms: infection in a child. J Pediatr Gastroenterol Nutr 1988;7:766-768.
135. Ectors N, Geboes K, Janssens J et al: Helicobacter pylori and the oesophagus. Rev Esp Enferm Dig 1990; 94 (I Suppl):78.
136. Castell DO: The lower esophageal sphincter. Physiologic and clinical aspects. Ann Intern Med 1975;83:390-401.
137. Wang HH, Hsieh CC, Antonioli DA: Rising incidence rate of esophageal adenocarcinoma and use of pharmaceutical agents that relax the lower esophageal sphincter (United States). Cancer Causes Control 1994;5:573-578.
138. Blot WJ, Devesa SS, Fraumeni JF Jr: Continuing climb in rates of esophageal adenocarcinoma: an update. [letter] JAMA 1993; 270:1320.
139. Zheng T, Mayne ST, Holford TR, et al: Time trend and age-period-cohort effects on incidence of esophageal cancer in Connecticut, 1935-89. Cancer Causes Control 1992;3:481-492.
140. Herbst JJ, Berenson MM, McCloskey DW, Wiser WC: Cell proliferation in esophageal columnar epithelium (Barrett's esophagus). Gastroenterology 1978;75:683-687.
141. Jankowski J, McMenemin R, Yu C, et al: Proliferating cell nuclear antigen in oesophageal disease: correlation with transforming growth factor alpha expression. Gut 1992;33:587-591.
142. Reid BJ, Haggitt RC, Rubin CE, Rabinovitch PS: Barrett's esophagus. Correlation between flow cytometry and histology in detection of patients at risk for adenocarcinoma. Gastroenterology 1987;93:1-11.
143. Reid BJ, Sanchez CA, Blount PL, Levine DS: Barrett's esophagus cell cycle abnormalities in advancing stages of neoplastic progression. [comment in: Gastroenterology 1994;106:553] Gastroenterology 1993;105:119-129.
144. Garewal HS, Sampliner RE, Fennerty MB: Flow cytometry in Barrett's esophagus: what have we learned so far? [editorial] [comment in: Dig Dis Sci 1992;37:635-636] Dig Dis Sci 1991;36: 548-551.
145. Rabinovitch PS, Reid BJ, Haggitt RC, et al: Progression to cancer in Barrett's esophagus is associated with genomic instability. Lab Invest 1988;60:65-71.
146. Reid BJ. Barrett's esophagus and esophageal adenocarcinoma. [Review] Gastroenterol Clin North Am 1991;20:817-834.
147. Rodriguez E, Rao PH, Ladanyi M, et al: 11p13-15 is a specific region of chromosomal rearrangement in gastric and esophageal adenocarcinomas. Cancer Res 1990;50:6410-6416.
148. Fearon ER, Feinberg AR Hamilton SH, Vogelstein B: Loss of genes on the short arm of chromosome 11 in bladder cancer. Nature 1985;318 (6044):377-380
149. Koufos A, Hansen MF, Copeland NG, et al: Loss of heterozygosity in three embryonal tumors suggests a common pathogenic mechanism. Nature 1985; 316 (6026):330-334.
150. Garewal HS, Sampliner R, Liu Y, Trent JM: Chromosomal rearrangements in Barrett's esophagus. A premalignant lesion of esophageal adenocarcinoma. Cancer Genet Cytogenet 1989;42.281-296.
151. Glesson CM, Sloan JM, McGuigan JA, et al: Multiple gene alterations in esophageal adenocarcinoma. [Abstract] Proc Annu Meet Am Assoc Cancer Res 1995;36 3251A.
152. Blount PL, Ramel S, Raskind WH, et al: 17p allelic deletions and p53 protein overexpression in Barrett's adenocarcinoma. Cancer Res 1991;51:5482-5486.
153. Boynton RF, Blount PL, Yin J, et al: Loss of heterozygosity involving the APC and MCC genetic loci occurs in the majority of human esophageal cancers. Proc Natl Acad Sci USA 1992;89:3385-3388.
154. Nishisho I, Nakamura Y, Miyoshi Y, et al: Mutations of chromosome 5q21 genes in FAP and colorectal cancer patients. Science 1991;253 (5020):665-669.
155. Kinzler KW, Nilbert MC, Vogelstein B, et al: Identification of a gene located at chromosome 5q21 that is mutated in colorectal cancers. [comment in: Science 1991;251(4999):1317] Science 1991;251 (4999):1366-1370.
156. Ashton-Rickardt PG, Wyllie AH, Bird CC, et al: MCC, a candidate familial polyposis gene in 5q21, shows frequent allele loss in colorectal and lung cancer. Oncogene 1991;6:1881-1886.
157. Blount PL, Meltzer SJ, Yin J, et al.: Clonal ordering of 17p and 5q allelic losses in Barrett dysplasia and adenocarcinoma Proc Natl Acad Sci USA 1993;90:3221-3225.
158. Swift A, Risk JM, Kingsnorth AN, et al: Frequent loss of heterozygosity on chromosome 17 at 17q11.2-q12 in Barrett's adenocarcinoma. Br J Cancer 1995;71:995-998.
159. Krishnadath KK, Tilanus HW, Alers JC, et al: Detection of genetic changes in Barrett's adenocarcinoma and Barrett's esophagus by DNA in situ hybridization and immunohistochemistry. Cytometry 1994;15:176-184.
160. Hunter S, Gramlich T, Abbott K, Varma V: Chromosome loss in esophageal carcinoma: an in situ hybridization study. Genes Chromosomes Cancer 1993;8:172-177.
161. Krishnadath KK, Tilanus HW, van Blankenstein M, et al: Accumulation of genetic abnormalities during neoplastic progression in Barrett's esophagus. Cancer Res 1995;55:1971-1976.
162. Lu SH, Hsieh LL, Luo FC, Weinstein IB: Amplification of the EGF receptor and c-myc genes in human esophageal cancers. Int J Cancer 1988;52:502-505.
163. Bos JL: Ras oncogenes in human cancer: a review. [published erratum appears in Cancer Res 1990;50:1352] Cancer Res 1989; 49:4682-4689.
164. Rodenhuis S. Ras and human tumors. [Review] Semin Cancer Biol 1992;3:241-247.
165. Nanus DM, Kelsen DP, Mentle IR, et al: Infrequent point mutations of ras oncogenes in gastric cancers. Gastroenterology 1990;98:955-960
166. Barserga R, Rubin R: Cell cycle and growth control. [Review] Crit Rev Eukaryot Gene Expr 1993;3:47-61.
167. Khosravi-Far R, Der CJ: The Ras signal transduction pathway. Cancer Metastasis Rev 1994;13.67-89.
168. Al-Kasspooles M, Moore JH, Orringer MB, Beer DG: Amplification and overexpression of the EGFR and erbB-2 genes in human esophageal adenocarcinomas. Int J Cancer 1993; 54.213-219.
169. Jankowski J, McMenemin R, Hopwood D, et al: Abnormal expression of growth regulatory factors in Barrett's oesophagus. Clin Sci 1991,81.663-668.
170. Donehower LA, Bradley A: The tumor suppressor p53. [Review] Biochem Biophys Acta 1993;1155:181-205.
171. Kuerbitz SJ, Plunkett BS, Walsh WV, Kastan MB: Wild-type p53 is a cell cycle checkpoint determinant following irradiation. Proc Natl Acad Sci USA 1992;89:7491-7495.
172. Yonish-Rouach E, Grunwald D, Wilder S, et al: p53 mediated cell death: relationship to cell cycle control. Mol Cell Biol 1993;13:1415-1423.
173. Almasan A, Link SP, Paulson TG, et al: Genetic instability as a consequence of inappropriate entry into and progression through S-phase. [Review] Cancer Metastasis Rev 1995;14:59-73.
174. Kastan MB, Canman CE, Leonard CJ: p53, cell cycle control and apoptosis: implications for cancer. [Review] Cancer Metastasis Rev 1995;14:3-15.
175. Hollstein M, Sidransky D, Vogelstein B, Harris CC: p53 mutations in human cancers. [Review] Science 1991;253 (5015):49-53.
176. Casson AG, Mukhopadhyay T, Cleary KR, et al: p53 gene mutations in Barrett's epithelium and esophageal cancer. Cancer Res 1991;51:4495-4499.
177. Ramel S, Reid BJ, Sanchez CA, et al: Evaluation of p53 protein expression in Barrett's esophagus by two-parameter flow cytometry. [comment in: Gastroenterology 1992;102 (4 Pt 1):1421-1424; Gastroenterology 1992;103:1121] Gastroenterology 1992;102 (4 Pt 1):1220-1228.
178. Neshat K, Sanchez CA, Galipeau PC, et al: p53 mutations in Barrett's adenocarcinoma and high-grade dysplasia. Gastroenterology 1994;106:1589-1595.
179. Younes M, Lebovitz RM, Lechago LV, Lechago J: p53 protein accumulation in Barrett's metaplasia, dysplasia, and carcinoma: a follow-up study. Gastroenterology 1993;105:1637-1642.
180. Chen PL, Riley DJ, Lee WH: The retinoblastoma protein as a fundamental mediator of growth and differentiation signals. Crit Rev Eukaryotic Gene Exp 1995;5:79-95.
181. Hunter T, Pines J: Cyclins and cancer II: cyclin D and CDK inhibitors come of age. [Review] [comment in: Cell 1994;79:547-550] Cell 1994;79:551-555.
182. Ewen ME: The cell cycle and the retinoblastoma protein family. [Review] Cancer Metastasis Rev 1994;13:45-66.
183. Jiang W, Zhang YJ, Kahn SM, et al: Altered expression of the cyclin D1 and retinoblastoma genes m human esophageal cancer. Proc Natl Acad Sci USA 1993;90:9026-9030.
184. Kamb A, Gruis NA, Weaver-Feldhaus J, et al: A cell cycle regulator potentially involved in genesis of many tumor types. Science 1994;264(5157) 436-440.
185. Marx J: New tumor suppressor may rival p53. [news] Science 1994;264.344-345.
186. Zhou X, Tannin L, Yin J, et al: The MTS1 gene is frequently mutated in primary human esophageal tumors. Oncogene 1994; 9:3737-3741.
187. Gonzalez-Zulueta M, Bender CM, Yang AS, et al: Methylation of the 5′ CpG island of the p16/CDKN2 tumor suppressor gene in normal and transformed human tissues correlates with gene silencing. Cancer Res 1995;55:4531-4535
188. Lukas J, Aagaard L, Strauss M, Bartek J: Oncogenic aberrations of p16INK4/CDKN2 and cyclin D1 cooperate to deregulate G1 control. Cancer Res 1995;55:4818-4823.
189. Fearon ER, Cho KR, Nigro JM, et al: Identification of a chromosome 18q gene that is altered in colorectal cancers. Science 1990;247(4938):49-56.