Pharmacodynamic modelling of the analgesic effects of piritramide in postoperative patients

Acta Anaesthesiologica Scandinavica

Volumn 41, Issue 7, 1997, Pages 888-894

  Kietzmann, D ^a   Bouillon, T ^a   Hamm, C ^a   Schwabe, K ^b   Schenk, H ^b   Gundert Remy, U ^a   Kettler, D ^a  

^a UNIVERSITY OF GÖTTINGEN   (Germany)

^b EVANGELISCHES KRANKENHAUS   (Germany)

Author keywords

Analgesics; Opioids; Pharmacokinetic pharmacodynamic modeling; Piritramide; Postoperative pain

Indexed keywords

OPIATE; PIRITRAMIDE;

ABDOMINAL SURGERY; ADULT; AGED; ANALGESIC ACTIVITY; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; DOSE TIME EFFECT RELATION; DRUG EFFECT; FEMALE; HUMAN; HYSTERESIS; INHALATIONAL DRUG ADMINISTRATION; INTRAVENOUS DRUG ADMINISTRATION; MALE; MODEL; PHARMACODYNAMICS; POSTOPERATIVE PAIN; PRIORITY JOURNAL;

EID: 0030791069     PISSN: 00015172     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1399-6576.1997.tb04805.x     Document Type: Article

References (23)

1. Saarne A. Clinical evaluation of the new analgesic piritramide. Acta Anaesthesiol Scand 1969: 13: 11-19.
2. Weyne F, Schluter J, Lust P. Piritramide, a potent postoperative analgesic with unusually low respiratory depressant, cardiovascular and emetic effects. Acta Anaesthesiol Belg 1968: 1: 33-45.
3. Gibb DB, Pickler N. Piritramide - a new long-acting analgesic. Anaesth Intensive Care 1973: 1: 308-314.
4. Kay B. A clinical investigation of piritramide in the treatment of postoperative pain. Br J Anaesth 1971: 43: 1167-1171.
5. Kietzmann D, Briede I, Bouillon T, Gundert-Remy U, Kettler D. Pharmacokinetics of piritramide after an intravenous bolus in surgical patients. Acta Anaesthesiol Scand 1996: 40 (part I): 898-903.
6. Michaelis HC, Kietzmann D, Neurath H, Jongepier U, Schilling B. Sensitive determination of piritramide in human plasma by gas chromatography. J Chromatogr Biomed Appl 1991: 571: 257-262.
7. Hull CJ, van Beem H, McLeod K, Watson MJ. A pharmacodynamic model for pancuronium. Br J Anaesth 1978: 50: 1113-1123.
8. Sheiner LB, Stanski DR, Vozeh S, Miller RD, Ham J. Simultaneous modeling of pharmacokinetics and pharmacodynamics: Application to d-tubocurarine. Clin Pharmacol Ther 1979: 25: 358-371.
9. P-PHARM User's guide. Creteil Cedex France: SIMED, 1994.
10. Yamaoka K, Nakagawa T, Uno T. Application of Akaike's Information Criterion (AIC) in the evaluation of linear pharmacokinetic equations. J Pharmacokinet Biopharm 1978: 6: 165-175.
11. Holford NHG, Sheiner LB. Kinetics of pharmacologic response. Pharmacol Ther 1982: 16: 143-166.
12. Scott JC, Stanski DR. Decreased fentanyl and alfentanil requirements with age. A simultaneous pharmacokinetic and pharmacodynamic evaluation. J Pharmacol Exp Ther 1987: 240: 159-166.
13. Maitre PO, Vozeh S, Heykants J, Thomson DA, Stanski DR. Population pharmacokinetics of alfentanil: The average dose-plasma concentration relationship and interindividual variability in patients. Anesthesiology 1987: 66: 3-12.
14. Gepts E, Shafer SL, Camu F, Stanski DR, Woestenborghs R, van Peer A, et al. Linearity of pharmacokinetics and model estimation of sufentanil. Anesthesiology 1995: 83: 1194-1204.
15. Scott JC, Cooke JE, Stanski DR. Electroencephalographic quantitation of opioid effect: Comparative dynamics of fentanyl and sufentanil. Anesthesiology 1991: 74: 34-42.
16. Duranti R, Pantaleo T, Bellini F, Bongianni F, Scano G. Respiratory responses induced by the activation of somatic nociceptive afferents in humans. J Appl Physiol 1991: 71: 2440-2448.
17. Flor H, Birbaumer N. Multifaktorielle Determination des Schmerzes. In: Zenz M, Jurna J, eds. Lehrbuch der Schmerztherapie. Stuttgart: Wissenschaftliche Verlagsgesellschaft mbH, 1993: 95.
18. Inturrisi CE. Pharmacokinetic considerations in analgesic study design. In: Max MB, Portenoy RK, Laska E, eds. Advances in pain research and therapy: The design of analgesic clinical trials (chapter). New York: Raven, 1991: 533-558.
19. Hughes MA, Glass PSA, Jacobs JR. Context-sensitive half-time in multicompartment pharmacokinetic models for intravenous anesthetic drugs. Anesthesiology 1992: 76: 334-341.
20. Kapila A, Glass PSA, Jacobs JR, Muirk T, Hermann DJ, Shiraishi M, et al. Measured context-sensitive half-times of remifentanil and alfentanil. Anesthesiology 1995: 83: 968-975.
21. Kwentus JA, Harkins SW, Lignon N, Silverman JJ. Current concepts of geriatric pain and its treatment. Geriatrics 1985: 40: 48-57.
22. Scott JC, Stanski DR. Decreased fentanyl and alfentanil dose requirements with age. A simultaneous pharmacokinetic and pharmacodynamic evaluation. J Pharmacol Exp Ther 1987: 240: 159-166.
23. Gourlay GK, Wilson PR, Glynn CJ. Pharmacodynamics and pharmacokinetics of methadone during the perioperative period. Anesthesiology 1982: 57: 458-467.