Genetic predictors of common disease: Apolipoprotein E genotype as a paradigm

Annals of Epidemiology

Volumn 7, Issue 5, 1997, Pages 357-362

  Jarvik, Gail Pairitz ^a  

^a UNIVERSITY OF WASHINGTON MEDICAL CENTER   (United States)

Author keywords

Alzheimer Disease; Apolipoprotein E; Genetic Polymorphisms; Review; Serum Lipids

Indexed keywords

APOLIPOPROTEIN E; LIPID;

ALZHEIMER DISEASE; ARTICLE; CORONARY ARTERY DISEASE; GENE FREQUENCY; GENETIC MARKER; GENETIC POLYMORPHISM; GENOTYPE; HUMAN; HYPERLIPIDEMIA; PRIORITY JOURNAL;

EID: 0030790913     PISSN: 10472797     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1047-2797(97)00028-8     Document Type: Article

References (39)

1. Sing CF, Davignon J. Role of the apolipoprotein E polymorphism in determining normal plasma lipid and lipoprotein variation. Am J Hum Genet. 1985;37:268-285.
2. Zannis VI, Just PW, Breslow JL. Human apolipoprotein E isoprotein subclasses are genetically determined. Am J Hum Genet. 1981; 33:11-24.
3. Cumming AM, Robertson FW. Genetics of the apolipoprotein-E isoprotein system in man. J Med Genet. 1982;19:417-423.
4. Mahley RW. Apolipoprotein E and cholesterol metabolism. Klin Wochenschr. 1983;61:225-232.
5. Gregg RE, Zech LA, Schaefer EJ, Stark D, Wilson D, Brewer HB, Jr. Abnormal in vivo metabolism of apolipoprotein E4 in humans. J Clin Invest. 1986;78:815-821.
6. Demant T, Bedford D, Packard CJ, Shepherd J. Influence of apolipoprotein E polymorphism on apolipoprotein B-100 metabolism in normolipemic subjects. J Clin Invest. 1991;88:1490-1501.
7. Utermann G. Morgagni Lecture: Genetic polymorphism of apolipoprotein E - Impact on plasma lipoprotein metabolism. In: G. Crepaldi, Editor. Diabetes, Obesity and Hyperlipidemias. New York: Elsevier; 1985:1-28.
8. Davignon J, Gregg RE, Sing CF. Apolipoprotein E polymorphism and atherosclerosis. Arteriosclerosis. 1988;8:1-21.
9. Boerwinkle E, Sing CF. The use of measured genotype information in the analysis of quantitative phenotypes in man. III. Simultaneous estimation of the frequencies and effects of the apolipoprotein E polymorphism and residual polygenetic effects on cholesterol, betalipoprotein and triglyceride levels. Ann Hum Genet. 1987;51(Pt 3):211-226.
10. Davignon J, Bouthillier D, Nestruck AC, Sing CF. Apolipoprotein E polymorphism and atherosclerosis: Insight from a study in octogenarians. Trans Am Clin Climatol Assoc. 1987;99:100-110.
11. Mahley RW. Apolipoprotein E: Cholesterol transport protein with expanding role in cell biology. Science. 1988;240:622-630.
12. Cumming AM, Robertson FW. Polymorphism at the apoprotein-E locus in relation to risk of coronary disease. Clin Genet. 1984; 25:310-313.
13. Lenzen HJ, Assmann G, Buchwalsky R, Schulte H. Association of apolipoprotein E polymorphism, low-density lipoprotein cholesterol, and coronary artery disease. Clin Chem. 1986;32:778-781.
14. Kuusi T, Nieminen MS, Ehnholm C, Yki Jarvinen H, Valle M, Nikkila EA, Taskinen MR. Apoprotein E polymorphism and coronary artery disease. Increased prevalence of apolipoprotein E-4 in angiographically verified coronary patients. Arteriosclerosis. 1989;9:237-241.
15. Corder EH, Saunders AM, Strittmatter WJ. Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families [see comments]. Science. 1993;261:921-923.
16. Poirier J, Davignon J, Bouthillier D, Kogan S, Bertrand P, Gauthier S. Apolipoprotein E polymorphism and Alzheimer's disease [see comments]. Lancet. 1993;342:697-699.
17. Saunders A, Strittmatter W, Schmechel D, St. George H, Pericak-Vance M, Joo S. Association of apolipoprotein E allele epsilon 4 with late onset familial and sporadic Alzheimer's disease. Neurology. 1993;43:1467-1472.
18. Tsai MS, Tangalos EG, Petersen RC, Smith GE, Schaid D, Kokmen E, et al. Apolipoprotein E: risk factor for Alzheimer disease. Am J Hum Genet. 1994;54:643-649.
19. Yu CE, Payami H, Olson JM, Buehnke M, Wijsman EM, Orr HT, et al. The apolipoprotein E/CI/CII gene cluster and late-onset Alzheimer disease. Am J Hum Genet. 1994;54:631-642.
20. van Duijn CM, de Knijff P, Cruts M, Whehnert A, Havekes L, Hofman A, et al. Apolipoprotein E4 allele in a population-based study of early-onset Alzheimer's disease [see comments]. Nat Genet. 1994;7:74-78.
21. Corder EH, Saunders AM, Risch NJ, Strittmatter WJ, Schmechel DE, Gaskell P, et al. Protective effect of apolipoprotein E type 2 allele for late onset Alzheimer disease. Nat Genet. 1994;7:180-184.
22. Jarvik GP, Wijsman EM, Kukull WA, Schellenberg GD, Yu C, Larson EB. Interactions of apolipoprotein E genotype, total cholesterol level, age, and sex in prediction of Alzheimer's disease: A case-control study. Neurology. 1995;45:1092-1096.
23. Namba Y, Tomonaga M, Kawasaki H, Otomo E, Ikeda K. Apolipoprotein E immunoreactivity in cerebral amyloid deposits and neurofibrillary tangles in Alzheimer's disease and kuru plaque amyloid in Creutzfeldt-Jakob disease. Brain Res. 1991;541:163-166.
24. Strittmatter WJ, Saunders AM, Schmechel D, Pericak VM, Enghild J, Salvesen GS, et al. Apolipoprotein E: High-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease. Proc Natl Acad Sci USA. 1993;90:1977-1981.
25. Han SH, Einstein G, Weisgraber KH, Strittmatter WJ, Saunders AM, Pericak VM, et al. Apolipoprotein E is localized to the cytoplasm of human cortical neurons: A light and electron microscopic study. J. Neuropathol Exp Neurol. 1994;53:535-544.
26. Fleming LM, Weisgraber KH, Strittmatter WJ, Troncoso JC, Johnson GV. Differential binding of apolipoprotein E isoforms to tau and other cytoskeletal proteins. Exp Neurol. 1996;138:252-260.
27. Cauley JA, Eichner JE, Kamboh MI, Ferrell RE, Kuller LH. Apo E allele frequencies in younger (age 42-50) vs older (age 65-90) women. Genet Epidemiol. 1993;10:27-34.
28. Schachter F, Faure Delanef L, Gu'enot F, Rouget H, Froguel P, Lesueur GL, et al. Genetic associations with human longevity at the APOE and ACE loci. Nat Genet. 1994;6:29-32.
29. Stengard JH, Zerba KE, Pekkanen J, Ehnholm C, Nissinen A, Sing CF. Apolipoprotein E polymorphism predicts death from coronary heart disease in a longitudinal study of elderly Finnish men. Circulation 1995;91:265-269.
30. Jarvik GP, Austin MA, Fabsitz RR, Auwerx J, Reed T, Christian JC, Deeb S. Genetic influences on age-related change in total cholesterol, low density lipoprotein-cholesterol, and triglyceride levels: Longitudinal apolipoprotein E genotype effects. Genet Epidemiol. 1994;11: 375-384.
31. Jarvik GP, Goode EL, Austin MA, Auwerx J, Deeb S, Schellenberg GD, et al. Evidence that the apolipoprotein E genotype effects on lipid levels can change with age in males: A longitudinal analysis. Am J Human Genetics. 1997 (in press).
32. Reilly SL, Ferrell RE, Kottke BA, Sing CF. The gender-specific apolipoprotein E genotype influence on the distribution of plasma lipids and apolipoproteins in the population of Rochester, Minnesota. II. Regression relationships with concomitants. Am J Hum Genet. 1992;51:1311-1324.
33. Zerba K, Ferrell R, Sing C. Genotype-environment interaction: Apolipoprotein E (ApoE) gene effects and age as an index of time and spatial context in the human. Genetics. 1996;143:463-478.
34. Jarvik G., Larson EB, Goddard K, Kukull WA, Schellenberg GD, Wijsman E. Influence of apolipoprotein E genotype on the transmission of Alzheimer disease in a community-based sample. Am J Hum Genet. 1996;58:191-200.
35. Gueguen R, Visvikis S, Steinmetz J, Siest G, Boerwinkle E. An analysis of genotype effects and their interactions by using the apolipoprotein E polymorphism and longitudinal data. Am J Hum Genet. 1989; 45:793-802.
36. Lehtimaki T, Moilanen T, Solakivi T, Laippala P, Ehnholm C. Cholesterol-rich diet induced changes in plasma lipids in relation to apolipoprotein E phenotype in healthy students. Ann Med. 1992;24:61-66.
37. Uusitupa MI, Ruuskanen E, Makinen E, Laitinen J, Toskala E, Kervinenk, et al. A controlled study on the effect of beta-glucan-rich oat bran on serum lipids in hypercholesterolemic subjects: Relation to apolipoprotein E phenotype. J Am Coll Nutr. 1992;11:651-659.
38. Jenkins DJ, Hegele RA, Jenkins AL, Connelly PW, Hallak K, Bracci P, et al. The apolipoprotein E gene and the serum low-density lipoprotein cholesterol response to dietary fiber. Metabolism. 1993;42:585-593.
39. Lopez Miranda J, Ordovas JM, Mata P, Lichtenstein AH, Clevidence B, Judd JT, et al. Effect of apolipoprotein E phenotype on diet-induced lowering of plasma low density lipoprotein cholesterol. J Lipid Res. 1994;35:1965-1975.