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Volumn 132, Issue 2, 1997, Pages 187-197

Antiatherogenic effects of long-term benfluorex treatment in male insulin resistant JCR:LA-cp rats

Author keywords

Atherosclerosis; Benfluorex; Insulin resistance; JCR:LA cp rat; Myocardial lesions

Indexed keywords

BENFLUOREX; CHOLESTEROL; CHOLESTEROL ESTER; INSULIN; TRIACYLGLYCEROL;

EID: 0030790134     PISSN: 00219150     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0021-9150(97)00092-0     Document Type: Article
Times cited : (16)

References (37)
  • 1
    • 0015891045 scopus 로고
    • Obese spontaneously hypertensive rats: A model for the study of atherosclerosis
    • Koletsky S. Obese spontaneously hypertensive rats: A model for the study of atherosclerosis. Exp Mol Pathol 1973;19:52-60.
    • (1973) Exp Mol Pathol , vol.19 , pp. 52-60
    • Koletsky, S.1
  • 2
    • 0016750056 scopus 로고
    • Pathological findings and laboratory data in a new strain of obese hypertensive rats
    • Koletsky S. Pathological findings and laboratory data in a new strain of obese hypertensive rats. Am J Pathol 1975;80:129-42.
    • (1975) Am J Pathol , vol.80 , pp. 129-142
    • Koletsky, S.1
  • 3
    • 0022873264 scopus 로고
    • Myocardial and vascular lesions in the LA/N-corpulent rat
    • Russell JC, Amy RM. Myocardial and vascular lesions in the LA/N-corpulent rat. Can J Physiol Pharmacol 1986;64:1270-80.
    • (1986) Can J Physiol Pharmacol , vol.64 , pp. 1270-1280
    • Russell, J.C.1    Amy, R.M.2
  • 4
    • 0023196820 scopus 로고
    • Serum lipids and lipoproteins in the atherosclerosis-prone LA/N-corpulent rat
    • Dolphin PJ, Stewart B, Amy RM, Russell JC. Serum lipids and lipoproteins in the atherosclerosis-prone LA/N-corpulent rat. Biochim Biophys Acta 1987;919:140-8.
    • (1987) Biochim Biophys Acta , vol.919 , pp. 140-148
    • Dolphin, P.J.1    Stewart, B.2    Amy, R.M.3    Russell, J.C.4
  • 5
    • 0024306038 scopus 로고
    • Plasma lipid secretion and clearance in the hyperlipidemic JCR:LA-corpulent rat
    • Russell JC, Koeslag DG, Amy RM, Dolphin PJ. Plasma lipid secretion and clearance in the hyperlipidemic JCR:LA-corpulent rat. Arteriosclerosis 1989;9:869-76.
    • (1989) Arteriosclerosis , vol.9 , pp. 869-876
    • Russell, J.C.1    Koeslag, D.G.2    Amy, R.M.3    Dolphin, P.J.4
  • 6
    • 0023507148 scopus 로고
    • Age-related qualitative and quantitative changes in the endocrine pancreas of the LA/N-corpulent rat
    • Ahuja SK, Manickavel V, Amy RM, Russell JC. Age-related qualitative and quantitative changes in the endocrine pancreas of the LA/N-corpulent rat. Diabetes Res 1987;6:137-44.
    • (1987) Diabetes Res , vol.6 , pp. 137-144
    • Ahuja, S.K.1    Manickavel, V.2    Amy, R.M.3    Russell, J.C.4
  • 7
    • 0023489310 scopus 로고
    • Insulin resistance and impaired glucose tolerance in the atherosclerosis-prone LA/N-corpulent rat
    • Russell JC, Ahuja SK, Manickavel V, Rajotte R, Amy RM. Insulin resistance and impaired glucose tolerance in the atherosclerosis-prone LA/N-corpulent rat. Arteriosclerosis 1987;7:620-6.
    • (1987) Arteriosclerosis , vol.7 , pp. 620-626
    • Russell, J.C.1    Ahuja, S.K.2    Manickavel, V.3    Rajotte, R.4    Amy, R.M.5
  • 8
    • 0023873247 scopus 로고
    • Atherogenesis in two strains of obese rats: The fatty Zucker and LA/N-corpulent
    • Amy RM, Dolphin PJ, Pederson RA, Russell JC. Atherogenesis in two strains of obese rats: The fatty Zucker and LA/N-corpulent. Atherosclerosis 1988;69:199-209.
    • (1988) Atherosclerosis , vol.69 , pp. 199-209
    • Amy, R.M.1    Dolphin, P.J.2    Pederson, R.A.3    Russell, J.C.4
  • 9
    • 0026403420 scopus 로고
    • Comparison of the enteroinsular axis in two strains of obese rats, the fatty Zucker and the JCR:LA-corpulent
    • Pederson RA, Campos RV, Buchan AMJ, Chisholm CB, Russell JC, Brown JC. Comparison of the enteroinsular axis in two strains of obese rats, the fatty Zucker and the JCR:LA-corpulent. Int J Obes 1991;15:461-70.
    • (1991) Int J Obes , vol.15 , pp. 461-470
    • Pederson, R.A.1    Campos, R.V.2    Buchan, A.M.J.3    Chisholm, C.B.4    Russell, J.C.5    Brown, J.C.6
  • 10
    • 0028299395 scopus 로고
    • Abnormal insulin and glucose metabolism in the JCR:LA-corpulent rat
    • Russell JC, Graham S, Hameed M. Abnormal insulin and glucose metabolism in the JCR:LA-corpulent rat. Metabolism 1994;43:538-43.
    • (1994) Metabolism , vol.43 , pp. 538-543
    • Russell, J.C.1    Graham, S.2    Hameed, M.3
  • 11
    • 0022525174 scopus 로고
    • Early atherosclerotic lesions in a susceptible rat model: The LA/N-corpulent rat
    • Russell JC, Amy RM. Early atherosclerotic lesions in a susceptible rat model: The LA/N-corpulent rat. Atherosclerosis 1986;60:119-29.
    • (1986) Atherosclerosis , vol.60 , pp. 119-129
    • Russell, J.C.1    Amy, R.M.2
  • 13
    • 0028290475 scopus 로고
    • Defective endothelium-dependent relaxation in the JCR:LA-corpulent rat
    • McNamee CJ, Kappagoda CT, Kunjara R, Russell JC. Defective endothelium-dependent relaxation in the JCR:LA-corpulent rat. Circ Res 1994;74:1126-32.
    • (1994) Circ Res , vol.74 , pp. 1126-1132
    • McNamee, C.J.1    Kappagoda, C.T.2    Kunjara, R.3    Russell, J.C.4
  • 14
    • 0025495639 scopus 로고
    • Effects of advancing age and severe food restriction on pathological processes in the insulin-resistant JCR:LA-corpulent rat
    • Russell JC, Koeslag DG, Manickavel V, Amy RM, Dolphin PJ. Effects of advancing age and severe food restriction on pathological processes in the insulin-resistant JCR:LA-corpulent rat. Diabetes Res 1990;15:53-62.
    • (1990) Diabetes Res , vol.15 , pp. 53-62
    • Russell, J.C.1    Koeslag, D.G.2    Manickavel, V.3    Amy, R.M.4    Dolphin, P.J.5
  • 15
    • 0029016886 scopus 로고
    • Inhibition of atherosclerosis and myocardial lesions in the JCR:LA-cp rat by β,β′-tetramethylhexadecanedioic acid (MEDICA 16)
    • Russell JC, Amy RM, Graham SE, Dolphin PJ, Bar-Tana J. Inhibition of atherosclerosis and myocardial lesions in the JCR:LA-cp rat by β,β′-tetramethylhexadecanedioic acid (MEDICA 16). Arterioscler Thromb Vasc Biol 1995;15:918-23.
    • (1995) Arterioscler Thromb Vasc Biol , vol.15 , pp. 918-923
    • Russell, J.C.1    Amy, R.M.2    Graham, S.E.3    Dolphin, P.J.4    Bar-Tana, J.5
  • 16
    • 0024548105 scopus 로고
    • Effects of chronic ethanol consumption in atherosclerosis-prone JCR:LA-corpulent rat
    • Russell JC, Amy RM, Manickavel V, Dolphin PJ. Effects of chronic ethanol consumption in atherosclerosis-prone JCR:LA-corpulent rat. Arteriosclerosis 1989;9:122-8.
    • (1989) Arteriosclerosis , vol.9 , pp. 122-128
    • Russell, J.C.1    Amy, R.M.2    Manickavel, V.3    Dolphin, P.J.4
  • 17
    • 0027503302 scopus 로고
    • Beneficial effects of acarbose in the atherosclerosis-prone JCR:LA-corpulent rat
    • Russell JC, Koeslag DG, Dolphin PJ, Amy RM. Beneficial effects of acarbose in the atherosclerosis-prone JCR:LA-corpulent rat. Metabolism 1993;42:218-23.
    • (1993) Metabolism , vol.42 , pp. 218-223
    • Russell, J.C.1    Koeslag, D.G.2    Dolphin, P.J.3    Amy, R.M.4
  • 18
    • 0025354137 scopus 로고
    • Prevention of myocardial lesions in JCR:LA-corpulent rats by nifedipine
    • Russell JC, Koeslag DG, Dolphin PJ, Amy RM. Prevention of myocardial lesions in JCR:LA-corpulent rats by nifedipine. Arteriosclerosis 1990;10:658-64.
    • (1990) Arteriosclerosis , vol.10 , pp. 658-664
    • Russell, J.C.1    Koeslag, D.G.2    Dolphin, P.J.3    Amy, R.M.4
  • 19
    • 0025998977 scopus 로고
    • Independence of myocardial disease in the JCR:LA-corpulent rat on plasma cholesterol concentration
    • Russell JC, Koeslag DG, Amy RM, Dolphin PJ. Independence of myocardial disease in the JCR:LA-corpulent rat on plasma cholesterol concentration. Clin Invest Med 1991;14:288-95.
    • (1991) Clin Invest Med , vol.14 , pp. 288-295
    • Russell, J.C.1    Koeslag, D.G.2    Amy, R.M.3    Dolphin, P.J.4
  • 20
    • 0026346889 scopus 로고
    • Effect of dietary n-3 fatty acids on atherosclerosis prone JCR:LA-corpulent rats
    • Russell JC, Amy RM, Dolphin PJ. Effect of dietary n-3 fatty acids on atherosclerosis prone JCR:LA-corpulent rats. Exp Mol Pathol 1991;55:285-98.
    • (1991) Exp Mol Pathol , vol.55 , pp. 285-298
    • Russell, J.C.1    Amy, R.M.2    Dolphin, P.J.3
  • 21
    • 0027238692 scopus 로고
    • Effect of castration on hyperlipidemic, insulin resistant JCR:LA-corpulent rats
    • Russell JC, Amy RM, Graham S, Wenzel LM, Dolphin PJ. Effect of castration on hyperlipidemic, insulin resistant JCR:LA-corpulent rats. Atherosclerosis 1993;199:113-22.
    • (1993) Atherosclerosis , vol.199 , pp. 113-122
    • Russell, J.C.1    Amy, R.M.2    Graham, S.3    Wenzel, L.M.4    Dolphin, P.J.5
  • 22
    • 6844238732 scopus 로고
    • Phenylethylamines and their effects on the synthesis of fatty acids, triacylglycerols and phospholipids
    • Curtis-Prior PB, editor. Amsterdam: Elsevier
    • Brindley DN, Phenylethylamines and their effects on the synthesis of fatty acids, triacylglycerols and phospholipids. In: Curtis-Prior PB, editor. Biochemical Pharmacology of Obesity, Amsterdam: Elsevier, 1983:285-308.
    • (1983) Biochemical Pharmacology of Obesity , pp. 285-308
    • Brindley, D.N.1
  • 23
    • 0000164082 scopus 로고
    • Antiobesity and lipid-lowering agents with antidiabetic activity
    • Bailey CJ, Flatt RP, editors. London: Smith-Gordon
    • Arnaud O, Nathan C. Antiobesity and lipid-lowering agents with antidiabetic activity. In: Bailey CJ, Flatt RP, editors. New Anti-Diabetic Drugs, London: Smith-Gordon, 1990:133-142.
    • (1990) New Anti-Diabetic Drugs , pp. 133-142
    • Arnaud, O.1    Nathan, C.2
  • 24
    • 0027484118 scopus 로고
    • Mechanisms for the effects of benfluorex on the obese-diabetic-dyslipidemic syndrome
    • Brindley DN. Mechanisms for the effects of benfluorex on the obese-diabetic-dyslipidemic syndrome. Diabetes Metab Rev 1993;9(Suppl 1):51S-6S.
    • (1993) Diabetes Metab Rev , vol.9 , Issue.1 SUPPL.
    • Brindley, D.N.1
  • 26
    • 0025785127 scopus 로고
    • Decreased serum lipids, serum insulin and triacylglycerol synthesis in adipose tissue of JCR:LA-corpulent rats treated with benfluorex
    • Brindley DN, Hales P, Al-Sieni AII, Russell JC. Decreased serum lipids, serum insulin and triacylglycerol synthesis in adipose tissue of JCR:LA-corpulent rats treated with benfluorex. Biochim Biophys Acta 1991;1085:119-25.
    • (1991) Biochim Biophys Acta , vol.1085 , pp. 119-125
    • Brindley, D.N.1    Hales, P.2    Al-Sieni, A.I.I.3    Russell, J.C.4
  • 27
    • 0012973004 scopus 로고    scopus 로고
    • Role of fatty acids, glucocorticoids and insulin resistance in the dyslipidaemia of the metabolic syndrome
    • Angel A, Anderson H, Bouchard C, Lau D, Leiter L, Mendelson R, editors. London: John Libbey
    • Brindley DN, Wang C-N. Role of fatty acids, glucocorticoids and insulin resistance in the dyslipidaemia of the metabolic syndrome. In: Angel A, Anderson H, Bouchard C, Lau D, Leiter L, Mendelson R, editors. Progress in Obesity Research 7, London: John Libbey, 1996:505-510.
    • (1996) Progress in Obesity Research 7 , pp. 505-510
    • Brindley, D.N.1    Wang, C.-N.2
  • 28
    • 0029121196 scopus 로고
    • Effects of dexamethasone on the synthesis, degradation, and secretion of apolipoprotein B in cultured rat hepatocytes
    • Wang C-N, McLeod RS, Yao Z, Brindley DN. Effects of dexamethasone on the synthesis, degradation, and secretion of apolipoprotein B in cultured rat hepatocytes. Arterioscler Thromb Vasc Biol 1995;15:1481-91.
    • (1995) Arterioscler Thromb Vasc Biol , vol.15 , pp. 1481-1491
    • Wang, C.-N.1    McLeod, R.S.2    Yao, Z.3    Brindley, D.N.4
  • 29
    • 0018163104 scopus 로고
    • Comparative determination of plasma cholesterol and triacylglycerol levels by automated gasliquid chromatographic and autoanalyzer techniques
    • Kuksis A, Myher JJ, Geher K, Hoffman AGD, Breckenridge WC, Jones GJL, Little JA. Comparative determination of plasma cholesterol and triacylglycerol levels by automated gasliquid chromatographic and autoanalyzer techniques. J Chromatogr 1978;146:393-412.
    • (1978) J Chromatogr , vol.146 , pp. 393-412
    • Kuksis, A.1    Myher, J.J.2    Geher, K.3    Hoffman, A.G.D.4    Breckenridge, W.C.5    Jones, G.J.L.6    Little, J.A.7
  • 30
    • 0018001339 scopus 로고
    • Simultaneous analysis of families of sigmoid dose-response curves: Application to bioassay, radioligand assay, and physiological dose-response curves
    • DeLean A, Munson PJ, Rodbard D. Simultaneous analysis of families of sigmoid dose-response curves: Application to bioassay, radioligand assay, and physiological dose-response curves. Am J Physiol 1978;235:E97-E102.
    • (1978) Am J Physiol , vol.235
    • DeLean, A.1    Munson, P.J.2    Rodbard, D.3
  • 31
    • 0342868089 scopus 로고
    • Anatomy and physiology of the endocrine pancreas
    • Kloppel G, Heitz PV, editors. Edinburgh: Churchill Livingston
    • Kloppel G, Lanzen S. Anatomy and physiology of the endocrine pancreas. In: Kloppel G, Heitz PV, editors. Pancreatic Pathology, Edinburgh: Churchill Livingston, 1984:133-153.
    • (1984) Pancreatic Pathology , pp. 133-153
    • Kloppel, G.1    Lanzen, S.2
  • 34
    • 0030460371 scopus 로고    scopus 로고
    • Effects of benfluorex on serum triacylglycerols and insulin sensitivity in the corpulent rat
    • Russell JC, Graham SE, Dolphin PJ, Brindley DN. Effects of benfluorex on serum triacylglycerols and insulin sensitivity in the corpulent rat. Can J Physiol Pharmacol 1996;74:879-86.
    • (1996) Can J Physiol Pharmacol , vol.74 , pp. 879-886
    • Russell, J.C.1    Graham, S.E.2    Dolphin, P.J.3    Brindley, D.N.4
  • 35
    • 0030582841 scopus 로고    scopus 로고
    • Evidence for posttrancriptional regulation of GLUT4 expression in muscle and adipose tissue from streptozotocin-induced diabetic and benfluorex-treated rats
    • Muñoz P, Chillarón J, Camps M, Castelló A, Furriols M, Testar X, Palacín M, Zorzano A. Evidence for posttrancriptional regulation of GLUT4 expression in muscle and adipose tissue from streptozotocin-induced diabetic and benfluorex-treated rats. Biochem Pharmacol 1996;52:1665-73.
    • (1996) Biochem Pharmacol , vol.52 , pp. 1665-1673
    • Muñoz, P.1    Chillarón, J.2    Camps, M.3    Castelló, A.4    Furriols, M.5    Testar, X.6    Palacín, M.7    Zorzano, A.8
  • 36
    • 0027489897 scopus 로고
    • Improvement of glucose tolerance of insulin resistant rats after chronic or acute administration of benfluorex
    • Lacour F, Espinal J, Arnaud O, Duhault J. Improvement of glucose tolerance of insulin resistant rats after chronic or acute administration of benfluorex. Life Sci 1993;53:1525-9.
    • (1993) Life Sci , vol.53 , pp. 1525-1529
    • Lacour, F.1    Espinal, J.2    Arnaud, O.3    Duhault, J.4
  • 37
    • 0024991998 scopus 로고
    • Classification of obese patients and complications related to distribution of surplus fat
    • Bjorntorp B. Classification of obese patients and complications related to distribution of surplus fat. Nutrition 1990;5:131-7.
    • (1990) Nutrition , vol.5 , pp. 131-137
    • Bjorntorp, B.1


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