Recruitment of multiple Vβ genes in the TCR repertoire against a single pathogenic thyroglobulin epitope

Immunology

Volumn 91, Issue 4, 1997, Pages 623-627

  Rao, V P ^a   Russell, R S ^a   Carayanniotis, G ^a,b  

^a MEMORIAL UNIVERSITY OF NEWFOUNDLAND   (Canada)

^b MEMORIAL UNIVERSITY OF NEWFOUNDLAND   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIGEN; EPITOPE; T LYMPHOCYTE RECEPTOR; THYROGLOBULIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; FEMALE; HASHIMOTO DISEASE; HELPER CELL; LYMPH NODE CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE RECEPTOR GENE; T LYMPHOCYTE SUBPOPULATION;

EID: 0030791260     PISSN: 00192805     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2567.1997.00293.x     Document Type: Article

References (37)

1. COOKE A. (1991) Is there restricted T cell receptor usage in autoimmune disease? Clin Exp Immunol 83, 345.
2. GOLD D.P. (1994) TCR V gene usage in autoimmunity. Curr Opin Immunol 6, 907.
3. KONO D.H. & THEOFILOPOULOS, A.N. (1993) T cell antigen receptor and autoimmunity. In: The Molecular Pathology of Autoimmune Diseases (eds C.A. Bona, K.A. Siminovitch, M. Zanetti & A.N. Theofilopoulos) p. 113. Hardwood Academic Publishers, Langhorne, PA.
4. DAVIES T.F., MARTIN A., CONCEPCION E.S., GRAVES P., COHEN L. & BEN-NUN A. (1991) Evidence of limited variability of antigen receptors on intrathyroidal T cells in autoimmune thyroid disease. N Engl J Med 325, 238.
5. DAVIES T.F., MARTIN A., CONCEPCION, E.S. et al. (1992) Evidence for selective accumulation of intrathyroidal T lymphocytes in human autoimmune thyroid disease based on T cell receptor V gene usage. J Clin Invest 89, 157.
6. DAVIES T.F., CONCEPCION E.S., BEN-NUN A., GRAVES P.N. & TARJAN G. (1993) T-cell receptor V gene use in autoimmune thyroid disease: Direct assessment by thyroid aspiration. J Clin Endocrinol Metab 76, 660.
7. MCINTOSH R.S., WATSON P.F., PICKERILL A.P., DAVIES R. & WEETMAN A.P. (1993) No restriction of intrathyroidal T cell receptor Vα families in the thyroid of Graves' disease. Clin Exp Immunol 91, 147.
8. CASO-PELÁEZ E., MCGREGOR A.M. & BANGA J.P. (1995) A polyclonal T cell repertoire of V-alpha and V-beta T cell receptor gene families in intrathyroidal T lymphocytes of Graves' disease patients. Scand J Immunol 41, 141.
9. MATSUOKA N., BERNARD N., CONCEPCION E.S., GRAVES P.N., BENNUN A. & DAVIES T.F. (1993) T-cell receptor V region β-chain gene expression in the autoimmune thyroiditis of non-obese diabetic mice. J Immunol 151, 1691.
10. SUGIHARA S., FUJIWARA H. & SHEARER G.M. (1993) Autoimmune thyroiditis induced in mice depleted of particular T cell subsets: Characterization of thyroiditis-inducing T cell lines and clones derived from thyroid lesions. J Immunol 150, 683.
11. MATSUOKA N., UNGER P., BEN-NUN A., GRAVES P. & DAVIES T.F. (1994) Thyroglobulin-induced murine thyroiditis assessed by intrathyroidal T cell receptor sequencing. J Immunol 152, 2562.
12. MCMURRAY R.W., HOFFMAN R.W., TANG H.W. & BRALEY-MULLEN H. (1996) T cell receptor Vβ usage in murine experimental autoimmune thyroiditis. Cell Immunol 172, 1.
13. RAO V.P., BALASA B. & CARAYANNIOTIS G. (1994) Mapping of thyroglobulin epitopes: Presentation of a 9mer pathogenic peptide by different mouse MHC class II isotypes. Immunogenetics 40, 352.
14. BEHLKE M.A., CHOU H.S., HUPPI K. & LOH D.Y. (1986) Murine T-cell receptor mutants with deletions of β-chain variable region genes. Proc Natl Acad Sci USA 83, 767.
15. CHRONOPOULOU E. & CARAYANNIOTIS G. (1992) Identification of a thyroiditogenic sequence within the thyroglobulin molecule. J Immunol 149, 1039.
16. KUPPERS R.C. HU Q. & ROSE N.R. (1996) Mouse thyroglobulin: Conservation of sequence homology in C-terminal immunogenic regions of thyroglobulin. Autoimmunity 23, 175.
17. + B cell hybridomas to H-2 restricted T cell hybridomas. Proc Natl Acad Sci USA 79, 3604.
18. GILLIS S. & SMITH K.A. (1977) Long term culture of tumor-specific cytotoxic T cells. Nature 268, 154.
19. WHITE J., BLACKMAN M., BILL, J. et al. (1989) Two better lines for making hybridomas expressing specific T cell receptors. J Exp Med 143, 1822.
20. RAO V.P. & CARAYANNIOTIS G. (1997) Contrasting immunopathogenic properties of highly homologous peptides from rat and human thyroglobulin. Immunology 90, 244.
21. WATERS S.H., O'NEIL J.J., MELICAN D.T. & APPEL M.C. (1992) Multiple TCR Vβ usage by infiltrates of young NOD mouse islets of Langerhans: A polymerase chain reaction analysis. Diabetes 41, 308.
22. CASANOVA J.-L., ROMERO P., WIDMANN C., KOURILSKY P. & MARYANSKI J.L. (1991) T cell receptor genes in a series of class I major histocompatibility complex-restricted cytotoxic lymphocyte clones specific for a Plasmodium berghei nonapeptide: implications for T cell allelic exclusion and antigen-specific repertoire. J Exp Med 174, 1371.
23. JU S.-T., PANKA D.J. CUI, H. et al. (1995) Fas (CD95)/FasL interactions required for programmed cell death after T-cell activation. Nature 373, 444.
24. NAKASHIMA M., KONG Y.C.M. & DAVIES T.F. (1996) The role of T cells expressing TcR Vβ13 in autoimmune thyroiditis induced by transfer of mouse thyroglobulin-activated lymphocytes: identification of two common CDR3 motifs. Clin Immunol Immunopathol 80, 204.
25. CARAYANNIOTIS G. & RAO V.P. (1997) Searching for pathogenic thyroglobulin T-cell epitopes: parameters and caveats. Immunol Today 18, 83.
26. LOMO L.C., MOTTE R.W., GIRALDO, A.A. et al. (1996) Vβ8.2 transgene expression interferes with development of experimental autoimmune thyroiditis in CBA k/q but not k/k mice. Cell Immunol 168, 297.
27. WEETMAN A.P. & MCGREGOR A.M. (1994) Autoimmune thyroid disease: Further developments in our understanding. Endocr Rev 15, 788.
28. DAVIES T.F. (1995) T-cell receptor gene expression in autoimmune thyroid disease: Some observations and possible mechanisms. Ann NY Acad Sci 756, 331.
29. DUNN T.B., MOLONEY J.B., GREEN A.W. & ARNOLD B. (1961) Pathogenesis of a virus-induced leukemia in mice. J Natl Cancer Inst 26, 189.
30. VLADUTIU A.O. & ROSE N.R. (1972) Aberrant thymus tissue in rat and mouse thyroid. Experientia 28, 79.
31. KARIN N., SZAFER F., MITCHELL D., GOLD D.P. & STEINMAN L. (1993) Selective and nonselective stages in homing of T lymphocytes to the central nervous system during experimental allergic encephalomyelitis. J Immunol 150, 4116.
32. SU X. & SRIRAM S. (1992) Analysis of TCR Vβ gene usage and encephalitogenicity of myelin basic protein peptide p91-103 reactive T cell clones in SJL mice: Lack of evidence for V gene hypothesis. Cell Immunol 141, 485.
33. BELL R.B., LINDSEY J.W., SOBEL R.A., HODGKINSON S. & STEINMAN L. (1993) Diverse T cell receptor Vβ gene usage in the cental nervous system in experimental allergic encephalomyelitis. J Immunol 150, 4085.
34. KUCHROO V.K., SOBEL R.A., LANING, J.C. et al. (1992) Experimental allergic encephalomyelitis mediated by cloned T cells specific for a synthetic peptide of myelin proteolipid protein: fine specificity and T cell receptor Vβ usage. J Immunol 148, 3776.
35. SOBEL R.A. & KUCHROO V.K. (1992) The immunopathology of acute experimental allergic encephalomyelitis induced in inflammatory lesions. J Immunol 149, 1444.
36. LEHMANN P.V., SERCARZ E.E., FORSTHUBER, T., DAYAN C.M. & GAMMON G. (1993) Determinant spreading and the dynamics of the autoimmune T-cell repertoire. Immunol Today 14, 203.
37. OLDSTONE M.B.A. (1987) Molecular mimicry and autoimmune disease. Cell 50, 819.