Loss of high-molecular-weight proteins in liver microsomes of rats treated with hepatocarcinogens

Journal of Environmental Pathology, Toxicology and Oncology

Volumn 16, Issue 1, 1997, Pages 27-31

  Khongwir, Bertarand S ^a   Dani, Harinder M ^a   Dhanda, Jasbir S ^a  

^a PANJAB UNIVERSITY   (India)

Author keywords

Carcinogenicity; Hepatocarcinogens; Microsomal degranulation; Microsomal proteins; Polyribosomes

Indexed keywords

4 DIMETHYLAMINOAZOBENZENE; PHENOBARBITAL; SEPHADEX;

ANIMAL EXPERIMENT; ARTICLE; CELL CYCLE; CELL DIVISION; LIVER MICROSOME; LIVER TOXICITY; MOLECULAR WEIGHT; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; RAT; TOXICITY TESTING;

2-ACETYLAMINOFLUORENE; ADMINISTRATION, ORAL; ANIMALS; CARCINOGENS; FEMALE; INJECTIONS, INTRAPERITONEAL; LIVER; MICROSOMES, LIVER; MOLECULAR WEIGHT; P-DIMETHYLAMINOAZOBENZENE; PROTEIN BIOSYNTHESIS; PROTEINS; RATS; RATS, WISTAR;

ANIMALIA;

EID: 0030790990     PISSN: 07318898     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (18)

1. Butler WM. Early hepatic parenchymal changes induced in the rat by aflatoxin B. Am J Pathol 1966; 49:113-119.
2. Purchase IFH, Longstaff E, Ashby J, Styles JA, Anderson A, Lefevre PA, Westwood FR. An evaluation of six short-term tests for detecting chemical carcinogens. Br J Cancer 1978; 37: 873-959.
3. Dani HM, Sharma S, Neelam, Harkirat. Anticarcinogenicity of flavonoids as studied by inhibition of lipid peroxidation, microsomal degranulation and their interaction with benzo(a) pyrene metabolites. In: Ong ASH, Packer L, eds. Lipid-soluble antioxidants: Biochemistry and clinical applications. Boston: Birkhauser Verlag, 1992: 320-329.
4. Gupta MM, Dani HM. Efficient prediction of chemical carcinogenicity by microsomal degranulation technique. Toxicol Lett 1986; 30:167-172.
5. Gupta R, Dani HM. 4-Dimethylaminoazobenzene interferes with the binding of ribosomes to reticular membranes. Toxicol Lett 1988; 42:73-78.
6. Rabin BR, Fey EG, White HA. Detection in vitro of carcinogens and tumour promoters. In: Gorrod JW, ed. Testing for toxicity. London: Taylor and Francis, 1981: 337-349.
7. Kunz W, Shaude G, Thomas C. The effect of phenobarbital and halogenated hydrocarbons on nitrosamine carcinogenesis. A. Krebsforsch 1969; 72:291-304.
8. Periano C, Fry RJM, Staffeldt E. Reduction and enhancement by phenobarbital of hepatocarcinogenesis induced in rat by 2-acetylaminofluorene. Cancer Res 1971; 31:1506-1512.
9. Periano C, Fry RJM, Staffeldt E. Effects of the onset and duration of exposure to phenobarbital on its enhancement of 2-acetyl-aminofluorene induced hepatic tumorigenesis. Cancer Res 1977; 37:3623-3627.
10. Periano C, Fry RJM, Staffeldt E, Kisielski WE. Effects of varying exposure to phenobarbital on its enhancement of 2-acetylaminofluorene-induced hepatic tumorigenesis in the rats. Cancer Res 1971; 33:2701-2705.
11. Schenkman JB, Cinti DL. Hepatic mixed function oxidase activity in rapidly prepared microsomes. Life Sci 1972; 11:247-252.
12. Jones THD, Kennedy EP. Characterization of the membrane protein component of the lactose transport system in Escherichia coli. J Biol Chem 1969; 244:5981-5987.
13. Blackburn GR, Bornens M, Kasper CB. Characterization of the membrane matrix derived from the microsomal fractions of rat hepatocytes. Biochem Biophys Acta 1976; 436:387-398.
14. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ. Protein measurement with the Folin phenol reagent. J Biol Chem 1951; 193:265-275.
15. Beck WT, Dedmon ML, Oufiletic MA. Biochemical basis for improved drug metabolism in tumour-bearing rats: evidence for altered regulation of hepatic microsomal hemoprotein synthesis. Biochem Pharmacol 1982; 31:1535-1543.
16. De Bruin A. Chemical carcinogenesis: nature, mechanisms, biological features and interaction with nucleic acids. In: Bruin AD, ed. Biochemical toxicology of environmental agents. New York: Elsevier/North Holland, 1976: 1307-1344.
17. De Pierre J, Dallner G. Biochemical methods in membrane studies. In: Maddy AH, ed. London: Chapman and Hall, 1975: 88.
18. Sharma S, Dani HM. Interference in the binding of ribosomes to reticular membranes by tannic acid. J Ind Ins Sci 1994; 74:777-779